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| 1 | role of the normal gut microbiota显示文摘Relation between the gut microbiota and human health is being increasingly recognised. It is now well established that a healthy gut flora is largely responsible for overall health of the host. The normal human gut microbiota comprises of two major phyla, namely Bacteroidetes and Firmicutes. Though the gut microbiota in an infant appears haphazard, it starts resembling the adult flora by the age of 3 years. Nevertheless, there exist temporal and spatial variations in the microbial distribution from esophagus to the rectum all along the individual's life span. Developments in genome sequencing technologies and bioinformatics have now enabled scientists to study these microorganisms and their function and microbehost interactions in an elaborate manner both in health and disease. The normal gut microbiota imparts specific function in host nutrient metabolism, xenobiotic and drug metabolism, maintenance of structural integrity of the gut mucosal barrier, immunomodulation, and protection against pathogens. Several factors play a role in shaping the normal gut microbiota. They include(1) the mode of delivery(vaginal or caesarean);(2) diet during infancy(breast milk or formula feeds) and adulthood(vegan based or meat based); and(3) use of antibiotics or antibiotic like molecules that are derived from the environment or the gut commensal community. A major concern of antibiotic use is the long-term alteration of the normal healthy gut microbiota and horizontal transfer of resistance genes that could result in reservoir of organisms with a multidrug resistant gene pool. | Sai Manasa Jandhyala Rupjyoti Talukdar Chivkula Subramanyam Harish Vuyyuru Mitnala Sasikala D Nageshwar Reddy | 2015 | World Journal of Gastroenterology2015，21，29： | 187 |
| 2 | Pancreatic stellate cell: Pandora's box for pancreatic disease biology显示文摘Pancreatic stellate cells(PSCs) were identified in the early 1980 s, but received much attention after 1998 when the methods to isolate and culture them from murine and human sources were developed. PSCs contribute to a small proportion of all pancreatic cells under physiological condition, but are essential for maintaining the normal pancreatic architecture. Quiescent PSCs are characterized by the presence of vitamin A laden lipid droplets. Upon PSC activation, these perinuclear lipid droplets disappear from the cytosol, attain a myofibroblast like phenotype and expresses the activation marker, alpha smooth muscle actin. PSCs maintain their activated phenotype via an autocrine loop involving different cytokines and contribute to progressive fibrosis in chronic pancreatitis(CP) and pancreatic ductal adenocarcinoma(PDAC). Several pathways(e.g., JAK-STAT, Smad, Wnt signaling, Hedgehog etc.), transcription factors and mi RNAs have been implicated in the inflammatory and profibrogenic function of PSCs. The role of PSCs goes much beyond fibrosis/desmoplasia in PDAC. It is now shown that PSCs are involved in significant crosstalk between the pancreatic cancer cells and the cancer stroma. These interactions result in tumour progression, metastasis, tumour hypoxia, immune evasion and drug resistance. This is the rationale for therapeutic preclinical and clinical trials that have targeted PSCs and the cancer stroma. | Ratnakar R Bynigeri Aparna Jakkampudi Ramaiah Jangala Chivukula Subramanyam Mitnala Sasikala G Venkat Rao D Nageshwar Reddy Rupjyoti Talukdar | 2017 | World Journal of Gastroenterology2017，23，3： | 25 |
| 3 | Contribution of contact toxicity and wheat condition to mortality of stored product insects exposed to spinosad显示文摘 | Toews M D Subramanyam B | 2003 | Pest Management Science2003，59，5： | 1 |
| 4 | Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem ceils 显示文摘 | Subramanyam D Lamouille S Judson R L | 2011 | Nat Biotechnol2011，29，5： | 1 |
| 5 | Investor Psychology and Security Market Under-and Overreactions显示文摘 | Daniel K Hirshleifer D Subramanyam A | 1998 | Journal of Finance1998，53，6： | 1 |
| 6 | The Effect of Aluminum on the Work Hardening and Wear Resistance of Hadfield Manganese Steel显示文摘 | Zuidema B K Subramanyam D K Leslie W C | 1987 | Metallurgical Transactions A1987，18，： | 1 |
| 7 | PML-RARα and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia显示文摘 | Subramanyam D Belair CD Barry-Holson KQ | | 0，，21： | 1 |
| 8 | Investor Psychology and Security Market Under and Overreactions 显示文摘 | Daniel K Hirshleifer D Subramanyam A | 1998 | Joumal of Finance1998，53，6： | 1 |
| 9 | Investor psychology and security market Under- and Overreactions 显示文摘 | HIRSHLEIFER D Subramanyam A | 1998 | Journal of Finance1998，，53： | 1 |
| 10 | Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis显示文摘 | Mittal S Subramanyam D Dey D | 2009 | Mol C:ncer2009，23，8： | 1 |
| 11 | Nuclear features in oral squamous cell carcinoma: A computer - assisted microscopic study 显示文摘 | Nandini D R Subramanyam | 2011 | J Oral MaxiUofac Pathol2011，15，2： | 1 |
| 12 | Solu- tion ELISA as a platform of choice for development of robust, drug tolerant immunogenicity assays in support of drug deve- lopment 显示文摘 | MIKULSKIS A YEUNG D SUBRAMANYAM M | 2011 | J Irnmunol Methods2011，365，12： | 1 |
| 13 | Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells显示文摘 | Subramanyam D Lamouille S Judson RL | 2011 | Nat Biotechnol2011，29，5： | 1 |
| 14 | Investor psychology and security market Under and Overreactions显示文摘 | Daniel K Hirshleifer D Subramanyam A | 1998 | Journal of Finance1998，53，6： | 1 |
| 15 | Temperature and rel- ative humidity profiles during heat treatment of mills and its efficacy against Triboliurn castaneurn (Herbst) life stages 显示文摘 | Mahroof R Subramanyam B Eustace D | 2003 | Journal of Stored Products Research2003，39，4： | 1 |
| 16 | Using Sankey diagrams to map energy flow from primary fuel to end use显示文摘 | SUBRAMANYAM V PARAMSHIVAN D KUMAR A | 2015 | Energy Conversion and Management2015，91，： | 1 |
| 17 | Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-I ,6- dione gamma-secretase modulators显示文摘 | Pettersson M Johnson D S Subramanyam C | 2014 | J Med Chem2014，57，3： | 1 |
| 18 | Evaluation of spinosad as a grain protectant on three Kansas farms显示文摘 | SUBRAMANYAM B TOEWS M D ILELEJI K E | 2007 | Crop Protection2007，26，7： | 1 |
| 19 | Notch signaling pathway as a therapeutic target in breast cancer显示文摘 | Al-Hussaini H Subramanyam D Reedijk M | 2011 | Mol Cancer Ther2011，10，1： | 1 |
| 20 | Susceptibility of laboratory and field strains of four stored product insect species to spinosad显示文摘 | HUANG F SUBRAMANYAM B TOEWS M D | 2004 | Journal of Economic Entomology2004，97，： | 1 |
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