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| 1 | Effect of single subconjunctival injection of bevacizumab on primary pterygium:clinical,histopathological and immunohistochemical study显示文摘AIM:To evaluate the effect(clinically,histopathologically and immunohistochemically) and safety of a single intrapterygium injection of bevacizumab.METHODS:Prospective interventional study comprised 40 eyes of 40 patients with primary fleshy pterygia who attended the Outpatient Clinic of Department of Ophthalmology,Assiut University Hospitals,Egypt from May 2015 to May 2016.Patients were randomly classified into 2 groups:the first group received a single intralesional injection of bevacizumab(Avastin;Genentech,San Francisco,CA,USA);the second group comprised patients who did not receive subconjunctival bevacizumab.Excision of pterygium and conjunctival auto graft was done in both groups.The excised pterygium tissues were subjected to histopathological and immunohistochemical evaluation.RESULTS:The study comprised 40 eyes of 40 patients(33 men,7 women) of age range from 31-58 y.The study group included 22 eyes.The control group included 18 eyes.A decrease in the vascularity of the pterygium was noted in all injected cases.The mean vessel count was higher in non-injected pterygia than that in injected pterygia and the difference was statistically significant(P=0.001).Also,the mean vessel count in both groups was significantly higher than normal conjunctive(P=0.005 and 0.001).A statistically significant difference in vascular endothelial growth factor(VEGF) expression between injected and non-injected cases was detected in the epithelial,stromal and endothelial cells(P=0.0001,0.016,0.014).No serious intraoperative complications occurred in both groups.CONCLUSION:The use of single intra lesional injection of Avastin in pterygium decreased vascularity and decreased VEGF expression in injected pterygium after one month.Our study proved the effect of single intra lesional injection of Avastin on pterygium.Further studies may enable limiting the need for surgery and improve quality of life for patients with pterygia. | Tarek A Mohamed Wael Soliman Ahmed M.Fathalla Abeer El Refaie | 2018 | International Journal of Ophthalmology(English edition)2018，11，5： | 2 |
| 2 | Addition of dexm- edetomidine to bupivaeaine for greater palatine nerve block prolongs post-operative analgesia after cleft palate repair 显示文摘 | Obayah GM Refaie A Aboushanab O | 2010 | Eur J Anaesthesiol2010，27，3： | 1 |
| 3 | Living -related -donor kidney transplantation outcome in recipients with primary focal - seg mental glomerulosclerosis 显示文摘 | Refaie A Sobh M Mousfafa F | 1999 | Am J Nephrol1999，19，1： | 1 |
| 4 | Efficacy of anterior fissureless technique for right upper lobectomies: a case-matched analysis 显示文摘 | Refai M Brunelli A Salati M | 2010 | European journal of cardiothoracic surgery:official journal of the European Association for Cardio-thoracic Surgery2010，11，3： | 1 |
| 5 | Tuberculosis in Egyptian kidney trasplant recipients:study of clinical couse and outcome显示文摘 | el-Agroudy A E Refaie A F Moussa O M Ghoneim -M-A | 2003 | J Nephrol2003，16，3： | 1 |
| 6 | Living- related - donor kidney transplantation outcome in recipients with primary focalsegment glom Crulosclerosis显示文摘 | REFAIE A SOBH M MOUSTAFA F | 1999 | Am J Nephrol1999，19，： | 1 |
| 7 | Role of CT in assessment of unresectable Wilms′ tumor response after preoperative chemotherapy in pediatrics显示文摘 | Refaie HD Sarhan M Hafez A | 2008 | Scientific World Journal2008，13，8： | 1 |
| 8 | Living-related-donor kidney transplantation outcome in recipients with primary focal-segmental glomerulosclerosis显示文摘 | Refaie A Sobh M Moustafa F | 1999 | Am J Nephrol1999，19，1： | 1 |
| 9 | Significance of serum matrix metalloproteinase -9 and tissue inhibitor of metalloproteinase - 1 in chronic hepatitis C patients 显示文摘 | Badra G Lotfy M E1 - Refaie A | 2010 | Acta Microbiol Immunol Hung2010，57，1： | 1 |
| 10 | Internal comparative audit in a thoracic surgery unit using the physiological and operative severity score for the enumeration of mortality and morbidity ( POSSUM) 显示文摘 | BruneUi A Fianehini A A1 Refai M etal | 2001 | Eur J Cardiothorac Surg2001，19，6： | 1 |
| 11 | Adrenal hemangioma:findings at multidetector CT with short review of the literature显示文摘 | Abou El-Ghar M Refaie H El-Hefnawy A | 2011 | Case Rep Radiol2011，2011，60： | 1 |
| 12 | Peak oxygen consumption during cardiopulmonary exercise test improves risk stratification in candidates to major lung resection显示文摘 | Brunelli A Belardinelli R Refai M | 2009 | Chest2009，135，5： | 1 |
| 13 | Living-related-donor kidney transplantation outcome in recipients with primary focal -segmental glomerulosclerosis显示文摘 | Refaie A Sobh M Moustafa F | 1999 | Am J Nephrol1999，19，1： | 1 |
| 14 | Physically crosslinked poly (vinyl alcohol) -hydroxyethyl starch blend hydrogel membranes: Synthesis and characterizatinn for biomedical applications显示文摘 | E1- Refaie K Elbadawy A Mohamed S Mohy E Mahmoud A | 2014 | Arabian Journal of Chemistu2014，7，3： | 1 |
| 15 | Carbon monoxide lung diffusion capacity improves risk stratification in patients with airflow limitation: evidence for systematic measurement before lung resection 显示文摘 | Brunelli A Refai MA Salati M | 2006 | Eur J Cardiothorac Surg2006，29，4： | 1 |
| 16 | Novel approach for attaining cotton fabric with multi-functional properties显示文摘 | Ibrahim N A Refaie R Ahmed A F | 2010 | Journal of Industri- al Textiles2010，40，1： | 1 |
| 17 | Addition of dexmedetomidine to bupivacaine for greater palatine nerve block prolongs postoperative analgesia after cleft palate repair 显示文摘 | Obayah G M Refaie A Aboushanab O et at | 2010 | Eur J Anaesthesiol2010，27，3： | 1 |
| 18 | Addition of dexme- detomidine to bupivacaine for greater palatine nerve block pro- longs postoperative analgesia after cleft palate re pair 显示文摘 | Obayah GM Refaie A Aboushanab O | 2010 | Eur J An- esthesiol2010，27，3： | 1 |
| 19 | Development of a patient-centered aggregate score to predict survival after lung resection for non-small cell lung cancer 显示文摘 | Brunelli A Salati M Refai M | 2013 | J Thorac Cardiovasc Surg2013，，： | 1 |
| 20 | Short-term perioperative treatment with ambroxol reduces pulmonary complications and hospital costs after pulmonary lobectomy:a randomized trial显示文摘 | Refai M Brunelli A XiuméF | 2009 | Eur J Cardiothorac Surg2009，35，3： | 1 |
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