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| 1 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 2 | Interactions among age, adiposity, bodyweight, lifestyle factors and sex steroid hormones in healthy Singaporean Chinese men显示文摘瞄准:为了在年龄,生活方式因素,人体测量的参数,百分比身体脂肪和类固醇之中检验相互关系,在 531 个健康新加坡人中国人的荷尔蒙参数在 29 和 72 岁之间变老。方法:各种各样的生活方式参数通过调查,和睾丸激素被确定(T) , estradiol (E2 ) , dehydroepi 雄甾酮硫酸盐(DHEAS ) 和性别荷尔蒙绑定血球素(SHBG ) 用确定的方法被测量。人体测量的参数镇定、计算,并且百分比身体脂肪(Siri ) 用 DEXA 扫描仪被测量。结果:SHBG, DHEAS, bioavailable-T (Bio-T ) , E2, Siri, Ht, W/H, W/Ht 和工作应力独立地与年龄被相关。多使用变量分析并且好久调整,吸烟并且另外的相关因素,锻练并且白酒消费在雄激素层次和身体作文上有积极影响。然而,黑色和绿茶消费在身体作文上并且与 E2 和免费 Estradiol 索引(FEI ) 的高水平与否定效果被联系。有更短的睡觉持续时间的人与夜里的睡觉的 6 h 或更多作为与那些相比有显著地更低的 T 层次。更高的 T 层次与脂肪过多的底层和脂肪过多的另外的索引被联系,而更高的 E2 层次与脂肪过多的高水平有关。有更高的 DHEAS 的人比有低 DHEAS 层次的那些显著地更高、重。结论:学习在 gonadal/adrenal 和新陈代谢的分隔空间之中显示出靠近的相互作用,与是的年龄在他们的相互作用的一个关键决定因素。生活方式因素象锻练那样,吸烟,睡觉并且酒精和茶消费可能显著地在在人决定健康的地位起作用。 | Victor H. H. Goh Terry Y. Y. Tong Helen E E Mok Baharudin Said | 2007 | Asian Journal of Andrology2007，9，5： | 2 |
| 3 | Upregula-tion of PD-1 expression on HIV-specific CD8 T cells leads to reversible immune dysfunction 显示文摘 | Trautmann L Janbazian L Chomont N Said EA Gimmig S Bessette B Boulassel MR Delwart E Sepulveda H Balderas RS Routy JP Haddad EK Sekaly RP | 2006 | Nat Med2006，12，10： | 1 |
| 4 | Testing for Unit Roots in Autoregressive-Moving Average Models of Unknown Order显示文摘 | Said E S Dickey D A | | 0，，03： | 1 |
| 5 | Activation of PAFreceptor by oxidised LDL in human monocytes releases but not umkinase- type plamimstmactivator expression 显示文摘 | BeaudetLx JL Said T Ninio E | 2004 | Clin Chim Aeta2004，344，2： | 1 |
| 6 | High sensitivity single beam n2 measurement显示文摘 | Sheik-Bahae M Said A A Van Stryland E W | 1989 | Optics Letter1989，14，3： | 1 |
| 7 | Detection of occult cervical micrometastases in patients with head and neck squamous cell cancer显示文摘 | Barrera J E Miller M E Said S | 2003 | Laryngoscope2003，113，5： | 1 |
| 8 | Metformin - mediated growth inhibition involves suppression of the IGF - I receptor signaling pathway in human pancreatic cancer cells 显示文摘 | Karnevi E Said K Andersson R | 2013 | BMC Cancer2013，13，： | 1 |
| 9 | GlycoproteinⅡb/Ⅲa inhibitor induced thrombocytopenia diagnosis and treatment显示文摘 | Said SM Hahn J Schleyer E | 2007 | Clin Res Cardiol2007，96，2： | 1 |
| 10 | Experts' knowledge renewal and maintenance actions effectiveness in high- mix low-volume industries ,using Bayesian approach显示文摘 | SAID A B SHAHZAD M K ZAMAI E | 2016 | Cognition technology & work2016，18，1： | 1 |
| 11 | High sensitivity single beam n2 measurement显示文摘 | SHEIK-BAHAE M SAID A A van STRYLAND E W | 1989 | Opt Lett1989，14，17： | 1 |
| 12 | Detection of occult cervical micrometastases in patients with head and neck squamous cell cancer显示文摘 | BARRERA J E MILLER M E SAID S | 2003 | Laryngoscope2003，113，5： | 1 |
| 13 | A fuzzy rotor resistance updating scheme for an IFOC induction motor drive显示文摘 | Zidani F Nait Said M S Benbouzid M E H | 2001 | IEEE Power Engineering Review2001，21，11： | 1 |
| 14 | High-sensitivity, single beam n2 measurements显示文摘 | Sheik-bahae M Said A A Van Stryland E W | 1989 | Opt Lett1989，14，17： | 1 |
| 15 | Surface nucleolin participates in both the binding and endocytosis of lactoferrin in target cells显示文摘 | LEGRAND D VIGIE K SAID E A | 2004 | Eur J Biochem2004，271，： | 1 |
| 16 | A Partial Image Encryption Scheme Based on the DWT and ELKNZ Chaotic Stream Cipher显示文摘 | Said E | 2009 | MASAUM Journal of Basic and Applied Sciences2009，1，3： | 1 |
| 17 | Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells显示文摘 | Karnevi E Said E Andersson R | 2013 | BMC Cancer2013，13，： | 1 |
| 18 | A low-cost rate-grade nickel microgyroscope显示文摘 | Said E A Kanber M S Tayfun A | 2006 | Sensors and Actuators A2006，132，： | 1 |
| 19 | Glycoprotein Ilb/IIIainhibitor-induced thrombocytopenia : diagnosis and treatment显示文摘 | Said SM Hahn J Schleyer E | 2007 | Clin Res Cardiol2007，96，2： | 1 |
| 20 | Association of single-nucleotide polymorphisms in TLR7 (GlnllLeu) and TLR9 (1635A/G) with a higher CD4T cell count during HIV infection 显示文摘 | Said E A A1-Yafei F Zadjali F | 2014 | Immunol Lett2014，160，1： | 1 |
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