|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Reconstruction of May——July precipitation in the north Helan Mountain, Inner Mongolia since A.D. 1726 from tree-ring late-wood widths显示文摘By analyzing statistical characteristics of five tree-ring standard chronologies, early-wood ring width (EWW), late-wood ring width (LWW), total ring width (TRW), minimum early-wood density (MinD), maximum late-wood density (MaxD) and, their climatic response re-spectively, we reconstructed the May to July precipitation using late-wood ring width (LWW) over the north Helan Mountain since A.D. 1726. The explained variance is 42% (R2adj = 41%, F = 31.46, p < 0.000001). After 11-a moving average, the explained variance reaches 82% (F = 156.9, p < 0.05). On the decadal scale, the rainfall reconstruction of the northern Helan Mountain displays a quite similar variation pattern with that of the April to early July precipitation in Baiyinaobao, east of Inner Mongolia for the last 150 years. It may reflect the intensity variation of the East Asia Summer Monsoon front to a certain extent. Spectrum analysis shows 11-a and 22-a periodicities in the May to July precipitation reconstruction at the north Helan Mountain. | LIU Yu SHI Jiangfeng V. Shishov E. Vaganov YANG Yinke CAI Qiufang SUN Junyan WANG Lei I. Djanseitov | 2004 | Chinese Science Bulletin2004，49，4： | 29 |
| 2 | Immunomodulatory effect of human amniotic epithelial cells on restoration of ovarian function in mice with autoimmune ovarian disease显示文摘Autoimmune ovarian disease(AOD)is considered to be a major cause of premature ovarian failure(POF).The immunomodulatory properties of human amniotic epithelial cells(hAECs)have been studied in many disease models.We previously reported that hAECs restored ovarian function in chemotherapy-induced POF mice,but the immunomodulatory mechanism of hAECs is still unclear.To investigate the effect of hAECs on recipient mice,especially on regulatory Treg cells,hAECs and hAEC-conditioned medium(hAEC-CM)were intravenously injected into AOD mice immunized with zona pellucida protein 3 peptides(pZP3).Ovarian function was evaluated through estrous cycle,hormone secretion,follicle development,and cell apoptosis analysis.Immune cells including CD3,CD4,CD8 and Treg cells in the spleens were tested by flow cytometry.To elucidate the effect of hAEC-CM on macrophage function,inflammation model in vitrowas established in RAW264.7 cells induced by lipopolysaccharide(LPS).hAECs and hAEC-CM regulated estrous cycles,promoted follicle development,ameliorated cell apoptosis and fibrosis in ovaries of AOD mice.In addition,hAECs significantly reversed the decrease of pZP3-induced Treg cells in the spleens.In vitro,hAEC-CM significantly inhibited the inflammatory reaction induced by LPS in RAW264.7 cells via up-regulating the expression of M2 macrophage genes.Further study demonstrated that hAECsecreted transforming growth factor-beta and macrophage inhibitory factor played important roles in the macrophage polarization and migration under inflammatory stimulation.Taken together,hAECs restored ovarian function by up-regulating Treg cells in the spleens and reduced the inflammatory reaction via modulating the activated macrophage function in a paracrine manner in the ovaries of AOD mice. | Qiuwan Zhang Yating Huang Junyan Sun Tingting Gu Xiaoyan Shao Dongmei Lai | 2019 | Acta Biochimica et Biophysica Sinica2019，51，8： | 14 |
| 3 | Artemisinin derivatives inhibit epithelial ovarian cancer cells via autophagy-mediated cell cycle arrest显示文摘Epithelial ovarian cancer (EOC)is the most fatal gynecologic malignancy due to its late diagnosis and lack of curative therapy.The antimalaria compound artemisinin and its derivatives,such as artesunate (ART)and dihydroartemisinin (DHA),have proven to be potent anticancer drugs and act through various anticancer mechanisms.To identify novel targets of artemisinin derivatives in EOC cells,we investigated the effects of ART and DHA on SKOV3 and primary EOC cell growth via CCK-8 assay.Both ART and DHA inhibited EOC cell growth.A cell cycle distribution analysis showed that ART and DHA caused G2/M cell cycle arrest.Moreover,ART and DHA induced autophagy in EOC cells,whereas autophagy inhibitors reversed the cell growth inhibition and cell cycle arrest induced by ART and DHA.Western blot analysis showed that ART and DHA also suppressed the cell cycle-related NF-κB-signaling pathway in EOC cells.These data suggest that artemisinin derivatives induce autophagy,block the cell cycle,and inhibit cell growth in EOC cells.Our research provides new targets for artemisinin derivatives for EOC treatment. | Boning Li Shixia Bu Junyan Sun Ying Guo Dongmei Lai | 2018 | Acta Biochimica et Biophysica Sinica2018，50，12： | 11 |
| 4 | Tree-ring-based reconstruction of the April to September mean temperature since 1826 AD for north-central Shaanxi Province,China显示文摘Long-time series of high-resolution temperature record from Chinese Loess Plateau is rare. An April-September mean temperature reconstruction (1826-2004) has been developed for the north-central Shaanxi Province, China, based on tree-ring width analysis. The reconstruction captures 39.3% (p<0.001) of the variance in the instrumental data over the calibration period from 1951 to 2002. The reconstruction shows a high temperature period of 1928-1933, which coincides with the timing of the extreme drought event in 1920s in the entire northern China. The two low temperature periods in reconstruction are 1883-1888 and 1938-1942. With the global warming, the April-September mean temperature in study area has also increased since the 1970s, but has not exceeded the temperature in 1928-1933. Besides the statistical analysis, the reconstruction is also verified by the local dryness/wetness index and other dendroclimatological results. | CAI QiuFang LIU Yu SONG HuiMing SUN JunYan | 2008 | Science China Earth Sciences2008，51，8： | 10 |
| 5 | The forecast of seasonal precipitation trend at the north Helan Mountain and Baiyinaobao regions, Inner Mongolia for the next 20 years显示文摘By using Caterpillar-SSA analysis method, through the process of embedding, singular value decompo-sition, grouping and diagonal averaging, the seasonal pre-cipitation trend at north Helan Mountain and Baiyinaobo regions, Inner Mongolia for the next 20 years is forecasted. The results show an increasing precipitation trend from 1992 to 2004. In the subsequent decade the precipitation should reduce quickly, and it will reach a minimum near 2012 to 2014 in both regions. The drought caused by the decrease of the precipitation from May to July in the north Helan Mountain area during the period of 2013—2014 is probably quite similar to that around 1929. Further, the period of pre-cipitation gradual increase follows in the researched regions. | LIU Yu V. Shishov SHI Jiangfeng E. Vaganov SUN Junyan CAI Qiufang I. Djanseitov AN Zhisheng | 2004 | Chinese Science Bulletin2004，49，4： | 8 |
| 6 | Tree-ring based PDSI reconstruction since 1853 AD in the source of the Fenhe River Basin,Shanxi Province,China显示文摘A robust tree-ring-width chronology was developed from two Pinus tabulaeformis sampling sites in the source of the Fenhe River,Shanxi Province,China.Based on the tree-ring-width indices,a 157-year long Palmer Drought Severity Index(PDSI) was reconstructed,which explains 53.7% of the variance of the modeled PDSI over the common period 1957-2008.The drought periods in the study area include 1914-1931 and 1970 to the present,whereas the wet periods were 1866-1892 and 1932-1969.The drought of 1914-1931 was a severe long-lasting drought with a low inter-annual variability,and the drought of 1970-2009 was an overall long-term drought with a high inter-annual variability.The period of 1866-1892 is a continuously wet period with a low inter-annual variability and the period of 1932-1969 is an overall long-term wet period with a high inter-annual variability.The reconstructed PDSI series in the source of the Fenhe River shows synchronous variations with the regional drought/wetness indices.Spatial correlation analyses indicate that the higher correlations lie exclusively in the Fenhe River Basin.This indicates that the reconstructed PDSI has regional representativeness and can represent the drought history of the entire Fenhe River Basin to some extent.Furthermore,the reconstructed PDSI matches with the variability of the per unit yield of summer grain crops in Shanxi Province very well and they have significant correlation.From a long-term perspective the reconstructed PDSI series could supply scientific and valuable information to the water resources management and then help the sustainable development in agricultural production,economic development,and ecosystem balance. | SUN JunYan LIU Yu SUN Bo WANG RuiYuan | 2012 | Science China Earth Sciences2012，55，11： | 6 |
| 7 | Properties and Structure of Microcrystal Muscovite Composite Superabsorbent显示文摘Microcrystal muscovite composite superabsorbents(MMCSA) were prepared by water solution polymerization using acrylic acid, acrylamide and itaconic acid as comonomers and microcrystal muscovite as an inorganic additive. Properties, such as water absorbency, salt absorbency, gel strength, water retention capacity and structure of MMCSA characterized by SEM and XRD, were investigated. Water absorbency, salt absorbency, gel strength, water retention capacity and thermostability were enhanced by incorporation of suitable amount of microcrystal muscovite. Water absorption of MMCSA was rapid, requiring 24.55 min to reach 63% of equilibrium absorbency(1218 g/g). Microcrystal muscovite was physically combined into the polymeric network without destroying its polycrystalline structure and microcrystal muscovite composite superabsorbent had some irregular, undulant, and small microporous holes with sheet-like microcrystal muscovite distributed in the polymeric matrix. | 万涛 XIONG Lei HUANG Runqiu SUN Mengmeng QIN Lili TAN Xuemei HU Junyan | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，6： | 2 |
| 8 | Imbalance between subpopulations of regulatory T cells in COPD显示文摘 | Jia Hou Yongchang Sun Yu Hao Jie Zhuo Xiaofang Liu Peng Bai Junyan Han Xiwei Zheng Hui Zeng | 2013 | Thorax2013，，12： | 2 |
| 9 | Identificaion and Quantification of coronary atherosclerotic plaques: a comparison of 64 -MSCT and intravaseular ultrasound显示文摘 | Junyan Sun Zhaoqi Zhang Biao Lu | 2008 | AJR2008，190，3： | 1 |
| 10 | Critical Amino Acid Residues for Nicotine 5'-Hydroxylation in Human CYP2A Enzymes显示文摘Objective: We have continued previous work in which we demonstrated that #117 and #372 amino acids contrib- uted to the high activities of human CYP2A13 in catalyzing 4-methylnitrosamino-1-(3-pyridyl)-1-butanone(NNK) and aflatoxin B1(AFB1) carcinogenic activation. The present study was designed to identify other potential amino acid residues that contribute to the different catalytic characteristics of two CYP2A enzymes, CYP2A6 and CYP2A13, in nicotine metabolism and provide insights of the substrate and related amino acid residues interactions. Methods: A series of reciprocally substituted mutants of CYP2A6Ile300 → Phe, CYP2A6Gly301Ala, CYP2A6Ser369 → Gly, CYP2A13Phe300 → Ile, CYP2A13Ala301 → Gly and CYP2A13Gly369 → Ser were generated by site-directed mutagenesis/baculovirus-Sf9 insect cells expression. Comparative kinetic analysis of nicotine 5'hydroxylatin by wild type and mutant CYP2A proteins was performed. Results:All amino acid residue substitutions at 300, 301 and 369 caused significant kinetic property changes in nicotine metabolism. While CYP2A6Ile300 → Phe and CYP2A6Gly301→Ala mutations had notable catalytic efficiency increases compared to that for the wild type CYP2A6, CYP2A13Phe300→Ile and CYP2A13Ala301→Gly replacement introduced remarkable catalytic efficiency decreases. CteIunfYtf iaioPcdni2de Aiontif1co #3yn3G ,v 6ali9ylal 3 r6tae9h s→seiisdge uSn ecei afrsit.iac gClanyonitnfti cicKc leaumfns fdtiilcoeyinc ea:rn#fecf3aey0sc 0eate ,l vtd#ee 3rbra0sot1uitoh san KnVsd mmw a#axe 3nree6dn 9 chV aarmuenassxcei evddmau bleueysen iVstn,. m whaCxu hYvmialPaer2in aAt htCi6eoYS noePspr 2r3pa6A9oth→6sei/t1reG 3t h lepyafl fnaien yKcc tirmsme cawphsoeea rrnttegha eenss etc. e raSontual ewlbyssi tttiiinhc- nicotine 5'-oxidation. Switching #300 or #301 residues did not affect the CYP2A protein affinities toward nicotine, although these amino acids are located in the active center. Ser369 to Gly substitution indirectly affected nicotine binding by creating more space and conformational flexibility for the nearby residues, such as Leu370 which is crucial for many hydroxylations. | Xiaoyang Hea Xu Xu Jian Shen Li Sun Anthony Y. H. Lu Clifford Weisel Junyan Hong | 2008 | Journal of Nanjing Medical University2008，22，6： | 1 |
| 11 | Research on experiments and action mechanism with water vapor as coolant and lubricant in green cutting显示文摘 | LIU Junyan HAN Rongdi SUN Yongfeng | 2005 | International Journal of Machine Tools and Manufacture2005，45，6： | 1 |
| 12 | Precipitation reconstruction from Hailar pine ( Pinus sylvestris var. mongolica ) tree rings in the Hailar region, Inner Mongolia, China back to 1865 AD显示文摘 | Yu Liu Guang Bao Huiming Song Qiufang Cai Junyan Sun | 2009 | Palaeogeography, Palaeoclimatology, Palaeoecology2009，，1： | 1 |
| 13 | Research on experiments and action mechanism with water vapor as coolant and lubricant in green cutting显示文摘 | Junyan Liu Rongdi Han Yongfeng Sun | 2005 | International Journal of Machine Tools and Manufacture2005，45，： | 1 |
| 14 | Hypocotyl elongation based on HY5 transcription factor in cold resistant winter rapeseed(Brassica napus L.)显示文摘Winter rape(Brassica napus L.)is better than other edible oil crops in China,but poor cold resistance is the key factor restricting its development.Hypocotyl length was found closely related to cold tolerance.The correlation between hypocotyl length and semi-lethal low temperature was significant,and the highest correlation between hypocotyl length and LT50 of autumn sowing was 0.9557.When the hypocotyl were treated at low temperature,the cells were seriously damaged and formed cavity structures,with cell walls seriously damaged or merged into each other.The positive regulation gene of hypocotyl length in resistant line of VHTSG 10 was identified as HY5(transcription factor HY5-like)by qPCR,and bZIP transcription factor was found to be its conserved domain.Fused gene by GFP and HY5 from VHTSG 10 was transient transferred into Nicotiana benthamiana cells.Corresponding to the 35S:GFP widely distributed in plasma membrane of leaf epidermis,the fusion protein 35S:HY5-GFP was mainly distributed in nucleus.Thus we regarded BnHY5 gene is a key gene related to cold tolerance and hypocotyl length in B.napus. | Jiaojiao Jin Wancang Sun Junyan Wu Yan Fang Xuecai Li Li Ma Lijun Liu Rui Zeng | 2022 | Oil Crop Science2022，7，1： | 1 |
| 15 | Identificaion and Quantification of coronary atheroscleroticplaques: a comparison of 64 - MSCT and intravascularultrasound显示文摘 | Junyan Sun ZhaoqiZhang Biat) Lu | 2008 | AJR2008，190，3： | 1 |
| 16 | Research on Experiments and Action Mechanism with Water Vapor as Coolant and Lubricant in Green Cutting显示文摘 | LIU Junyan HAN Rongdi SUN Yongfeng | | 0，，： | 1 |
| 17 | Research on experiments and action mechanism with water vapor as coolant and lubricant in Green cutting显示文摘 | Junyan Liu Rongdi Han Yougfeng Sun | 2005 | Machine tools&manufacture2005，，45： | 1 |
| 18 | Mitochondrial 12S rRNA variants in 1642 Han Chinese pediatric subjects with aminoglycoside-induced and nonsyndromic hearing loss显示文摘 | Jianxin Lu Zhiyuan Li Yi Zhu Aifen Yang Ronghua Li Jing Zheng Qin Cai Guanghua Peng Wuwei Zheng Xiaowen Tang Bobei Chen Jianfu Chen Zhisu Liao Li Yang Yongyan Li Junyan You Yu Ding Hong Yu Jindan Wang Dongmei Sun Jianyue Zhao Ling Xue Jiying Wang Min-Xin | 2010 | Mitochondrion2010，，4： | 1 |
| 19 | Survivin gene expression increases gastric cancer cell lymphatic metastasisby upregulating vascular endothelial growth factor-C expression levels显示文摘 | Junyan Zhang Zhi Zhu Zhe Sun Xuren Sun Zhenning Wang Huimian Xu | 2014 | Molecular Medicine Reports2014，，2： | 1 |
| 20 | Reasearch on experiments and action mechanism with water vapor as coolant and lubricant in green cutting 显示文摘 | Liu Junyan Hart Rongdi Sun Yongfeng | 2005 | Machine tools & manufacture2005，，45： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员