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| 1 | The apricot(Prunus armeniaca L.)genome elucidates Rosaceae evolution and beta-carotenoid synthesis显示文摘Apricots,scientifically known as Prunus armeniaca L,are drupes that resemble and are closely related to peaches or plums.As one of the top consumed fruits,apricots are widely grown worldwide except in Antarctica.A high-quality reference genome for apricot is still unavailable,which has become a handicap that has dramatically limited the elucidation of the associations of phenotypes with the genetic background,evolutionary diversity,and population diversity in apricot.DNA from P.armeniaca was used to generate a standard,size-selected library with an average DNA fragment size of~20 kb.The library was run on Sequel SMRT Cells,generating a total of 16.54 Gb of PacBio subreads(N50=13.55 kb).The high-quality P.armeniaca reference genome presented here was assembled using long-read single-molecule sequencing at approximately 70×coverage and 171×Illumina reads(40.46 Gb),combined with a genetic map for chromosome scaffolding.The assembled genome size was 221.9 Mb,with a contig NG50 size of 1.02 Mb.Scaffolds covering 92.88%of the assembled genome were anchored on eight chromosomes.Benchmarking Universal Single-Copy Orthologs analysis showed 98.0%complete genes.We predicted 30,436 protein-coding genes,and 38.28%of the genome was predicted to be repetitive.We found 981 contracted gene families,1324 expanded gene families and 2300 apricot-specific genes.The differentially expressed gene(DEG)analysis indicated that a change in the expression of the 9-cis-epoxycarotenoid dioxygenase(NCED)gene but not lycopene beta-cyclase(LcyB)gene results in a lowβ-carotenoid content in the white cultivar“Dabaixing”.This complete and highly contiguous P.armeniaca reference genome will be of help for future studies of resistance to plum pox virus(PPV)and the identification and characterization of important agronomic genes and breeding strategies in apricot. | Fengchao Jiang Junhuan Zhang Sen Wang Li Yang Yingfeng Luo Shenghan Gao Meiling Zhang Shuangyang Wu Songnian Hu Haoyuan Sun Yuzhu Wang | 2019 | Horticulture Research2019，6，1： | 9 |
| 2 | Cap-specific, terminal N^6-methylation by a mammalian m6Am methyltransferase显示文摘Dear Editor,Dynamic and reversible N6-methyladenosine (m6A) RNA methylation has been found to greatly impact gene expression, leading to the field of epitranscriptomics.1 Unlike m6A that is an internal modification, a terminal modification at mRNA cap in higher eukaryotes exists, termed as N6,2′-O-dimethyladenosine (m6Am) (Fig. 1a). | Hanxiao Sun Meiling Zhang Kai Li Dongsheng Bai Chengqi Yi | 2019 | Cell Research2019，29，1： | 7 |
| 3 | Endogenous level of TIGAR in brain is associated with vulnerability of neurons to ischemic injury显示文摘In previous studies,we showed that TP53-induced glycolysis and apoptosis regulator(TIGAR) protects neurons against ischemic brain injury.In the present study,we investigated the developmental changes of TIGAR level in mouse brain and the correlation of TIGAR expression with the vulnerability of neurons to ischemic injury.We found that the TIGAR level was high in the embryonic stage,dropped at birth,partially recovered in the early postnatal period,and then continued to decline to a lower level in early adult and aged mice.The TIGAR expression was higher after ischemia/reperfusion in mouse brain 8and 12 weeks after birth.Four-week-old mice had smaller infarct volumes,lower neurological scores,and lower mortality rates after ischemia than 8- and12-week-old mice.TIGAR expression also increased in response to oxygen glucose deprivation(OGD)/reoxygenation insult or H_2O_2 treatment in cultured primary neurons from different embryonic stages(E16 and E20).The neurons cultured from the early embryonic period had a greater resistance to OGD and oxidative insult.Higher TIGAR levels correlated with higher pentose phosphate pathway activity and less oxidative stress.Older mice and more mature neurons had more severe DNA and mitochondrial damage than younger mice and less mature neurons in response to ischemia/reperfusion or OGD/reoxygenation insult.Supplementation of cultured neurons with nicotinamide adenine dinuclectide phosphate(NADPH) significantly reduced ischemic injury.These results suggest that TIGAR expression changes during development and its expression level may be correlated with the vulnerability of neurons to ischemic injury. | Lijuan Cao Jieyu Chen Mei Li Yuan-Yuan Qin Meiling Sun Rui Sheng Feng Han Guanghui Wang Zheng-Hong Qin | 2015 | Neuroscience Bulletin2015，31，5： | 6 |
| 4 | Highly efficient base editing in human tripronuclear zygotes显示文摘 | Changyang Zhou Meiling Zhang Yu Wei Yidi Sun Yun Sun Hong Pan Ning Yao Wanxia Zhong Yixue Li Weiping Li3 Hui Yang Zi-jiang Chen | 2017 | Protein & Cell2017，8，10： | 6 |
| 5 | Sensitive electrochemical DNA sensor for the detection of HIV based on a polyaniline/graphene nanocomposite显示文摘A nanocomposite of polyaniline/graphene(PAN/GN)was prepared using reverse-phase polymerization.The nanocomposite material was dropcast onto a glassy carbon electrode(GCE).Then,a single-stranded DNA(ssDNA)probe for HIV-1 gene detection was immobilized on the modified electrode,and the negative charged phosphate backbone of the HIV-1 was bound to the modified electrode surface via p-p*stacking interactions.The hybridization between the ssDNA probe and the target HIV-1 formed doublestranded DNA(dsDNA),and the electron transfer resistance of the electrode was measured using impedimetric studies with a[Fe(CN)6]^(3-/4-)redox couple.Under the optimized experimental conditions,the change of the impedance value was linearly related to the logarithm of the concentration of HIV genes in the range from 5.0×10^(-16)M to 1.0×10^(-10)M(R=0.9930),and the HIV sensor exhibited a lower detection limit of 1.0×10^(-16)M(S/N=3).The results show that this biosensor presented wonderful selectivity,sensitivity and specificity for HIV-1 gene detection.Thus,this biosensor provides a new method for the detection of HIV gene fragments. | Qiaojuan Gong Haixia Han Haiying Yang Meiling Zhang Xiaoling Sun Yunxia Liang Zhaorong Liu Wenchan Zhang Jinli Qiao | 2019 | Journal of Materiomics2019，5，2： | 5 |
| 6 | Ni(OH)_(2) nanoparticles encapsulated in conductive nanowire array for high-performance alkaline seawater oxidation显示文摘Design and development of high-efficiency and durable oxygen evolution reaction(OER)electrocatalysts is crucial for hydrogen production from seawater splitting.Herein,we report the in situ electrochemical conversion of a nanoarray of Ni(TCNQ)2(TCNQ=tetracyanoquinodimethane)on graphite paper into Ni(OH)_(2) nanoparticles confined in a conductive TCNQ nanoarray(Ni(OH)_(2)-TCNQ/GP)by anode oxidation.The Ni(OH)_(2)-TCNQ/GP exhibits high OER performance and demands overpotentials of 340 and 382 mV to deliver 100 mA·cm^(−2) in alkaline freshwater and alkaline seawater,respectively.Meanwhile,the Ni(OH)_(2)-TCNQ/GP also demonstrates steady long-term electrochemical durability for at least 80 h under alkaline seawater. | Longcheng Zhang Jiaqian Wang Pengyu Liu Jie Liang Yongsong Luo Guanwei Cui Bo Tang Qian Liu Xuedong Yan Haigang Hao Meiling Liu Rui Gao Xuping Sun | 2022 | Nano Research2022，15，7： | 5 |
| 7 | Nanosheet-structured K–Co–MoS_2 catalyst for the higher alcohol synthesis from syngas: Synthesis and activation显示文摘The nanosheets structured K–Co–MoS_2 catalyst was prepared through a one-step hydrothermal synthesis combined with the wetness impregnation. The fresh catalyst has a high dispersion of Co–Mo–S active phase and no Co_9S_8 is found. The pure H_2 activated catalyst shows a higher intrinsic activity, especially the C_(2+) OH selectivity for the higher alcohol synthesis compared to the one activated by 5% H_2/N_2 atmosphere. The reason is attributed to that the pure H_2 activation more effectively suppresses the formation of Co_9S_8 and stabilizes the Co–Mo–S active phase during the reaction due to the formation of SH species. | Huan Li Wei Zhang Yinyin Wang Meiling Shui Song Sun Jun Bao Chen Gao | 2019 | Journal of Energy Chemistry2019，28，3： | 5 |
| 8 | Wheat breeding history reveals synergistic selection of pleiotropic genomic sites for plant architecture and grain yield显示文摘Diversity surveys of crop germplasm are important for gaining insights into the genomic basis for plant architecture and grain yield improvement,which is still poorly understood in wheat.In this study,we exome sequenced 287 wheat accessions that were collected in the past 100 years.Population genetics analysis identified that 6.7%of the wheat genome falls within the selective sweeps between landraces and cultivars,which harbors the genes known for yield improvement.These regions were asymmetrically distributed on the A and B subgenomes with regulatory genes being favorably selected.Genome-wide association study(GWAS)identified genomic loci associated with traits for yield potential,and two underlying genes,TaARF12 encoding an auxin response factor and TaDEP1 encoding the G-proteinγ-subunit,were located and characterized to pleiotropically regulate both plant height and grain weight.Elite single-nucleotide haplotypes with increased allele frequency in cultivars relative to the landraces were identified and found to have accumulated over the course of breeding.Interestingly,we found that TaARF12 and TaDEP1 function in epistasis with the classical plant height Rht-1 locus,leading to propose a“Green Revolution”-based working model for historical wheat breeding.Collectively,our study identifies selection signatures that fine-tune the gibberellin pathway during modern wheat breeding and provides a wealth of genomic diversity resources for the wheat research community. | Aili Li Chenyang Hao Zhenyu Wang Shuaifeng Geng Meiling Jia Fang Wang Xiang Han Xingchen Kong Lingjie Yin Shu Tao Zhongyin Deng Ruyi Liao Guoliang Sun Ke Wang Xingguo Ye Chengzhi Jiao Hongfeng Lu Yun Zhou Dengcai Liu Xiangdong Fu Xueyong Zhang Long Mao | 2022 | Molecular Plant2022，15，3： | 4 |
| 9 | RNA Regulations and Functions Decoded by Transcriptome-wide RNA Structure Probing显示文摘RNA folds into intricate structures that are crucial for its functions and regulations. To date, a multitude of approaches for probing structures of the whole transcriptome, i.e., RNA structuromes, have been developed. Applications of these approaches to different cell lines and tissues have generated a rich resource for the study of RNA structure–function relationships at a systems biology level. In this review, we first introduce the designs of these methods and their applications to study different RNA structuromes. We emphasize their technological differences especially their unique advantages and caveats. We then summarize the structural insights in RNA functions and regulations obtained from the studies of RNA structuromes. And finally, we propose potential directions for future improvements and studies. | meiling piao lei sun qiangfeng cliff zhang | 2017 | Genomics, Proteomics & Bioinformatics2017，15，5： | 3 |
| 10 | All-Climate Stretchable Dendrite-Free Zn-Ion Hybrid Supercapacitors Enabled by Hydrogel Electrolyte Engineering显示文摘Hybrid supercapacitors have shown great potentials to fulfill the demand of future diverse applications such as electric vehicles and portable/wearable electronics.In particular,aqueous zinc-ion hybrid supercapacitors(ZHSCs)have gained much attention due to their low-cost,high energy density,and environmental friendliness.Nevertheless,typical ZHSCs use Zn metal anode and normal liquid electrolyte,causing the dendrite issue,restricted working temperature,and inferior device flexibility.Herein,a novel flexible Zn-ion hybrid supercapacitor(FZHSC)is developed by using activated carbon(AC)anode,δ-MnO_(2) cathode,and innovative PVA-based gel electrolyte.In this design,heavy Zn anode and its dendrite issue are avoided and layered cathode with large interlayer spacing is employed.In addition,flexible electrodes are prepared and integrated with an anti-freezing,stretchable,and compressible hydrogel electrolyte,which is attained by simultaneously using glycerol additive and freezing/thawing technique to regulate the hydrogen bond and microstructure.The resulting FZHSC exhibits good rate capability,high energy density(47.86 Wh kg^(−1);3.94 mWh cm^(−3)),high power density(5.81 kW kg^(−1);480 mW cm^(−3)),and excellent cycling stability(~91%capacity retention after 30000 cycles).Furthermore,our FZHSC demonstrates outstanding flexibility with capacitance almost unchanged even after various continuous shape deformations.The hydrogel electrolyte still maintains high ionic conductivity at ultralow temperatures(≤−30℃),enabling the FZHSC cycled well,and powering electronic timer robustly within an all-climate temperature range of−30~80℃.This work highlights that the promising Zn metal-free aqueous ZHSCs can be designed with great multifunctionality for more practical application scenarios. | Yuqi Jiang Kun Ma Meiling Sun Yuanyuan Li Jinping Liu | 2023 | Energy & Environmental Materials2023，6，2： | 2 |
| 11 | A numerical study of the generation mechanism of internal solitary waves in the Luzon Strait显示文摘The South China Sea(SCS) is a hot spot for oceanic internal solitary waves due to many factors, such as the complexity of the terrain environment. The internal solitary waves in the northern SCS mainly originate in the Luzon Strait. The generation mechanism of the internal solitary waves in the Luzon Strait is discussed using a modulation instability. The energy gain of the modulation instability is derived based on the fully nonlinear Schr?dinger equation. The peak value of the gain is calculated under different conditions of stratification,wavelength and the initial amplitude of an internal tidal wave. The characteristics of the modulation instability in the Luzon Strait are investigated. The conditions that make the internal tidal wave evolve into an internal solitary wave in the Luzon strait are also obtained. The results show that the internal tide waves can generate the modulation instability in the Luzon Strait and that the maximum gain occur at the eastern sill of the Luzon Strait,where the internal tide waves start to break up into internal solitary trains. The magnitude and the scope of the peak gain are relevant to the stratification and the initial conditions of the internal tide waves. The numerical simulation results are consistent with the in-situ data. | WANG Jing SUN Meiling ZHANG Xudong SUN Lina MENG Junmin | 2015 | Acta Oceanologica Sinica2015，34，7： | 2 |
| 12 | Wet-spinning fabrication of shear-patterned alginate hydrogel microfibers and the guidance of cell alignment显示文摘Native tissue is naturally comprised of highly-ordered cell-matrix assemblies in a multi-hierarchical way,and the nano/submicron alignment of fibrous matrix is found to be significant in supporting cellular functionalization.In this study,a self-designed wet-spinning device appended with a rotary receiving pool was used to continuously produce shear-patterned hydrogel microfibers with aligned submicron topography.The process that the flow-induced shear force reshapes the surface of hydrogel fiber into aligned submicron topography was systematically analysed.Afterwards,the effect of fiber topography on cellular longitudinal spread and elongation was investigated by culturing rat neuron-like PC12 cells and human osteosarcoma MG63 cells with the spun hydrogel microfibers,respectively.The results suggested that the stronger shear flow force would lead to more distinct aligned submicron topography on fiber surface,which could induce cell orientation along with fiber axis and therefore form the cell-matrix dual-alignment.Finally,a multi-hierarchical tissue-like structure constructed by dual-oriented cell-matrix assemblies was fabricated based on this wet-spinning method.This work is believed to be a potentially novel biofabrication scheme for bottom-up constructing of engineered linear tissue,such as nerve bundle,cortical bone,muscle and hepatic cord. | You Yang Jing Sun Xiaolu Liu Zhenzhen Guo Yunhu He Dan Wei Meiling Zhong Likun Guo Hongsong Fan Xingdong Zhang | 2017 | Regenerative Biomaterials2017，4，5： | 2 |
| 13 | Sorption and diffusion of supercritical carbon dioxideinto nitrocellulose with or without cosolvents显示文摘 | Sun Meiling Ying Sanjiu | 2012 | Polymer-Plastics Technology and Engineering2012，51，13： | 1 |
| 14 | TOX deficiency facilitates the differentiation of IL-17A-producingγδT cells to drive autoimmune hepatitis显示文摘The specification of theαβ/γδlineage and the maturation of medullary thymic epithelial cells(mTECs)coordinate central tolerance to self-antigens.However,the mechanisms underlying this biological process remain poorly clarified.Here,we report that dual-stage loss of TOX in thymocytes hierarchically impaired mTEC maturation,promoted thymic IL-17A-producingγδT-cell(Tγδ17)lineage commitment,and led to the development of fatal autoimmune hepatitis(AIH)via different mechanisms.Transfer ofγδT cells from TOX-deficient mice reproduced AIH.TOX interacted with and stabilized the TCF1 protein to maintain the balance ofγδT-cell development in thymic progenitors,and overexpression of TCF1 normalizedαβ/γδlineage specification and activation.In addition,TOX expression was downregulated inγδT cells from AIH patients and was inversely correlated with the AIH diagnostic score.Our findings suggest multifaceted roles of TOX in autoimmune control involving mTEC and Tγδ17 development and provide a potential diagnostic marker for AIH. | Qifeng He Yijun Lu Wenfang Tian Runqiu Jiang Weiwei Yu Yong Liu Meiling Sun Fei Wang Haitian Zhang Ning Wu Zhongjun Dong Beicheng Sun | 2022 | Cellular & Molecular Immunology2022，19，10： | 1 |
| 15 | A Thorough Investigation of the Active Titanium Species in TS‐1 Zeolite by In Situ UV Resonance Raman Spectroscopy显示文摘 | Qiang Guo Keju Sun Zhaochi Feng Guanna Li Meiling Guo Fengtao Fan Can Li | 2012 | Chem Eur J2012，，43： | 1 |
| 16 | Electrochemically prepared coniferous leaf-like nickel black membrane for desalination by solar-thermal energy conversion显示文摘The structures of the solar-thermal membranes always influence the performance of light absorption and salt resistance in desalination.Inspired by the hierarchical structure of the coniferous leaves with excellent sunlight absorption in frigid regions,a coniferous leaf-like nickel black(L-Ni)membrane for desalination by solar-thermal energy conversion was prepared through electroplating method under a constant voltage.The light trapping effect of coniferous leaf-like structure led to the light absorption enhanced to 92%,the evaporation rate improved to 1.38 kg·m^(-2)·h^(-1),and the solar-vapor conversion efficiency of L-Ni membrane reaching up to 89.75%under 1 sun irradiation.The stability of the membrane was still excellent after 20 cycles desalination because the coniferous leaf-like structure could enhance the hydrophobicity(water contact angle:152°)of the L-Ni membrane,and it was beneficial to salt resistance.The promising performance of L-Ni membrane with coniferous leaf-like structure provides a possibility to replace the noble metal solar-thermal conversion materials. | Dongmin Yue Bingbing Li De Sun Hao Zhang Meiling Liu Jingtong Yu | 2023 | Nano Research2023，16，7： | 1 |
| 17 | Identification of yeast population dynamics of spontaneous fermentation in Beijing wine region,China显示文摘 | Huihui Sun Huiqin Ma Meiling Hao | | 0，，01： | 1 |
| 18 | Chronic accumulation of cadmium and its effects on antioxidant enzymes and malondialdehyde in Oxya chinensis (Orthoptera: Acridoidea)显示文摘 | Yuping Zhang Ge Sun Meiling Yang Haihua Wu Jianzhen Zhang Shaojuan Song Enbo Ma Yaping Guo | 2011 | Ecotoxicology and Environmental Safety2011，，5： | 1 |
| 19 | Metabolic and immune responses in Chinese mitten-handed crab (Eriocheir sinensis) juveniles exposed to elevated ambient ammonia 显示文摘 | Hong Meiling Chen Liqiao Sun Xinjin | 2007 | Comparative Biochemistry and Physiology2007，145，3： | 1 |
| 20 | A Liquid Chromatographic Method for Simultaneous Determination of Amoxicillin Sodium and Sulbactam Sodium in a Combination Formulation显示文摘 | Wang Peng Qi Meiling Sun Yan | | 0，，03： | 1 |
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