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| 1 | Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy显示文摘This review summarizes the safety and efficacy of statins in patients with cirrhosis.Due to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in cirrhosis.The most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver function.Rhabdomyolysis is the most serious and potentially life-threatening manifestation.It has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle injury.Likewise,simvastatin should not be administered to patients with Model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle injury.Due to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something useful.Through these effects,statins could prevent liver-related morbidity and mortality in cirrhotic patients.Observational studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and death.The few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic resistance.Another large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival rate.Despite these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies involved.Therefore,it is advisable to perform further randomized controlled trials on a large series of patients with hard clinical endpoints,using different statin types and varying doses.The objectives would be to prevent liver-related morbidity and mortality rather than treating cirrhosis complications to take additional information that makes it possible to add statins to the standard of care of these patients. | Alberto E Muñoz Florencia D Pollarsky Mónica Marino Mariano Cartier Horacio Vázquez Pablo Salgado Gustavo Romero | 2021 | World Journal of Gastroenterology2021，27，28： | 4 |
| 2 | The value of Cockcroft-Gault equation for the screening of decreased renal function in patients w ith systemic arterial hypertension显示文摘 | Santos E M Franca A K Salgado J V | 2011 | J Bras Nefrol2011，33，3： | 1 |
| 3 | A summary of the report on survey of controls and control performance in HVDC schemes显示文摘 | Szechtman M Ping W W Salgado E | 1994 | Electra1994，，155： | 1 |
| 4 | Genetic purity certificate in seeds of hybrid maize using molecular markers显示文摘 | Salgado K C P C Vieira M G G C Pinho E V R V | 2006 | Revista Brasileira de Sementes2006，28，1： | 1 |
| 5 | Performance limitations for linear feedback systems in the presence of plant uncertainty显示文摘 | Goodwin G C Salgado M E Yuz J I | 2003 | IEEE Trans on Automatic Control2003，48，8： | 1 |
| 6 | A stochastic embedding approach for quantifying uncertainty in the estimation of restricted complexity models显示文摘 | Goodwin G C Salgado M E | 1989 | Int J Adaptive Control Signal Processing1989，3，4： | 1 |
| 7 | The catabolism of amino acids to long chain and complex alcohols in Saccha- romyces cerevisiae显示文摘 | Dickinson J R Salgado L E Hewlins M J E | 2003 | The Journal of Biological Chemistry2003，278，10： | 1 |
| 8 | Genetic purity certificate in seeds of hybrid maize using molecular markers显示文摘 | Salgado K C P C Vieira M G G C Pinho E V R V | | 0，，： | 1 |
| 9 | Ge- netic purity certificate in seeds of hybrid maize using mo- lecular markers 显示文摘 | Salgado K C P C Vieira M G G C Von Pinho E V R | 2006 | Revista Brasileira de Sementes2006，28，1： | 1 |
| 10 | Hz optimal ripple-free deadbeat controller design显示文摘 | Salgado M E Oyarzun D A Silva E I | 2007 | Automatica2007，43，11： | 1 |
| 11 | Sunflower protein films incorporated with clove es- sential oil have potential application for the preservation of fish patties显示文摘 | Salgado P R Lopez-Caballero E L Gomez-Guillen M C | 2013 | Food Hydrocolloids2013，33，： | 1 |
| 12 | Performance limitations for linear feedback systems in the presence of plant uncertainty显示文摘 | Goodwin G C Salgado M E Yuz J I | 2003 | IEEE Trans on Automatic Control2003，48，8： | 1 |
| 13 | A stochastic embedding approach for quantifying uncertainty in the estimation of restricted complexity models显示文摘 | Goodwin G C Salgado M E | 1989 | Int J Adapt Control Signal Processing1989，3，4： | 1 |
| 14 | Lactic acid prop- erties, applications and production: a review显示文摘 | Martinez F A C Balciunas E M Salgado J M | 2013 | Trends in Food Sci- ence & Technology2013，30，1： | 1 |
| 15 | Bioinformatics resources for the study of gene regulation in bacteria显示文摘 | Collado-Vides J Salgado H Morett E Gama-Castro S Jimenez-Jacinto V Martinez-Flores I Medina-Rivera A Muniz-Rascado L Peralta-Gil M Santos-Zavaleta A | | 0，，： | 1 |
| 16 | Degradation of sodium dodeeyl sulphate in water using solar driven Fenton-like advanced oxidation processes 显示文摘 | Banda|a E R Pel6ez M A Salgado M ] | 2008 | Journal of Hazardous Materials2008，151，23： | 1 |
| 17 | The catabolism of amino acids to long chain and complex alcohols in Saccharomy ces cerevisiae显示文摘 | DICKINSON J R SALGADO L E J HEWLINS M J E | 2003 | Biol Chem2003，278，10： | 1 |
| 18 | Lactic acid properties, applications and production : a review 显示文摘 | Castillo Martinez F A Balciunas E M Salgado J M | 2013 | Trends Food Sci Technol2013，30，1： | 1 |
| 19 | Degradation of sodium dodecyl sulphate in water using solar driven Fenton-like advanced oxidation processes 显示文摘 | Bandala E R Pelaez M A Salgado M J | 2008 | J Hazard Mater2008，151，23： | 1 |
| 20 | Biodegradable foams based on cassava starch, sunflower proteins and cellulose fibers obtained by a baking process 显示文摘 | SALGADO P R SCHMIDT V C SARA E O M | 2008 | Journal of Food Engineering2008，85，： | 1 |
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