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| 1 | Neuroendocrine tumors of the gastrointestinal tract: Case reports and literature review显示文摘Neuroendocrine tumors(NET)previously called carcinoid tumors are neoplasms of enterochromaffin/neuroendocrine cell origin which display neurosecretory capacity that may result in the carcinoid syndrome.The annual incidence of patients with NET is 8.4 per 100000;yet many NET remain asymptomatic and clinically undetected.A majority of NET follows a benign course;however,some will display malignant characteristics.NET most commonly occur in the gastrointestinal tract(67%)and bronchopulmonary system(25%).Gastrointestinal NET occur within the stomach,small intestine,liver,and rectum.We report a retrospective study of 11 subjects:Eight with benign carcinoid tumors:duodenal bulb(n=2),terminal ileum(n=1),sigmoid colon(n=2),and rectum(n=3);three with malignant carcinoid:liver(n=1)and intra-abdominal site(n=2).The diagnosis,endoscopic images,outcome,treatment and review of the literature are presented. | William J Salyers Kenneth J Vega Juan Carlos Munoz Bruce W Trotman Silvio S Tanev | 2014 | World Journal of Gastrointestinal Oncology2014，6，8： | 8 |
| 2 | The limited influence of glaciations in Tibet on global climate over the past 170 000 yr显示文摘 | JORG M S SILVIO T ZHAO Z Z | 2002 | Earth and Planetary Science Letters2002，194，： | 1 |
| 3 | In vitro meas urement accuracy of an electronic apex locator in teeth with simulated apical root resorption显示文摘 | Goldberg F De Silvio AC Manfr6 S | 2002 | J Endod2002，28，6： | 1 |
| 4 | The use of gelatin as a vehicle for drug and peptide delivery显示文摘 | Silvio LDI Courteney-Harris RG Downes S | 1994 | J Mater Sci Mater Med1994，5，11： | 1 |
| 5 | In vitro measurement accuracy of an electronic apex locator in teeth with simulated apical root resorption显示文摘 | Goldberg F De Silvio AC Manfre S | 2002 | J Endod2002，28，6： | 1 |
| 6 | Xylitol production by Ca-alginate entrapped cells:comparison of different fermentation systems显示文摘 | Walter C Silvio S S Julio C S | 2003 | Enzyme and Microbial Technology2003，32，： | 1 |
| 7 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 8 | In vitro measurement accuracy of an electronic apex locator in teeth with simulate apical root resorption显示文摘 | Goldberq F De Silvio AC Manfre S | 2002 | Endod2002，28，6： | 1 |
| 9 | Spontaneous and idiopathic chronic spinal epidural hematoma two case reports and review of the literature显示文摘 | Silvio S Francesco G Maida G | | 0，，11： | 1 |
| 10 | Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis显示文摘BACKGROUND Hepatitis C virus(HCV)infection is responsible for a chronic liver inflammation,which may cause end-stage liver disease and hepatocellular carcinoma.Apolipoprotein E(protein:ApoE,gene:APOE),a key player in cholesterol metabolism,is mainly synthesized in the liver and APOE polymorphisms may influence HCV-induced liver damage.AIM To determine whether APOE alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation(OLT).METHODS This was a cohort study in which 179 patients,both genders and aged 34-70 years,were included before or after(up to 10 years follow-up)OLT.Liver injury severity was assessed using different criteria,including METAVIR and models for endstage liver disease.APOE polymorphisms were analyzed by quantitative real-time polymerase chain reaction.RESULTS The APOE3 allele was the most common(67.3%).In inflammation severity of biopsies from 89 OLT explants and 2 patients in pre-transplant,the degree of severe inflammation(A3F4,0.0%)was significantly less frequent than in patients with minimal and moderate degree of inflammation(≤A2F4,16.2%)P=0.048,in patients carrying the APOE4 allele when compared to non-APOE4.In addition,a significant difference was also found(≤A2F4,64.4%vs A3F4,0.0%;P=0.043)and(A1F4,57.4%vs A3F4,0.0%;P=0.024)in APOE4 patients when compared to APOE3 carriers.The fibrosis degree of the liver graft in 8 of 91 patients and the lack of the E4 allele was associated with more moderate fibrosis(F2)(P=0.006).CONCLUSION Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients. | José Carlos Rodrigues Nascimento Lianna C Pereira Juliana Magalhães C Rêgo Ronaldo P Dias Paulo Goberlânio B Silva Silvio Alencar C Sobrinho Gustavo R Coelho Ivelise Regina C Brasil Edmilson F Oliveira-Filho James S Owen Pierluigi Toniutto Reinaldo B Oriá | 2021 | World Journal of Gastroenterology2021，27，11： | 1 |
| 11 | Organization of the clinical activity of Geriatric Oncology: Report of a SlOG ( Inter-national society of Geriatric Oneology) task force 显示文摘 | Silvio M A Aapro M S Bennett J M | 2007 | Critical Reviews in Oneology 4-Iematology2007，62，1： | 1 |
| 12 | In vitro measurement accuracy of an electronic apex locator in teeth with simulated apical root resorption显示文摘 | Goldberg F De Silvio AC Manfre S | 2002 | J Endod2002，28，6： | 1 |
| 13 | In vitro measurement accuracy of an electronic apex locator in teeth with simulated apical root resorption显示文摘 | Goldberg F De Silvio AC Manfre S | 2002 | J Endodont2002，28，6： | 1 |
| 14 | In vitro measurement accuracy of an electronic apex locator in teeth with simulated apical root resorption显示文摘 | De Silvio AC Manfre S | 2002 | J Endod2002，28，6： | 1 |
| 15 | Bioresorbable glass fibres facilitate peripheral nerve regeneration显示文摘 | Bunting S Di Silvio L Deb S | 2005 | J Hand Surg[ Br]2005，30，3： | 1 |
| 16 | Ipilimumab and Nivolumab induced steroid-refractory colitis treated with infliximab: A case report显示文摘BACKGROUND A variety of immune-modulating drugs are becoming increasingly used for various cancers. Despite increasing indications and improved efficacy, they are often associated with a wide variety of immune mediated adverse events including colitis that may be refractory to conventional therapy. Although these drugs are being more commonly used by Hematologists and Oncologists, there are still many gastroenterologists who are not familiar with the incidence and natural history of gastrointestinal immune-mediated side effects, as well as the role of infliximab in the management of this condition.CASE SUMMARY We report a case of a 63-year-old male with a history of metastatic renal cell carcinoma who presented to our hospital with severe diarrhea. The patient had received his third combination infusion of the anti-CTLA-4 monoclonal antibody Ipilimumab and the immune checkpoint inhibitor Nivolumab and developed severe watery non-bloody diarrhea the same day. He presented to the hospital where he was found to be severely dehydrated and in acute renal failure. An extensive workup was negative for infectious etiologies and he was initiated on high dose intravenous steroids. However, he continued to worsen. A colonoscopy was performed and revealed no endoscopic evidence of inflammation. Random biopsies for histology were obtained which showed mild colitis, and were negative for Cytomegalovirus and Herpes Simplex Virus. He was diagnosed with severe steroid-refractory colitis induced by Ipilimumab and Nivolumab and was initiated on Infliximab. He responded promptly to it and his diarrhea resolved the next day with progressive resolution of his renal impairment. On follow up his gastrointestinal side symptoms did not recur.CONCLUSION Given the increasing use of immune therapy in a variety of cancers, it is important for gastroenterologists to be familiar with their gastrointestinal side effects and comfortable with their management, including prescribing infliximab. | Ammar B Nassri Valery Muenyi Ahmad AlKhasawneh Bruno De Souza Ribeiro James S Scolapio Miguel Malespin Silvio W de Melo Jr | 2019 | World Journal of Gastrointestinal Pharmacology and Therapeutics2019，10，1： | 1 |
| 17 | In vitro measurement accuracy of an electronic apex Locator in teeth with simulated apical root resorption显示文摘 | Goldberg F De Silvio AC Manfre S | 2002 | J Endod2002，28，6： | 1 |
| 18 | Xylitol production by Ca- alginate entrapped cells: comparison of different fermentation systems 显示文摘 | Walter Carvalho Silvio S Silva Julio C Santos | 2003 | Enzyme and Microbial Technology2003，32，5： | 1 |
| 19 | 3-(4-Aroyl-1 H-pyrrol2-yl)-N-hydroxy -2-propenamides, a new class of synthetic histone deacetylase inhibitors 显示文摘 | Antonello M Gianluca S | 2001 | J Med Chem2001，44，13： | 1 |
| 20 | Novel isolates for biological detoxification of lignocellulosic hydrolyate显示文摘 | Zhang Hourui Qin Xiangxiang Silvio S S | 2009 | Appl Biochem Biotechnol2009，152，2： | 1 |
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