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| 1 | Significance of serum leptin and adiponectin levels in Egyptian patients with chronic hepatitis C virus associated hepatic steatosis and fibrosis显示文摘AIM:To study serum levels of leptin and adiponectin in patients with chronic hepatitis C virus infection genotype-4(HCV-4) related steatosis and fibrosis.METHODS:We prospectively studied 45 untreated men with chronic HCV-4,with proven steatosis(group Ⅰ,30 patients),and fibrosis(group Ⅱ,15 patients),on liver biopsy.In addition,15 healthy men(group Ⅲ),matched for age,and body mass index were included.However,we excluded another five patients with steatohepatitis,and six patients with cirrhosis.We measured total serum leptin and adiponectin levels,as potential predictors for liver steatosis and fibrosis.Also,a correlation between these adipokines and various clinical and laboratory data were evaluated.All subjects were selected from Tropical and Internal medicine departments,Menoufiya University Hospital,Menoufiya,Egypt,during the period from February 2010 to August 2011.RESULTS:In group Ⅰ,severity of hepatic steatosis was mild,moderate,and severe,in 19 patients(63.5%),8 patients(26.5%),and 3 patients(10%),respectively.In contrast,in group Ⅱ,hepatic fibrosis was found to be in stage 1,2,and 3,in 6 patients(40%),in 6 patients(40%),and in 3 patients(20%),respectively.On comparing group Ⅰ with group Ⅱ,there was a significant decrease in serum adiponectin levels(131.4 ± 7.91 pg/mL vs 436 ± 9.75 pg/mL,P < 0.001),while there was no significant difference between both groups regarding serum leptin levels(34.69 ± 7.69 ng/mL vs 35.17 ± 1.06 ng/mL,P > 0.05).However,in the same group,when compared with group Ⅲ,there was a significant increase in serum leptin levels(34.69 ± 7.69 ng/mL vs 10.69 ± 0.84 ng/mL,P < 0.001),while there was a significant decrease in serum adiponectin levels(131.4 ± 7.91 pg/mL vs 342.4 ± 44.48 pg/mL,P < 0.001).In contrast,in group Ⅱ,when compared with group Ⅲ,there was a significant increase in serum leptin and adiponectin levels(35.17 ± 1.06 ng/mL vs 10.69 ± 0.84 ng/mL,P < 0.001,and 436 ± 9.75 pg /mL vs 342.4 ± 44.48 pg/mL,P < 0.05,respectively),while there was no significant difference between both groups regarding serum creatinine(0.83 ± 0.34 vs 0.89 ± 0.24,P > 0.05).On the other hand,serum leptin was not correlated with serum adiponectin in group Ⅰ and in group Ⅱ(r = 0.09,P > 0.05,and r =-0.1,P > 0.05,respectively).However,serum adiponectin was significantly negatively correlated with serum aspartate transaminase in group Ⅰ,but no correlation detected in group Ⅱ(r =-0.39,P > 0.05,and r =-0.03,P > 0.05).CONCLUSION:In male patients with chronic HCV-4,serum adiponectin levels are elevated in hepatic fibrosis,but decreased in steatosis.Therefore,in contrast to leptin,adiponectin may be used as a non-invasive marker. | Tarek E Korah Sawsan El-Sayed Maathir K ElShafie Ghada E Hammoda Manal A Safan | 2013 | World Journal of Hepatology2013，5，2： | 7 |
| 2 | Removal of arsenite by reductive precipitation in dithionite solution activated by UV light显示文摘This study investigates the removal of arsenite(As(III)) from water using dithionite activated by UV light. This work evaluated the removal kinetics of As(III) under UV light irradiation as affected by dithionite dose and light intensity, and characterized the nature of the precipitated solids using XPS and SEM-EDS. Photolysis of dithionite was observed by measuring dithionite concentration using UV absorbance at 315 nm. This study also investigated the effect of UV light path length on soluble As concentrations to understand resolubilization mechanisms. Total soluble As concentrations were observed to decrease with reaction time due to reduction of arsenite to form solids having a yellow-orange color.The removal mechanism was found to be reductive precipitation that formed solids of elemental arsenic or arsenic sulfide. However, these solids were observed to resolubilize at later times after dithionite had been consumed. Resolubilization of As was prevented and additional As removal was obtained by frequent dosing of dithionite throughout the experiment. As(III) removal is attributed to photolysis of dithionite by UV light and production of reactive radicals that reduce As(III) and convert it to solid forms. | Bahngmi Jung Aya Safan Yuhang Duan Vishakha Kaushik Bill Batchelor Ahmed Abdel-Wahab | 2018 | Journal of Environmental Sciences2018，30，12： | 3 |
| 3 | Renal-artery stenosis显示文摘 | Textor SC | 2001 | N Engl J Med2001，344，： | 1 |
| 4 | Monoethyl- glycinexylidide extraction level as a measure of hepatic detoxification and excretion functions in cirrhotics under- going laparoscopic chole cystectomy under general anes- thesia显示文摘 | Mohamed AA Ibrahim WA Safan TF | 2014 | Egypt J Anaesth2014，30，1： | 1 |
| 5 | Test anxiety, and Skills of Time Management Among Faculty Nursing Students显示文摘 | Elazizl TA Eid NM Safan SM | 2012 | J Am Sci2012，8，4： | 1 |
| 6 | Behavior and strength of beams cast with ultra high strength concrete containing different types of fibers显示文摘 | M.M. Kamal M.A. Safan Z.A. Etman R.A. Salama | 2014 | HBRC Journal2014，，1： | 1 |
| 7 | Monoethylglycinexylidide extrac-tion level as a measure of hepatic detoxification and excretion functions in cirrhoticsundei^oing laparoscopic chole cystectomy under general anesthesia 显示文摘 | Mohamed A A Ibrahim W A Safan T F | 2014 | Egypt JAnaesth2014，30，1： | 1 |
| 8 | Monoethylglycinexylidide extrac-tion level as a measure of hepatic detoxification and excretion functions in cirrhoticsundei^oing laparoscopic chole cystectomy under general anesthesia 显示文摘 | Mohamed A A Ibrahim W A Safan T F | 2014 | Egypt JAnaesth2014，30，1： | 1 |
| 9 | The predictive value of immunohistochemical markers in untreated Wilms’ tumour: are they useful?显示文摘 | Mazen A. Ghanem Theo H. van der Kwast W. M. Molenaar Manal A. Safan Rien J. Nijman Gert Jan van Steenbrugge | 2013 | World Journal of Urology2013，，4： | 1 |
| 10 | Evaluation of a method to determine the natural occurrence of aflatoxins in commercial traditional herbal medicines from Malaysia and Indonesia显示文摘 | N. Ali N.H. Hashim B. Saad K. Safan M. Nakajima T. Yoshizawa | 2005 | Food and Chemical Toxicology2005，，12： | 1 |
| 11 | Theoretical analysis of suspension bridges 显示文摘 | Safan S A | 1966 | Journal of the Structural Division ASCE1966，92，4： | 1 |
| 12 | The role of varicocele sclerotherapy in men with severe ol igo-astheno-teratozoos perm ia显示文摘这研究的目的是验证 antegrade 的角色阴囊的为在有严重 oligo-astheno-teratozoospermia (燕麦) 的不肥沃的人的精索静脉曲张的处理的 sclerotherapy。有在这研究的严重燕麦的 59 个病人经历了 antegrade 为精索静脉曲张的治疗的阴囊的 sclerotherapy。结果在精液参数和自发的概念率以改进被估计。精液参数和繁殖荷尔蒙在 antegrade sclerotherapy 前被评估(作为) 并且 6 个月在以后作为。在 34.8 ± 的一平均后续时间以后; 3.2 个月,重要改进在 36 个病人在吝啬的精子集中,活动性和形态学被注意(61 %) 。自发的怀孕发生在九对夫妇(15 %) 。在治疗以后的六个月, inhibin B 层次显著地更高(P< 0.04 ) ,而刺激滤泡的荷尔蒙(FSH ) 层次显著地更低(P< 0.001 ) 比以前治疗。Antegrade 内部精子的静脉 sclerotherapy 能显著地与严重燕麦在人改进精液的参数和神经质的参数并且可以甚至在将另外是 intracytoplasmic 精子注射(ICSI ) 的候选人的夫妇导致自发的怀孕。 | Mazen A Ghanem Manal A Safan Ashraf A Ghanem Gert R Dohle | 2011 | Asian Journal of Andrology2011，13，6： | 1 |
| 13 | Effect of rectal stump washout on the presence of free malignant cells in the rectum during anterior resection for rectal cancer显示文摘 | Safan J Averbuch F Koltun L | 2000 | Dis Colon Rectum2000，43，8： | 1 |
| 14 | Lipoprotein-associat- ed phospholipase A2 ( Lp-PLA2 ) and tumor necrosis factor-alpha (TNF-ct) and their relation to premature atherosclerosis in J3-thalas- semia children 显示文摘 | RAGAB S M SAFAN M A OBEID O M | 2015 | Hematology ( Amsterdam Netherlands)2015，204，： | 1 |
| 15 | Flexural behavior and design of steel- GFRP reinforced concrete beams显示文摘 | SAFAN M A | 2013 | ACI Materials Journal2013，110，6： | 1 |
| 16 | Transmission potential of the new influenza A (H1N1) virus and its age-specifi city in Japan 显示文摘 | Nishiura H Castillo-Chavez C Safan M | 2009 | Euro Surveill2009，14，22： | 1 |
| 17 | High platelet distribution width can independently predict testicular survival in testicular torsion among patients with steady-state sickle cell anemia显示文摘Objective This study aimed to evaluate the predictive value of platelet volume indices(PVI),such as mean platelet volume(MPV),platelet distribution width(PDW),and plateletcrit(PCT),as prognostic indicators of testicular viability in torsion patients with steady-state sickle cell anemia(SCA)who underwent surgical exploration.Methods Forty-eight patients with SCA with testicular torsion and 46 male control subjects were enrolled in the study.All patients underwent scrotal color Doppler ultrasonography before surgery,and PVI(MPV,PDW,and PCT)values were measured in all participants.Symptom duration and testicular volume were also recorded.Results The testicular salvage rate in patients with SCA was 73%after surgery.Analyses showed that MPV,PDW,and PCT values were significantly higher in torsed SCA as compared with controls(p<0.05).Orchiectomy in patients with SCA showed significantly higher MPV,PDW,and PCT values than the orchiopexy group(p<0.05).The MPV values of orchiectomy patients showed a higher significant cut-off of≥11.5 fL,which is higher than in torsed patients without SCA,as an indicator of testis survival.PDW also demonstrated a higher significant cut-off of≥12.7 fL for detorsion outcomes in patients with SCA.Symptom duration of less than 7 hours was also significantly correlated with orchiopexy(p≤0.001).Univariate analysis showed that higher MPV,increased PDW,and symptom duration were indicative of the outcome of testicular detorsion in SCA.Multivariable analysis showed that increased PDW and symptom duration are prognostic parameters for testicular viability in SCA.Conclusion Increased PDW and symptom duration can be used as parameters for predicting testicular detorsion outcomes in patients with steady-state SCA. | Essa A Adawi Mazen Ahmed Ghanem Ahmed Mazen Ghanem Manal A Safan Mohamed G Elsayed Mohammed A Aqeel | 2022 | World Journal of Pediatric Surgery2022，5，1： | 0 |
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