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| 1 | Venous thrombosis and prothrombotic factors in inflammatory bowel disease显示文摘Patients with inflammatory bowel disease(IBD)may have an increased risk of venous thrombosis(VTE).PubMed,ISI Web of Knowledge and Scopus were searched to identify studies investigating the risk of VTE and the prevalence of acquired and genetic VTE risk factors and prothrombotic abnormalities in IBD.Overall,IBD patients have a two-to fourfold increased risk of VTE compared with healthy controls,with an overall incidence rate of 1%-8%.The majority of studies did not show significant differences in the risk of VTE between Crohn’s disease and ulcerative colitis.Several acquired factors are responsible for the increased risk of VTEin IBD:inflammatory activity,hospitalisation,surgery,pregnancy,disease phenotype(e.g.,fistulising disease,colonic involvement and extensive involvement)and drug therapy(mainly steroids).There is also convincing evidence from basic science and from clinical and epidemiological studies that IBD is associated with several prothrombotic abnormalities,including initiation of the coagulation system,downregulation of natural anticoagulant mechanisms,impairment of fibrinolysis,increased platelet count and reactivity and dysfunction of the endothelium.Classical genetic alterations are not generally found more often in IBD patients than in nonIBD patients,suggesting that genetics does not explain the greater risk of VTE in these patients.IBD VTE may have clinical specificities,namely an earlier first episode of VTE in life,high recurrence rate,decreased efficacy of some drugs in preventing further episodes and poor prognosis.Clinicians should be aware of these risks,and adequate prophylactic actions should be taken in patients who have disease activity,are hospitalised,are submitted to surgery or are undergoing treatment. | Fernando Magro Jo?o-Bruno Soares Dália Fernandes | 2014 | World Journal of Gastroenterology2014，20，17： | 27 |
| 2 | Differential expression of apoptosis related proteins and nitric oxide synthases in Epstein Barr associated gastric carcinomas显示文摘瞄准:为了决定 Epstein Barr 的发生,病毒在巴西联系了胃的癌(GC ) 并且比较 apoptosis 的表情在 EBV 之间的相关蛋白质和氮的氧化物 synthases 积极、否定的胃的癌。方法:编码 EBV 的小 RNA-1 (EBER-1 ) 和 PCR 的原位杂交被执行在 GC 识别 EBV 的存在。Immunohistochemistry 被用来在 25 EBV 积极 GC 并且在 103 EBV 否定 GCS 识别 bcl-2, bcl-xl, bak, bax, p53, NOS-1, NOS-2,和 NOS-3 蛋白质的表情。结果:GC (25/208 ) 的 12% 盒子显示出 EBER-1 和 EBNA-1 表示。盒子是优先地 diffuse 打字与强烈淋巴在基质渗入。EBV 联系了 GC bcl-2 蛋白质的显示出的更高的表示和 bak 蛋白质的更低的表示与比在 EBV 否定 GC。确实, NOS-1 和 NOS-3 的表情经常在 EBV 被观察联系 GC。结论:我们的数据建议 EBV 感染可以保护肿瘤房间免受 apoptosis 的伤害,为永久房间骑车和增长给他们能力。另外, EBV 积极 GC 显示出能影响肿瘤前进和攻击性的组成的 NOS 的高表示。 | Maria D Begnami Andre L Montagnini Andre L Vettore Sueli Nonogaki Mariana Brait Alex Y Simoes-Sato Andrea Q A Seixas Fernando A Soares | 2006 | World Journal of Gastroenterology2006，12，31： | 5 |
| 3 | Fractional Fourier transforms and optical systems显示文摘 | BERNARDO L M SOARES O D D | 1994 | Opt Comm1994，110，： | 1 |
| 4 | Influence ofvibrationon the solidification behaviour and tensile properties of an Al-18wt% Si alloy显示文摘 | Chirita G Stefanescu I Soares D | 2009 | Materialsand Design2009，30，： | 1 |
| 5 | Prolonged exposure of naive CD8+T cells to interleukin-7 or interleukin-15 stimulates proliferation without differentiation or loss of telomere length 显示文摘 | Wallace D L B~rard M Soares M V | 2006 | Immunology2006，119，2： | 1 |
| 6 | Plantar pressures and ground reaction forces during walking of individuals with uni- lateral transfemoral amputation 显示文摘 | Castro ME Soares D Mendes E | 2014 | PM R2014，6，8： | 1 |
| 7 | All-cause and car- diovascular diseases mortality in three Brazilian states, 1980 to 2006显示文摘 | Soares G P Brum J D Oliveira G M | 2010 | Rev Panam Salud Publica2010，28，4： | 1 |
| 8 | Diversity of rotavirus strains circulating in Northern Brazil after introduction of a rotavirus vaccine: High prevalence of G3P[6] genotype显示文摘 | Luana da Silva Soares Sylvia de Fátima dos Santos Guerra Alessilva do Socorro Lima de Oliveira Fabiola da Silva dos Santos Euzeni Maria de Fátima Costa de Menezes Joana d’Arc Pereira Mascarenhas Alexandre C. Linhares | 2014 | Virol2014，，6： | 1 |
| 9 | Influence of the nitriding and TiAlN/TiN coating thickness on the sliding wear behavior of duplex treated AISI H13 steel显示文摘 | TORRES R D SOARES P C SCHMITZ C | | 0，，05： | 1 |
| 10 | Relationships among soil fertility dynamics and remotely sensed measures across pasture chronosequences in Rondonia, Brazil 显示文摘 | NUMATA I SOARES J V ROBERTS D A | 2003 | Remote Sensing of Environment2003，87，4： | 1 |
| 11 | Diabetes mellitus and intracranial stenosis显示文摘 | BAPTISTA D SOARES F | 1999 | Rev Neurol1999，28，11： | 1 |
| 12 | Time-dependent reliability of the primary ship structure 显示文摘 | Guedes Soares C Ivanov L D | 1989 | Reliability Engineering and System Safety1989，26，： | 1 |
| 13 | Meta-datasnapshotting : A simple mechanism for file systemconsistency显示文摘 | Soares L Krieger 0 Da Silva D | 2003 | SNAPI2003，3，： | 1 |
| 14 | A no- vel three-dimensional dynamic anorectal ultrasonography technique for the assessment of perineal descent, com- pared with defaecography显示文摘 | Murad-Regadas SM dos Santos D Soares G | 2012 | Colorectal Dis2012，14，6： | 1 |
| 15 | Blends of cross- linked high amylose starch/pectin loaded with diclofenac显示文摘 | Soares G A de Castro A D Cury B S F | 2013 | Car- bohydrate Polymers2013，91，1： | 1 |
| 16 | A high fat diet inhibits delta- aminolevulinate dehydratase and increases lipid perexi- dation in mice (Mus musculus) 显示文摘 | Folmer V Soares JC Gabriel D | 2003 | J Nutr2003，133，7： | 1 |
| 17 | Diesel-like fuel obtained by pyrolysis of vegetable oils显示文摘 | Lima D G Soares V C D Ribeiro E B | 2004 | Journal of Analytical and Applied Pyrolysis2004，71，2： | 1 |
| 18 | Evaluation of a new chromogenic medium,MRSA select,for detection of methicillin-resistant Staphylococcus aureus显示文摘 | Louie L Soares D Meaney H | 2006 | J Clin Microbiol2006，44，12： | 1 |
| 19 | Effects of oxidative stress on adiponectin secretion and lactate production in 3T3-LI adipecytes显示文摘 | Soares AF Guichardant M Cozzone D | | 0，，： | 1 |
| 20 | TEM and XRD study of early crystallization of lithium disilicate glasses显示文摘 | Soares P C ganotto E D Fokin V M | 2003 | J Non-Crystall Solid2003，331，： | 1 |
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