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| 1 | Epidural anesthesia improves pancreatic perfusion and decreases the severity of acute pancreatitis显示文摘AIM: To study the safety of epidural anesthesia(EA),its effect on pancreatic perfusion and the outcome of patients with acute pancreatitis(AP).METHODS: From 2005 to August 2010,patients with predicted severe AP [Ranson score ≥ 2,C-reactive protein > 100 or necrosis on computed tomography(CT)] were prospectively randomized to either a group receiving EA or a control group treated by patientcontrolled intravenous analgesia. Pain management was evaluated in the two groups every eight hours using the visual analog pain scale(VAS). Parameters for clinical severity such as length of hospital stay,use of antibiotics,admission to the intensive care unit,radiological/clinical complications and the need for surgical necrosectomy including biochemical data were recorded. A CT scan using a perfusion protocol was performed on admission and at 72 h to evaluate pancreatic blood flow. A significant variation in blood flow was defined as a 20% difference in pancreatic perfusion between admission and 72 h and was measured in the head,body and tail of the pancreas.RESULTS: We enrolled 35 patients. Thirteen were randomized to the EA group and 22 to the control group. There were no differences in demographic characteristics between the two groups. The Balthazar radiological severity score on admission was higher in the EA group than in the control group(mean score 4.15 ± 2.54 vs 3.38 ± 1.75,respectively,P = 0.347) and the median Ranson scores were 3.4 and 2.7 respectively(P = NS). The median duration of EA was 5.7 d,and no complications of the epidural procedure were reported. An improvement in perfusion of the pancreas was observed in 13/30(43%) of measurements in the EA group vs 2/27(7%) in the control group(P = 0.0025). Necrosectomy was performed in 1/13 patients in the EA group vs 4/22 patients in the control group(P = 0.63). The VAS improved during the first ten days in the EA group compared to the control group(0.2 vs 2.33,P = 0.034 at 10 d). Length of stay and mortality were not statistically different between the 2 groups(26 d vs 30 d,P = 0.65,and 0% for both respectively).CONCLUSION: Our study demonstrates that EA increases arterial perfusion of the pancreas and improves the clinical outcome of patients with AP. | Samira M Sadowski Axel Andres Philippe Morel Eduardo Schiffer Jean-Louis Frossard Alexandra Platon Pierre-Alexandre Poletti Leo Bühler | 2015 | World Journal of Gastroenterology2015，21，43： | 21 |
| 2 | Systemic regulation of vascular NAD(P)H oxidase activity and Nox isoform expression in human arteries and veins 显示文摘 | Guzik TJ Sadowski J Kapelak B | 2004 | Arterioscler Thromb Vasc Biol2004，24，： | 1 |
| 3 | Routine bilat-eral central lymph node clearance for papillary thyroid eancer显示文摘 | Sadowski B M Snyder S K Lairmore T C | 2009 | Surgery2009，146，4： | 1 |
| 4 | Sleep quantity versus sleep quantity:relationships between sleep and measures of health,wellbeing and sleepiness in college students显示文摘 | Pilcher JJ Ginter DR Sadowsky B | 1997 | J Psychosom Res1997，42，6： | 1 |
| 5 | Detecting color vision in a malingerer显示文摘 | Jagle H Sadowski B Kremers J | 2003 | Doc Ophthalmol2003，106，2： | 1 |
| 6 | An evaluation of mandibular asymmetry in adults with unilateral posterior crossbite显示文摘 | O' Byrn B L Sadowsky C Schneider B | 1995 | Am J Orthod Dentofacial Orthop1995，107，4： | 1 |
| 7 | The Transition from Strategic Technology Alliances to Mergers and Acquisitions: An Exploratory Study显示文摘 | HAGGERDORN J SADOWSKI B | 1999 | Journal of Management Studies1999，36，1： | 1 |
| 8 | Treatment of differentiated thyroid cancer显示文摘 | SADOWSKI S M K?HLER B B MEYER P | | 0，，346： | 1 |
| 9 | Cardiac rupture in acute myocardial infarction with ST segment elevation, clinical course and prognosis显示文摘 | Janion M Wozakow Ska~kaplon B Sadowski J | 2004 | Kar- diol Pol2004，1，8： | 1 |
| 10 | A Voltage Fed AC Contactor using 3D Edge Elements显示文摘 | Sadowski J Bastos P A Albuquerque A B | | 0，，： | 1 |
| 11 | An evaluation of mandibular asymmetry in adults with unilateral poste- rior crossbite显示文摘 | O'Byrn BL Sadowsky C Schneider B | 1995 | Am J Orthod Dentofacial Orthop1995，107，4： | 1 |
| 12 | Biodegradation of atrazine and related s-triazine compounds: from enzymes to field studies显示文摘 | Wackett LP Sadowsky MJ Martinez B | 2002 | Applied Microbiology and Biotechnology2002，58，1： | 1 |
| 13 | Cardiac rupture in acute myocardial infarction with ST segment elevation显示文摘 | Janion M Wozakowska-Kaplon B Sadowski J | 2004 | Clinical course and prognosis Kardiol Pol2004，61，8： | 1 |
| 14 | Opposite effects of alcohol in regulating stress-induced changes in body weight between the two mouse lines with enhanced or low opioid system activity 显示文摘 | SacharczukM Sadowski B Jaszczak K | 2010 | Physiol Behav2010，99，62： | 1 |
| 15 | A voltage fed AC contactor modeling using 3D edge element 显示文摘 | Sadowski N Bastos J P A Albuquerque A B | 1998 | IEEE Trans on Magn1998，34，5： | 1 |
| 16 | Synthesis of silver nanoparticles using microorganisms 显示文摘 | Sadowski Z Maliszewska I Grochowalska B | 2008 | Materials Science: Poland2008，26，2： | 1 |
| 17 | Nidogen-1 and nidogen-2 in healthy human cartilage and in late-stage osteoarthritis cartilage 显示文摘 | Kruegel J Sadowski B Miosge N | 2008 | Arthritis Rheum2008，58，5： | 1 |
| 18 | PDGF induces phosphorylation of multiple JAK family kinases and STAT proteins显示文摘 | Sadowski H B Watling D | 1996 | Mol Cell Biol1996，16，4： | 1 |
| 19 | Biodegradation of atrazine and related s-atrazine compounds: from enzymes to fieledstudies 显示文摘 | Wackett L P Sadowsky M J Martinez B | 2002 | Appl Mirobiol Biotech2002，58，： | 1 |
| 20 | Control of cell cycle progression by phosphorylation of cyclin-dependent kinase (CDK) substrates 显示文摘 | Suryadinata R Sadowski M Sarcevic B | 2010 | Biosci Rep2010，30，4： | 1 |
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