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| 1 | Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma显示文摘Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis,cancer,and liver failure.Liver cancer is the third leading cause of cancer-associated mortality,of which hepatocellular carcinoma(HCC)represents 90%of all primary liver cancers.Solid tumors like HCC are complex and have heterogeneous tumor genomic profiles contributing to complexity in diagnosis and management.Chronic infection with hepatitis B virus(HBV),hepatitis delta virus(HDV),and hepatitis C virus(HCV)are the greatest etiological risk factors for HCC.Due to the significant role of chronic viral infection in HCC development,it is important to investigate direct(viral associated)and indirect(immune-associated)mechanisms involved in the pathogenesis of HCC.Common mechanisms used by HBV,HCV,and HDV that drive hepatocarcinogenesis include persistent liver inflammation with an impaired antiviral immune response,immune and viral protein-mediated oxidative stress,and deregulation of cellular signaling pathways by viral proteins.DNA integration to promote genome instability is a feature of HBV infection,and metabolic reprogramming leading to steatosis is driven by HCV infection.The current review aims to provide a brief overview of HBV,HCV and HDV molecular biology,and highlight specific viral-associated oncogenic mechanisms and common molecular pathways deregulated in HCC,and current as well as emerging treatments for HCC. | Simmone D'souza Keith CK Lau Carla S Coffin Trushar R Patel | 2020 | World Journal of Gastroenterology2020，26，38： | 25 |
| 2 | Integrin-mediated interactions between human bone marrow stromal precursor cells and the extracellular matrix显示文摘 | S Gronthos P.J Simmons S.E Graves P G. Robey | 2001 | Bone2001，，2： | 2 |
| 3 | Order-restricted inference for ordered gene expression(OPIOGEN)data under heteroscedastic variances显示文摘 | SIMMONS S PEDDADA S | 2007 | Bioinformatics2007，1，10： | 1 |
| 4 | Energy use associated with different travel choices 显示文摘 | Becken S Simmons D Frampton C | 2003 | Tourism Management2003，24，3： | 1 |
| 5 | The establishment success of native versus non-native herbaceous seed mixes on a revegetated roadside in central Texas显示文摘 | Tinsley M J Simmons M T Windhager S | 2006 | Ecological Engineering2006，26，3： | 1 |
| 6 | The effect of initial injec- tion conditions on the oil droplet motion in a simplified bearing chamber显示文摘 | Farrall M Hibberdl S Simmons K | 2008 | Transactions of the ASME-Journal of Engi- neering for Gas Turbines and Power2008，130，1： | 1 |
| 7 | Use of artificialneural networks in evaluating prognostic factors determining the re-sponse to dendritic cells pulsed with PSMA peptides in prostatecancer patients 显示文摘 | MURPHY G P SNOW P SIMMONS S J | 2000 | Prostate2000，42，1： | 1 |
| 8 | Energy consumption patterns in the accommodation sector:The New Zealand case显示文摘 | Becken S Frampton C Simmons D | 2001 | Ecological Economics2001，39，3： | 1 |
| 9 | The accuracy of tibial intramedullary alignment devices in total knee arthroplasty 显示文摘 | Simmons ED Jr Sullivan JA Rackemann S | 1991 | J Arthroplasty1991，6，1： | 1 |
| 10 | Understanding energy consumption pa- tterns of tourist attractions and activities in New Zealand显示文摘 | Becken S Simmons D | 2002 | Tourism Management2002，23，4： | 1 |
| 11 | Contributions of pre-silking assimilates to grain yield of maize显示文摘 | SIMMONS S R JONES R J | 1985 | Crop Sci1985，25，： | 1 |
| 12 | Consumption of atmospheric carbonyl sulfide by coniferous boreal forest soils 显示文摘 | Simmons J S Klemedtsson L Hultberg H | 1999 | Journal of Geophysical Research1999，104，： | 1 |
| 13 | Characteristics and genesis of epithermal gold deposits 显示文摘 | Cooke D R Simmons S F | 2000 | Reviews in Economic Geology2000，13，2： | 1 |
| 14 | Perioperative efficacy of laparoscopic partial nephrectomy for tumors larger than 4 cm显示文摘 | SIMMONS M N CHUNG B I GILL I S | 2009 | Eur Urol2009，55，1： | 1 |
| 15 | Functional subdivisions within anterior cingulated cortex and their relationship to autonomic nervous system function显示文摘 | Matthews S C Paulus M P Simmons A N Nelesen R A Dimsdale J E | 2004 | NeuroImage2004，22，： | 1 |
| 16 | A numerical model for oil film flow in an aeroengine bearing chamber and comparison to ex- perimental data 显示文摘 | Farrall M Simmons K Hibberd S | 2006 | Transactions of the ASME-Journal of Engineering for Gas Turbines and Power2006，128，1： | 1 |
| 17 | Thecooperative/competitive strategy scale: A measure ofmotivation to use cooperative or competitive strategiesfor success显示文摘 | Simmons C H Wehner E A Tucker S S | 1988 | The Journal of Social Psychology1988，，： | 1 |
| 18 | Methylene blue dye as an alternative to isosulfan blue dye for sentinel lymph node localization 显示文摘 | SIMMONS R THEVARAJAH S BRENNAN M B | 2003 | Ann Surg Oncol2003，10，： | 1 |
| 19 | Prediction of air/oil exit flows in a commercial aero-engine bearing chamber 显示文摘 | Farrall M Hibberd S Simmons K | 2006 | Proceedings IMeehE Part G: Journal of Aerospace Engi- neering2006，220，： | 1 |
| 20 | Understanding energy consumption patterns of tourist attractions and activities in New Zealand显示文摘 | Becken S Simmons D G | 2002 | Tourism Management2002，23，4： | 1 |
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