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| 1 | ZmMs30 Encoding a Novel GDSL Lipase Is Essential for Male Fertility and Valuable for Hybrid Breeding in Maize显示文摘Genic male sterility (GMS) is very useful for hybrid vigor utilization and hybrid seed production. Although a large number of GMS genes have been identified in plants, little is known about the roles of GDSL lipase members in anther and pollen development. Here, we report a maize GMS gene, ZmMs30, which encodes a novel type of GDSL lipase with diverged catalytic residues. Enzyme kinetics and activity assays show that ZmMs30 has lipase activity and prefers to substrates with a short carbon chain. ZmMs30 is specifically expressed in maize anthers during stages 7-9. Loss of ZmMs30 function resulted in defective anther cuticle, irregular foot layer of pollen exine, and complete male sterility. Cytological and lipidomics analyses demonstrate that ZmMs30 is crucial for the aliphatic metabolic pathway required for pollen exine formation and anther cuticle development. Furthermore, we found that male sterility caused by loss of ZmMs30 function was stable in various inbred lines with different genetic background, and that it didn't show any negative effect on maize heterosis and production, suggesting that ZmMs30 is valuable for crossbreeding and hybrid seed production. We then developed a new multi-control sterility system using ZmMs30 and its mutant line, and demonstrated it is feasible for generating desirable GMS lines and valu. able for hybrid maize seed production. Taken together, our study sheds new light on the mechanisms of anther and pollen development, and provides a valuable male-sterility system for hybrid breeding maize. | Xueli An Zhenying Dong Youhui Tian Ke Xie Suowei Wu Taotao Zhu Danfeng Zhang Van Zhou Canfang Niu Biao Ma Quancan Hou Jianxi Bao Simiao Zhang Ziwen Li Yanbo Wang Tingwei Yan Xiaojing Sun Yuwen Zhang Jinping Li Xiangyuan Wan | 2019 | Molecular Plant2019，12，3： | 15 |
| 2 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 3 | Mammalian target of rapamycin pathway inhibition enhances the effects of 5-aza-dC on suppressing cell proliferation in human gastric cancer cell lines显示文摘The present study aimed to evaluate the relationship between mTOR signaling pathway and DNA methylation in cell survival,cell cycle,gene expression and protein level on human gastric cancer cells. Human gastric cancer cell lines,MKN45 and SGC7901 were treated with 5-aza-dC,rapamycin and/or LY294002.Cell viability was analyzed by MTT.Cell cycle distribution was evaluated by flow cytometry (FCM).The transcription level of PTEN and p27 Kip1 genes was detected by using real-time PCR.Protein expressions were detected by Western blotting.We found that cell viability was moderately reduced when treated with 5-aza-dC alone,but remarkably reduced when mTOR pathway was inhibited together (P<0.01).mTOR inhibition enhances the effects of 5-aza-dC on arresting cell cycle at G2 phase in human gastric cancer cell lines.The expression of PTEN and p27 Kip1 mRNA was remarkably increased in the gastric cancer cells treated with combind drugs(P<0.01).Phosphorylation of Akt,p70S6K and 4E-BP1 were significantly reduced in the cells treated with LY294002 or RAPA(P<0.01),but we failed to find that 5-aza-dC enhance these effects.We suggested that mTOR inhibition could enhance the effects of 5-aza-dC on suppressing cell proliferation and arresting cell cycle in human gastric cancer cell lines, which might be a potential target for tumor therapy. | SUN DanFeng,TIAN XiaoQing,ZHANG YanJie,CHEN YingXuan,LU Rong,WANG Xia &FANG JingYuan Shanghai Jiao-Tong University Sc0hool of Medicine Renji Hospital,Shanghai Institute of Digestive Disease,Shanghai 200001, China | 2008 | Science China(Life Sciences)2008，51，7： | 12 |
| 4 | High precision topographic data on Lop Nor basin's Lake 'Great Ear' ? and the timing of its becoming a dry salt lake显示文摘High precision elevation measurements using DGPS were carried out along three representative tran- sects for the 'Great Ear' area, a dry salt lake within the Lop Nor basin. Results indicate that the Lop Nor basin is only 5.2 m deep and its lowest point occurs at the center of the 'Great Ear'. In addition, the basin is asymmetric - steeper in the southwest (0.19‰) and gentler in the northeast (0.09‰). Points along the same 'Great Ear' ring were found to have an identical elevation value, but different when from different ones (lower towards the center). The spacing of the 'Great Ear' rings was found to be closely related with the surface steepness. The closer the 'Great Ear' rings are spaced, the steeper the ground surface, and vice versa. These findings support the argument that the 'Great Ear' rings are the former shoreline trails left behind by Lop Nor water during the last few episodes of recession towards its total dry up. A comprehensive analysis of the high precision elevation data, historical accounts, aerial and satellite photographs and imagery, and official topographic maps of the study area suggests that the 'Great Ear' area in the Lop Nor basin was incorrectly mapped as being covered by a great body of water on the 1963 topographic maps. A re-interpretation of the 1958 aerial photographs and newer remote sensing imagery indicated that the 'Great Ear' ring structure was already in place in 1958 and it continued to appear on the subsequent remote sensing data without any major changes. It is estimated that lake water in the 'Great Ear' area of the Lop Nor basin disappeared between the late 1930s and early 1940s. | LI BaoGuo MA LiChun JIANG PingAn DUAN ZengQiang SUN DanFeng QIU HongLie ZHONG JunPing WU HongQi | 2008 | Chinese Science Bulletin2008，53，6： | 11 |
| 5 | Percent free prostate-specific antigen for prostate cancer diagnosis in Chinese men with a PSA of 4.0-10.0 ng/mL:Results from the Chinese Prostate Cancer Consortium显示文摘Objective:To test the diagnostic performance of percent free prostate-specific antigen(%fPSA)in predicting any prostate cancer(PCa)and high-grade prostate cancer(HGPCa)in a retrospective multi-center biopsy cohort with a PSA level of 4.0e10.0 ng/mL in China.Methods:Consecutive patients with a PSA of 4.0-10.0 ng/mL who underwent transrectal ultrasound-guided biopsy were enrolled at 16 Chinese medical centers from January 1st,2010 to December 31st,2013.Total and free serum PSA determinations were performed using three types of electro-chemiluminescence immunoassays recalibrated to the World Health Organization(WHO)standard.The diagnostic accuracy of PSA,%fPSA,and %fPSA in combination with PSA(%fPSA t PSA)was determined using the area under the receiver operating characteristic(ROC)curve(AUC).Results:A total of 2310 consecutive men with PSA levels between 4.0 and 10.0 ng/mL were included,and the detection rate of PCa was 25.1%.The AUC of%fPSA and %fPSA t PSA in predicting any PCa was superior to PSA alone in men aged≥60 years(0.623 vs.0.534,p<0.0001)but not in men aged 40e59 years(0.517 vs.0.518,p=0.939).Similar result was yield in predicting HGPCa.Conclusion:In a clinical setting of Chinese men with 4.0e10.0 ng/mL PSA undergoing initial prostate biopsy,adding %fPSA to PSA can moderately improve the diagnostic accuracy for any PCa and HGPCa compared with PSA alone in patients≥60 but not in patients aged 40-59 years. | Rui Chen Liping Xie Xiaobing Cai Yiran Huang Liqun Zhou Lulin Ma Xu Gao Chuanliang Xu Shancheng Ren Pengfei Shao Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Li Lu Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tie Zhou Fubo Wang Biming He Yinghao Sun | 2015 | Asian Journal of Urology2015，2，2： | 8 |
| 6 | Zinc finger protein 278, a potential oncogene in human colorectal cancer显示文摘(ZNF278 ) 锌手指蛋白质 278 是在人的纸巾是无所不在地分布式的新奇 Krueppel Cys2-His2-type 锌手指蛋白质。ZNF278 是否与 colorectal 癌症的发展有关,仍然是不清楚的。ZNF278 的 tran-scriptional 水平被即时聚合酶链反应在 colorectal 癌症学习。结果证明那 ZNF278 表情与相应非癌的纸巾相比在 53% colorectal 癌症纸巾被增加。ZNF278 的 Thetranscriptional 下面规定被检测在仅仅三(6%) 与相应非癌症纸巾相比的人的 colorectal 癌症纸巾。没有重要差别在 19 被检测(41%) 一些样品。然而,我们没能发现在抄写和年龄,性别,渗入的度,或肿瘤 colorectal 癌症缩放的 ZNF278 的起来规定之间的一个重要协会。在 colorectal carcinogenesis 学习 ZNF278 的函数,结肠癌房间线 SW1116 是稳定地有到构造的野类型的 ZNF278 plasmid 的 transfected 一个 overexpression 系统,并且短暂地有到构造的 ZNF278 的小介入 RNA 的 transfected 一个 ZNF278 击倒的系统。房间增长与 3- 被估计[4, 5-dimethylthiazol-2-yl ]-2,5-diphenyltetrazolium 溴化物染料和一个房间柜台。结果证明 ZNF278 支持房间生长,并且它的击倒压制房间增长。ZNF278 能是在 colorectal 癌症的潜在的 proto-oncogene。 | Xiaoqing Tian Danfeng Sun Yanjie Zhang Shuliang Zhao Hua Xiong Jingyuan Fang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，4： | 4 |
| 7 | Modeling Patch Characteristics of Farmland Loss for Site Assessment in Urban Fringe of Beijing, China显示文摘Farmland protection and delimitation in the urban fringe considers not only natural factors but also the spatial characters and site factors. Taking Daxing District, Beijing in China as a case study, this paper used landscape ecology and power-law methods to analyze and evaluate farmland loss during the period of 2004-2007 based on the interpretation results of SPOT5 remote sensing images in 2004 and 2007. At the patch level, we selected four landscape indices, namely patch size, shape index, the nearest neighbor distance between farmland and construction land (including residential land and other construction land), and cropping type, to evaluate the risk of farmland loss and establish a farmland site analysis indicator system. The results showed that patch size and shape index have a significant positive correlation with farmland loss, whereas the distance to construction land has a clear negative correlation with farmland loss. As regards cropping type, fallow farmland is much easier for non-agricultural use than cultivated farmland. The relative transition ratio among vegetable land, fallow farmland and cultivated farmland is 1︰5.6︰1. The patch size of lost farmland follows a power-law distribution, indicating that not only small parcels but also large parcels can be lost. Patch size less than 4 ha or more than 15 ha is in high loss risk, between 4 ha and 10 ha in medium loss risk, and larger than 10 ha and less than 15 ha in low risk. Farmland with a more regular shape has a higher likelihood of loss. Patch shape index less than 2.0 is in high loss risk, between 2.0 and 3.0 in medium loss risk, and larger than 3.0 in low risk. Construction land has a varying impact on farmland loss, the residential land effected distance is 1000 m, and that of the other construction land is 2000 m. This analysis showed the relationships between site factors and farmland loss, and the analysis framework can provide support and reference for farmland protection and delimitation of prime farmland in China. | LIU Xiaona ZHANG Weiwei LI Hong SUN Danfeng | 2013 | Chinese Geographical Science2013，23，3： | 3 |
| 8 | Cytoplasmic and nuclear genome variations of rice hybrids and their parents inform the trajectory and strategy of hybrid rice breeding显示文摘The male sterility(MS)line is a prerequisite for efficient production of hybrid seeds in rice,a self-pollinating species.MS line breeding is pivotal for hybrid rice improvement.Understanding the historical breeding tra-jectory will help to improve hybrid rice breeding strategies.Maternally inherited cytoplasm is an appro-priate tool for phylogenetic reconstruction and pedigree tracing in rice hybrids.In this study,we analyzed the cytoplasmic genomes of 1495 elite hybrid rice varieties and identified five major types of cytoplasm,which correspond to different hybrid production systems.As the cytoplasm donors for hybrids,461 MS lines were also divided into five major types based on cytoplasmic and nuclear genomic architecture.Spe-cific core accessions cooperating with different fertility-associated genes drove the sequence divergence of MS lines.Dozens to hundreds of convergent and divergent selective sweeps spanning several agro-nomic trait-associated genes were identified among different types of MS lines.We further analyzed the cross patterns between different types of MS lines and their corresponding restorers.This study system-atically analyzed the cytoplasmic genomes of rice hybrids revealed their relationships with nuclear ge-nomes of MS lines,and illustrated the trajectory of hybrid rice breeding and the strategies for breeding different types of MS lines providing new insights for future improvement of hybrid rice. | Zhoulin Gu Zhou Zhu Zhen Li Qilin Zhan Qi Feng Congcong Zhou Qiang Zhao Yan Zhao Xiaojian Peng Bingxin Dai Rongrong Sun Yan Li Hengyun Lu Lei Zhang Tao Huang Junyi Gong Danfeng Lv Xuehui Huang Bin Han | 2021 | Molecular Plant2021，14，12： | 2 |
| 9 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 10 | Suitability evaluation of fruit trees in Beijing western mountain areas based on DEM and GIS显示文摘 | Li Hong Sun Danfeng Zhang Fengrong | 2002 | Transactions of CSAE2002，18，51： | 1 |
| 11 | Quantitative identification and the evolution characteristics of production–living–ecological space in the mountainous area:From the perspective of multifunctional land显示文摘Developed here is an integrated framework for identifying production–living–ecological space(PLES)quantitatively at grid scale from the perspective of multifunction land use,and 25 compound space types are classified to highlight the multiple functions of PLES.As a typical mountainous city in northern Hebei province,Zhangjiakou is used as a case study,and the results show that more than 80%of the land space in Zhangjiakou has remarkable triple functionality.The living-dominated space and the production-dominated space are distributed mainly in the valleys of the Yanghe,Sanggan,and Huliu rivers and have obvious spatial consistency,while the ecological-dominated space is concentrated mostly at the eastern Yanshan Mountains and southern Taihang Mountains and complements the other two types of space.The former two are spatially fragmented,while the latter has been expanding to the periphery over time.From 1990 to 2015,the ecological-dominated space has increased the most by 1555.02 km^(2),while the living-dominated space has increased the least by 816.79 km^(2).The types of PLES are more diverse in the medium and low mountains and the areas with gentle slope,and the influencing factors include natural ecological environment,socioeconomic development,human consumption demand,and institutional policies.Therefore,these findings can mitigate conflicts among PLES in mountainous and similar areas,and promote the balanced development of land space. | JI Zhengxin LIU Chao XU Yueqing SUN Minxuan WEI Hejie SUN Danfeng LI Yaoyao ZHANG Ping SUN Qiangqiang | 2023 | Journal of Geographical Sciences2023，33，4： | 1 |
| 12 | Trust-Compensation-Based Access Control Model for Web Services显示文摘For most current Web Service access control methods,Web Service providers create a series of access control rules based on specified attributes.Only by meeting all the rules can a subject obtain the access to necessary operations and resources.However,because of the dynamic and open traits of Web Services,it is difficult for Web Service providers to work out an access control policy with moderate intensity and to realize a satisfactory balance between protecting the security of resources and maintaining the service reachable rate.To provide a solution to the above problem,this paper proposed a trust compensation access control method based on the Attribute-Based Access Control model.Our main contributions include a formal description of the access control method,a method to calculate the attribute trust degree based on time decay,and the trust compensation value of the attribute trust degree,as well as a new Service Oriented Architecture(SOA) architecture and its procedures based on a detailed trust compensation access control method. | Yan Danfeng Sun Jing Zhang Liying Yang Fangchun | 2012 | China Communications2012，9，12： | 1 |
| 13 | Suitability evaluation of fruit trees in Beijing western mountain areas based on DEM and GIS显示文摘 | Li Hong Sun Danfeng Zhang Fengrong | 2002 | Transactions of the CSAE2002，，5： | 1 |
| 14 | Influence of the microbiota on epigenetics in colorectal cancer显示文摘Colorectal cancer is one of the most common malignancies and is the second leading cause of cancer death worldwide.Generally;there are three categories of colorectal cancer development mechanism-genetic,epigenetic and aberrant immunological signaling pathways-all of which may be initiated by an imbalanced gut microbiota.Epigenetic modifications enable host cells to change gene expression without modifying the gene sequence.The microbiota can interact with the host genome dynamically through the interface presented by epigenetic modifications.In particular,bacterially derived short-chain fatty acids have been identified as one clear link in the interaction of the microbiota with host epigenetic pathways.This review discusses recent findings relating to the cross talk between the microbiota and epigenetic modifications in colorectal cancer. | Danfeng Sun Yingxuan Chen Jing-Yuan Fang | 2019 | National Science Review2019，6，6： | 1 |
| 15 | Modeling Desertification Change in Minqin County, China显示文摘 | Danfeng Sun Richard Dawson Hong Li Baoguo Li | 2005 | Environmental Monitoring and Assessment (-)2005，，1： | 1 |
| 16 | Suitability evaluation of fruit trees in Beijing western mountain areas based on DEM and GIS显示文摘 | Li Hong Sun Danfeng Zhang Fengrong | 2002 | Transactions of the CSAE2002，18，5： | 1 |
| 17 | MANAGEMENT OF PROSTATE CANCER IN CHINA: A MULTICENTER REPORT OF 6 INSTITUTIONS显示文摘 | MICHA?L PEYROMAURE BERNARD DEBRé KAILI MAO GUOQIANG ZHANG YIRAN WANG ZHONGQUAN SUN DANFENG XU JUN JIANG YINGHAO SUN | 2005 | The Journal of Urology2005，，5： | 1 |
| 18 | Agricultural causes of desertification risk in Minqin, China显示文摘 | Sun Danfeng Dawson R Li Baoguo | 2006 | Journal of Environmental Management2006，79，： | 1 |
| 19 | An Early Stage Detecting Method against SYN Flooding Attacks显示文摘Existing detection methods against SYN flooding attacks are effective only at the later stages when attacking signatures are obvious.In this paper an early stage detecting method(ESDM) is proposed.The ESDM is a simple but effective method to detect SYN flooding attacks at the early stage.In the ESDM the SYN traffic is forecasted by autoregressive integrated moving average model, and non-parametric cumulative sum algorithm is used to find the SYN flooding attacks according to the forecasted traffic.Trace-driven simulations show that ESDM is accurate and efficient to detect the SYN flooding attacks. | Sun Qibo Wang Shangguang Yan Danfeng Yang Fangchun | 2009 | China Communications2009，6，4： | 1 |
| 20 | Improved iterative convergence method in Q-ary LDPC coded high order PR-CPM显示文摘The Q-ary low-density parity-check(LDPC) coded high order partial response continuous phase modulation(PR-CPM) with double iterative loops is investigated. This scheme shows significant improvements in power and bandwidth efficiency, but at the expense of long iterative decoding delay and computational complexity induced by the improper match between the demodulator and the decoder. To address this issue, the convergence behavior of Q-ary LDPC coded CPM is investigated for the Q=2 and Q>2 cases, and an optimized design method based on the extrinsic information transfer chart is proposed to improve the systematic iterative efficiency. Simulation results demonstrate that the proposed method can achieve a perfect tradeoff between iterative decoding delay and bit error rate performance to satisfy real-time applications. | Danfeng Zhao Yanbo Sun Rui Xue | 2016 | Journal of Systems Engineering and Electronics2016，27，3： | 0 |
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