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| 1 | Immunology of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is primarily a malignancy of the liver, advancing from a damaged, cirrhotic liver to HCC. Globally, HCC is the sixth most prevalent cancer and the third-most prevalent reason for neoplastic disease-related deaths. A diverse array of infiltrating immunocytes regulates the development and progression of HCC, as is the case in many other cancers. An understanding of the various immune components during HCC becomes necessary so that novel therapeutic strategies can be designed to combat the disease. A dysregulated immune system(including changes in the number and/or function of immune cells, cytokine levels, and the expression of inhibitory receptors or their ligands) plays a key role in the development of HCC. Alterations in either the innate or adaptive arm of the immune system and cross-talk between them make the immune system tolerant to tumors, leading to disease progression. In this review, we have discussed the status and roles of various immune effector cells(e.g., dendritic cells, natural killer cells, macrophages, and T cells), their cytokine profile, and the chemokine-receptor axis in promoting or impeding HCC. | Meenakshi Sachdeva Yogesh K Chawla Sunil K Arora | 2015 | World Journal of Hepatology2015，7，17： | 14 |
| 2 | Dendritic cells: The warriors upfront-turned defunct in chronic hepatitis C infection显示文摘Hepatitis C virus(HCV) infection causes tremendousmorbidity and mortality with over 170 million people infected worldwide. HCV gives rise to a sustained, chronic disease in the majority of infected individuals owing to a failure of the host immune system to clear the virus. In general, an adequate immune response is elicited by an efficient antigen presentation by dendritic cells(DCs), the cells that connect innate and adaptive immune system to generate a specific immune response against a pathogen. However, HCV seems to dysregulate the activity of DCs, making them less proficient antigen presenting cells for the optimal stimulation of virusspecific T cells, hence interfering with an optimal antiviral immune response. There are discordant reports on the functional status of DCs in chronic HCV infection(CHC), from no phenotypic or functional defects to abnormal functions of DCs. Furthermore, the molecular mechanisms behind the impairment of DC function are even so not completely elucidated during CHC. Understanding the mechanisms of immune dysfunction would help in devising strategies for better management of the disease at the immunological level and help to predict the prognosis of the disease in the patients receiving antiviral therapy. In this review, we have discussed the outcomes of the interaction of DCs with HCV and the mechanisms of DC impairment during HCV infection with its adverse effects on the immune response in the infected host. | Meenakshi Sachdeva Yogesh K Chawla Sunil K Arora | 2015 | World Journal of Hepatology2015，7，19： | 2 |
| 3 | Manual aspiration thrombectomy in acute ST elevation myocardial infarction:New gold standard?显示文摘Percutaneous coronary intervention(PCI) is the preferred method to treat ST segment myocardial infarction(STEMI).The use of thrombus aspiration(TA) may be particularly helpful as part of the PCI process,insofar as the presence of thrombus is essentially a universal component of the STEMI process.This article reviews evidence favoring the routine use of TA,and the limitations of these data.Based on current evidence,we consider TA to be an important maneuver during STEMI PCI,even in the absence of visible angiographic thrombus,and recommend it whenever the presence of thrombus is likely. | Brent Rochon Youssef Chami Rajesh Sachdeva Joe K Bissett Nick Willis Barry F Uretsky | 2011 | World Journal of Cardiology2011，3，2： | 2 |
| 4 | Acute respiratory distress syndrome显示文摘 | Sachdeva R C Guntupalli K K | 1997 | Crit Care Clin1997，13，： | 1 |
| 5 | Studyof aerosol behavior on the basis of morphologicalcharacteristics during festival events in India 显示文摘 | Agrawal A Upadhyay V K Sachdeva K | 2011 | Atmospheric Environment 92011，45，： | 1 |
| 6 | Desmethoxyyangonin and Dihydromethysticin are Two Major Pharmacological Kavalactones with Marked Activity on the Induction of CYP3A23显示文摘 | Ma Y Sachdeva K Liu J | 2004 | Drug Metabolism and Disposition2004，32，11： | 1 |
| 7 | Studyof aerosol behavior on the basis of morphologicalcharacteristics during festival events in India 显示文摘 | Agrawal A Upadhyay V K Sachdeva K | 2011 | Atmospheric Environment 92011，45，： | 1 |
| 8 | Sucrose metabolism and ex- preasion enzyme activities in low and high storing sugarcane genotypes of key sucrose显示文摘 | Sachdeva M Mann A P S Batta S K | 2003 | Sugar Technol2003，5，4： | 1 |
| 9 | Effects of titanium nitride coatings on surface and corrsion characteristics of Ni-Ti alloy显示文摘 | SACHDEVA R ARAKI Y | 1994 | Dent Mater J1994，13，2： | 1 |
| 10 | Attenuation of renoinflammatory cascade in experimental model of diabetic nephropathy by sesamol显示文摘 | KUHAD A SACHDEVA AK Chopra K | 2009 | J Agric Food Chem2009，57，14： | 1 |
| 11 | Clinical effica- cy of noninvasive cryolipolysis and its effects on periph- cral nerbes显示文摘 | Coleman SR Sachdeva K Egbert BM | 2009 | Aesthetic Plast Surg2009，33，： | 1 |
| 12 | Deep desulfurization of diesel via peroxide oxidation using phosphotungstic acid phase transfer catalyst 显示文摘 | SACHDEVA T O PANT K K | 2010 | Fuel Processing Technology2010，91，9： | 1 |
| 13 | Cytological observations on some west Himalayan monocots: Liliaceae and Trilliaceae 显示文摘 | Mehra P N Sachdeva S K | 1976 | Cytologia1976，41，： | 1 |
| 14 | Clinical efficacy of noninvasive cryolipolysis and its effects on peripheral nerves 显示文摘 | Coleman SR Sachdeva K Egbert BM | 2009 | Aesthetic Plast Surg2009，33，4： | 1 |
| 15 | The critical role ofaccreditation in establishing the ACS Education Institutes toadvance patient safety through simulation 显示文摘 | Johnson K A Sachdeva A K Pellegrini C A | 2008 | J GastrointestSurg2008，12，2： | 1 |
| 16 | Acute respiratory distress syndrome显示文摘 | Sachdeva R C Guntupalli K K | 1997 | Crit Care Clin1997，13，13： | 1 |
| 17 | Use of ethnicity-specific sequence tag site markers for Y chromosome microdeletion studies 显示文摘 | Sachdeva K Saxena R Majumdar A | 2011 | Genet Test Mol Biomarkers2011，15，6： | 1 |
| 18 | Attenuation of renoinflammatory cascade in experimental model of di- abetic nephropathy by sesamol显示文摘 | KUHAD A SACHDEVA AK CHOPRA K | 2009 | J Agric Food Chem2009，57，14： | 1 |
| 19 | Solitary fibrous tumour of lung显示文摘 | Sachdeva R Gupta K B Mathur S K | 2013 | Indian J Chest Dis Allied Sci2013，55，3： | 1 |
| 20 | Serine threonine protein kinases of mycobacterial genus:phylogeny to function显示文摘 | Narayan A Sachdeva P Sharma K Saini AK Tyagi AK Singh Y | 2007 | Physiol Genomics2007，29，1： | 1 |
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