|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Ultras0und simulation in bone显示文摘 | Kaufman J J Luo G Siffert R S | 2008 | IEEE Traus Uhrason Ferroelectr Freq Control2008，55，6： | 1 |
| 3 | Association of a human G-protein β 3 subunit variant with hypertension显示文摘 | Siffert W B Rosskopf D Siffert G | 1998 | Nat Genet1998，18，： | 1 |
| 4 | Ultrasound simulation in bone显示文摘 | Kaufman J J Luo G Siffert RS | 2008 | IEEE Trans Ultrason Ferroelectr Freq Control2008，55，12： | 1 |
| 5 | Association of a human G-protein beta-3 subunit variant with hypertension显示文摘 | Siffert W Rosskopf D Siffert G | 1998 | Nat Genet1998，18，： | 1 |
| 6 | Association of a human G-protein beta 3 subunit variant with hypertension显示文摘 | Siffert W Rosskopf D Siffert G | 1998 | Nature Genet1998，，： | 1 |
| 7 | Ultrasound simulation in bone显示文摘 | Kaufman J J Luo G Siffert RS | 2008 | IEEE Trans Ultrason Ferroelectr Freq Control2008，55，6： | 1 |
| 8 | Ultrasound simulation in bone 显示文摘 | Kaufman J J Luo G Siffert RS | 2008 | IEEE Trans Ultrason Ferroelectr Freq Control2008，55，6： | 1 |
| 9 | Catalytic performance of core-shell and alloy Pd-Au nanoparticles for total oxidation of VOC: The effect of metal deposition显示文摘 | HOSSEINI M BARAKAT T COUSIN R ABOUKAIS A SUC B-L DE WEIRELD G SIFFERT S | 2012 | Appl Catal B: Environ2012，，： | 1 |
| 10 | Nanostruetured macro-mesoporous zirconia impregnated by noble metal for catalytic total oxidation of toluene显示文摘 | TIDAHY H L HOSSEN M SIFFERT S COUSIN R LAMONIER J F ABOUKIS A Su B L GIRAUDON J M LECLERCQ G | 2008 | Catal Today2008，137，24： | 1 |
| 11 | Studies of the activation process over Pd perovskite-type oxides used for catalytic oxidation of toluene显示文摘 | GIRAUDON J M ELHANCHIMI A WYRWALSKI F SIFFERT S ABOUKAIS A LAMONIER J F LECLERCQ G | 2007 | Appl Catal B: Environ2007，75，34： | 1 |
| 12 | Association of a human Gprotein beta 3 subunit variant with hypertension显示文摘 | Siffert W Rosskopf D Siffert G | 1998 | Nat Genet1998，18，1： | 1 |
| 13 | Dynamic relationships of trabecular bone density, architecture, and strength in a computational model of osteopenia显示文摘 | Siffert R S Luo G M Cowin S C | 1996 | Bone1996，18，2： | 1 |
| 14 | Association of a human G-protein beta3 subunit variant with hypertension 显示文摘 | SIFFERT W ROSSKOPF D SIFFERT G | 1998 | Nat Genet1998，18，1： | 1 |
| 15 | Association of a human G-protein beta 3 subunit variant with hypertension显示文摘 | Siffert W Rosskopf D Siffert G | 1998 | Nat Genet1998，18，1： | 1 |
| 16 | Association of a human G-protein β3 subunit variant with hypertension显示文摘 | Rosskopf D Siffert G | 1998 | Nat Genet1998，18，1： | 1 |
| 17 | Ultrasound simulation inbone 显示文摘 | Kaufman JJ Luo G Siffert RS | 2008 | IEEE Trans Ultrason Ferroelectr Freq Control2008，55，： | 1 |
| 18 | G-protein beta 3 subunit 825 CC genotype is associated with unexplained(functional)dyspepsia显示文摘 | Hohmann G Siffert W Hang S | 2004 | Gastroenterology2004，126，4： | 1 |
| 19 | Association of a human G-protein β3 subunit variant with hypertension显示文摘 | Rosskopf D Siffert G | 1998 | Nat Genet1998，18，： | 1 |
| 20 | Ultrasound simulation in bone 显示文摘 | Kaufman JJ Luo G Siffert RS | 2008 | IEEE Trans Ultrason Ferroelectr Freq Control2008，55，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员