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| 1 | Impact of liver steatosis on response to pegylated interferon therapy in patients with chronic hepatitis B显示文摘AIM: To evaluate the impact of liver steatosis upon response to given therapy in chronic hepatitis B (CHB) patients. METHODS: 84 consecutive CHB patients treated with 48-wk PEGylated interferon (PEG-IFN) therapy were enrolled. Baseline characteristics and sustained viral response (SVR) to PEG-IFN therapy were evaluated. RESULTS:Mean body mass index (BMI) was 27.36 ± 4.4 kg/m 2 . Six (7.1%) had hypertension and three (3.5%) had diabetes mellitus. Steatosis was present in 22.6% (19/84) of liver biopsy samples. Age, BMI, and triglyceride levels of the patients with hepatic steatosis were significantly higher than those without hepatic steatosis (P < 0.05). SVR to PEG-IFN therapy was 21.4% (18/84). Sixteen of these 18 CHB patients with SVR (88.9%) did not have any histopathologically determined steatosis. On the other hand, only two of the 19 CHB patients with hepatic steatosis had SVR (10.5%). Although the SVR rate observed in patients without steatosis (16/65, 24.6%) was higher compared to those with steatosis (2/19, 10.5%), the difference was not statistically significant (P > 0.05). CONCLUSION:Occurrence of hepatic steatosis is significantly high in CHB patients and this association leads to a trend of decreased, but statistically insignificant, SVR rates to PEG-IFN treatment. | Fehmi Ates Mehmet Yalnlz Saadet Alan | 2011 | World Journal of Gastroenterology2011，17，40： | 15 |
| 2 | Does N ratio affect survival in D1 and D2 lymph node dissection for gastric cancer?显示文摘AIM:To identify whether there could have been changes in survival if lymph node ratio (N ratio) had been used.METHODS:We assessed 334 gastric adenocarcinoma cases retrospectively between 2001 and 2009.Two hundred and sixteen patients out of 334 were included in the study.Patients were grouped according to disection1 (D1) or dissection 2 (D2) dissection.We compared the estimated survival and actual survival determined by Pathologic nodes (pN) class and N ratio,and SPSS 15.0 software was used for statistical analysis.RESULTS:Ninety-six (44.4%) patients underwent D1 dissection and 120 (55.6%) had D2 dissection.When groups were evaluated,23 (24.0%) patients in D1 and 21 (17.5%) in D2 had stage migration (P=0.001).When both D1 and D2 groups were evaluated for number of pathological lymph nodes,despite the fact that there was no difference in N ratio between D1 and D2 groups,a statistically significant difference was found between them with regard to pN1 and pN2 groups (P=0.047,P=0.044 respectively).In D1,pN0 had the longest survival while pN3 had the shortest.In D2,pN0 had the longest survival whereas pN3 had the shortest survival.CONCLUSION:N ratio is an accurate staging system for defining prognosis and treatment plan,thus decreasing methodological errors in gastric cancer staging. | Ibrahim Sakcak Baris Dogu Yildiz Fatih Mehmet Avsar Saadet Akturan Kemal Kilic Erdal Cosgun Enver O Hamamci | 2011 | World Journal of Gastroenterology2011，17，35： | 3 |
| 3 | Protective effect of Spirulina platensis enriched in phenolic compounds against hepatotoxicity induced by CCl 4显示文摘 | Remziye Aysun Kepek?i Sait Polat Ahmet ?elik Nuray Bayat Saadet Demir?rs Saygideger | 2013 | Food Chemistry2013，，3： | 2 |
| 4 | Coexistence of duodenum derived aggressive fibromatosis and paraduodenal hydatid cyst: A case report and review of literature显示文摘Intra-abdominal aggressive fibromatosis is a locally aggressive tumor mostly originating from the mesentery or retroperitoneal space, infiltrating adjacent tissues, and very rarely metastasizing to distant organs. There are only two case reports in the English language literature where intra-abdominal aggressive fibromatosis originated from the intestinal wall. In this study, we aimed to report a case of aggressive fibromatosis originating from the muscularis propria layer of the duodenum and invading pancreas. Another interesting aspect of this case is that a primary paraduodenal hydatid cyst was incidentally detected in the surgical specimen. A 46-year-old female patient presented to our clinic with postprandial nausea and vomiting. A contrast-enhanced abdominal computerized tomography revealed a mass lesion with a size of 100 mm × 80 mm which originated from the distal pancreas and compressed the gastric pilor externally. Upon exploration the distal part of duodenum, proximaljejunum, and pancreatic mass were noted to form a conglomerated structure. Therefore, the fourth part of the duodenum, a 25 cm part of the proximal jejunum, distal pancreas, and the spleen were excised enbloc. The pathology report of the specimen indicated fibromatosis with a diameter of 55 mm that originated from the muscularis propria of the duodenum and extended into the pancreatic parenchyma. There was also an incidentally detected 10 mm paraduodenal hydatid cyst. No tumor recurrence was detected at a follow-up period of 24 mo. In conclusion, the most ideal treatment of desmoid-type fibromatosis is surgical resection of the mass lesion with clean surgical borders. Although rare, this tumor may originate from the intestinal wall. Histopathological verification is of great significance for a proper diagnosis. | Sami Akbulut Mehmet Yilmaz Saadet Alan Mehmet Kolu Nese Karadag | 2018 | World Journal of Gastrointestinal Surgery2018，10，8： | 2 |
| 5 | Modified polyacrylamide hydrogels and their application in removal of heavy metal ions 显示文摘 | Hasine Kasgoz Saadet Zgumtus Murat Orbay | 2003 | Polymer2003，44，6： | 1 |
| 6 | Effect of adsorbent concentration to the adsorption of phenol on hexadecyl trimethyl ammonium-bentonite显示文摘 | Saadet Yapar Vesile ?zbudak Ana Dias Ana Lopes | 2005 | Journal of Hazardous Materials2005，，1： | 1 |
| 7 | Effect of lead and pH on lead uptake, chlorophyll and nitrogen content of Typha latifolia L and Ceratophyllum demersum L 显示文摘 | Saadet S Muhittin D Gonca K | 2004 | Int J Agri Biol2004，6，1： | 1 |
| 8 | Simultaneous glycolysis and hydrolysis of polyethylene terephthalate and characterization of products by differential scanning calorimetry显示文摘 | Gamze G Tuncer Y Saadet O | 2003 | Polymer2003，，44： | 1 |
| 9 | Dual Long Memory Property in Returns and Volatility: Evidence from the CEE Countries' Stock Markets显示文摘 | Adnan K Saadet K Erdost T | 2009 | Emerging Markets Review2009，02，002： | 1 |
| 10 | Dual long memory property in returns and volatility: Evidence from the CEE countries' stock markets显示文摘 | ADNAN K SAADET K ERDOST T | 2009 | Emerging Markets Review2009，，2： | 1 |
| 11 | A novel type of Si-containing poly(urethane-imide) s:synthesis,characterization and electrical properties显示文摘 | Hüseyin D Tuncer Y Saadet | 2005 | European Polymer Journal2005，41，4： | 1 |
| 12 | Preparation of modified polyacrylamide hydrogels and application in removal of Cu(II) ion 显示文摘 | HASINE K SAADET O MURAT O | 2001 | Polymer2001，42，18： | 1 |
| 13 | Removal of Phenol by Using Montmorillonite, Clinoptilolite and Hydrotalcite显示文摘 | Saadet Yapar Meric Yilmaz | 2004 | Adsorp- tion2004，10，4： | 1 |
| 14 | Modified polyacrylamine hydrogels and their application in removal of heavy metal ions显示文摘 | Hasine Kasgoz Saadet Ozgumus Murat Orbag | 2003 | Polymer2003，44，6： | 1 |
| 15 | Bond strength of three porcelains to two forms of titanium using two firing atmospheres显示文摘 | Saadet Atsü DDS Semih Berksun DDS | 2000 | The Journal of Prosthetic Dentistry2000，84，5： | 1 |
| 16 | Study of Cu (II) biosorption by dried activated sludge: effect ofphysico-chemical environment and kinetics study显示文摘 | Osman G Saadet S Erdal K | 2005 | Journal of Hazardous Materials2005，120，13： | 1 |
| 17 | Study of Cu(Ⅱ) biosorption by dried activated sludge:effect of physic-chemical environment and kinetics study显示文摘 | Osman G Saadet S Erdal K | 2005 | Hazardous Materials2005，120，123： | 1 |
| 18 | Abraham Antioxidant mechanism of heine oxygenase - 1 involves an increase in superox ide dismutase and catalase in experimental diabetes显示文摘 | Saadet T Adam K Christopher J | 2005 | Am J Physiol Heart Circ Physioi2005，289，： | 1 |
| 19 | Adsorption of Cd(Ⅱ),Cu (Ⅱ) and Ni (Ⅱ) ions by Lemna minor L:Effect of physicochemical environment显示文摘 | Saadet Saygideger Osman Gulnaz Erman Salih Istifli | 2005 | Journal of Hazardous Materials2005，126，1： | 1 |
| 20 | Bond strength of three porcelains to two forms of titanium using two firing atmospheres显示文摘 | Saadet Atsü Semih Berksun | 2000 | The Journal of Prosthetic Dentistry2000，84，5： | 1 |
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