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| 1 | Environmental issues from coal mining and their solutions显示文摘The environmental challenges from coal mining include coal mine accidents,land subsidence,damage to the water environment,mining waste disposal and air pollution.These are either environmental pollution or landscape change.A conceptual framework for solving mine environmental issues is proposed.Clean processes,or remediation measures,are designed to address environmental pollution.Restoration measures are proposed to handle landscape change.The total methane drainage from 56 Chinese high methane concentration coal mines is about 101.94 million cubic meters.Of this methane,19.32 million,35.58 million and 6.97 million cubic meters are utilized for electricity generation,civil fuel supplies and other industrial purposes,respectively.About 39% of the methane is emitted into the atmosphere.The production of coal mining wastes can be decreased 10% by reuse of mining wastes as underground fills,or by using the waste as fuel for power plants or for raw material to make bricks or other infrastructure materials.The proper use of mined land must be decided in terms of local physical and socio-economical conditions.In European countries more than 50% of previously mined lands are reclaimed as forest or grass lands.However,in China more than 70% of the mined lands are reclaimed for agricultural purposes because the large population and a shortage of farmlands make this necessary.Reconstruction of rural communities or native residential improvement is one environmental problem arising from mining.We suggest two ways to reconstruct a farmer's house in China. | BIAN, Zhengfu INYANG, Hilary I DANIELS, John L OTTO, Frank STRUTHERS, Sue | 2010 | Mining Science and Technology2010，20，2： | 47 |
| 2 | Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer显示文摘Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer. | Jonathan Landy Emma Ronde Nick English Sue K Clark Ailsa L Hart Stella C Knight Paul J Ciclitira Hafid Omar Al-Hassi | 2016 | World Journal of Gastroenterology2016，22，11： | 39 |
| 3 | Acupuncture for irritable bowel syndrome: A blinded placebo-controlled trial显示文摘AIM: Irritable bowel syndrome (IBS) is a common disorder and many patients fail to find adequate relief from conventional therapies for their symptoms. This study tests the claim that acupuncture is effective for a majority of these patients.METNODS: A prospective, blinded, sham acupuncturecontrolled trial of traditional Chinese acupuncture was performed at a single postgraduate teaching hospital in Europe. Sixty patients with well-established IBS were recruited. The blinded comparator was sham acupuncture administered by the second of two acupuncturists who alone was aware of the randomization, and who otherwise followed the prescription of the first. The primary endpoint was a defined fall in the symptom score at 13 wk (by intention to treat). The prior expectation was a 30%placebo response, and a response rate of 70% from acupuncture, for which the study was adequately powered.RESULTS: Patients in treated and sham groups improved significantly during the study-mean improvement in scores being equal (minus 1.9) and significant for both (P<0.05;one-tailed t test). There was a small numeric but nonsignificant difference between the response rate in patients receiving acupuncture (40.7%) and sham treatment (31.2%). Several secondary end-points marginally favored active treatment, but an improved symptom score of any degree of magnitude occurred more often with sham therapy (65.6% vs 59.2%). For no criterion was statistical significance approached.CONCLUSION: Traditional Chinese acupuncture is relatively ineffective in IBS in the European hospital setting,and the magnitude of any effect appears insufficient to warrant investment in acupuncture services. | Alastair Forbes Sue Jackson Clare Walter Shafi Quraishi Meron Jacyna Max Pitcher | 2005 | World Journal of Gastroenterology2005，11，26： | 22 |
| 4 | 阿尔茨海默病神经细胞凋亡与小胶质细胞活化的关系显示文摘目的 探讨阿尔茨海默病 (Alzheimer′sdisease ,AD)神经细胞凋亡与小胶质细胞活化的关系及活化的小胶质细胞在AD老年斑形成和进展中的作用。方法 收集 10例AD尸检材料及 4例非神经系统疾病死亡的老年尸检材料作为对照 ,进行白细胞介素 1α(IL 1α)免疫组织化学和原位DNA末端转移酶技术 (TUNEL)双重标记及淀粉样 β蛋白免疫组织化学和TUNEL双重标记。 结果 AD组静止的小胶质细胞数与对照组差异无显著性 (P >0 0 5 ) ,但活化的小胶质细胞数明显比对照组高 (P <0 0 1)。活化的小胶质细胞增大、变形 ,可进一步分为初级活化的小胶质细胞、增大的小胶质细胞及巨噬细胞 3种亚型。上述 3种活化的小胶质细胞数分别为 (5 4 0± 0 87)、(11 5 0± 1 2 5 )、(3 4 0± 0 32 )个 /mm2 ,占所有活化的小胶质细胞的比例分别为 2 6 6 0 % ,5 6 6 5 % ,16 75 %。AD组TUNEL阳性的凋亡的神经细胞数明显比对照组高 (P <0 0 5 ) ,且凋亡的神经细胞与活化的小胶质细胞之间具有相关性 (P <0 0 1)。活化的小胶质细胞在 4种类型老年斑中的分布比例不同 ,许多初级活化的小胶质细胞 (4 2 3% ) ,大多数增大的小胶质细胞和巨噬细胞 (分别是 5 6 2 %、70 6 % )分布在弥漫性神经突斑中。结论 小胶质细胞增生。 | 刘冬戈 何淑蓉 张伟 崔娣 Yue kui Li W. Sue T. Griffin | 2004 | 中华病理学杂志2004，33，5： | 17 |
| 5 | 连栽杉木(Cunninghamia lancelata(Lamb) Hook)林中树桩分解过程中的化学组分变化趋势显示文摘采用以空间代替时间的方法,对连栽杉木(Cunninghamialancelata(Lamb)Hook)人工林中采伐剩余树桩的分解过程进行了研究.根据Olson的分解模型,计算出连栽杉木纯林中树桩的分解速率为0.02695,树桩在分解过程中的前2年是一个氮素增加积累过程,当杉木树桩的C/N在463.2±27.3时开始净氮释放.树桩磷含量的变化与氮变化模式相类似,但钾的表现不同,钾的含量在树桩分解过程中一直是单调降低.利用固体高分辨核磁共振技术结合魔角旋转(MAS)和交叉极化(CP)技术,研究了杉木树桩的腐殖化过程及碳结构的变化.树桩中由纤维素和半纤维素组成的多糖碳和乙缩醛被首先分解,而由蜡质和表皮素等化合物组成的烷基碳,由酚类、木质素、单宁和石蜡等化合物组成的芳香族碳,及由酯、有机酸、酮和醛等化合物组成的羧基碳的分解速度较多糖碳和乙缩醛慢. | 黄志群 徐志红 Sue Boyd David Williams | 2005 | 科学通报2005，50，21： | 15 |
| 6 | Varietal identification of tea(Camellia sinensis)using nanofluidic array of single nucleotide polymorphism(SNP)markers显示文摘Apart from water,tea is the world’s most widely consumed beverage.Tea is produced in more than 50 countries with an annual production of approximately 4.7 million tons.The market segment for specialty tea has been expanding rapidly owing to increased demand,resulting in higher revenues and profits for tea growers and the industry.Accurate varietal identification is critically important to ensure traceability and authentication of premium tea products,which in turn contribute to on-farm conservation of tea genetic diversity.Using a set of single nucleotide polymorphism(SNP)markers developed from the expressed sequence tag(EST)database of Camilla senensis,we genotyped deoxyribonucleic acid(DNA)samples extracted from a diverse group of tea varieties,including both fresh and processed commercial loose-leaf teas.The validation led to the designation of 60 SNPs that unambiguously identified all 40 tested tea varieties with high statistical rigor(p<0.0001).Varietal authenticity and genetic relationships among the analyzed cultivars were further characterized by ordination and Bayesian clustering analysis.These SNP markers,in combination with a high-throughput genotyping protocol,effectively established and verified specific DNA fingerprints for all tested tea varieties.This method provides a powerful tool for variety authentication and quality control for the tea industry.It is also highly useful for the management of tea genetic resources and breeding,where accurate and efficient genotype identification is essential. | Wan-Ping Fang Lyndel W Meinhardt Hua-Wei Tan Lin Zhou Sue Mischke Dapeng Zhang | 2014 | Horticulture Research2014，1，1： | 13 |
| 7 | 远程皮肤病学的现状和展望显示文摘远程医学泛指应用远程通讯技术交换医学信息,以达到诊断、咨询、治疗和教学目的。远程放射学、远程病理学和远程皮肤病学是目前应用较为广泛的远程医学领域。文中对远程皮肤病学的发展简史、现状和可能的发展趋势进行综述。 | 崔勇 W.P. Daniel Sue Mark D.P. Davis Mark R. Pittelkow 张学军 | 2011 | 中国皮肤性病学杂志2011，25，11： | 12 |
| 8 | Exogenous abscisic acid significantly affects proteome in teaplant (Camellia sinensis) exposed to drought stress显示文摘Tea[Camellia sinensis(L.)O.Kuntze]is an important economic crop,and drought is the most important abiotic stress affecting yield and quality.Abscisic acid(ABA)is an important phytohormone responsible for activating drought resistance.Increased understanding of ABA effects on tea plant under drought stress is essential to develop drought-tolerant tea genotypes,along with crop management practices that can mitigate drought stress.The objective of the present investigation is evaluation of effects of exogenous ABA on the leaf proteome in tea plant exposed to drought stress.Leaf protein patterns of tea plants under simulated drought stress[(polyethylene glycol(PEG)-treated]and exogenous ABA treatment were analyzed in a time-course experiment using two-dimensional electrophoresis(2-DE),followed by matrix-assisted laser desorption/ionization time-of-flight(MALDI-TOF)mass spectrometry(MS).Among the 72 protein spots identified by MALDI-TOF MS,16 proteins were downregulated and two were upregulated by exogenous ABA.The upregulated proteins have roles in glycolysis and photosystem II stabilization.Twenty-one protein spots were responsive to drought stress and most participate in carbohydrate and nitrogen metabolism,control of reactive oxygen species(ROS),defense,signaling or nucleic acid metabolism.The combined treatments of exogenous ABA and drought showed upregulation of 10 protein spots at 12 h and upregulation of 11 proteins at 72 h after initiation of drought stress.The results support the importance of the role that ABA plays in the tea plant during drought stress,by improving protein transport,carbon metabolism and expression of resistance proteins. | Lin Zhou Hui Xu Sue Mischke Lyndel W Meinhardt Dapeng Zhang Xujun Zhu Xinghui Li Wanping Fang | 2014 | Horticulture Research2014，1，1： | 12 |
| 9 | Proton pump inhibitors as a risk factor for recurrence of Clostridium-difficile-associated diarrhea显示文摘AIM:To investigate the risk factors for Clostridiumdifficile-associated diarrhea(CDAD)recurrence,and its relationship with proton pump inhibitors(PPIs). METHODS:Retrospective data of 125 consecutive hospitalized patients diagnosed with CDAD between January 2006 and December 2007 were collected by medical chart review.Collected data included patient characteristics at baseline,underlying medical disease, antibiotic history before receiving a diagnosis of CDAD, duration of hospital stay,severity of CDAD,concurrenttreatment with PPIs,laboratory parameters,response to CDAD therapy,and recurrence of disease within 90 d of successful treatment.Various clinical and laboratory parameters were compared in patients in whom CDAD did or did not recur. RESULTS:Of the 125 patients(mean age,67.6± 13.9 years)that developed CDAD,98(78.4%)did not experience recurrence(non-recurrent group)and 27 (21.6%)experienced one or more recurrences(recurrent group).Prior to the development of CDAD,96% of the 125 patients were prescribed antibiotics,and 56(44.8%)of the patients received PPIs.Age older than 65 years(P=0.021),feeding via nasogastric tube(NGT)(P=0.045),low serum albumin level(P =0.025),and concurrent use of PPIs(P=0.014) were found to be risk factors for CDAD recurrence by univariate analysis.However,sex,length of hospital stay,duration and type of antibiotics used,severity of disease,leukocyte count and C-reactive protein(CRP) were not associated with risk of CDAD recurrence.On multivariate analysis,the important risk factors were advanced age(>65 years,adjusted OR:1.32,95% CI:1.12-3.87,P=0.031),low serum albumin level(< 2.5 g/dL,adjusted OR:1.85,95%CI:1.35-4.91,P= 0.028),and concurrent use of PPIs(adjusted OR:3.48, 95%CI:1.64-7.69,P=0.016). CONCLUSION:Advanced age,serum albumin level< 2.5 g/dL,and concomitant use of PPIs were found to be significant risk factors for CDAD recurrence. | Ji Won Kim Kook Lae Lee Ji Bong Jeong Byeong Gwan Kim Sue Shin Joo Sung Kim Hyun Chae Jung In Sung Song | 2010 | World Journal of Gastroenterology2010，16，28： | 10 |
| 10 | 高分子材料刮擦行为研究进展显示文摘随着高分子材料在光学、包装、汽车及建筑装饰等领域的广泛应用,市场对其表面质量的要求越来越高.刮擦是尖锐硬物在材料表面滑动时产生的一种力学变形和破坏行为.多维复杂应力的作用使材料表面因塑性变形而形成可见划痕,从而对材料的美观性、完整性和持久性带来负面影响.近年来,随着刮擦测试方式和相关标准的建立,并结合计算机的模拟预测,研究者们对高分子材料在刮擦过程中的破坏模式与机理及其内在多层次结构与刮擦性能关系的理解日趋深入,从而为高分子材料的耐刮擦性能改性提供了重要的实验和理论依据.基于此,本文综述了国内外在高分子材料刮擦性能测试和表征方法、刮擦过程中的变形与破坏机理、刮擦行为的影响因素以及耐刮擦改性方法等方面的研究进展. | 徐杨 李顿 沈佳斌 郭少云 Hung-Jue Sue | 2018 | 高分子学报2018，28，10： | 9 |
| 11 | Effective treatment of depression improves post-myocardial infarction survival显示文摘AIM: To examine the contribution of treatment resistant depression(TRD) to mortality in depressed postmyocardial infarction(MI) patients independent of biological and social predictors.METHODS: This secondary analysis study utilizes the Enhancing Recovery in Coronary Heart Disease(ENRICHD) clinical trial data.From 1834 depressed patients in the ENRICHD study,there were 770 depressed post-MI patients who were treated for depression.In this study,TRD is defined as having a less than 50% reduction in Hamilton Depression(HAM-D) score from baseline and a HAM-D score of greater than 10 in 6 mo after depression treatment began.Cox regression analysis was used to examine the independent contributions of TRD to mortality after controlling for the biological and social predictors.RESULTS: TRD occurred in 13.4%(n = 103) of the 770 patients treated for depression.Patients with TRD were significantly younger in age(P = 0.04)(mean = 57.0 years,SD = 11.7) than those without TRD(mean = 59.2 years,SD = 12.0).There was a significantly higher percentage of females with TRD(57.3%) compared to females without TRD(47.4%) [χ2(1) = 4.65,P = 0.031].There were significantly more current smokers with TRD(44.7%) than without TRD(33.0%) [χ2(1) = 7.34,P = 0.007].There were no significant differences in diabetes(P = 0.120),history of heart failure(P = 0.258),prior MI(P = 0.524),and prior stroke(P = 0.180) between patients with TRD and those without TRD.Mortality was 13%(n = 13) in patients with TRD and 7%(n = 49) in patients without TRD,with a mean follow-up of 29 mo(18 mo minimum and maximum of 4.5 years).TRD was a significant independent predictor of mortality(HR =1.995; 95%CI: 1.011-3.938,P = 0.046) after controlling for age(HR = 1.036; 95%CI: 1.011-1.061,P = 0.004),diabetes(HR = 2.912; 95%CI: 1.638-5.180,P < 0.001),heart failure(HR = 2.736; 95%CI: 1.551-4.827,P = 0.001),and smoking(HR = 0.502; 95%CI: 0.228-1.105,P = 0.087).CONCLUSION: The analysis of TRD in the ENRICHD study shows that the effective treatment of depression reduced mortality in depressed post-MI patients.It is important to monitor the effectiveness of depression treatment and change treatments if necessary to reduce depression and improve cardiac outcomes in depressed post-MI patients. | Soudabeh Khojasteh Banankhah Erika Friedmann Sue Thomas | 2015 | World Journal of Cardiology2015，7，4： | 8 |
| 12 | 认知行为治疗对大脑活动的影响有别于抗抑郁药显示文摘一项小型预试验首次根据脑扫描的证据证明,不同的治疗方式作用于不同途径。该试验报道与抗抑郁药帕罗西汀治疗不同,认知行为治疗启动了一种变化了的大脑活动模式。 研究人员对17例未经治疗的单相抑郁症门诊患者在接受15-20次认知行为治疗之前和之后进行了脑扫描。 | Sue Mayor 张新凯 | 2004 | 英国医学杂志中文版2004，7，4： | 8 |
| 13 | The USDA cucumber (Cucumis sativus L.) collection: genetic diversity, population structure, genome-wide association studies, and core collection development显示文摘Germplasm collections are a crucial resource to conserve natural genetic diversity and provide a source of novel traits essential for sustained crop improvement.Optimal collection,preservation and utilization of these materials depends upon knowledge of the genetic variation present within the collection.Here we use the high-throughput genotyping-by-sequencing(GBS)technology to characterize the United States National Plant Germplasm System(NPGS)collection of cucumber(Cucumis sativus L.).The GBS data,derived from 1234 cucumber accessions,provided more than 23 K high-quality single-nucleotide polymorphisms(SNPs)that are well distributed at high density in the genome(~1 SNP/10.6 kb).The SNP markers were used to characterize genetic diversity,population structure,phylogenetic relationships,linkage disequilibrium,and population differentiation of the NPGS cucumber collection.These results,providing detailed genetic analysis of the U.S.cucumber collection,complement NPGS descriptive information regarding geographic origin and phenotypic characterization.We also identified genome regions significantly associated with 13 horticulturally important traits through genome-wide association studies(GWAS).Finally,we developed a molecularly informed,publicly accessible core collection of 395 accessions that represents at least 96%of the genetic variation present in the NPGS.Collectively,the information obtained from the GBS data enabled deep insight into the diversity present and genetic relationships among accessions within the collection,and will provide a valuable resource for genetic analyses,gene discovery,crop improvement,and germplasm preservation. | Xin Wang Kan Bao Umesh K.Reddy Yang Bai Sue A.Hammar Chen Jiao Todd C.Wehner Axel O.Ramírez-Madera Yiqun Weng Rebecca Grumet Zhangjun Fei | 2018 | Horticulture Research2018，5，1： | 7 |
| 14 | 雌激素神经保护作用机制:线粒体功能的调节显示文摘大量研究表明雌激素具有神经保护作用,但其机制尚不清楚。近年来研究提示,雌激素的神经保护作用与线粒体有着密切联系。线粒体是细胞内能量和活性氧自由基(ROS)的主要来源,对细胞内信号转导、细胞存活与死亡调节等具有十分重要的影响。在生理和病理条件下,雌激素可多方面调节线粒体功能,包括影响ATP与ROS的生成、稳定线粒体膜电位、维护细胞内钙稳态,以及调节线粒体基因和蛋白表达等。本文主要从线粒体角度综述了雌激素神经保护作用及其机制。 | 郭家彬 铁璐 Diana N Krause Sue P Duckles 李学军 | 2010 | 生理科学进展2010，41，3： | 7 |
| 15 | 国外自闭症谱系障碍儿童远程诊疗:现状与启示显示文摘自新冠疫情爆发以来,各国加大了对自闭症儿童远程诊疗的研究和实践。本文对2010-2021年间国外自闭症谱系障碍儿童远程诊疗的研究案例作了梳理,从技术手段、诊疗对象、诊疗措施和治疗效果等几个方面进行实证分析,发现远程诊疗在提升患儿言语语言交流能力、日常生活技能、社交技能和行为管理能力方面都产生了实际疗效。此外,远程指导下的治疗结束后家长和患儿的压力和焦虑情绪得到极大缓解、家长满意度高且坚持训练项目的意愿较为强烈。最后,本文对自闭症儿童远程诊疗在我国的发展作了积极展望,以期为疫情下国内自闭症儿童的诊疗提供思路和启发。 | 陈雯珺 余英 Sue Ann Lee 马博森 | 2022 | 中国特殊教育2022，，1： | 7 |
| 16 | Etiopathogenesis of primary sclerosing cholangitis显示文摘Primary sclerosing cholangitis(PSC) is a chronic cholestatic liver disease of unknown etiology but lymphocytic portal tract infiltration is suggestive of an immune-mediated basis for this disease.Associations with inflammatory bowel disease(IBD) especially ulcerative colitis(UC),and with particular autoimmune diseases,as well as the genetic associations further suggest PSC may be an immune-mediated disease.The immunogenetics of PSC have been the subject of active research and several HLA and non-HLA associated genes have been implicated in the development of the disease.Lymphocytes derived from the inflamed gut may enter the liver via the enterohepatic circulation to cause hepatic disease.PSC may be triggered in genetically susceptible individuals by infections or toxins entering the portal circulation through a permeable colon and hence evoking an abnormal immune response. | Roger Chapman Sue Cullen | 2008 | World Journal of Gastroenterology2008，14，21： | 6 |
| 17 | Developing single nucleotide polymorphism(SNP)markers from transcriptome sequences for identification of longan(Dimocarpus longan)germplasm显示文摘Longan(Dimocarpus longan Lour.)is an important tropical fruit tree crop.Accurate varietal identification is essential for germplasm management and breeding.Using longan transcriptome sequences from public databases,we developed single nucleotide polymorphism(SNP)markers;validated 60 SNPs in 50 longan germplasm accessions,including cultivated varieties and wild germplasm;and designated 25 SNP markers that unambiguously identified all tested longan varieties with high statistical rigor(P<0.0001).Multiple trees from the same clone were verified and off-type trees were identified.Diversity analysis revealed genetic relationships among analyzed accessions.Cultivated varieties differed significantly from wild populations(Fst=0.300;P<0.001),demonstrating untapped genetic diversity for germplasm conservation and utilization.Within cultivated varieties,apparent differences between varieties from China and those from Thailand and Hawaii indicated geographic patterns of genetic differentiation.These SNP markers provide a powerful tool to manage longan genetic resources and breeding,with accurate and efficient genotype identification. | Boyi Wang Hua-Wei Tan Wanping Fang Lyndel W Meinhardt Sue Mischke Tracie Matsumoto Dapeng Zhang | 2015 | Horticulture Research2015，2，1： | 6 |
| 18 | 高职高专学前创业型人才培养面临的主要问题及解决对策显示文摘分别从我国幼儿园发展、幼教从业者整体素质、高职高专学前毕业生就业等方面来论述高职高专学前创业型人才培养的必要性,从政府、机构组织和高职高专三个层面分析学前创业型人才培养存在的突出问题,指出,政府、机构组织与高职高专须开展三位一体、职责分明的合作,从创业支持、教师培训、培养方案、教材和课程等方面进行制度化、弹性化、模块化改革,从而开创新时代学前创业型人才培养新局面。 | 李传瑛 Sue Saltmarsh | 2018 | 广西科技师范学院学报2018，33，4： | 5 |
| 19 | Lipid nanoparticle-encapsulated mRNA antibody provides longterm protection against SARS-CoV-2 in mice and hamsters显示文摘Monoclonal antibodies represent important weapons in our arsenal to against the CO VID-19 pandemic.However,this potential is severely limited by the time-consuming process of developing effective antibodies and the relative high cost of manufacturing.Herein,we present a rapid and cost-effective lipid nanoparticle(LNP)encapsulated-mRNA platform for in vivo delivery of SARS-CoV-2 neutralization antibodies.Two mRNAs encoding the light and heavy chains of a potent SARS-CoV-2 neutralizing antibody HB27,which is currently being evaluated in clinical trials,were encapsulated into clinical grade LNP formulations(named as mRNA-HB27-LNP).I n vivo characterizatio n dem on strated that intravenous administratio n of mRNA-HB27-LNP in mice resulted in a longer circulating half-life compared with the original HB27 antibody in protein format.More importantly,a single prophylactic administration of mRNA-HB27-LNP provided protection against SARS-CoV-2 challenge in mice at 1,7 and even 63 days post administration.In a close contact transmission model,prophylactic administration of mRNA-HB27-LNP prevented SARS-CoV-2 in fecti on betwee n hamsters in a dose-depende nt mariner.Overall,our results dem on strate a superior Ion g-term protect!on agai nst SARS-CoV-2 conferred by a single administration of this unique mRNA antibody,highlight!ng the potential of this universal platform for antibody-based disease prevention and therapy against COVID-19 as well as a variety of other infectious diseases. | Yong-Qiang Deng Na-Na Zhang Yi-Fei Zhang Xia Zhong Sue Xu Hong-Ying Qiu Tie-Cheng Wang Hui Zhao Chao Zhou Shu-Long Zu Qi Chen Tian-Shu Cao Qing Ye Hang Chi Xiang-Hui Duan Dan-Dan Lin Xiao-Jing Zhang Liang-Zhi Xie Yu-Wei Gao Bo Ying Cheng-Feng Qin | 2022 | Cell Research2022，32，4： | 5 |
| 20 | Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease显示文摘AIM To study the genetic association and epistatic interaction of the interleukin(IL)-10 and IL-10/STAT3 pathways in pediatric inflammatory bowel disease(IBD). METHODS A total of 159 pediatric inflammatory IBD patients(Crohn's disease,n = 136; ulcerative colitis,n = 23) and 129 matched controls were studied for genetic association of selected single nucleotide polymorphisms(SNPs) of the IL-10 gene and the genes IL10 RA,IL10 RB,STAT3,and HO1,from the IL-10/STAT3 signaling pathway. As interactions between SNPs from different loci may significantly affect the associated risk for disease,additive(a) and dominant(d) modeling of SNP interactions was also performed to examine highorder epistasis between combinations of the individual SNPs. RESULTS The results showed that IL-10 rs304496 was associated with pediatric IBD(P = 0.022),but no association was found for two other IL-10 SNPs,rs1800872 and rs2034498,or for SNPs in genes IL10 RA,IL10 RB,STAT3,and HO1. However,analysis of epistatic interaction among these genes showed significant interactions:(1) between two IL-10 SNPs rs1800872 and rs3024496(additive-additive P = 0.00015,Bonferroni P value(Bp) = 0.003);(2) between IL-10 RB rs2834167 and HO1 rs2071746(dominant-additive,P = 0.0018,Bp = 0.039); and(3) among IL-10 rs1800872,IL10 RB rs2834167,and HO1 rs2071746(additivedominant-additive,P = 0.00015,Bp = 0.005),as well as weak interactions among IL-10 rs1800872,IL-10 rs3024496,and IL-10RA(additive-additive-additive,P = 0.003; Bp = 0.099),and among IL10 RA,IL10 RB,and HO1 genes(additive-dominant-additive,P = 0.008,Bp = 0.287).CONCLUSION These results indicate that both the IL-10 gene itself,and through epistatic interaction with genes within the IL-10/STAT3 signaling pathway,contribute to the risk of pediatric IBD. | Zhenwu Lin Zhong Wang John P Hegarty Tony R Lin Yunhua Wang Sue Deiling Rongling Wu Neal J Thomas Joanna Floros | 2017 | World Journal of Gastroenterology2017，23，27： | 5 |
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