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| 1 | Neurotrophic factors and corneal nerve regeneration显示文摘The cornea has unique features that make it a useful model for regenerative medicine studies. It is an avascular, transparent, densely innervated tissue and any pathological changes can be easily detected by slit lamp examination. Corneal sensitivity is provided by the ophthalmic branch of the trigeminal nerve that elicits protective reflexes such as blinking and tearing and exerts trophic support by releasing neuromediators and growth factors. Corneal nerves are easily evaluated for both function and morphology using standard instruments such as corneal esthesiometer and in vivo confocal microscope. All local and systemic conditions that are associated with damage of the trigeminal nerve cause the development of neurotrophic keratitis, a rare degenerative disease. Neurotrophic keratitis is characterized by impairment of corneal sensitivity associated with development of persistent epithelial defects that may progress to corneal ulcer, melting and perforation. Current neurotrophic keratitis treatments aim at supporting corneal healing and preventing progression of corneal damage. Novel compounds able to stimulate corneal nerve recovery are in advanced development stage. Among them, nerve growth factor eye drops showed to be safe and effective in stimulating corneal healing and improving corneal sensitivity in patients with neurotrophic keratitis. Neurotrophic keratitis represents an useful model to evaluate in clinical practice novel neuro-regenerative drugs. | Marta Sacchetti Alessandro Lambiase | 2017 | Neural Regeneration Research2017，12，8： | 16 |
| 2 | Restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis:A narrative review显示文摘Restorative proctocolectomy with ileal pouch-anal anastomosis(RP-IPAA) is the gold standard surgical treatment for ulcerative colitis.However,despite the widespread use of RP-IPAA,many aspects of this treatment still remain controversial,such as the approach(open or laparoscopic),number of stages in the surgery,type of pouch,and construction type(hand-sewn or stapled ileal pouch-anal anastomosis).The present narrative review aims to discuss current evidence on the short-,mid-,and long-term results of each of these technical alternatives as well as their benefits and disadvantages.A review of the MEDLINE,EMBASE,and Ovid databases was performed to identify studies published through March 2016.Few large,randomized,controlled studies have been conducted,which limits the conclusions that can be drawn regarding controversial issues.The available data from retrospective studies suggest that laparoscopic surgery has no clear advantages compared with open surgery and that one-stage RP-IPAA may be indicated in selected cases.Regarding 2- and 3-stage RP-IPAA,patients who underwent these surgeries differed significantly with respect to clinical and laboratory variables,making any comparisons extremely difficult.The long-term results regarding the pouch type show that the W- and J-reservoirs do not differ significantly,although the J pouch is generally preferred by surgeons.Hand-sewn and stapled ileal pouch-anal anastomoses have their own advantages,and there is no clear benefit of one technique over the other. | Luigi Sofo Paola Caprino Franco Sacchetti Maurizio Bossola | 2016 | World Journal of Gastrointestinal Surgery2016，8，8： | 3 |
| 3 | Prognostic criteria for postoperative mortality in 170 patients undergoing major right hepatectomy显示文摘BACKGROUND: Postoperative hepatic failure is a dreadful complication after major hepatectomy and carries high morbidity and mortality rates. In this study, we assessed the accuracy of the 50/50 criteria (bilirubin >2.9 mg/dL and international normalized ratio >1.7 on postoperative day 5) and the Mullen criteria (bilirubin peak >7 mg/dL on postoperative days 1-7) in predicting death from hepatic failure in patients undergoing right hepatectomy only. In addition, we identified prognostic factors linked to intra-hospital morbidity and mortality in these patients. METHODS: One hundred seventy consecutive patients underwent major right hepatectomy at a tertiary medical center from 2000 to 2008. Nineteen (11.2%) patients suffered from liver cirrhosis. Univariate and multivariate analyses were performed to identify predictors of intra-hospital mortality, morbidity and death from hepatic failure. RESULTS: The intra-hospital mortality was 6.5% (11/170). Of the six patients who died from hepatic failure, one was positive for the 50/50 criteria, but all six patients were positive for the Mullen criteria. Multivariate analysis showed that male gender, hepatitis C (HCV), hepatocellular carcinoma, postoperative bilirubin >7 mg/dL and ALT<188 U/L on postoperative day 1 were predictive of death from hepatic failure in the postoperative period. Age >65 years, HCV, reoperation, andrenal failure were significant predictors of overall intra-hospital mortality on multivariate analysis. CONCLUSIONS: The Mullen criteria were more accurate than the 50/50 criteria in predicting death from hepatic failure in patients undergoing right hepatectomy. A bilirubin peak >7 mg/dL in the postoperative period, HCV positivity, hepatocellular carcinoma, and an ALT level <188 U/L on postoperative day 1 were associated with death from hepatic failure in our patient population. | Filippo Filicori Xavier M Keutgen Matteo Zanello Giorgio Ercolani Salomone Di Saverio Federico Sacchetti Antonio Daniele Pinna Gian Luca Grazi | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，5： | 2 |
| 4 | Amniotic membrane transplantation associated with conjunctival peritomy in the management of Mooren' s ulcer: a case report 显示文摘 | Lambiase A Sacchetti M Sgrulletta R | 2005 | Eur J Ophthalmol2005，15，2： | 1 |
| 5 | Effects of extrusion tem-perature and feed composition on the functional,physical and sensory proper ties of chestnut and rice flour-based snack-like products显示文摘 | Sacchetti G Pinnavaia G Guidolin E | 2004 | Food Research Inter2004，37，： | 1 |
| 6 | Group management for mobile ad hoc networks: design, implementation and experiment显示文摘 | LIU J SACCHETTI D SAILHAN F | 2005 | Proceedings of the 6th conference on MDM2005，，： | 1 |
| 7 | Pituitary adenylate cyclase- activating polypeptide hormone (PACAP) at very low dosages impro- ves memory in the rat 显示文摘 | Sacchetti B Lorenzini CA Baldi E | 2001 | Neurobiol Learn Mem2001，76，1： | 1 |
| 8 | Amniotic membrane transplantation associated with conjunctival peritomy in the management of Mooren ' s ulcer : a case report 显示文摘 | Lambiase A Sacchetti M Sgrulletta R | 2005 | Eur J Ophthalmol2005，15，2： | 1 |
| 9 | Performance of a full -scale membrane b i o r e a c t o r s y s t e m i n t r e a t i n g m u n i c i p a l wastewater for reuse purposes显示文摘 | Franca Zanetti Giovanna De Luca Rossella Sacchetti | | 0，，： | 1 |
| 10 | Open reduction and internal fixation combined with hinged elbow fixator in capitellum and trochlea fractures 显示文摘 | Giannicola G Sacchetti FM Greco A | 2010 | Acta Orthop2010，81，2： | 1 |
| 11 | Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanism显示文摘 | Sacchetti P Mitchell TR Granneman JG | 2001 | J Neurochem2001，76，5： | 1 |
| 12 | Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment显示文摘 | Sacchetti B Funari A Michienzi S | 2007 | Cell2007，131，2： | 1 |
| 13 | Cancer cell killing by Celecoxib : Reality or just in vitro pre- cipitation-related artifact? 显示文摘 | Sacchetti A | 2013 | Journal of cellular biochemistry2013，114，6： | 1 |
| 14 | Acute cardiogenic pulmonary edema; What's the latest emergency treatment? 显示文摘 | Sacchetti A D Harris R H | 1998 | Postgrad Med1998，103，2： | 1 |
| 15 | Open reduction and internalfixation combined with hinged elbow fixator in capitellum and trochle-a fractures显示文摘 | Giannicola G Sacchetti FM Greco A | 2010 | Acta Orthop2010，2，： | 1 |
| 16 | Oral ziprasidone in thetreatment of patients with bipolar disorders: a critical review显示文摘 | Sacchetti E Galluzzo A Valsecchi P | 2011 | Expert Rev Clin Pharmacol2011，4，2： | 1 |
| 17 | 显示文摘 | Croce F Sacchetti S Scrosati B | 2006 | J Power Sources2006，161，： | 1 |
| 18 | Nurrl enhances transcription of the human dopamine transporter gene through a novel mechanism显示文摘 | Sacchetti P Mitchell T R Granneman J G | 2001 | J Neuroehem2001，76，5： | 1 |
| 19 | 'Isehemia modified albumin': a new biochemical marker of myocardial ischmaia显示文摘 | Sacchetti A | 2004 | Emerg Med J2004，21，1： | 1 |
| 20 | lschemia modified albumin:a new biochemical marker of myocardial ischemia显示文摘 | Sacchetti A | 2004 | Emerg Med2004，21，： | 1 |
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