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| 1 | CXCL5/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target显示文摘The components of the tumor microenvironment(TME)in solid tumors,especially chemokines,are currently attracting much attention from scientists.C-X-C motif chemokine ligand 5(CXCL5)is one of the important chemokines in TME.Over-expression of CXCL5 is closely related to the survival time,recurrence and metasta-sis of cancer patients.In TME,CXCL5 binds to its receptors,such as C-X-C motif chemokine receptor 2(CXCR2),to participate in the recruitment of immune cells and promote angiogenesis,tumor growth,and metastasis.The CXCL5/CXCR2 axis can act as a bridge between tumor cells and host cells in TME.Blocking the trans-mission of CXCL5/CXCR2 signals can increase the sensitivity and effectiveness of immunotherapy and slow down tumor progression.CXCL5 and CXCR2 are also regarded as biomarkers for predicting prognosis and molecular targets for customiz-ing the treatment.In this review,we summarized the current literature regarding the biological functions and clinical significance of CXCL5/CXCR2 axis in TME.The possibility to use CXCL5 and CXCR2 as potential prognostic biomarkers and thera-peutic targets in cancer is also discussed. | Wen Zhang Huishan Wang Mingyang Sun Xueting Deng Xueru Wu Yilan Ma Mengjing Li Said Maisam Shuoa Qiang You Lin Miao | 2020 | Cancer Communications2020，40，2： | 19 |
| 2 | Small-animal PET demonstrates brain metabolic change after using bevacizumab in a rat model of cerebral ischemic injury显示文摘To evaluate the effect of bevacizumab on cerebral ischemia,we used 2-deoxy-2-^(18)F-fluoro-D-glucose(^(18)F-FDG)small-animal positron emission tomography(PET)in the middle cerebral artery occlusion(MCAO)rat model.After baseline neurologic function tests and PET studies,MCAO Sprague-Dawley rats received bevacizumab or normal saline(controls).Weekly PET imaging and neurologic function tests showed that the^(18)F-FDG accumulation in the bevacizumab group was similar to that in the controls during the first 2 weeks,but lower than in controls at weeks 3 and 4.However,no difference was found in neurological scores between the groups.The number of von Willebrand factor-positive cells in the bevacizumab group was lower than that in controls.The expression of vascular endothelial growth factor was higher than in controls at week 4.These results suggested that bevacizumab does not influence functional recovery in this model of cerebral ischemia during a 4-week period,but inhibits vascular formation and metabolic recovery,which may be considered in cancer patients with a recent ischemic stroke. | Ying Dong Fahuan Song Jianjuan Ma Xuexin He Said Amer Weizhong Gu Mei Tian | 2014 | Neuroscience Bulletin2014，30，5： | 3 |
| 3 | A carrier-mediated mechanism for pyridoxine uptake by human intestinal epithelial Caco-2 cells:regulation by a PKA-mediated pathway显示文摘 | Said HM Ortiz A Ma TY | 2003 | Am J Physiol Cell Physiol2003，285，5： | 1 |
| 4 | A new mutation in PRKAG2 gene causing hypertrophic cardiomyopathy with conduction system disease and muscular glycogenosis 显示文摘 | Laforet P Richard P Said MA | 2006 | Neuromuscul Disord2006，16，3： | 1 |
| 5 | Reduced renal function in patients with simple renal cysts 显示文摘 | Al -Said J Brumback MA Moghazi S et al | 2004 | Kidney Int2004，65，6： | 1 |
| 6 | Estimating the burden of pneumococcal pneumonia among adults : a systematic review and meta-a- nalysis of diagnostic techniques 显示文摘 | Said MA Johnson HL Nonyane BA | 2013 | PLoS One2013，8，60： | 1 |
| 7 | Efficacy,predictability,and safety of wavefront-guided refrac-tive laser treatment: meta-analysis显示文摘 | Fares U Suleman H Al-Aqaba MA Otri AM Said DG Dua HS | 2011 | J Cataract Refract Surg2011，37，8： | 1 |
| 8 | Reduced renal function in patients with simple renal cysts显示文摘 | A1 - Said J Brumback MA Moghazi S | 2004 | Kidney Int2004，65，6： | 1 |
| 9 | Effect of treatment of anaemia with erythropoietin on neuromuscular function in patients on long-term haemodialysis 显示文摘 | Sobh MA el-Tantawy AE Said E Atta MG Refaie A Nagati M | 1992 | Scand J Urol Nephrol1992，26，3： | 1 |
| 10 | IL-1β-Induced Increase in Intestinal Epithelial Tight Junction Permeability Is Mediated by MEKK-1 Activation of Canonical NF-κB Pathway显示文摘 | Rana Al-Sadi Dongmei Ye Hamid M. Said Thomas Y. Ma | 2010 | The American Journal of Pathology2010，，5： | 1 |
| 11 | A new mutation in PRK- AG2 gene causing hypertrophic cardiomyopathy with conduc- tion system disease and muscular glycogenosis显示文摘 | Laforet P Richard P Said MA | 2006 | Neuromuscul Disord2006，16，3： | 1 |
| 12 | Metabolic syndrome and cardiovascular risk among patients with schizophrenia receiving antipsychotics in Malaysia显示文摘 | Said MA Sulaiman AH Habil MH | 2012 | Singapore Med J2012，53，12： | 1 |
| 13 | Role of diffusion- weighted imaging with ADC mapping and in vivo II-I-MR spectros- copy in thyroid nodulesand in vivo 1 H-MR spectroscopy in thyroid nodules显示文摘 | E1-Hariri MA Gouhar GK Said NS | 2012 | The Egyptian Journal of Radiology and Nuclear Medi- cine2012，43，： | 1 |
| 14 | A randomized, placebo-controlled trial of aripiprazole for the treatment of methamphetamine dependence and associated psychosis 显示文摘 | Sulaiman AH Gill JS Said MA | 2013 | Int J Psychiatry Clin Pract2013，17，2： | 1 |
| 15 | Peroxide prevuleanization of natural rubber latex 显示文摘 | SAID Ma'zam M D Pendle T D Blaekley D C | 1990 | J Nat Rubber Res1990，5，1： | 1 |
| 16 | Ca MKⅡinhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury显示文摘 | Vila-Petroff M Salas MA Said M | 2007 | Cardiovasc Res2007，73，4： | 1 |
| 17 | An equine herpesvirus type 1 (EHV-1)expressing VP2 and VP5 of serotype 8 bluetongue virus (BTV-8) induces protection in a murine infectionmodel 显示文摘 | Ma Guanggang Eschbaumer Michael Said Abdelrahman | 2012 | PL o S One2012，7，34： | 1 |
| 18 | CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury显示文摘 | Petroff MV Salas MA Said M | 2007 | Cardiovasc Res2007，73，4： | 1 |
| 19 | Zizyphus jujuba and Origanum majorana extracts protect against hydroquinone-induced clastogenicity显示文摘 | Ghaly I S Said A Abdel-Wahhab MA | 2008 | Environmental toxicology and pharmacology2008，25，1： | 1 |
| 20 | 显示文摘 | Ma'zam MD SAID Pendle T D Blackley D C | 1990 | Journal of Natural Rubber Research1990，5，1： | 1 |
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