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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Laparcscopic evalustion of tangential abdominal gunshot wounds显示文摘 | Sims D Martin L | 1992 | Arch Surg1992，127，8： | 1 |
| 3 | A new approach to accelerated drug-excipient compatibility testing显示文摘 | SIMS JL CARREIRA JA CARRIER DJ | 2003 | Pharm Dev Technol2003，8，2： | 1 |
| 4 | Combination therapy using interferon and lamivudine in pediatric patients with hepatitis B显示文摘 | Patricia H Yvatte Sims | 2003 | Hepatelogy2003，38，1： | 1 |
| 5 | Laparoscopic evaluation of tangential abdominal gunshot wounds显示文摘 | Sosa JL Sims D Martin L | 1992 | Arch Surg1992，127，8： | 1 |
| 6 | Combination therapy using interferon and lamivudine in pediatric patients with hepatitis B显示文摘 | Sreven JL Patricia H Yvette Sims | 2003 | Hepatology2003，38，： | 1 |
| 7 | Laparoscopic evaluation of tangential abdominal gunshot wounds显示文摘 | Sosa JL Sims D Martin L | | 0，，01： | 1 |
| 8 | Innate immune signals modulate antiviral and polyreactiveantibody responses dunng severe respiratory syncytial virus infection显示文摘 | Reed JL Welliver TP Sims GP et a1 | 2009 | J Infect Dis2009，199，11： | 1 |
| 9 | Acute retinal necrosis: a case series with clinical features and treatment outcomes 显示文摘 | Sims JL Yeoh J Stawell RJ | 2009 | Clin Experiment Ophthalmol2009，37，5： | 1 |
| 10 | Potassium nutrition of tobacco in agriculture显示文摘 | Sims JL | 1985 | ASA -CSS-SSSA Madison Wisconsin USA1985，1023，： | 1 |
| 11 | Potassium nutrition of tobacco显示文摘 | Sims JL | 1983 | Potassium in Agriculture1983，43，： | 1 |
| 12 | Acute retinal necrosis: a case series with clinical features and treatment outcomes 显示文摘 | Sims JL Yeoh J Stawell RJ | 2009 | Clin Experiment Ophthalmol2009，37，5： | 1 |
| 13 | Interleukin 1 signaling occurs exclusively via the type I receptor显示文摘 | Sims JE Gayle MA Slack JL | 1993 | Proc Natl Acad Sei USA1993，90，13： | 1 |
| 14 | Citation analysis and journal impact factors in ophthalmology and vision science joumals显示文摘 | Sims JL | 2003 | Clinical & Experimental Ophthalmology2003，31，1： | 1 |
| 15 | Nitrogen composition of burley tobacco to nitrogen fertilization 显示文摘 | Atkison WO Ragland JL Sims JL | 1969 | Tobacco Science1969，17，： | 1 |
| 16 | Poly(ADP-ribose) polymerase mediates the suicide response to massive DNA damage: studies in normal and DNA-repair defective cells 显示文摘 | BERGER NA SIMS JL CATINO DM | 1983 | Princess Takamatsu Symp1983，13，： | 1 |
| 17 | Proposed Performance Qualification and Calibration Method for Evaporative Light- Scattering Detector 显示文摘 | Sims JL | 2001 | Chro- matographia2001，53，7： | 1 |
| 18 | Dengue virus infection of the Aedes aegypti salivary gland and chemosensory apparatus induces genes that modulate infection and blood-feeding behavior显示文摘 | Sim S Ramirez JL Dimopoulos G | 2012 | PLoS Pathog2012，8，10： | 1 |
| 19 | Iikelyhood of ret- rograde double-J stenting according to ureteral obslructing patholo- gy 显示文摘 | Danilovi A Antonopoulo SIM Mesquita Jl | 2005 | Int Braz J Urol2005，31，5： | 1 |
| 20 | Widespread genomic divergence during sympatric speciation显示文摘 | Michel AP Sim S Powell THQ Taylor MS Nosil P Feder JL | | 0，，： | 1 |
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