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| 1 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 2 | Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders显示文摘 | Kim J M Stewart R Kim S W | 2007 | Biol Psychiatry2007，62，5： | 1 |
| 3 | Predictive value of C D lymphocyte numbers for the development of opportunistic infections and malignancies in HIV-infected persons 显示文摘 | Growes S M Carlin J B Stewart K L | 1991 | J Acquir Immune Defic Sydr1991，4，： | 1 |
| 4 | A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta2 integrins Mac-1 and Laf-1显示文摘 | Hogg N Stewart M P Scarth S L | 1999 | J Clin Invest1999，103，1： | 1 |
| 5 | Radiation stress in water waves; a physical discussion,with applications显示文摘 | LONGUET-HIGGINS M S STEWART R W | 1964 | Deep-Sea Res1964，11，4： | 1 |
| 6 | Fusobacterium necrophorum leukotoxin indnces activation and apopotosis of bovine leukocytes显示文摘 | NARAYANAN S K STEWART G C CHENGAPPA M M | 2002 | Infect Immun2002，70，： | 1 |
| 7 | Spatial time - dependent reliability analysis of corroding pretensioned prestressed concrete bridge girders显示文摘 | DARMAWAN M S STEWART M G | 2007 | Structural Safety2007，29，： | 1 |
| 8 | A gene map of the human genome显示文摘 | Schuler G D Boguski M S Stewart E A | 1996 | Science1996，274，： | 1 |
| 9 | Differentiation of Hunmn Embryonic Stem Cells into Corneal Epithelia|-like Cells by In Vitro Replication of theComeal Epithelial Stem Cell Niche 显示文摘 | Ahtnad S Stewart R Yung S Kolli S Armstrong L Stojkovie M Figueiredo F IAko M | 2007 | StemCells2007，255，： | 1 |
| 10 | Acute toxicity of high dose of the glycoalkaloids, alpha-solanine and alpha- chaconine, in the Syrian golden hamster显示文摘 | Langkilde S SchrCder M Stewart D | 2008 | J Agric Food Chem2008，56，18： | 1 |
| 11 | IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro显示文摘 | Bendall S C Stewart M H Menendez P | | 0，，7157： | 1 |
| 12 | The use of tan- nins as silage additives: Effects on silage composition and mo- bile bag disappearance of dry matter and Protein显示文摘 | Salawu M B Acamovica T Stewart C S | 1999 | Animal Feed Science and Technology1999，82，： | 1 |
| 13 | Immunogenicity and protective effects of truncated recombinant teukotoxin proteins of Fusobacterium necrophorum in mice显示文摘 | Narayanan S K Chengappa M M Stewart G C | 2003 | Vet Microbiol2003，93，4： | 1 |
| 14 | Changes in inorganic and organic soil phosphorvs fractions by cultivation practice and by laboratory incubations显示文摘 | Hedley M J Stewart J w B Chauhan B S | 1982 | Soil Science Society of American Journal1982，46，： | 1 |
| 15 | In the eyes of the beholder: a non-self-report measure of workplace deviance显示文摘 | STEWART S M BING M N DAVISON H K | 2009 | Journal of Applied Psychology2009，94，1： | 1 |
| 16 | Physiological heterogeneity in biofilms显示文摘 | Stewart P S Franklin M J | 2008 | Nature Reviews Microbiology2008，6，3： | 1 |
| 17 | Changes in inorganic and organic soil phosphorus fractions induced by cultivation practices and by laboratory incubations显示文摘 | Hedley M J Stewart J W B Chauhan B S | 1982 | Soil Science Society of America Journal1982，46，： | 1 |
| 18 | Metabolic syndrome and its components as predictors of incident type 2 diabetes mellitus in an Aboriginal community显示文摘 | Ley Sylvia H Harris Stewart B Mamakeesick Mary Noon Tina Fiddler Edith Gittelsohn Joel Wolever Thomas M S Connelly Philip W Hegele Robert A Zinman Bernard Hanley Anthony J G | 2009 | Canadian Medical Association. Journal2009，，6： | 1 |
| 19 | Changes in the form of short gravity waves on long waves and tidal currents显示文摘 | LONGUET-HIGGINS M S STEWART R W | 1960 | J Fluid Mech1960，8，： | 1 |
| 20 | Ground-based laser scanners: Operation,systems and applications显示文摘 | Lichti D D Gordon S Stewart M | 2002 | Geomatica2002，56，： | 1 |
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