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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Association of a human G-protein β 3 subunit variant with hypertension显示文摘 | Siffert W B Rosskopf D Siffert G | 1998 | Nat Genet1998，18，： | 1 |
| 3 | G protein and hypertension: an alternative candidate gene approach显示文摘 | Siffert W | 1998 | Kidney Int1998，53，6： | 1 |
| 4 | The angiotensin II receptor antagonist valsartan inhibits endothelin 1-induced vasoconstriction in the skin microcirculation in humans in vivo: influence of the G- protein beta3 subunit (GNB3) C825T polymorphism 显示文摘 | Mitchell A Rushentsova U Siffert W | 2006 | Clin Pharmaeol Ther2006，79，3： | 1 |
| 5 | Association of a human G-protein beta-3 subunit variant with hypertension显示文摘 | Siffert W Rosskopf D Siffert G | 1998 | Nat Genet1998，18，： | 1 |
| 6 | Association of a human G-protein beta 3 subunit variant with hypertension显示文摘 | Siffert W Rosskopf D Siffert G | 1998 | Nature Genet1998，，： | 1 |
| 7 | G protein polymorphisms in hypertension, atherosclerosis, and diabetes显示文摘 | SIFFERT W | 2005 | Annu Rev Med2005，56，： | 1 |
| 8 | Successful amplification of extremely GC-rich promoter regions using a novel' slowdown PCR' technique显示文摘 | Bachmann HS Siffert W Frey UH | 2003 | Pharmacogenetics2003，13，12： | 1 |
| 9 | G protein beta3 subunit 825T allele is associated with depression in young,healthy subjects显示文摘 | Exton MS Artz M Siffert W | 2003 | Neuroreport2003，14，3： | 1 |
| 10 | Association of a human Gprotein β3 variant with hypertension显示文摘 | Siffert W Rosskopf D Siffert S | 1998 | Nat Genet1998，18，1： | 1 |
| 11 | Association of a human Gprotein beta 3 subunit variant with hypertension显示文摘 | Siffert W Rosskopf D Siffert G | 1998 | Nat Genet1998，18，1： | 1 |
| 12 | G protein and hypertension : an alternative candidategene approach 显示文摘 | Siffert W | 1998 | Kidney Int1998，53，6： | 1 |
| 13 | G-protein and hypertension :an alternative candidate gene approach显示文摘 | Siffert W | 1998 | Kidney Int1998，53，6： | 1 |
| 14 | Association of a human G-protein beta3 subunit variant with hypertension 显示文摘 | SIFFERT W ROSSKOPF D SIFFERT G | 1998 | Nat Genet1998，18，1： | 1 |
| 15 | Worldwide ethnic distribution of the G-protein beta 3 subunit 825T allele and its association with obesity in Caucasian,Chinese and Black African individual显示文摘 | Siffert W Forster P Jochel KH | 1999 | J Am Soc Nephrol1999，10，9： | 1 |
| 16 | G protein beta 3 subunit 825T allele,hypertension,obesity,and diabetic nephropathy显示文摘 | Siffert W | 2000 | Nephrol Dial Transplant2000，15，9： | 1 |
| 17 | Association of a human G-protein beta 3 subunit variant with hypertension显示文摘 | Siffert W Rosskopf D Siffert G | 1998 | Nat Genet1998，18，1： | 1 |
| 18 | Effects of the G-protein beta3 subunit 825T allele on adipogenesis and lipolysis in cultured human preadipocytes and adipocytes显示文摘 | Hauner H Rohrig K Siffert W | 2002 | Horm Metab Res2002，34，9： | 1 |
| 19 | Association of a human G-protein β3 subunit variant with hypertension显示文摘 | Rosskopf D Siffert G | 1998 | Nat Genet1998，18，1： | 1 |
| 20 | G-protein beta 3 subunit 825 CC genotype is associated with unexplained(functional)dyspepsia显示文摘 | Hohmann G Siffert W Hang S | 2004 | Gastroenterology2004，126，4： | 1 |
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