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| 1 | Recent Advances in Cuticular Wax Biosynthesis and Its Regulation in Arabidopsis显示文摘The aerial parts of land plants are covered with cuticular waxes that limit non-stomatal water loss and gaseous exchanges,and protect plants from ultraviolet radiation and pathogen attacks.They are composed of very-long-chain fatty acids (VLCFAs;C20 to C34) in addition to their derivatives,aldehydes,alkanes,primary and secondary alcohols,and wax esters.Due to their physical properties,such as solidity at room temperature and a translucency ranging from transparent to opaque,plant waxes have been used as raw materials in the production of cosmetics,detergents,plastics,soaps,paints,drugs,lubricants,and high-value renewable fuels.Many genes involved in cuticular wax biosynthesis and export have been characterized by forward and reverse genetic approaches as well as by stem epidermis transcriptome analysis.The regulatory mechanisms of cuticular wax biosynthesis have been reported at the transcriptional,posttranscriptional,and translational levels.Recent advances in cuticular wax biosynthesis and its regulation are reviewed in this paper. | Saet Buyl Lee Mi Chung Suh | 2013 | Molecular Plant2013，6，2： | 24 |
| 2 | Pharmaeokinetie and phamacodynamic comparison of fluoropyrimidine derivatives, capecitabine and 5-deoxy-5-fluorouridine(5-DFUR) 显示文摘 | Ebi H Sigeoka Y Saet~i T | 2005 | Cancer Chemother Pharmaeol2005，56，2： | 1 |
| 3 | Up-regulation of hepatic low-density lipoprotein receptor–related protein 1: a possible novel mechanism of antiatherogenic activity of hydroxymethylglutaryl–coenzyme A reductase inhibitor显示文摘 | Jae Hoon Moon Saet Byol Kang Jong Suk Park Byung Wan Lee Eun Seok Kang Chul Woo Ahn Hyun Chul Lee Bong Soo Cha | 2011 | Metabolism2011，，7： | 1 |
| 4 | Dietary Monounsaturated Fatty Acids but not Saturated Fatty Acids Preserve the Insulin Signaling Pathway via IRS-1/PI3K in Rat Skeletal Muscle显示文摘 | Jae Hoon Moon Ji Young Lee Saet Byol Kang Jong Suk Park Byung Wan Lee Eun Seok Kang Chul Woo Ahn Hyun Chul Lee Bong Soo Cha | 2010 | Lipids2010，，12： | 1 |
| 5 | The Mycobacterial 38-Kilodalton Glycolipoprotein Antigen Activates the Mitogen-Activated Protein Kinase Pathway and Release of Proinflammatory Cytokines through Toll-Like Receptors 2 and 4 in Human Monocytes显示文摘 | SAET BYEL JUNG CHUL SU YANG JI SOOK LEE | | 0，，： | 1 |
| 6 | Penalty and Eulerian-Lagrang- ian VOF methods for impact and solidification of metal droplets plasma spray process 显示文摘 | Vincent S Le C Bot Saet F | 2014 | Computers & Fluids2014，，4： | 1 |
| 7 | Up-regulation of hepatic low-density lipoprotein receptor–related protein 1: a possible novel mechanism of antiatherogenic activity of hydroxymethylglutaryl–coenzyme A reductase inhibitor显示文摘 | Jae Hoon Moon Saet Byol Kang Jong Suk Park Byung Wan Lee Eun Seok Kang Chul Woo Ahn Hyun Chul Lee Bong Soo Cha | 2011 | Metabolism2011，，7： | 1 |
| 8 | Overexpression of Arabidopsis MYB96 confers drought resistance in Camelina sativa via cuticular wax accumulation显示文摘 | Saet Buyl Lee Hyojin Kim Ryeo Jin Kim Mi Chung Suh | 2014 | Plant Cell Reports2014，，9： | 1 |
| 9 | The MYB96 Transcription Factor Regulates Cuticular Wax Biosynthesis under Drought Conditions in Arabidopsis(W)显示文摘 | Seo Pil Joon Lee Saet Buyl Suh Mi Chung Park Mi-Jeong Go Young Sam Park Chung-Mo | 2011 | EN2011，，3： | 1 |
| 10 | Gene editing of authentic Brassica rapa flavonol synthase 1 generates dihydroflavonol-accumulating Chinese cabbage显示文摘Flavonols are the major class of flavonoids of green Chinese cabbage(Brassica rapa subsp.pekinensis).The B.rapa genome harbors seven flavonol synthase genes(BrFLSs),but they have not been functionally characterized.Here,transcriptome analysis showed four BrFLSs mainly expressed in Chinese cabbage.Among them,only BrFLS1 showed major FLS activity and additional flavanone 3β-hydroxylase(F3H)activity,while BrFLS2 and BrFLS3.1 exhibited only marginal F3H activities.We generated BrFLS1-knockout(BrFLS1-KO)Chinese cabbages using CRISPR/Cas9-mediated genome editing and obtained transgene-free homozygous plants without off-target mutation in the T1 generation,which were further advanced to the T2 generation showing normal phenotype.UPLC-ESI-QTOF-MS analysis revealed that flavonol glycosides were dramatically decreased in the T2 plants,while dihydroflavonol glycosides accumulated concomitantly to levels corresponding to the reduced levels of flavonols.Quantitative PCR analysis revealed that the early steps of phenylpropanoid and flavonoid biosynthetic pathway were upregulated in the BrFLS1-KO plants.In accordance,total phenolic contents were slightly enhanced in the BrFLS1-KO plants,which suggests a negative role of flavonols in phenylpropanoid and flavonoid biosynthesis in Chinese cabbage.Phenotypic surveys revealed that the BrFLS1-KO Chinese cabbages showed normal head formation and reproductive phenotypes,but subtle morphological changes in their heads were observed.In addition,their seedlings were susceptible to osmotic stress compared to the controls,suggesting that flavonols play a positive role for osmotic stress tolerance in B.rapa seedling.In this study,we showed that CRISPR/Cas9-mediated BrFLS1-KO successfully generated a valuable breeding resource of Chinese cabbage with distinctive metabolic traits and that CRISPR/Cas9 can be efficiently applied in functional Chinese cabbage breeding. | Sangkyu Park Hyo Lee Jaeeun Song Chan Ju Lim Jinpyo Oh Sang Hoon Lee Saet Buyl Lee Jong-Yeol Lee Sunhyung Lim Jin A.Kim Beom-Gi Kim | 2023 | Horticulture Research2023，10，12： | 0 |
| 11 | 基于辣椒基因组测序探究辣味在种群中的进化显示文摘辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表明辣椒基因组大小约为番茄的4倍,辣椒基因组上存在大量gypsy转座子和花椰菜病毒家族元件的积累。结合转录组综合分析认为,辣椒素合成酶基因表达模式的改变及新功能化是导致辣椒素生物合成的原因,研究还发现辣椒与番茄在乙烯合成及果实成熟调控方面存在明显不同的分子模式。辣椒参考基因组的发布为辣椒营养品质和药用价值的改善提供了重要平台。 | Seungill Kim Minkyu Park Seon-In Yeom Yong-Min Kim Je Min Lee Hyun-Ah Lee Eunyoung Seo Jaeyoung Choi Kyeongchae Cheong Ki-Tae Kim Kyongyong Jung Gir-Won Lee Sang-Keun Oh Chungyun Bae Saet-Byul Kim Hye-Young Lee Shin-Young Kim Myung-Shin Kim Byoung-Cheorl Kang Yeong Deuk Jo Hee-Bum Yang Hee-Jin Jeong Won-Hee Kang Jin-Kyung Kwon Chanseok Shin Jae Yun Lim June Hyun Park Jin Hoe Huh June-Sik Kim Byung-Dong Kim Oded Cohen Ilan Paran Mi Chung Suh Saet Buyl Lee Yeon-Ki Kim Younhee Shin Seung-Jae Noh Junhyung Park Young Sam Seo Suk-Yoon Kwon Hyun A Kim Jeong Mee Park Hyun-Jin Kim Sang-Bong Choi Paul W Bosland Gregory Reeves Sung-Hwan Jo Bong-Woo Lee Hyung-Taeg Cho Hee-Seung Choi Min-Soo Lee Yeisoo Yu Yang Do Choi Beom-Seok Park Allen van Deynze Hamid Ashrafi Theresa Hill Woo Taek Kim Hyun-Sook Pai Hee Kyung Ahn Inhwa Yeam James J Giovannoni Jocelyn K C Rose Iben Sφrensen Sang-Jik Lee Ryan W Kim Ik-Young Choi Beom-Soon Choi Jong-Sung Lim Yong-Hwan Lee Doil Choi 刘峰 张西露 | 2014 | 辣椒杂志2014，0，2： | 0 |
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