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| 1 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 2 | Study on regional material flow analysis of Chengyang District in Qingdao显示文摘Base on the framework of material flow analysis (MFA) proposed by Eurostat, this paper collected relateddata and conducted a regional MFA for the Chengyang District in Qingdao. The indicators such as Direct Material Input(DMI), Direct Material Consumption (DMC) and Exports are calculated or estimated for the period of year 1995through 2004. Several derivable indicators defining direct material productivity and material intensity are also evaluatedand some valuable conclusions were drawn. DMI in absolute number increased from about 1645.9 kilotons in 1995 toabout 8052.5 kilotons in 2004. Imports contribute to about 47 to 69% of DMI, and the biggest component of imports isfossil fuel that approximately accounts for 50% of imports. DMI per capita of Chengyang District increased rapidly andreached 17.4 tons in 2004. Compared with other five economies studied by WRI, material consumption intensity ofChengyang District is significantly lower than developed countries, which indicates that Chengyang District is still in adevelopment stage. The direct material productivity (actual GDP per DMI) increased 59.1% from 1995 to 2004 and hasbeen higher than either of studies in China, which indicates efficiency of resources utilization has improved obviously inChengyang District. But there was significant increase in material input in the last decade, which shows that rapidincrease of economy is highly dependent on requirement and consumption of natural resources. Therefore, in order topromote the sustainability, it is essential to develop circular economy and improve utilization efficiency of resources. | Zhou Zhenfeng Sun Yinglan Wang Jun | 2006 | Ecological Economy2006，2，1： | 5 |
| 3 | Management of marine cage aquaculture: environmental carrying capacity method based on dry feed conversion rate 显示文摘 | Cai Huiwen Sun Yinglan | 2007 | Environmental Science and Pollution Research2007，14，7： | 1 |
| 4 | The Inorganic-organic Hybrid Junction with n-ZnO Nanorods/p-polyfluorene Structure Grown with Low-temperature Aqueous Chemical Growth Method显示文摘The inorganic-organic hybrid junction was synthesized on ITO glass substrate,which was consisted of an n-type ZnO nanorods(NRs)grown by low-temperature aqueous chemical growth method and a p-type polyfluorene(PF)organic film fabricated by spin-coating.The experimental results indicate that densely and uniformly distributed ZnO nanorods are successfully grown on the PF layer.The thickness of the PF layer plays a dominant role for the current-voltage(I-V)characteristic of the ZnO NRs/PF inorganic-organic hybrid junction device,and a p-n junction with obviously rectifying behavior is achieved with optimal PF layer thickness.The photoluminescence(PL)spectrum covering the broad visible range was obtained from the n-ZnO nanorods/p-polyfluorene(PF)structure,which was originated from the combination of the PF-related blue emission and the ZnO-related deep level emission. | 吴伟 边继明 SUN Yinglan CHENG Chuanhui SUN Jingchang LIANG Hongwei LUO Yingmin DU Guotong | 2012 | Journal of Wuhan University of Technology(Materials Science)2012，27，2： | 0 |
| 5 | Mulberry leaf flavonoids activate BAT and induce browning of WAT to improve type 2 diabetes via regulating the AMPK/SIRT1/PGC-1α signaling pathway显示文摘Mulberry (Morus alba L.) leaf is a well-established traditional Chinese botanical and culinary resource. It has found widespread application in the management of diabetes. The bioactive constituents of mulberry leaf, specifically mulberry leaf flavonoids (MLFs), exhibit pronounced potential in the amelioration of type 2 diabetes (T2D). This potential is attributed to their ability to safeguard pancreatic β cells, enhance insulin resistance, and inhibit α-glucosidase activity. Our antecedent research findings underscore the substantial therapeutic efficacy of MLFs in treating T2D. However, the precise mechanistic underpinnings of MLF’s anti-T2D effects remain the subject of inquiry. Activation of brown/beige adipocytes is a novel and promising strategy for T2D treatment. In the present study, our primary objective was to elucidate the impact of MLFs on adipose tissue browning in db/db mice and 3T3-L1 cells and elucidate its underlying mechanism. The results manifested that MLFs reduced body weight and food intake, alleviated hepatic steatosis, improved insulin sensitivity, and increased lipolysis and thermogenesis in db/db mice. Moreover, MLFs activated brown adipose tissue (BAT) and induced the browning of inguinal white adipose tissue (IWAT) and 3T3-L1 adipocytes by increasing the expressions of brown adipocyte marker genes and proteins such as uncoupling protein 1 (UCP1) and beige adipocyte marker genes such as transmembrane protein 26 (Tmem26), thereby promoting mitochondrial biogenesis. Mechanistically, MLFs facilitated the activation of BAT and the induction of WAT browning to ameliorate T2D primarily through the activation of AMP-activated protein kinase (AMPK)/sirtuin 1 (SIRT1)/peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) signaling pathway. These findings highlight the unique capacity of MLF to counteract T2D by enhancing BAT activation and inducing browning of IWAT, thereby ameliorating glucose and lipid metabolism disorders. As such, MLFs emerge as a prospective and innovative browning agent for the treatment of T2D. | CHENG Long SHI Lu HE Changhao WANG Chen LV Yinglan LI Huimin AN Yongcheng DUAN Yuhui DAI Hongyu ZHANG Huilin HUANG Yan FU Wanxin SUN Weiguang ZHAO Baosheng | 2023 | Chinese Journal of Natural Medicines2023，21，11： | 0 |
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