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| 1 | Bone mineral density and disorders of mineral metabolism in chronic liver disease显示文摘AIM:To estimate the prevalence and identify the risk factors for metabolic bone disease in patients with cirrhosis.METHODS:The study was performed on 72 Indian patients with cirrhosis(63 male, 9 female;aged < 50 years).Etiology of cirrhosis was alcoholism(n = 37), hepatitis B(n = 25) and hepatitis C(n = 10).Twenty-three patients belonged to Child class A, while 39 were in class B and 10 in class C.Secondary causes for metabolic bone disease and osteoporosis were ruled out.Sunlight exposure, physical activity and dietary constituents were calculated.Complete metabolic profiles were derived, and bone mineral density(BMD) was measured using dual energy X ray absorptiometry.Low BMD was defined as a Z score below-2.RESULTS:Low BMD was found in 68% of patients.Lumbar spine was the most frequently and severely affected site.Risk factors for low BMD included low physical activity, decreased sunlight exposure, and low lean body mass.Calcium intake was adequate, with unfavorable calcium:protein ratio and calcium:phosphorus ratio.Vitamin D deficiency was highly prevalent(92%).There was a high incidence of hypogonadism(41%).Serum estradiol level was elevated significantly in patients with normal BMD.Insulin-like growth factor(IGF) 1 and IGF binding protein 3 levels were below the age-related normal range in both groups.IGF-1 was signiflcantly lower in patients with low BMD.Serum osteocalcin level was low(68%) and urinary deoxypyridinoline to creatinine ratio was high(79%), which demonstrated low bone formation with high resorption.CONCLUSION:Patients with cirrhosis have low BMD.Contributory factors are reduced physical activity, low lean body mass, vitamin D def iciency and hypogonadism and low IGF-1 level. | Joe George Hosahithlu K Ganesh Shrikrishna Acharya Tushar R Bandgar Vyankatesh Shivane Anjana Karvat Shobna J Bhatia Samir Shah Padmavathy S Menon Nalini Shah | 2009 | World Journal of Gastroenterology2009，15，28： | 15 |
| 2 | Current status of imaging in nonalcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is the most common diffuse liver disease, with a worldwide prevalence of 20% to 46%. NAFLD can be subdivided into simple steatosis and nonalcoholic steatohepatitis. Most cases of simple steatosis are non-progressive, whereas nonalcoholic steatohepatitis may result in chronic liver injury and progressive fibrosis in a significant minority. Effective risk stratification and management of NAFLD requires evaluation of hepatic parenchymal fat, fibrosis, and inflammation. Liver biopsy remains the current gold standard; however, non-invasive imaging methods are rapidly evolving and may replace biopsy in some circumstances. These methods include well-established techniques, such as conventional ultrasonography, computed tomography, and magnetic resonance imaging and newer imaging technologies, such as ultrasound elastography, quantitative ultrasound techniques, magnetic resonance elastography, and magnetic resonancebased fat quantitation techniques. The aim of this article is to review the current status of imaging methods for NAFLD risk stratification and management, including their diagnostic accuracy, limitations, and practical applicability. | Qian Li Manish Dhyani Joseph R Grajo Claude Sirlin Anthony E Samir | 2018 | World Journal of Hepatology2018，10，8： | 6 |
| 3 | Harvey, Phase pupil functions for reduction of defocus and spherical aberrations显示文摘 | Samir Mezouari and Andrew R | 2003 | Optics Express2003，28，10： | 1 |
| 4 | Wavelet based identification of dominant scales for self-affine road roughness in context of riding com- fort in vehicles显示文摘 | Sudib K Samir R | 2009 | Geotech Geol Eng2009，，26： | 1 |
| 5 | p53-dependentexpression of the stress-induced protein ( SIP) 显示文摘 | Tomasini R Samir A A Pebusque M J ef al | 2002 | Eur J CellBiol2002，81，5： | 1 |
| 6 | Pefformance of muhipath routing for on-demand protocols in mobile ad hoc networks 显示文摘 | Asis Nasipuri Robert Castaneda Samir R Das | 2001 | in ACM Mobile Networks and Applications(MONET)2001，5，： | 1 |
| 7 | A new cell secreting insulin显示文摘 | Sib S R Mohua M Samir B | 2003 | Endocrinology2003，4，144： | 1 |
| 8 | Detoxification of aflatoxin M1 in yoghurt using probiotics and lactic acidbacteria显示文摘 | Rafaat M E Samir A S Mohamed F R | 2014 | Food Control2014，43，： | 1 |
| 9 | Geometrical optical approach for electromngnetic wave propagation in rectangular mine tunnels显示文摘 | Samir F Mahmoud James R Wait | 1974 | Radio Science1974，9，12： | 1 |
| 10 | TP53INPIs and homeodomain-interaeting protein kinase-2(HIPK2) are partners in regulating p53 activity 显示文摘 | Tomasini R Samir AA Carrier A | 2003 | J Biol Chem2003，278，37： | 1 |
| 11 | Some experiences on the stabilization of Irish peats显示文摘 | Samir H Farrell E R | 2003 | Canadian Journal of Geogechnical Engineering2003，，40： | 1 |
| 12 | High - risk HPV infection and CIN grade correlates to the expression of c - myc, CD4 ^+ , FHIT, E - cad- herin, Ki- 67, and pl6INK4a 显示文摘 | Samir R Asplund A Tot T | 2011 | J Low Genit Tract Dis2011，15，4： | 1 |
| 13 | 显示文摘 | SAMIR B RAMY R HASSAN A E | 2008 | Eur J Med Chem2008，43，10： | 1 |
| 14 | Minimum inter- ference channel assignment in multi-radio wireless mesh networks 显示文摘 | Anandprabhu S Himanshu G Samir R D | 2008 | Mobile Computing2008，7，12： | 1 |
| 15 | L-Cysteine and sodium hydrosulphide inhibit spontaneous contractility in isolated pregnant rat uterine strips in vitro 显示文摘 | Sidhu R Singh M Samir G | 2001 | Pharmacology & Tox- icology2001，88，4： | 1 |
| 16 | A new view on the metastable zone width during cooling crystallization显示文摘 | Somnath S K Samir A K Roger C R | | 0，，： | 1 |
| 17 | Performance comparison of two on-demand routing protocols for ad hoc networks显示文摘 | Chareles E Perkins Elizabeth M Royer Samir R Das | 2001 | IEEE Personal Communications Special Issue on Advances in Mobile Ad Hoc Networking2001，8，1： | 1 |
| 18 | Anomalous pancreatico biliary junction-report of a new experimental model and review of the literature显示文摘 | Tahar B Samir S Brigit R | 1996 | J Pediatr Surg1996，31，2： | 1 |
| 19 | High-risk HPV infection and CIN grad correlates to the expression of c-myc, CD4^ + , FHIT, E-cadherin, Ki-67,and P16 ink4 显示文摘 | Samir R Asplund A Tot T | 2011 | Low Genit Tract Dis2011，15，4： | 1 |
| 20 | L-cysteine and sodium hydrosulphide inhibit spontaneous contractility in isolated pregnant rat uterine strips in vitro 显示文摘 | Sidhu R Singh M Samir G | 2001 | Pharmacol Toxi- col2001，88，4： | 1 |
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