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| 1 | Prognostic criteria for postoperative mortality in 170 patients undergoing major right hepatectomy显示文摘BACKGROUND: Postoperative hepatic failure is a dreadful complication after major hepatectomy and carries high morbidity and mortality rates. In this study, we assessed the accuracy of the 50/50 criteria (bilirubin >2.9 mg/dL and international normalized ratio >1.7 on postoperative day 5) and the Mullen criteria (bilirubin peak >7 mg/dL on postoperative days 1-7) in predicting death from hepatic failure in patients undergoing right hepatectomy only. In addition, we identified prognostic factors linked to intra-hospital morbidity and mortality in these patients. METHODS: One hundred seventy consecutive patients underwent major right hepatectomy at a tertiary medical center from 2000 to 2008. Nineteen (11.2%) patients suffered from liver cirrhosis. Univariate and multivariate analyses were performed to identify predictors of intra-hospital mortality, morbidity and death from hepatic failure. RESULTS: The intra-hospital mortality was 6.5% (11/170). Of the six patients who died from hepatic failure, one was positive for the 50/50 criteria, but all six patients were positive for the Mullen criteria. Multivariate analysis showed that male gender, hepatitis C (HCV), hepatocellular carcinoma, postoperative bilirubin >7 mg/dL and ALT<188 U/L on postoperative day 1 were predictive of death from hepatic failure in the postoperative period. Age >65 years, HCV, reoperation, andrenal failure were significant predictors of overall intra-hospital mortality on multivariate analysis. CONCLUSIONS: The Mullen criteria were more accurate than the 50/50 criteria in predicting death from hepatic failure in patients undergoing right hepatectomy. A bilirubin peak >7 mg/dL in the postoperative period, HCV positivity, hepatocellular carcinoma, and an ALT level <188 U/L on postoperative day 1 were associated with death from hepatic failure in our patient population. | Filippo Filicori Xavier M Keutgen Matteo Zanello Giorgio Ercolani Salomone Di Saverio Federico Sacchetti Antonio Daniele Pinna Gian Luca Grazi | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，5： | 2 |
| 2 | Amniotic membrane transplantation associated with conjunctival peritomy in the management of Mooren' s ulcer: a case report 显示文摘 | Lambiase A Sacchetti M Sgrulletta R | 2005 | Eur J Ophthalmol2005，15，2： | 1 |
| 3 | Amniotic membrane transplantation associated with conjunctival peritomy in the management of Mooren ' s ulcer : a case report 显示文摘 | Lambiase A Sacchetti M Sgrulletta R | 2005 | Eur J Ophthalmol2005，15，2： | 1 |
| 4 | Interleukin-6 stimulates lipolysis and fat oxidation in humans显示文摘 | Hall GV Steensberg A Sacchetti M | 2003 | J Clin Endocrinol Metab2003，88，： | 1 |
| 5 | Prospective observation al study of pneumonia in an Italian hospital 显示文摘 | Sacchetti R Aporti M Bianco L | 2008 | Infez Med2008，16，21： | 1 |
| 6 | Acute IL-6 treatment increases fatty acid turnover in elderly humansin vivo and in tissue culturein vitro显示文摘 | Petersen EW Carey AL Sacchetti M | 2005 | Am J Physiol Endocrinol Metab2005，288，： | 1 |
| 7 | Dynamics of low temperature PECVD growth of microcrystalline silicon thin films: Impact of substrate surface treatments 显示文摘 | Losurdo M Giangregorio M M Sacchetti A et ol | 2006 | Journal of Non-Crystalline Solids2006，352，： | 1 |
| 8 | Limbal stem cell deficiency associated with LADD syndrome显示文摘 | Cortes M Lambiase A Sacchetti M | | 0，，： | 1 |
| 9 | Nerve growth factor therapy for corneal disease显示文摘 | Lambiase A Sacchetti M Bonini S | 2012 | Curr Opin Ophthalmol2012，23，4： | 1 |
| 10 | Comparative evaluation of 11 essential oils of different origin as functional antioxidants, antiradieals and antirnicrobials in foods显示文摘 | SACCHETTI G MAIETTI S MUZZOLI M | 2005 | Food Chemistry2005，91，： | 1 |
| 11 | Determination of phthalate esters in wine using solid - phase extraction and gas chromatography - mass spectrometry 显示文摘 | Del Carlo M Pepe A Sacchetti G | 2008 | Food Chem2008，111，3： | 1 |
| 12 | Capsaicin-induced corneal sensory denervation and healing impairment are reversed by NGF treatment 显示文摘 | Lambiase A Aloe L Mantelli F Sacchetti M Perrella E Bianchi P | 2012 | Invest Ophtholmot Vis Sci2012，53，13： | 1 |
| 13 | Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction显示文摘 | Febbaraio M A Hiscock N Sacchetti M | 2004 | Diabetes2004，53，7： | 1 |
| 14 | Clinical applications of NGF in ocular diseases 显示文摘 | Lambiase A Mantelli F Sacchetti M | 2011 | Arch hal Biol2011，149，2： | 1 |
| 15 | Clinical applications of NGF in ocular diseases显示文摘 | Lambiase A Mantelli F Sacchetti M | 2011 | Arch Ital Biol2011，149，2： | 1 |
| 16 | Corneal changes in neurosurgieally induced neurotrophic keratitis显示文摘 | Lambiase A Sacchetti M Mastropasqua A | 2013 | JAMA Oph- thalmol2013，131，12： | 1 |
| 17 | Topical azithromycinas a novel treatment for ocular rosacea显示文摘 | Mantelli F Di Zazzo A Sacchetti M | 2013 | Ocul ImmunolInflamm2013，21，5： | 1 |
| 18 | Sex hormones in allergic conjunctivitis:altered levels of circulating androgens and estrogens in children and adolescents with vernal keratoconjunctivitis显示文摘 | Sacchetti M Lambiase A Moretti C | 2015 | J Immunol Res2015，2015，94： | 1 |
| 19 | Diagnosis and management of neurotrophic keratitis显示文摘 | Sacchetti M Lambiase A | 2014 | Clin Ophthalmol2014，198，： | 1 |
| 20 | Clinical applications of NGF in ocular diseases 显示文摘 | Lambiase A Mantelli F Sacchetti M | 2011 | Archives Italiennes de Biologic2011，149，： | 1 |
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