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| 1 | Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma显示文摘Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis,cancer,and liver failure.Liver cancer is the third leading cause of cancer-associated mortality,of which hepatocellular carcinoma(HCC)represents 90%of all primary liver cancers.Solid tumors like HCC are complex and have heterogeneous tumor genomic profiles contributing to complexity in diagnosis and management.Chronic infection with hepatitis B virus(HBV),hepatitis delta virus(HDV),and hepatitis C virus(HCV)are the greatest etiological risk factors for HCC.Due to the significant role of chronic viral infection in HCC development,it is important to investigate direct(viral associated)and indirect(immune-associated)mechanisms involved in the pathogenesis of HCC.Common mechanisms used by HBV,HCV,and HDV that drive hepatocarcinogenesis include persistent liver inflammation with an impaired antiviral immune response,immune and viral protein-mediated oxidative stress,and deregulation of cellular signaling pathways by viral proteins.DNA integration to promote genome instability is a feature of HBV infection,and metabolic reprogramming leading to steatosis is driven by HCV infection.The current review aims to provide a brief overview of HBV,HCV and HDV molecular biology,and highlight specific viral-associated oncogenic mechanisms and common molecular pathways deregulated in HCC,and current as well as emerging treatments for HCC. | Simmone D'souza Keith CK Lau Carla S Coffin Trushar R Patel | 2020 | World Journal of Gastroenterology2020，26，38： | 25 |
| 2 | Statistical optics applied to high-power glass lasers显示文摘 | Manes K R Simmons W W | 1985 | J Opt Soc Am A1985，2，4： | 2 |
| 3 | Application of DNA barcodes in Hedyotis L.(Spermacoceae,Rubiaceae)显示文摘The potential application of DNA barcodes of plastid(matK,trnH-psbA,petD,and rbcL) and nuclear(internal transcribed spacer(ITS) of rDNA) DNA regions was investigated for 25 Hedyotis taxa.The ITS showed the best species discrimination by resolving 23 of the species as exclusive lineages with no shared alleles between any of the 24 distinct species(H.assimilis and H.mellii are not supported as distinct species based on our molecular and morphological data).Conversely,rbcL performed the worst and only resolved 10 of the species as exclusive lineages,and 10 species with shared alleles.Using ITS has the advantage of high PCR amplification success and it provides good intra-and interspecific variation distribution patterns.The most powerful plastid markers were petD and trnH-psbA,but we could amplify and sequence trnH-psbA for only 83% of the accessions sampled.Combination of ITS and petD performed extremely well,with all 24 of the distinct species resolved as exclusive lineages and no shared alleles between any of the distinct species.We therefore recommend ITS,or a combination of ITS and petD,as the standard DNA barcode in Hedyotis,but acknowledge that there are no shared alleles between distinct species for matK and rbcL combined. | Xing GUO Mark R SIMMONS Paul Pui-Hay BUT Pang-Chui SHAW Rui-Jiang WANG | 2011 | Journal of Systematics and Evolution2011，49，3： | 2 |
| 4 | Nitrate dynamics in riparian forests:microbial studies显示文摘 | Groffman P M Gold A J Simmons R C | 1992 | Journal of Environmental Quality1992，，21： | 1 |
| 5 | cDNA cloning and tissue-specific gene expression of ovine leptin, NPY -Y1 receptor, and NPY - Y2 receptor显示文摘 | Dyer C J Simmons J M Matteri R L | 1997 | Domestic Animal Endocrinology1997，14，5： | 1 |
| 6 | Alternaria themes and variations显示文摘 | Simmons E G Roberts G R | | 0，，： | 1 |
| 7 | Effect of the angle of the femoral and tibial tunnels in the coronal plane and incremental excision of the posterior cruciate ligament on tension of an anterior cruciate ligament graft:an in vitro study显示文摘 | Simmons R Howell SM Hull ML | 2003 | J Bone Joint Surg(Am)2003，85，6： | 1 |
| 8 | Apolipoprotein E epsilon4 allele affects the relationship between stress and depres- sion in caregivers of patients with Alzheimer' s disease显示文摘 | Gallagher-Thompson D O'Hara R Simmons A | 2001 | J Geriatr Psychiatry Neurol2001，14，： | 1 |
| 9 | Vasopressin for refractory hypotension in extremely low birth weight neonates显示文摘 | Bidegain M Greenberg R Simmons C | | 0，，03： | 1 |
| 10 | A maize defense-inducible gene is a major facilitator superfamily member related to bacterial multidrug resistance efflux antiporters显示文摘 | SIMMONS C R Fridlender M Navarro P A | | 0，，： | 1 |
| 11 | Stable aqueous dispersions of noncovalently functionalized graphene from graphite and their muhifunctional high-performance applications 显示文摘 | AN X SIMMONS T SHAH R | 2010 | Nano letters2010，10，11： | 1 |
| 12 | Contributions of pre-silking assimilates to grain yield of maize显示文摘 | SIMMONS S R JONES R J | 1985 | Crop Sci1985，25，： | 1 |
| 13 | Using the Strengths and Difficulties Questionnaire (SDQ) to screen for child psychiatric disor ders in a community sample显示文摘 | Goodman R Ford T Simmons H | 2003 | Int Rev Psychiatry2003，15，： | 1 |
| 14 | Characteristics and genesis of epithermal gold deposits 显示文摘 | Cooke D R Simmons S F | 2000 | Reviews in Economic Geology2000，13，2： | 1 |
| 15 | Functional subdivisions within anterior cingulated cortex and their relationship to autonomic nervous system function显示文摘 | Matthews S C Paulus M P Simmons A N Nelesen R A Dimsdale J E | 2004 | NeuroImage2004，22，： | 1 |
| 16 | Using the Strengths and Difficulties Questionnaire (SDQ) to screen for child psychiatric disorders in a community sample显示文摘 | Goodman R Ford T Simmons H | 2000 | Br J Psychiatry2000，177，： | 1 |
| 17 | Urban Population Densities:Structure and Change显示文摘 | Berry B J L Simmons L W Tennant R J | 1963 | Geographical Review1963，，53： | 1 |
| 18 | Solar sail parking in restricted three-body system显示文摘 | Mclnnes C R Mcdonald A J C Simmons J F L MacDonald E W | 1994 | Journal of Guidance Control and Dynamics1994，17，2： | 1 |
| 19 | XPS and FTIR Surface Characterization of TiO2 Particles Used in Polymer En- capsulation 显示文摘 | Erdem B Hunsicker R A Simmons G W | 2001 | Langmuir2001，17，9： | 1 |
| 20 | Use of ligand-modified micellar-enhanced ultra filtration in the selective removal of metal ions from water显示文摘 | KLEPAC J SIMMONS D L TAYLOR R W | 1991 | Separate Science Technology1991，26，： | 1 |
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