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| 1 | Immunology of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is primarily a malignancy of the liver, advancing from a damaged, cirrhotic liver to HCC. Globally, HCC is the sixth most prevalent cancer and the third-most prevalent reason for neoplastic disease-related deaths. A diverse array of infiltrating immunocytes regulates the development and progression of HCC, as is the case in many other cancers. An understanding of the various immune components during HCC becomes necessary so that novel therapeutic strategies can be designed to combat the disease. A dysregulated immune system(including changes in the number and/or function of immune cells, cytokine levels, and the expression of inhibitory receptors or their ligands) plays a key role in the development of HCC. Alterations in either the innate or adaptive arm of the immune system and cross-talk between them make the immune system tolerant to tumors, leading to disease progression. In this review, we have discussed the status and roles of various immune effector cells(e.g., dendritic cells, natural killer cells, macrophages, and T cells), their cytokine profile, and the chemokine-receptor axis in promoting or impeding HCC. | Meenakshi Sachdeva Yogesh K Chawla Sunil K Arora | 2015 | World Journal of Hepatology2015，7，17： | 14 |
| 2 | Efficacy of fermented milk and whey proteins in Helicobacter pylori eradication:A review显示文摘Helicobacter pylori(H.pylori)eradication is considered a necessary step in the management of peptic ulcer disease,chronic gastritis,gastric adenocarcinoma and mucosa associated lymphoid tissue lymphoma.Standard triple therapy eradication regimens are inconvenient and achieve unpredictable and often poor results.Eradication rates are decreasing over time with increase in antibiotic resistance.Fermented milk and several of its component whey proteins have emerged as candidates for complementary therapy.In this context the current review seeks to summarize the current evidence available on their role in H.pylori eradication.Pertinent narrative/systematic reviews,clinical trials and laboratory studies on individual components including fermented milk,yogurt,whey proteins,lactoferrin,α-lactalbumin(α-LA),glycomacropeptide and immunoglobulin were comprehensively searched and retrieved from Medline,Embase,Scopus,Cochrane Controlled Trials Register and abstracts/proceedings of conferences up to May 2013.A preponderance of the evidence available on fermented milk-based probiotic preparations and bovine lactoferrin suggests a beneficial effect in Helicobacter eradication.Evidence forα-LA and immunoglobulins is promising while that for glycomacropeptide is preliminary and requires substantiation.The magnitude of the potential benefit documented so far is small and the precise clinical settings are ill defined.This restricts the potential use of this group as a complementary therapy in a nutraceutical setting hinging on better patient acceptability/compliance.Further work is necessary to identify the optimal substrate,fermentation process,dose and the ideal clinical setting(prevention/treatment,first line therapy/recurrence,symptomatic/asymptomatic,gastritis/ulcer diseases etc.).The potential of this group in high antibiotic resistance or treatment failure settings presents interesting possibilities and deserves further exploration. | Aarti Sachdeva Swapnil Rawat Jitender Nagpal | 2014 | World Journal of Gastroenterology2014，20，3： | 7 |
| 3 | All ileo-cecal ulcers are not Crohn's:Changing perspectives of symptomatic ileocecal ulcers显示文摘AIM To investigated clinical,endoscopic and histopathological parameters of the patients presenting with ileocecal ulcers on colonoscopy.METHODS Consecutive symptomatic patients undergoing colonoscopy,and diagnosed to have ulcerations in the ileocecal(I/C) region,were enrolled.Biopsy was obtained and theirclinical presentation and outcome were recorded.RESULTS Out of 1632 colonoscopies,104 patients had ulcerations in the I/C region and were included in the study.Their median age was 44.5 years and 59% were males.The predominant presentation was lower GI bleed(55,53%),pain abdomen ± diarrhea(36,35%),fever(32,31%),and diarrhea alone(9,9%).On colonoscopy,terminal ileum was entered in 96(92%) cases.The distribution of ulcers was as follows:Ileum alone 40%(38/96),cecum alone 33%(32/96),and both ileum plus cecum 27%(26/96).The ulcers were multiple in 98% and in 34% there were additional ulcers elsewhere in colon.Based on clinical presentation and investigations,the etiology of ulcers was classified into infective causes(43%) and noninfective causes(57%).Fourteen patients(13%) were diagnosed to have Crohn's disease(CD).CONCLUSION Non-specific ileocecal ulcers are most common ulcers seen in ileo-cecal region.And if all infections are clubbed together then infection is the most common(> 40%) cause of ulcerations of the I/C region.Cecal involvement and fever are important clues to infective cause.On the contrary CD account for only 13% cases as a cause of ileo-cecalulcers.So all symptomatic patients with I/C ulcers on colonoscopy are not Crohn's. | Jay Toshniwal Romesh Chawlani Amit Thawrani Rajesh Sharma Anil Arora Hardik L Kotecha Mohan Goyal Vijendra Kirnake Pankaj Jain Pankaj Tyagi Naresh Bansal Munish Sachdeva Piyush Ranjan Mandhir Kumar Praveen Sharma Vikas Singla Rinkesh Bansal Vineet Shah Sunita Bhalla Ashish Kumar | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，7： | 5 |
| 4 | Impact of gout on in-hospital outcomes of acute coronary syndrome-related hospitalizations and revascularizations: Insights from the national inpatient sample显示文摘BACKGROUND Previous studies have established a role of gout in predicting risk and prognosis of cardiovascular diseases. However, large-scale data on the impact of gout on inpatient outcomes of acute coronary syndrome (ACS)-related hospitalizations and post-revascularization is inadequate. AIM To evaluate the impact of gout on in-hospital outcomes of ACS hospitalizations, subsequent healthcare burden and predictors of post-revascularization inpatient mortality. METHODS We used the national inpatient sample (2010-2014) to identify the ACS and goutrelated hospitalizations, relevant comorbidities, revascularization and postrevascularization outcomes using the ICD-9 CM codes. A multivariable analysis was performed to evaluate the predictors of post-revascularization in-hospital mortality. RESULTS We identified 3144744 ACS-related hospitalizations, of which 105198 (3.35%) also had gout. The ACS-gout cohort were more often older white males with a higher prevalence of comorbidities. Coronary artery bypass grafting was required more often in the ACS-gout cohort. Post-revascularization complications including cardiac (3.2% vs 2.9%), respiratory (3.5% vs 2.9%), and hemorrhage (3.1% vs 2.7%) were higher whereas all-cause mortality was lower (2.2% vs 3.0%) in the ACSgout cohort (P < 0.001). An older age (OR 15.63, CI: 5.51-44.39), non-elective admissions (OR 2.00, CI: 1.44-2.79), lower household income (OR 1.44, CI: 1.17- 1.78), and comorbid conditions predicted higher mortality in ACS-gout cohort undergoing revascularization (P < 0.001). Odds of post-revascularization inhospital mortality were lower in Hispanics (OR 0.45, CI: 0.31-0.67) and Asians (OR 0.65, CI: 0.45-0.94) as compared to white (P < 0.001). However, postoperative complications significantly raised mortality odds. Mean length of stay, transfer to other facilities, and hospital charges were higher in the ACS-gout cohort. CONCLUSION Although gout was not independently associated with an increased risk of postrevascularization in-hospital mortality in ACS, it did increase postrevascularization complications. | Rupak Desai Tarang Parekh Hemant Goyal Hee Kong Fong Dipen Zalavadia Nanush Damarlapally Rajkumar Doshi Sejal Savani Gautam Kumar Rajesh Sachdeva | 2019 | World Journal of Cardiology2019，11，5： | 4 |
| 5 | 因拒食而由家庭成员对其鼻饲四年的精神分裂症和强迫症共病患者一例(英文)显示文摘在许多精神障碍中(包括强迫症和精神分裂症),拒食是常见的表现。当突然出现拒食时,这可能需要急诊处理;一旦变成慢性,它就成为一种难以改变的根深蒂固的行为。对拒食患者的诊断可能有难度,尤其是对有共病问题、智力受损或对自身状况缺乏自知力的患者。鼻饲是一种有效的短期干预方法,当患者重新进食时即可中止这一干预。然而,在某些情况下,患者可能变得依赖于鼻饲。我们介绍一个病例,报告一名患有精神分裂症、强迫症、边缘智力以及癫痫的患者由于拒绝进食而由其家庭成员用鼻饲管喂食超过三年。 | Sachdeva A Chandra M Saxena A Beniwal R Kandpal M Kumar A | 2015 | 上海精神医学2015，27，4： | 3 |
| 6 | Dendritic cells: The warriors upfront-turned defunct in chronic hepatitis C infection显示文摘Hepatitis C virus(HCV) infection causes tremendousmorbidity and mortality with over 170 million people infected worldwide. HCV gives rise to a sustained, chronic disease in the majority of infected individuals owing to a failure of the host immune system to clear the virus. In general, an adequate immune response is elicited by an efficient antigen presentation by dendritic cells(DCs), the cells that connect innate and adaptive immune system to generate a specific immune response against a pathogen. However, HCV seems to dysregulate the activity of DCs, making them less proficient antigen presenting cells for the optimal stimulation of virusspecific T cells, hence interfering with an optimal antiviral immune response. There are discordant reports on the functional status of DCs in chronic HCV infection(CHC), from no phenotypic or functional defects to abnormal functions of DCs. Furthermore, the molecular mechanisms behind the impairment of DC function are even so not completely elucidated during CHC. Understanding the mechanisms of immune dysfunction would help in devising strategies for better management of the disease at the immunological level and help to predict the prognosis of the disease in the patients receiving antiviral therapy. In this review, we have discussed the outcomes of the interaction of DCs with HCV and the mechanisms of DC impairment during HCV infection with its adverse effects on the immune response in the infected host. | Meenakshi Sachdeva Yogesh K Chawla Sunil K Arora | 2015 | World Journal of Hepatology2015，7，19： | 2 |
| 7 | Elevation of Carbohydrate Antigen 19.9 in Benign Hepatobiliary Conditions and Its Correlation with Serum Bilirubin Concentration显示文摘 | S. L. Ong A. Sachdeva G. Garcea G. Gravante M. S. Metcalfe D. M. Lloyd D. P. Berry A. R. Dennison | 2008 | Digestive Diseases and Sciences2008，，12： | 2 |
| 8 | Probiotics Prevent Hepatic Encephalopathy in Patients With Cirrhosis: A Randomized Controlled Trial显示文摘 | Manish Kumar Lunia Barjesh Chander Sharma Praveen Sharma Sanjeev Sachdeva Siddharth Srivastava | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 2 |
| 9 | Hyponatremia with olanzapine - A suspected association显示文摘低钠血症是一种罕见的具有潜在生命危险的抗精神病药物治疗的不良反应。这里,我们报告一个病例,45岁女性精神分裂症患者在奥氮平治疗后不久出现低钠血症。为此我们评估了低钠血症和奥氮平治疗之间的关系,因为及时的药物监测至关重要。根据Naranjo算法,在奥氮平和低钠血症之间的关联性评价,可评价为'可能'。因此有必要探究低钠血症这一临床上重大、危及生命的不良事件产生的可能原因。我们报告的病例聚焦于奥氮平治疗引起的低钠血症的不良事件。由于精神疾病患者有时无法主诉或主诉不被重视,内科疾病常常被忽视或错过。在处理这种可能的不良反应时,应保持高度警觉性。 | Ankur SACHDEVA Mona CHOUDHARY | 2017 | 上海精神医学2017，29，3： | 2 |
| 10 | Topological Studies of Three-dimensional Flows in a High Pressure Compressor Stator Blade Row without and with Boundary Layer Aspiration显示文摘This paper presents a numerical study of the flow topologies of three-dimensional (3D) flows in a high pressure compressor stator blade row without and with boundary layer aspiration on the hub wall. The stator blade is representative of the first stage operating under transonic inlet conditions and the blade design encourages development of highly complex 3D flows. The blade has a small tip clearance. The computational fluid dynamics (CFD) studies show progressive increase of hub corner stall with the increase in incidence. Aspiration is implemented on the hub wall via a slot in the corner between the hub wall and the suction surface. The CFD studies show aspiration to be sensitive to the suction flow rate; lower rate leads to very complex flow structures and increased level of losses whereas higher rate renders aspiration effective for control of hub corner separation. The flow topologies are studied by trace of skin friction lines on the walls. The nature of flow can be explained by the topological rules of closed separation. Furthermore, a deeper analysis is done for a particular case with advanced criterion to test the non-degeneracy of critical points in the flow field. | Ankit SACHDEVA Francis LEBOEUF | 2011 | Chinese Journal of Aeronautics2011，24，5： | 2 |
| 11 | Manual aspiration thrombectomy in acute ST elevation myocardial infarction:New gold standard?显示文摘Percutaneous coronary intervention(PCI) is the preferred method to treat ST segment myocardial infarction(STEMI).The use of thrombus aspiration(TA) may be particularly helpful as part of the PCI process,insofar as the presence of thrombus is essentially a universal component of the STEMI process.This article reviews evidence favoring the routine use of TA,and the limitations of these data.Based on current evidence,we consider TA to be an important maneuver during STEMI PCI,even in the absence of visible angiographic thrombus,and recommend it whenever the presence of thrombus is likely. | Brent Rochon Youssef Chami Rajesh Sachdeva Joe K Bissett Nick Willis Barry F Uretsky | 2011 | World Journal of Cardiology2011，3，2： | 2 |
| 12 | An indicator-based approach to assess village-level social and biophysical vulnerability of agriculture communities in Uttarakhand,India显示文摘With the growing recognition to myriad forms of current and future threats in the mountain agriculture systems,there is a pressing need to holistically understand the vulnerability of mountain agriculture communities.The study aims to assess the biophysical and social vulnerability of agriculture communities using an indicator-based approach for the state of Uttarakhand,India.A total of 14 indicators were used to capture biophysical vulnerability and 22 for social vulnerability profiles of15285 villages.Vulnerability analysis was done at village level with weights assigned to each indicator using Analytical Hierarchical Process(AHP).The results of the study highlight the presence of very high biophysical vulnerability(0.82 ± 0.10) and high social vulnerability(0.65 ± 0.15) within the state.Based on the results,it was found that incidences of high biophysical vulnerability coincide with presence of intensified agriculture land and absence of dense forest.Higher social vulnerability scores were found in villages with an absence of local institutions(like Self Helping Groups(SHGs)),negligible infrastructure facilities and higher occupational dependence on agriculture.A contrast was observed in the vulnerability scores of villages present in the three different altitudinal zones in the study area,indicating respective vulnerability generating conditions existing in these three zones.Biophysical vulnerability was recorded to be highest in the villages falling in the lower zone and lowest in the upper zone villages;whereas,social vulnerability was found to be highest in the middle zone villages and lowest in lower zone villages.Our study aids policy makers in identifying areas for intervention to expedite agriculture adaptation planning in the state.Additionally,the adaptation programmes in the region need to be more context-specific to accommodate the differential altitudinal vulnerability profiles. | Roopam SHUKLA Kamna SACHDEVA Pawan Kumar JOSHI | 2016 | Journal of Mountain Science2016，13，12： | 2 |
| 13 | A finite element solution for the 2D elastic contact problems with friction显示文摘 | Ramakrishnan C V | 1981 | International Journal for Numerical Methods in Engineering1981，17，： | 1 |
| 14 | MicroRNA - 145 suppresses cell invasion and metastasis by directly targeting mucin 1 显示文摘 | Sachdeva M Mo YY | 2010 | Cancer Res2010，70，： | 1 |
| 15 | The initial vascu- lar access type contributes to inflammation inincident hemodi- alysis patients显示文摘 | Sachdeva M Hung A Kovalehuk O | 2012 | International Journal of Nephrology2012，，8： | 1 |
| 16 | Acute respiratory distress syndrome显示文摘 | Sachdeva R C Guntupalli K K | 1997 | Crit Care Clin1997，13，： | 1 |
| 17 | Repetitive elements sequence (REP/ERIC) -PCR based genotyping of clinical and environmental strains of Yersinia enterocolitica biotype 1A reveal existence of limited number of clonal groups 显示文摘 | Sachdeva P Virdi JS | 2004 | FEMS Microbiol Lett2004，240，： | 1 |
| 18 | ST-segment elevationmyocardial infarction in severe coronary artery stenosis: acase series显示文摘 | Agarwal M Uretsky B Sachdeva R | 2010 | J Invasive Cardiol2010，22，3： | 1 |
| 19 | Studyof aerosol behavior on the basis of morphologicalcharacteristics during festival events in India 显示文摘 | Agrawal A Upadhyay V K Sachdeva K | 2011 | Atmospheric Environment 92011，45，： | 1 |
| 20 | Impaired restoration of plasmacytoid dendritic cells in HIV-1-infected patients with poor CD4 T cell reconstitution is associated with decrease in capacity to produce IFN-alpha but not proinflammatory cytokines显示文摘 | Sachdeva N Asthana V Brewer TH | 2008 | J Immunol2008，181，4： | 1 |
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