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| 1 | Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human skeletal muscle显示文摘Background: Exercise promotes numerous phenotypic adaptations in skeletal muscle that contribute to improved function and metabolic capacity. An emerging body of evidence suggests that skeletal muscle also releases a myriad of factors during exercise, termed 'myokines'. The purpose of this study was to examine the effects of high-intensity interval training(HIIT) on the acute regulation of the mRNA expression of several myokines, including the prototypical myokine interleukin-6(IL-6), and recently identified myokines fibronectin type III domain-containing protein 5(FNDC5)(irisin) and meteorin-like protein(METRNL).Methods: Both before and after a 20-day period of twice-daily high-volume HIIT, 9 healthy males(20.5 ± 1.5 years performed a standardized bout of high-intensity interval exercise(HIIE; 5 × 4 min at ~80% pretraining peak power output) with skeletal muscle biopsy samples(vastus lateralis) obtained at rest, immediately following exercise, and at 3 h recovery.Results: Before training, a single bout of HIIE increased IL-6(p < 0.05) and METRNL(p < 0.05) mRNA expression measured at 3 h recovery when compared to rest. Following 20 days of HIIT, IL-6 and FNDC5 mRNA were increased at 3 h recovery from the standardized HIIE bout when compared to rest(both p < 0.05). Resting METRNL and FNDC5 mRNA expression were higher following training(p < 0.05), and there was an overall increase in FNDC5 mRNA post-training(main effect of training, p < 0.05).Conclusion: In human skeletal muscle(1) an acute bout of HIIE can induce upregulation of skeletal muscle IL-6 mRNA both before and after a period of intensified HIIT;(2) Resting and overall FNDC5 mRNA expression is increased by 20 days of HIIT; and(3) METRNL mRNA expression is responsive to both acute HIIE and short-term intense HIIT. Future studies are needed to confirm these findings at the protein and secretion level in humans. | Malcolm Eaton Cesare Granata Julianne Barry Adeel Safdar David Bishop Jonathan P.Little | 2018 | Journal of Sport and Health Science2018，7，2： | 15 |
| 2 | 煤炭腐植酸作为土壤改良剂对土壤物理性质和小麦产量的影响显示文摘在巴基斯坦旁遮普的波特瓦地区(33°N,74°E),集约化土壤耕作,土壤侵蚀和低量作物残体的投入是导致土壤结构退化的原因。结构不稳定的土壤很容易受到侵蚀,反过来,土壤侵蚀又会造成作物产量的下降。因此,为了改善土壤的物理性状,在巴基斯坦旁遮普的干旱地区进行了田间试验。试验地点位于大学(拉瓦尔品第PMAS干旱农业大学)研究农场的园区内。2种不同等级(实验室级和商品级)的腐植酸(HA)各分8个水平,施用2年,处理分别为HL_0(对照,不施腐植酸),HL_1 10 kg HA/hm^2,HL_2 20 kg HA/hm^2,HL_3 30 kg HA/hm^2,HL_4 60 kg HA/hm^2,HL_5 90 kg HA/hm^2,HL_6 120 kg HA/hm^2和HL_7 150 kg HA/hm^2,各处理同时配合施用N-P-K(120-90-60 kg/hm^2)。试验期间,检测土壤总有机碳、饱和导水率、团聚体稳定性、容重、土壤含水量和作物产量。试验结果表明,腐植酸能通过影响土壤总有机碳、饱和导水率、团聚体稳定性、容重和土壤含水量等指标来改善土壤的物理性状。2年试验结果均表现为,实验室级的腐植酸比商品级的腐植酸能更好地改善土壤物理性状,从而提高小麦产量。2种不同级别的腐植酸各施用水平与对照相比,差异均显著。在120 kg/hm^2和150 kg/hm^2的腐植酸施用水平下,大多数指标均显示出了相似的结果,因此,从经济角度考虑,120 k g/hm^2的腐植酸用量为最佳施用量。 | Ijaz Ahmad Safdar Ali Khalid Saifullah Khan Fayyazul Hassan Kashif Bashir 何一通 孙志梅 | 2016 | 腐植酸2016，，3： | 10 |
| 3 | Rituximab for troublesome cases of childhood nephrotic syndrome显示文摘Nephrotic syndrome(NS) is the most common glomerular disease of childhood. Steroid-dependent and steroid-resistant nephrotic syndrome present challenges in their pharmaceutical management; patients may need several immunosuppressive medication for optimum control, each of which medication has its own safety profile. Rituximab(RTX) is a monoclonal antibody that targets B cells and has been used successfully for management of lymphoma and rheumatoid arthritis. Recent clinical studies showed that rituximab may be an efficacious and safe alternative for the treatment of complicated nephrotic syndrome. In this review article, we aim to review the efficacy and safety of RTX therapy in nephrotic syndrome. We reviewed the literature pertaining to this topic by searching for relevant studies on Pub Med and Medline using specific keywords. The initial search yielded 452 articles. These articles were then examined to ensure their relevance to the topic of research. We focused on multicenter randomized controlled trials with relatively large numbers of patients. A total of 29 articles were finally identified and will be summarized in this review. The majority of clinical studies of RTX in complicated pediatric NS showed that rituximab is effective in approximately 80% of patients with steroid-dependent NS, as it decreases the number of relapses and steroid dosage. However, RTX is less effective at achieving remission in steroid-resistant NS. RTX use was generally safe, and most side effects were transient and infusion-related. More randomized, double-blinded clinical studies are needed to assess the role of RTX in children with nephrotic syndrome. | Osama Y Safdar Adila Aboualhameael Jameela A Kari | 2014 | World Journal of Clinical Pediatrics2014，3，4： | 5 |
| 4 | 半乳甘露聚糖试验诊断侵袭性曲霉病的评价——一项荟萃分析显示文摘侵袭性曲霉病(invasive aspergillosis,IA)多见于免疫缺陷患者,据报道在异体造血干细胞移植受者中IA发生率为8%~15%,在实体器官移植受者中为5%~15%,且病死率可高达30%~70%。然而IA的早期诊断仍是临床上的难题,因为确诊标准需要组织活检镜检或培养阳性,但真菌培养阳性率低且费时,而组织活检可行性差。目前已研究了很多非培养检测方法,包括检测真菌特异抗原、真菌代谢产物或真菌DNA,如抗原β-葡聚糖(存在于大部分真菌,除外隐球菌和接合菌)、半乳甘露聚糖(galactomannan,GM);GM大部分存在于曲霉,是曲霉生长过程中释放的细胞壁多糖成分,还存在于青霉)等具有很好的发展前景。 | Pferffer CD Fine JP Safdar N 唐晓丹 | 2007 | 中国感染与化疗杂志2007，7，1： | 5 |
| 5 | Identification of key gene networks controlling organic acid and sugar metabolism during watermelon fruit development by integrating metabolic phenotypes and gene expression profiles显示文摘The organoleptic qualities of watermelon fruit are defined by the sugar and organic acid contents,which undergo considerable variations during development and maturation.The molecular mechanisms underlying these variations remain unclear.In this study,we used transcriptome profiles to investigate the coexpression patterns of gene networks associated with sugar and organic acid metabolism.We identified 3 gene networks/modules containing 2443 genes highly correlated with sugars and organic acids.Within these modules,based on intramodular significance and Reverse Transcription Quantitative polymerase chain reaction(RT-qPCR),we identified 7 genes involved in the metabolism of sugars and organic acids.Among these genes,Cla97C01G000640,Cla97C05G087120 and Cla97C01G018840(r^(2)=0.83 with glucose content)were identified as sugar transporters(SWEET,EDR6 and STP)and Cla97C03G064990(r^(2)=0.92 with sucrose content)was identified as a sucrose synthase from information available for other crops.Similarly,Cla97C07G128420,Cla97C03G068240 and Cla97C01G008870,having strong correlations with malic(r^(2)=0.75)and citric acid(r^(2)=0.85),were annotated as malate and citrate transporters(ALMT7,CS,and ICDH).The expression profiles of these 7 genes in diverse watermelon genotypes revealed consistent patterns of expression variation in various types of watermelon.These findings add significantly to our existing knowledge of sugar and organic acid metabolism in watermelon. | Muhammad Jawad Umer Luqman Bin Safdar Haileslassie Gebremeskel Shengjie Zhao Pingli Yuan Hongju Zhu M.O.Kaseb Muhammad Anees Xuqiang Lu Nan He Chengsheng Gong Wenge Liu | 2020 | Horticulture Research2020，7，1： | 4 |
| 6 | Effect of seedling age and water depth on morphological and physiological aspects of transplanted rice under high temperature显示文摘To study the effect of high temperature, rice seedlings 20, 30, 40 and 50 d were kept at 5, 10, 15 and 20 cm water depth in a water pool. Meteorological findings indicated that water temperature varied up to 10 cm but became stable below this depth. Deep water inflicted higher tiller mortality, minimal increase in dry weight of aerial parts and leaf area, decrease in root length, and decrease in root dry weight especially at 20 cm water depth and produced an unbalanced T/R ratio (top versus root dry weight). However, deep water tended to increase plant length. These parameters, however, excel in shallow water. Older seedlings, with the exception of root dry weight, could not perform well compared to young seedlings in all physiological and morphological aspects. The study revealed that seedlings, particularly young ones, stand well in shallow water and can cope with high temperature. | KHAKWANI Abdul Aziz SHIRAISHI Masaaki ZUBAIR Muhammad BALOCH Mohammad Safdar NAVEED Khalid AWAN Inayatullah | 2005 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2005，6，5： | 4 |
| 7 | Growth and yield of rice as affected by transplanting dates and seedlings per hill under high temperature of Dera Ismail Khan, Pakistan显示文摘Studies were initiated for two consecutive years to find out the effect of time of transplanting and seedlings hill?1 on the productivity of rice in Dera Ismail Khan district of North West Frontier Province (NWFP), Pakistan. The experiment was laid out in a randomized complete block design with split plot arrangements. Main plots consisted of four transplanting dates viz. 20th and 27th of June and 4th and 11th of July while sub-plots contained 1, 2, 3 or 4 seedlings hill?1. Among transplanting dates, June 20th planted crop gave highest paddy yield and net return with 1 seedling hill–1. It explains that the use of more seedlings hill?1 not only adds to cost but is also a mere wastage of natural resources. Based on research findings, we conclude that the use of 1 seedling hill?1 is most appropriate for timely sowing otherwise 4 seedlings hill–1 should be used to compensate for the yield gap in late transplanted rice. | BALOCH Mohammad Safdar AWAN Inayat Ullah HASSAN Gul | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，7： | 3 |
| 8 | Mutation of the PHYTOENE DESATURASE 3 gene causes yellowish-white petals in Brassica napus显示文摘Oilseed rape (Brassica napus) with yellow flowers is an attractive ornamental landscape plant during the flowering period,and the development of different petal colors has become a breeding objective.Although yellowish flower color is a common variant observed in field-grown oilseed rape,the genetics behind this variation remains unclear.We obtained a yellowish-white flower (ywf) mutant from Zhongshuang 9 (ZS9) by ethyl methanesulfonate mutagenesis (EMS) treatment.Compared with ZS9,ywf exhibited a lower carotenoid content with a reduced and defective chromoplast ultrastructure in the petals.Genetic analysis revealed that the yellowish-white trait was controlled by a single recessive gene.Using bulked-segregant analysis sequencing (BSA-seq) and kompetitive allele-specific PCR(KASP),we performed map-based cloning of the ywf locus on chromosome A08 and found that ywf harbored a C-to-T substitution in the coding region,resulting in a premature translation termination.YWF,encoding phytoene desaturase 3 (PDS3),was highly expressed in oilseed rape petals and involved in carotenoid biosynthesis.Pathway enrichment analysis of the transcriptome profiles from ZS9 and ywf indicated the carotenoid biosynthesis pathway to be highly enriched.Further analyses of differentially expressed genes and carotenoid components revealed that the truncated Bna A08.PDS3 resulted in decreased carotenoid biosynthesis in the mutant.These results contribute to an understanding of the carotenoid biosynthesis pathway and manipulation of flower-color variation in B.napus. | Chuanji Zhao Luqman Bin Safdar Meili Xie Meijuan Shi Zhixue Dong Li Yang Xiaohui Cheng Yueying Liu Zetao Bai Yang Xiang Chaobo Tong Junyan Huang Lijiang Liu Shengyi Liu | 2021 | The Crop Journal2021，9，5： | 3 |
| 9 | Effect of Establishment Methods and Weed Management Practices on Some Growth Attributes of Rice显示文摘Studies were carried out for two years to evaluate the effect of methods of sowing and weed control practices on the productivity of transplanted and direct wet-seeded rice in Dera Ismail Khan, NWFP, Pakistan. The experiment was laid out in a randomized complete block design with a split plot arrangement. The planting techniques viz. transplanting and direct seeding were maintained in main plots while weed control practices included the use of granular herbicide Sunstar 15WG (ethoxy sulfuron), Machete 60EC (butachlor), conventional hand weeding, and the weedy check (control) were assigned to the sub-plots. Data were recorded on weed parameters like weed density and dry weed biomass 60 and 90 days after sowing (DAS); agronomic parameters including plant population, number of panicles and paddy yield and physiological parameters like leaf area index and net assimilation rate 45 and 90 DAS. The planting methods and weed management significantly influenced most of the parameters studied. The data revealed that the paddy yield and its components were significantly higher in the transplanted method than that in direct-seeded method, while the weed density and biomass were lower in the transplanted plots than the direct-seeded plots. Among weed management tools, the maximum paddy yield was obtained in hand weeding, closely followed by herbicide application Machete 60EC during both cropping seasons. | Mohammad Safdar BALOCH Inayat Ullah AWAN Gul HASSAN Abdul Aziz KHAKWANI | 2006 | Rice science2006，13，2： | 2 |
| 10 | 成人单纯型单侧先天性肺动脉发育不全的X线表现显示文摘 | 张娜 陈志凡 Safdar Mozher | 2008 | 西部医学2008，20，5： | 2 |
| 11 | 结合PCA和GWAS解析甘蓝型油菜株型相关性状的遗传调控位点显示文摘作物株型改良是提高收获指数和产量的重要途径,为了解其复杂的遗传调控机制,以373份甘蓝型油菜组成的自然群体为基础,对4个株型相关性状(株高、第一分枝高度、有效分枝数和主花序长度)进行多环境下表型鉴定,组合利用全基因组关联分析(GWAS)和主成分分析(PCA)方法对株型的遗传调控进行解析。研究表明,PCA可以合理地解释株型的相关表型,基于主成分的GWAS和基于单个性状的GWAS的结果可互相验证和互为补充,挖掘更多的调控位点和信息。进一步,从染色体A01、A10和C06中筛选到19个株型相关的候选基因,其中,位于染色体C06上的两个候选基因跟PC1-GWAS鉴定到的新位点相关。此方法和结果为株型等复杂性状的形成机制解析提供了新的思路和策略。 | 张旭 Luqman Bin Safdar 唐敏强 刘越英 张园园 刘胜毅 | 2021 | 中国油料作物学报2021，43，3： | 2 |
| 12 | The pathogenesis of ventilator-associated pneumonia: its relevance to developing effective strategies for prevention 显示文摘 | Safdar N Crnich C J Maki DG | 2005 | Respir Care2005，，50： | 1 |
| 13 | Adherence to evidence-based recommendations for prevention of ventilator-associated pneumonia:the survey says显示文摘 | Safdar N Abad CI | 2007 | Respir Care2007，52，12： | 1 |
| 14 | Does combination anti- microbial therapy reduce mortality in Gram-negative bacterae- mia? A meta-analysis显示文摘 | Safdar N Handelsman J Maki DG | 2004 | Lancet Infect Dis2004，4，8： | 1 |
| 15 | Risk of catheter - related bloodstream infection with peripherally inserted central venous catheters used in hospital- ized patients显示文摘 | Safdar N Maki DG | 2005 | Chest2005，128，2： | 1 |
| 16 | The pathogenesis of ventilator -associated pneumonia: its relevance to developing effective strategies for prevention显示文摘 | Safdar N Crnich C J Maki IX) | 2005 | Respir Care2005，50，： | 1 |
| 17 | Acute endurance exercise increases the nuclear abundance of PGC-lct in trained human skeletal muscle显示文摘 | Little JP Safdar A Cermak N | 2010 | Am J Physiol Regul Integr Comp PhysioL2010，298，91： | 1 |
| 18 | Submental versus platysma flap for the reconstruction of complex facial defects following resection of head and neck tumors显示文摘 | Jawad Safdar Fa-Yu Liu Yousuf Moosa | 2014 | Oral Maxillofac Surg Clin North Am2014，26，3： | 1 |
| 19 | The pathogenesis of ventilator - associated pneumonia: its relevance to developing effective strategies for prevention显示文摘 | Safdar N Crnich CJ Maki DG | 2005 | Respir Care2005，50，6： | 1 |
| 20 | Bone growth faetor显示文摘 | Safdar NK Mathias PG Joseph ML | 2000 | Or thop Clin Nor Am2000，31，3： | 1 |
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