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| 1 | Pancreatic stellate cell: Pandora's box for pancreatic disease biology显示文摘Pancreatic stellate cells(PSCs) were identified in the early 1980 s, but received much attention after 1998 when the methods to isolate and culture them from murine and human sources were developed. PSCs contribute to a small proportion of all pancreatic cells under physiological condition, but are essential for maintaining the normal pancreatic architecture. Quiescent PSCs are characterized by the presence of vitamin A laden lipid droplets. Upon PSC activation, these perinuclear lipid droplets disappear from the cytosol, attain a myofibroblast like phenotype and expresses the activation marker, alpha smooth muscle actin. PSCs maintain their activated phenotype via an autocrine loop involving different cytokines and contribute to progressive fibrosis in chronic pancreatitis(CP) and pancreatic ductal adenocarcinoma(PDAC). Several pathways(e.g., JAK-STAT, Smad, Wnt signaling, Hedgehog etc.), transcription factors and mi RNAs have been implicated in the inflammatory and profibrogenic function of PSCs. The role of PSCs goes much beyond fibrosis/desmoplasia in PDAC. It is now shown that PSCs are involved in significant crosstalk between the pancreatic cancer cells and the cancer stroma. These interactions result in tumour progression, metastasis, tumour hypoxia, immune evasion and drug resistance. This is the rationale for therapeutic preclinical and clinical trials that have targeted PSCs and the cancer stroma. | Ratnakar R Bynigeri Aparna Jakkampudi Ramaiah Jangala Chivukula Subramanyam Mitnala Sasikala G Venkat Rao D Nageshwar Reddy Rupjyoti Talukdar | 2017 | World Journal of Gastroenterology2017，23，3： | 25 |
| 2 | Occurrence of recurrent aphthous stomatitisonly on lining mucosa and its relationship to smoking-a possible hy-pothesis显示文摘 | Subramanyam R V | 2011 | Med Hypotheses2011，77，2： | 1 |
| 3 | The effect of audit quality on earnings management 显示文摘 | Becker C M DeFond J Jiambalvo Subramanyam K R | 1998 | Contemporary Accounting Research1998，，15： | 1 |
| 4 | Positive correlations between serum calcineurin activity and left ventricular hypertrophy显示文摘 | Choudhary R Sastry BK Subramanyam C | 2005 | Int J Cardiol2005，105，3： | 1 |
| 5 | Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem ceils 显示文摘 | Subramanyam D Lamouille S Judson R L | 2011 | Nat Biotechnol2011，29，5： | 1 |
| 6 | The Pricing ofDiscretionary Accruals 显示文摘 | Subramanyam K R | 1996 | Journal of Accounting and Economics1996，，22： | 1 |
| 7 | Internal control weakness and cost of equity: evidence from SOX section 404 disclosures 显示文摘 | OGNEVA M SUBRAMANYAM K R RAGHU- NANDAN K | 2007 | The Accounting Review2007，82，5： | 1 |
| 8 | Auditor Changes and Discretionary Accruals显示文摘 | Subramanyam K R | 1998 | Journal of Accounting and Economics1998，25，1： | 1 |
| 9 | The pricing of discretionary accruals显示文摘 | Subramanyam K R | 1996 | Journal of Accounting and Economics1996，22，1： | 1 |
| 10 | The Pricing of Discretionary Accruals显示文摘 | Subramanyam K R | 1996 | Journal of Accounting and Economics1996，22，13： | 1 |
| 11 | Antibacterial and Antifungal Activity of Aromatic Constitu ents of Essential Oils显示文摘 | Pattnaik S Subramanyam V R Bapaji M | 1997 | Microbios1997，89，： | 1 |
| 12 | Auditor Changes and Discretionary Accruals显示文摘 | Subramanyam K R | 1998 | Journal of Accounting and Economics1998，25，1： | 1 |
| 13 | The pricing of discretionary accruals显示文摘 | Subramanyam K R | 1996 | Journal of Accounting and Economics1996，22，1： | 1 |
| 14 | Co-degradation of resorcinol and catechol in an UASB reactor显示文摘 | SUBRAMANYAM R MISHRA I M | 2008 | Bioreso(u)r Technol2008，99，10： | 1 |
| 15 | Preparation of Ti- TiB-TiC & Ti-TiB Composites by In-Situ Reaction Hot Pressing 显示文摘 | Bhat B V R Subramanyam J Prasad V V B | 2002 | Materials Science & Engineering A2002，325，12： | 1 |
| 16 | Do non-audit service fees impair auditor independence? Evidence from going concern audit opinions显示文摘 | DeFond M L Raghunandan K Subramanyam K R | 2002 | Journal of Accounting Research2002，40，4： | 1 |
| 17 | Do non-audit service fees impair auditor independence? Evidence from going concern opinions显示文摘 | DEFOND Mark L RAGHUNANDAN K SUBRAMANYAM K R | 2002 | Journal of Accounting Research2002，40，4： | 1 |
| 18 | The Pricing of Discretionary Accruals 显示文摘 | Subramanyam K R | 1996 | Journal of Accounting and Economics1996，22，： | 1 |
| 19 | Key Factors in the Market for Remanufactured Products 显示文摘 | Subramanian R Subramanyam R | 2012 | Manufacturing Service Operation Management2012，14，2： | 1 |
| 20 | Positive correlations between serum calcineurin activity and left ventricular hypertrophy显示文摘 | Choudhary R Sastry BK Subramanyam C | 2005 | Int J Cardiol2005，105，3： | 1 |
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