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| 1 | Degenerative meniscus: Pathogenesis, diagnosis, and treatment options显示文摘The symptomatic degenerative meniscus continues to be a source of discomfort for a significant number of patients. With vascular penetration of less than onethird of the adult meniscus, healing potential in the setting of chronic degeneration remains low. Continued hoop and shear stresses upon the degenerative meniscus results in gross failure, often in the form of complex tears in the posterior horn and midbody. Patient history and physical examination are critical to determine the true source of pain, particularly with the significant incidence of simultaneous articular pathology. Joint line tenderness, a positive Mc Murray test, and mechanical catching or locking can be highly suggestive of a meniscal source of knee pain and dysfunction. Radiographs and magnetic resonance imaging are frequently utilized to examine for osteoarthritis and to verify the presence of meniscal tears, in addition to ruling out other sources of pain. Non-operative therapy focused on nonsteroidal anti-inflammatory drugs and physical therapy may be able to provide pain relief as well as improve mechanical function of the knee joint. For patients re-fractory to conservative therapy, arthroscopic partial meniscectomy can provide short-term gains regarding pain relief, especially when combined with an effective, regular physiotherapy program. Patients with clear mechanical symptoms and meniscal pathology may benefit from arthroscopic partial meniscectomy, but surgery is not a guaranteed success, especially with concomitant articular pathology. Ultimately, the long-term outcomes of either treatment arm provide similar results for most patients. Further study is needed regarding the short and long-term outcomes regarding conservative and surgical therapy, with a particular focus on the economic impact of treatment as well. | Richard Howell Neil S Kumar Nimit Patel James Tom | 2014 | World Journal of Orthopedics2014，5，5： | 8 |
| 2 | Origins of breast cancer subtypes and therapeutic implications 显示文摘 | Sims AH Howell A Howell S J Clarke R B | 2007 | Nature Clin Pract Oncol2007，4，12： | 1 |
| 3 | Drug interaction: Volatile anesthetics and opiates显示文摘 | Glass PSP Gan TJ Howell S | 1997 | J Clin Anesth1997，9，： | 1 |
| 4 | Identification of casein kinase l ct interacting protein partners 显示文摘 | DUBOIS T HOWELL S ZEMLICKOVA E | 2002 | FEBS2002，517，： | 1 |
| 5 | A review of the pharmacokinetics and pharcodynamics of remifentanil显示文摘 | Glass PS Gan TJ Howell S | 1999 | Anesth Analg1999，89，4： | 1 |
| 6 | The Relationship between the Angle of the Tibial Tunnel in the Coronal Plane and Loss of Flexion and Anterior Laxity after Anterior Cruciate Ligament Reconstruction 显示文摘 | Howell S M Gittins M E Gottlieb J E | 2001 | Am J Sports Med (S0363-5465)2001，29，5： | 1 |
| 7 | Gastroesophageal reflux in infants with wheezing 显示文摘 | Sheikh S Stephen T Howell L Eid N | 1999 | Pediatr Pulmonol1999，28，3： | 1 |
| 8 | A review of the pharmacokinetics and pharmacodynamics of remifentanil显示文摘 | GLASS P S GAN T J HOWELL S | 1999 | Anesth Analg1999，，： | 1 |
| 9 | Spherical lamina emergent mechanisms显示文摘 | Wilding S E Howell L L Magleby S P | 2012 | Mechanism and Machine Theory2012，49，： | 1 |
| 10 | Risk factors for card- chovascular death after elective surgery under general ana- ethesta显示文摘 | Howell S J Sear YM Yeates D | 1998 | Br JAnaesth1998，80，1： | 1 |
| 11 | Non-linear un- stable response of hanging chains 显示文摘 | TRIANTAFYLLOU M S HOWELL C T | 1993 | Journal of Sound and Vibration1993，162，： | 1 |
| 12 | Child/adolescent behavioral and enmotion alproblems: Implication of cross informant correlations for situational specificity 显示文摘 | Achenbach T M Mcconaughy S H Howell C T | 1987 | Psychological Bulletin1987，，101： | 1 |
| 13 | Increasing autism prevalence in metropolitan New Jersey 显示文摘 | Zahorodny W Shenouda J Howell S | 2014 | Autism2014，18，2： | 1 |
| 14 | Comparision of pentastarch and Hartmann's solution for volume preloading in spinal anesthesia for elective caesarean section显示文摘 | French GWG White JB Howell S J | 1999 | Br J Anesth1999，83，： | 1 |
| 15 | Genetic determinants of volatile-thiol release by Saccharomyces cerevisiae during wine fermentation 显示文摘 | Kate S Howell Mathias Klein Jan H Swiegers | 2005 | Appl Environ Microbiol2005，71，9： | 1 |
| 16 | A review of the pharmacokinetics and pharmacodynamics of remifentanil显示文摘 | Glass PS Gan TJ Howell S | 1999 | Anesth Analg1999，89，： | 1 |
| 17 | L-selectin and ICAM-1 mediate reperfusion injury and neutrophil adhesion in the warm ischemia mouse liver显示文摘 | Yadav S Howell D Gao W | 1998 | Am J Phy1998，275，10： | 1 |
| 18 | Relevance of mitogen activated protein kinase (MAPK) and phospho-tidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells 显示文摘 | SquiresM S Hudson E A Howells L | 2003 | Biochem Pharmacol2003，65，3： | 1 |
| 19 | The Bowen ratio-energy balance method for estimating latent heat flux of irrigated alfalfa evaluated in a semi-arid,advective environment显示文摘 | Todd R W Evett S R Howell T A | 2000 | Agic For Meteorol2000，103，： | 1 |
| 20 | Influence of vascular endothelial growth factor single nucleotide polymorphisms on tumour development in cutaneous malignant melanoma显示文摘 | HOWELL W M BATEMAN A C TURNER S J | 2002 | Hums Immun2002，3，： | 1 |
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