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| 1 | Renin angiotensin system in liver diseases: Friend or foe?显示文摘In the last three decades,the understanding of the renin angiotensin system(RAS)has been changed by the discoveries of functional local systems,novel biologically active peptides,additional specific receptors,alternative pathways of angiotensin(Ang)?Ⅱ?generation,and new roles for enzymes and precursor components other than those in Ang?Ⅱ?synthesis.In this regard,the discovery that Ang-(1-7)opposes the pressor,proliferative,pro-fibrotic,and pro-inflammatory effects mediated by Ang?Ⅱ?has contributed to the realization that the RAS is composed of two axes.The first axis consists of the angiotensin-converting enzyme(ACE),with Ang?Ⅱ?as the end product,and the angiotensin type 1(AT1)receptor as the main effector mediating the biological actions of Ang?Ⅱ.The second axis results from ACE2-mediated hydrolysis of Ang?Ⅱ,leading to the production of Ang-(1-7),with the Mas receptor as the main effector conveying the vasodilatory,antiproliferative,anti-fibrotic,and anti-inflammatory effects of Ang-(1-7).Experimental and clinical studies have shown that both axes of the RAS may take part in the pathogenesis of liver diseases.In this manuscript,we summarize the current evidence regarding the role of RAS in hepatic cirrhosis and its complications,including hemodynamic changes and hepatorenal syndrome.The therapeutic potential of the modulation of RAS molecules in liver diseases is also discussed. | Ana Cristina Simoes e Silva Aline S Miranda Natália P Rocha Antonio L Teixeira | 2017 | World Journal of Gastroenterology2017，23，19： | 12 |
| 2 | 冷战和环境:芬兰在波罗的海地区国际环境政治方面的角色显示文摘1974年在赫尔辛基签署的关于《波罗的海区域海洋环境保护公约》可能是在波罗的海地区最重要的环境保护协议。本篇文章是首次运用原始档案资料第一次探究本公约的历史,也称之为《赫尔辛基公约》。这些原始资料主要出自芬兰外交部的档案。我们从国际政治角度研究了《赫尔辛基公约》整个签署的过程中芬兰的作用。本研究主要集中在芬兰、瑞典和苏联从20世纪60年代末到1974年的国家政党。我们表明,冷战政治从若干方面影响《赫尔辛基公约》的谈判和内容。我们也认为苏联利用新出现的国际环境问题作为一种新的强权政治的工具。 | Tuomas Rsnen Simo Laakkonen 翟伟康 | 2007 | AMBIO-人类环境杂志2007，36，2： | 4 |
| 3 | Physiological Effect of Kinetin on the Photosynthetic Apparatus and Antioxidant Enzymes Activities During Production of Anthurium显示文摘The results observed in the literature raise the hypothesis according to which cytokinin plays important roles in photosynthetic metabolisms and antioxidant enzymes. Thus, the study aimed to evaluate the effect of foliar application of the isolated cytokinin kinetin at the production cycle, seeking to analyze its effects on enzyme activity and photosynthetic parameters. The plants treated with CK presented reduction of leaf CO_2 assimilation rate(Pn) and stomatal conductance(Gs), while that transpiration rate(Tr) was unaffected. The internal CO_2 concentrations decreased with the increase in cytokinin levels, but were maintained under CK 50 mg·L^(-1). The plants treated with CK 75 mg·L^(-1) was verified higher carboxylation efficiency(Pn/Ci), which was associated to values of CO_2 assimilation and transpiration unaltered. Apparent electron transport rate showed variations in the concentration of 25 mg·L^(-1). Considering the study of enzyme activity, on the other hand, it cannot be stated that kinetin has an effective action in delaying oxidative damage. It presents mixed results, since an efficiency in the application of cytokinin was not observed, presenting induction levels of ascorbate peroxidase activity. Thus, further research is needed to determine more precisely the effects of kinetin on gas exchange and antioxidant enzymes in anthurium plants. | de MOURA Fabiana B. VIEIRA Marcos R. da S. SIMOES Adriano do N. FERREIRA-SILVA Sérgio L. de SOUZA Carlos A.V. de SOUZA Eduardo S. da ROCHA Alexandre T. da SILVA Luzia F. JUNIOR Miguel A. | 2018 | Horticultural Plant Journal2018，4，5： | 3 |
| 4 | A class of mixed assumed strain methods and the method of incompatible modes显示文摘 | Simo J C Rifai M S | 1990 | International Journal for Numerical Methods in Engineering1990，29，： | 2 |
| 5 | Influence of Temperature on the Dielectric and Ferroelectric Properties of Bismuth Titanate Thin Films Obtained by the Polymeric Precursor Method 显示文摘 | Simoes A Z Ramireic M A Riccardi C S | 2005 | Materials Chemistry and Physics2005，92，23： | 1 |
| 6 | Distributed intelligent energy management system for a single-phase high- frequency AC mierogrid 显示文摘 | CHAKRABORTY S WEISS M D SIMOES M G | 2007 | IEEE Trans on Industrial Electronics2007，54，1： | 1 |
| 7 | Developments in the rat adjuvant arthritis model and its use in therapeutic evaluation of novelnoninvasive treatment by SOD in transfersomes 显示文摘 | Simoes S I Delgado T C Lopes R M | 2005 | J Controlled Release2005，103，2： | 1 |
| 8 | Paclitaxel-loaded PLGA nanoparticles: preparation, physicochemical characterization and in vitro anti-tumoral activity显示文摘 | Fonseca C Simoes S Gaspar R | 2002 | J Control Release2002，83，2： | 1 |
| 9 | Composition and behavior of cerium films on galvanised steel 显示文摘 | MONTEMOR M F SIMOES A M FERREIRA M G S | 2001 | Progress in Organic Coatings2001，43，4： | 1 |
| 10 | Analytical charac- terization of the passive film formed on steel in solutions simulat- ing the concrete interstitial electrolyte 显示文摘 | Montemor M F Simoes A M P Ferreira M G S | 1998 | Corrosion1998，54，： | 1 |
| 11 | The role of steroid hor- mones in breast cancer stem cells 显示文摘 | Simoes BM Alferez D Howell S | 2015 | Endocr Relat Cancer2015，35，7： | 1 |
| 12 | 显示文摘 | Montemor M F Simoes A M P Ferreira M G S | 2005 | Cem Concr Compos2005，25，： | 1 |
| 13 | Liposome-mediated delivery of antiviral agents to human immunodeficiency virus-infected cells显示文摘 | Duzgunes N Pretzer E Simoes S | 1999 | Mol Membr Biol1999，16，1： | 1 |
| 14 | 显示文摘 | Montemor M F Simoes A M P Ferreira M G S | 2003 | Cement & Concrete Composites2003，25，： | 1 |
| 15 | Optical spectral refectance of human articular cartilage-relationships with tissue structure, composition and mechanical properties显示文摘 | Jussi K Simo S Markku HK | 2011 | Biomedical Optics Express2011，2，5： | 1 |
| 16 | Cullin 5 regulates Dabl protein levels and neuron positioning during cortical development 显示文摘 | Feng L Allen NS Simo S | 2007 | Genes Dev2007，21，21： | 1 |
| 17 | Cationic Liposomes for Gene Delivery显示文摘 | SIMOES S FILIPE A FANECA H | 2005 | Expert Opin Drug Delivy2005，2，2： | 1 |
| 18 | Unscented Rauch-Tung-Striebel Smoother 显示文摘 | Simo S | 2008 | IEEE Transactions on Automatic Control2008，53，3： | 1 |
| 19 | Distributed intelligent energy management system for a single-phase high-fi:equancy AC microgrid 显示文摘 | Chakraborty S Weiss M D Simoes M G | 2007 | IEEE Transactions on Industrial Electronics2007，，： | 1 |
| 20 | Paclitaxel-loaded PLGA nanoparticles: preparation, physicochemical characterization and in vitro anti- tumoral activity 显示文摘 | Fonseca C Simoes S Gaspar R | 2002 | J Control Release2002，83，2： | 1 |
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