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| 1 | Epidural anesthesia improves pancreatic perfusion and decreases the severity of acute pancreatitis显示文摘AIM: To study the safety of epidural anesthesia(EA),its effect on pancreatic perfusion and the outcome of patients with acute pancreatitis(AP).METHODS: From 2005 to August 2010,patients with predicted severe AP [Ranson score ≥ 2,C-reactive protein > 100 or necrosis on computed tomography(CT)] were prospectively randomized to either a group receiving EA or a control group treated by patientcontrolled intravenous analgesia. Pain management was evaluated in the two groups every eight hours using the visual analog pain scale(VAS). Parameters for clinical severity such as length of hospital stay,use of antibiotics,admission to the intensive care unit,radiological/clinical complications and the need for surgical necrosectomy including biochemical data were recorded. A CT scan using a perfusion protocol was performed on admission and at 72 h to evaluate pancreatic blood flow. A significant variation in blood flow was defined as a 20% difference in pancreatic perfusion between admission and 72 h and was measured in the head,body and tail of the pancreas.RESULTS: We enrolled 35 patients. Thirteen were randomized to the EA group and 22 to the control group. There were no differences in demographic characteristics between the two groups. The Balthazar radiological severity score on admission was higher in the EA group than in the control group(mean score 4.15 ± 2.54 vs 3.38 ± 1.75,respectively,P = 0.347) and the median Ranson scores were 3.4 and 2.7 respectively(P = NS). The median duration of EA was 5.7 d,and no complications of the epidural procedure were reported. An improvement in perfusion of the pancreas was observed in 13/30(43%) of measurements in the EA group vs 2/27(7%) in the control group(P = 0.0025). Necrosectomy was performed in 1/13 patients in the EA group vs 4/22 patients in the control group(P = 0.63). The VAS improved during the first ten days in the EA group compared to the control group(0.2 vs 2.33,P = 0.034 at 10 d). Length of stay and mortality were not statistically different between the 2 groups(26 d vs 30 d,P = 0.65,and 0% for both respectively).CONCLUSION: Our study demonstrates that EA increases arterial perfusion of the pancreas and improves the clinical outcome of patients with AP. | Samira M Sadowski Axel Andres Philippe Morel Eduardo Schiffer Jean-Louis Frossard Alexandra Platon Pierre-Alexandre Poletti Leo Bühler | 2015 | World Journal of Gastroenterology2015，21，43： | 21 |
| 2 | 阿特拉津降解菌株Alcalegenes sp.SG1的分离鉴定和降解特性研究显示文摘用富集培养法,从农药厂的工业废水中分离到降解除草剂阿特拉津的SG1菌株,经16S rRNA基因序列分析,该菌株被鉴定为产碱杆菌(Alcalegenes sp.).Alcalegenes sp.SG1能以葡萄糖、果糖、蔗糖、麦芽糖、丙酮酸钠或柠檬酸钠为碳源,以阿特拉津为唯一氮源生长,将阿特拉津完全矿化.PCR分析表明,SG1菌株含有阿特拉津降解基因atzA、atzB、atzC和trzD.生物降解实验表明,与模式菌株Pseudomonas sp.ADP不同,额外加入氮源NH_4Cl或KNO_3,并不影响SG1菌株对阿特拉津的降解,30℃震荡培养16 h后阿特拉津降解率在98%以上,这一特性使其成为应用于阿特拉津污染土壤生物修复的优良候选菌株. | 李清艳 Boundy-Mills K L Sadowsky M J Wackett L P 蔡宝立 | 2010 | 南开大学学报(自然科学版)2010，43，3： | 9 |
| 3 | Treatment of reverse o6-lique and transverse interochanteric fractures with the use of an intr-amedullary nail or a 95 0 screw-plate显示文摘 | Sadowski C Lubbeke A Saudan M | 2002 | J Bone Joint Surg(Am)2002，84，3： | 1 |
| 4 | Growth and early bearing of apple trees as affected by the type of nursery trees used for planting 显示文摘 | Sadowski A Mackiewicz M Dziuban R | 2007 | Acta Horticulturae2007，732，： | 1 |
| 5 | Treatment of re- verse oblique and transverse intertrochanteric fractures with use of an intramedullary nail or a 95 degrees screw - plate : a prosepec- tive, randomized study 显示文摘 | Sadowski C Lubbeke A Saudan M | 2002 | J Bone Joint Surg (Am)2002，84，： | 1 |
| 6 | Landau level spectroscopy of ultrathin graphite layers显示文摘 | Sadowski M L Martinez G Potemski M | | 0，，26： | 1 |
| 7 | Investigation on the diagnostic sensitivity of molecular tools used for detection of koi herpesvirus 显示文摘 | Bergmarm S M Sadowski J Kielpinski M et ai | 2010 | Journal of Virological Methods2010，163，2： | 1 |
| 8 | Long-term stability of dental relationships after orthodontic treatment 显示文摘 | UHDE M SADOWSKY C BEGOLE E A | 1983 | Angle Orthod1983，53，： | 1 |
| 9 | Treatment of reverse oblique and transverse intertrochanteric fractures with use of an intramedullarynail or a 95 degrees screw - plate, a prospective randomized study 显示文摘 | Sadowski C Lubbeke A Saudan M | 2002 | J Bone Joint Surgery(Am)2002，84，： | 1 |
| 10 | Treatment of reverse obliqueand transverse intertrochanteric fractures with use of an intramedullarynail or a 95 degrees screw-plate:a prospective,randomized study显示文摘 | Sadowski C Lübbeke A Saudan M | 2002 | JBone Joint Surg Am2002，84，3： | 1 |
| 11 | Pertrochameric fractures: is there an advantage to an intramedullary nail? A randomised,prospective study of 206 patients comparing the dy- namic hip screw and proximal femoral nail显示文摘 | SAUDAN M LUBBEKE A SADOWSKI C | 2002 | J Orthop Trauma2002，16，： | 1 |
| 12 | Routine bilat-eral central lymph node clearance for papillary thyroid eancer显示文摘 | Sadowski B M Snyder S K Lairmore T C | 2009 | Surgery2009，146，4： | 1 |
| 13 | Long-term changes in calbindin D(28k) immunoreactivity in the rat hippocumpus after cardiac arrest显示文摘 | Sadowski M Lazarewicz JW Jakubowska-Sadowska K | 2002 | Neurosci Lett2002，321，： | 1 |
| 14 | Tteatment of reverse obhque and transverse intertrochanteoic fractures with use of an intameduillary nail or a 95 degrees screw-plate:a prospective randomized study显示文摘 | Sadowski C Lübbeks A Saudan M | | 0，，03： | 1 |
| 15 | Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection 显示文摘 | Hamilton M J Weingarden AR Sadowsky M J | 2012 | Am J Gastroenterol2012，107，5： | 1 |
| 16 | Three dimensional solution for the stress concentration around a circular hole in a plate of arbitrary thickness 显示文摘 | Sternberg E Sadowsky M A | 1949 | Journal of Applied Mechanics1949，16，1： | 1 |
| 17 | Resolution of mandibular arch crowding in growing patients with Class I malocclusions treated nonextraction显示文摘 | WEINBERG M SADOWSKY C | 1996 | Am J Orthod Dentofacial Orthop1996，110，： | 1 |
| 18 | Applications of the rep-PCR DNA fingerprinting technique to study microbial diversity,ecology and evolution显示文摘 | Ishii S Sadowsky M J | | 0，，04： | 1 |
| 19 | Treatment of reverse oblique and transverse intertrochanterie fractures with use of an intramedul- lary nail or a 95screw-plate:a prospective, randomized study显示文摘 | Sadowski C Ltlbbeke A Saudan M | 2002 | J Bone Joint Surg Series A2002，84，3： | 1 |
| 20 | Treatment of reverse oblique and transverse intertrochanteric fractures with use of an intrameedullary nail or a 95 degrees screw-plate:a prospective,randomize study显示文摘 | Sadowski C Lubbeke A Saudan M | | 0，，03： | 1 |
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