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| 1 | Ischemic preconditioning inhibits development of edematous cerulein-induced pancreatitis: Involvement of cyclooxygenases and heat shock protein 70显示文摘AIM: To determine whether ischemic preconditioning (IP)affects the development of edematous cerulein-induced pancreatitis and to assess the role of cyclooxygenase-1 (COX-1), COX-2, and heat shock protein 70 (HSP 70) in this process.METHODS: In male Wistar rats, IP was performed by damping of celiac artery (twice for 5 min at 5-min intervals).Thirty minutes after IP or sham operation, acute pancreatitis was induced by cerulein. Activity of COX-1 or COX-2 was inhibited by resveratrol or rofecoxib, respectively (10 mg/kg).RESULTS: IP significantly reduced pancreatic damage in cerulein-induced pancreatitis as demonstrated by the improvement of pancreas histology, reduction in serum lipase and poly-C ribonuclease activity, and serum concentration of pro-inflammatory interleukin (IL)-1β.Also, IP attenuated the pancreatitis-evoked fall in pancreatic blood flow and pancreatic DNA synthesis.Serum level of anti-inflammatory IL-10 was not affected by IP. Cerulein-induced pancreatitis and IP increased the content of HSP 70 in the pancreas. Maximal increase in HSP 70 was observed when IP was combined with cerulein-induced pancreatitis. Inhibition of COXs, especially COX-2, reduced the protective effect of IP in edematous pancreatitis.CONCLUSION: Our results indicate that IP reduces pancreatic damage in cerulein-induced pancreatitis and this effect, at least in part, depends on the activity of COXs and pancreatic production of HSP 70. | Zygmunt Warzecha Artur Dembinski Piotr Ceranowicz Stanislaw J Konturek Marcin Dembinski Wieslaw W Pawlik Romana Tomaszewska Jerzy Stachura Beata Kusnierz-Cabala Jerzy W Naskalski Peter C Konturek | 2005 | World Journal of Gastroenterology2005，11，38： | 2 |
| 2 | Application of membrane techniques in a water softening process显示文摘 | Michali B Stanislaw K Klaudia W | 2002 | Desalination2002，145，1： | 1 |
| 3 | Application of membrane techniques in a water softening process显示文摘 | Michali B Stanislaw K Klaudia W | 2002 | Desalination2002，145，13： | 1 |
| 4 | Economic growth and energy consumption in the UK,1700-1975显示文摘 | Humphrey W S Stanislaw J | | 0，，01： | 1 |
| 5 | Plasma kinetics and tissue residues of fenbendazole following oral administration to pigs显示文摘 | Teresa S J Stanislaw S Bogdan W | 2002 | Bull Vet Inst Pulawy2002，，46： | 1 |
| 6 | Synthesis and characterization of nickel (Ⅱ),copper (Ⅱ),manganese (Ⅲ) and iron (Ⅲ) complexes with new chiral salen-type ligand {N,N’-bis(3,5-di-tert-butylsalieylidene)-(IR,3S)-l,3-diamine-1,2,2-trimeth-yl cyclopentane}显示文摘 | ANDRZEJ V STANISLAW W RAM L | 1998 | Polyhedron1998，17，8： | 1 |
| 7 | Synthesis,immunomodulating effects and structure-activity relationships of new N-phenyl-5-amino-3-methylisoxazole-4-carboxamides显示文摘 | Stanislaw R Zdzislaw M Zbigniew W | 1998 | Eur J Med Chem1998，33，： | 1 |
| 8 | Structure and mechanical properties of NiAl and Ni3Al-based alloys显示文摘 | TOMASZ C STANISLAW W | 2000 | International Journal of Mechanical Sciences2000，42，8： | 1 |
| 9 | Grapefruit-seed extract attenuates ethanol-and stress-induced gastric lesions via activation of prostaglandin, nitric oxide and sensory nerve pathways显示文摘AIM: Grapefruit-seed extract (GSE) containing flavonoids, possesses antibacterial and antioxidative properties but whether it influences the gastric defense mechanism and gastroprotection against ethanol- and stress-induced gastric lesions remains unknown. METHODS: We compared the effects of GSE on gastric mucosal lesions induced in rats by topical application of 100% ethanol or 3.5 h of water immersion and restraint stress (WRS) with or without (A) inhibition of cyclooxygenase (COX)-1 activity by indomethacin and rofecoxib, the selective COX-2 inhibitor, (B) suppression of NO-synthase with L-NNA (20 mg/kg ip), and (C) inactivation by capsaicin (125 mg/kg sc) of sensory nerves with or without intragastric (ig) pretreatment with GSE applied 30 min prior to ethanol or WRS. One hour after ethanol and 3.5 h after the end of WRS, the number and area of gastric lesions were measured by planimetry, the gastric blood flow (GBF) was assessed by H2-gas clearance technique and plasma gastrin levels and the gastric mucosal generation of PGE2, superoxide dismutase (SOD) activity and malonyldialdehyde (MDA) concentration, as an index of lipid peroxidation were determined. RESULTS: Ethanol and WRS caused gastric lesions accompanied by the significant fall in the GBF and SOD activity and the rise in the mucosal MDA content. Pretreatment with GSE (8-64 mg/kg i g) dose-dependently attenuated gastric lesions induced by 100% ethanol and WRS; the dose reducing these lesions by 50% (ID50) was 25 and 36 mg/kg, respectively, and this protective effect was similar to that obtained with methyl PGE2 analog (5 μg/kg i g). GSE significantly raised the GBF, mucosal generation of PGE2, SOD activity and plasma gastrin levels while attenuating MDA content. Inhibition of PGE2 generation with indomethacin or rofecoxib and suppression of NO synthase by L-NNA or capsaicin denervation reversed the GSE-induced protection and the accompanying hyperemia. Co-treatment of exogenous calcitonine gene-related peptide (CGRP) with GSE restored the protection and accompanying hyperemic effects of GSE in rats with capsaicin denervation. CONCLUSION: GSE exerts a potent gastroprotective activity against ethanol and WRS-induced gastric lesions via an increase in endogenous PG generation, suppression of lipid peroxidation and hyperemia possibly mediated by NO and CGRP released from sensory nerves. | Tomasz Brzozowski Peter C Konturek Danuta Drozdowicz Stanislaw J Konturek Oxana Zayachivska Robert Pajdo Slawomir Kwiecien Wieslaw W Pawlik Eckhart G Hahn | 2005 | World Journal of Gastroenterology2005，11，41： | 1 |
| 10 | Efficient conversions of thioethers to a - fluoro thioethers with DAST or DAST/antimony ( Ⅲ ) ehloride显示文摘 | Morris J R Stanislaw F W | 1993 | J Org Chem1993，58，： | 1 |
| 11 | Express of TGF-β1 and urokinase type plasminogen activator genes during arterial repair in the pig显示文摘 | Stanislaw J W Minghao Z Ying F | 1996 | Cardiovascular Res1996，31，1： | 1 |
| 12 | Simultaneous identification of ryanodine receptor 1(RYR1) and estrogen receptor (ESR) genotypes with the multiplex PCR-RFLP method in Polish Large white and Polish Landrace pigs显示文摘 | STANISLAW K ANNA R KATARZYNA W | 2002 | J Appl Genet2002，43，3： | 1 |
| 13 | Investigation of the influence of the steady position on the shape errors of cen- treless ground shafts 显示文摘 | Kazimierz W Stanislaw L Tomasz K | 2007 | Manufacturing Engineering (Vy- robne Inzinierstvo)2007，6，2： | 1 |
| 14 | 生物可降解多聚体biolimus洗脱支架与不可降解多聚体西罗莫司洗脱支架用于冠状动脉血运乖建(LEADERS):一项随机非劣效性试验显示文摘背景初步研究表明,从生物可降解多聚体中释出biolimus(西罗莫司类似物)的一种新型洗脱支架有望获得良好的临床效果。本研究比较了biolimus洗脱支架(具有生物可降解多聚体)和西罗莫司洗脱支架(具有不可降解多聚体)的安全性和疗效。方法作者在欧洲的10个研究中心进行了一项多中心、评估音设盲的非劣效性研究。1707例年龄≥18岁、患有慢性稳定性冠心病或急性冠状动脉综合征的患者经计算机产生的一组随机分配序列进行集中随机分组,分别接受biolimus,先脱支架(n=857)或西罗莫司洗脱支架(n=850)植入主要终点是在9个月内心脏性死亡、心肌梗死或具有临床指征的靶血管血运重建(TVR)的复合事件、采用意向治疗分析法对结果进行分析、随机抽取427例患者接受血管造影随访,主要结果指标为9个月时史巢内直径狭窄的百分比。本临床试验在ClinicalTrials.gov网站上注册,注册号为NCT00389220。结果对研究中所有随机分组的患者进行了分析。9个月时biolimus洗脱支架组在主要终点指标上并不劣于西罗莫司洗脱支架组[79例(9%)vs89例(11%),RR0.88,95%CI0.64~1.19,非劣效P=0.003,优势P=0.39]。心脏性死亡发生率[14例(1.6%)vs21例(2.5%),优势P=0.22]、心肌梗死发生率[49例(5.7%)vs39例(4.6%),P=0.30]以及具有临床指征的TVR实施率[38例(4.4%)vs547例(5.5%),P=0.29]在两组中相似.Biolimus洗脱支架组有168例(79%)患者的资料可用于血管造影随访,西罗莫司洗脱支架组有167例(78%)Biolimus洗脱支架组在支架内直径狭窄百分比上不劣于西罗莫司洗脱支架组(20.9%vs 23.3%,差值-2.2%.95%CI-6.0%~1.6%,非劣效P=0.001,优势P=0.26)、结论研究结果表明,从生物可降解多聚体中释出biolimus的洗脱支架安全有效,在对慢性稳定性冠心病或急性冠状动脉综合征患者进行治疗时,它可以取代从不可降解多聚体中释出西罗莫司的洗脱支架。 | Stephan Windecker Patrick W Serruys Simon Wandel Pawel Buszman Stanislaw Trznadel Axel Linke Karsten Lenk Thomas Ischinger Volker Klauss Franz Eberli Roberto Corti William Wijns Marie-Claude Morice Carlo di Mario Simon Davies Robert-Jan van Geuns Pedro Eerdmans Gerrit- Anne van Es Bernhard Meier Peter Jüni 刘少伟(译) | 2009 | 世界临床医学2009，3，3： | 0 |
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