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| 1 | Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy显示文摘This review summarizes the safety and efficacy of statins in patients with cirrhosis.Due to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in cirrhosis.The most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver function.Rhabdomyolysis is the most serious and potentially life-threatening manifestation.It has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle injury.Likewise,simvastatin should not be administered to patients with Model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle injury.Due to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something useful.Through these effects,statins could prevent liver-related morbidity and mortality in cirrhotic patients.Observational studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and death.The few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic resistance.Another large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival rate.Despite these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies involved.Therefore,it is advisable to perform further randomized controlled trials on a large series of patients with hard clinical endpoints,using different statin types and varying doses.The objectives would be to prevent liver-related morbidity and mortality rather than treating cirrhosis complications to take additional information that makes it possible to add statins to the standard of care of these patients. | Alberto E Muñoz Florencia D Pollarsky Mónica Marino Mariano Cartier Horacio Vázquez Pablo Salgado Gustavo Romero | 2021 | World Journal of Gastroenterology2021，27，28： | 4 |
| 2 | Fast method for DNA extraction in Nocardia and Saccharomonospora 显示文摘 | SALGADO A RAMIIREZ N SANDOVAL E | 2008 | Journal de Mycologie Medicale/Journal nf Medical Mycology2008，18，2： | 1 |
| 3 | The value of Cockcroft-Gault equation for the screening of decreased renal function in patients w ith systemic arterial hypertension显示文摘 | Santos E M Franca A K Salgado J V | 2011 | J Bras Nefrol2011，33，3： | 1 |
| 4 | A summary of the report on survey of controls and control performance in HVDC schemes显示文摘 | Szechtman M Ping W W Salgado E | 1994 | Electra1994，，155： | 1 |
| 5 | On the contribution of lakes in predicting near-surface temperature in a global weather forecasting model显示文摘 | Balsamo G Salgado R Dutra E | 2012 | TcllusA2012，64，： | 1 |
| 6 | Safety profile of protein kinase inhibitors in rheumatoid arthritis:systematic review and meta-analysis显示文摘 | Salgado E Maneiro JR Carmona L | 2013 | Ann Rheum Dis2013，，： | 1 |
| 7 | Nitrate pollution of surface water induced by agricuhural non-point pollution in the pocochay wa- tershed, Chile显示文摘 | RIBBE L DELGADO P SALGADO E | 2008 | Article Desalination2008，226，13： | 1 |
| 8 | Treatment ofauricular pseudocyst with aspiration and local pressure显示文摘 | Salgado C J Hardy J E Mardini S | 2006 | J Plast Reconstr Aesthet Surg2006，59，12： | 1 |
| 9 | Pt-Co/C electrocatalysts for oxygen reduction in H2/O2 PEMFCs synthesized by borohydride method显示文摘 | Salgado J R C Antolini E Gonzalez E R | 2004 | J Electrochem Soc2004，151，12： | 1 |
| 10 | Structure and activity of carbon-supported Pt-Co electrocatalysts for oxygen reduction显示文摘 | Salgado J R C Antolini E Gonzalez E R | 2004 | J Phys Chem B2004，108，17： | 1 |
| 11 | Carbon supported Pt70Co30 electrocatalyst prepared by the formic acid method for the oxygen reduction reaction in polymer electrolyte fuel cells显示文摘 | Salgado J R C Antolini E Gonzalez E R | 2005 | J Power Sources2005，141，1： | 1 |
| 12 | Nitrate pollution of surface water induced by agricultural non-point pollution in the pocochay watershed, Chile 显示文摘 | Ribbe L Delgado P Salgado E | 2008 | Desalination2008，226，13： | 1 |
| 13 | Nano- and micro-fiber combined scaffolds: A new architecture for bone tissue engineering显示文摘 | Tuzlakoglu K Bolgen N Salgado AJ Gomes ME Piskin E Reis RL | 2005 | J Mater Sci Mater Med2005，16，： | 1 |
| 14 | Genetic purity certificate in seeds of hybrid maize using molecular markers显示文摘 | Salgado K C P C Vieira M G G C Pinho E V R V | 2006 | Revista Brasileira de Sementes2006，28，1： | 1 |
| 15 | Comparative analysis of human and bovine teeth: Radiographic den- sity显示文摘 | Tanaka JL Medici Filho E Salgado JA | 2008 | Braz Oral Res2008，22，4： | 1 |
| 16 | Biological nitrogen fixation:The acetobacter diazotrophicus,an inddeacetic acid producing bacterium isolated from sugarcane cultivars of Mexico显示文摘 | Ramirez F L E Salgado J T Ocampo A | 1993 | Plant Siol1993，154，： | 1 |
| 17 | Trehalose accumulation in Saccharomyces cerevisiae cells:experimental data and structured modeling显示文摘 | ARANDA J S SALGADO E TAIL LANDIER P | 2004 | Biochemical Engineering2004，17，： | 1 |
| 18 | Acetobacter di-azotrophicus ,an indoleacetic acid producing bacterium isolated from sugarcane cultivars of Mexico 显示文摘 | FUENTES_ RAMIREZ L E JIMENEZ - SALGADO T Abarca - Ocampo I R | 1986 | Int JSyst Bacteriol1986，36，： | 1 |
| 19 | Performance limitations for linear feedback systems in the presence of plant uncertainty显示文摘 | Goodwin G C Salgado M E Yuz J I | 2003 | IEEE Trans on Automatic Control2003，48，8： | 1 |
| 20 | Carbon supportedPt75M25 (M = Co, Ni) alloys as anode and cathode electrocatalysts for direct methanol fuel cells 显示文摘 | ANTOLINI E SALGADO J R C GONZALEZ E R | 2005 | J Electroanal Chem2005，580，1： | 1 |
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