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| 1 | Reduced incidence and mortality from colorectal cancer with flexible-sigmoidoscopy screening: A meta-analysis显示文摘AIM:To conduct a systematic review and meta-analysis of published population-based randomized controlled trials(RCTs).METHODS:RCTs evaluating the difference in mortality and incidence of colorectal cancer(CRC)between a screening flexible sigmoidoscopy(FS)group and control group(not assigned to screening FS)with a minimum 5 years median follow-up were identified by a search of MEDLINE and EMBASE databases and the Cochrane Central Register for Controlled Trials through August 2013.Random effects model was used for meta-analysis.RESULTS:Four RCTs with a total of 165659 patientsin the FS group and 249707 patients in the control group were included in meta-analysis.Intention-totreat analysis showed that there was a 22%risk reduction in total incidence of CRC(RR=0.78,95%CI:0.74-0.83),31%in distal CRC incidence(RR=0.69,95%CI:0.63-0.75),and 9%in proximal CRC incidence(RR=0.91,95%CI:0.83-0.99).Those who underwent screening FS were 18%less likely to be diagnosed with advanced CRC(OR=0.82,95%CI:0.71-0.94).There was a 28%risk reduction in overall CRC mortality(RR=0.72,95%CI:0.65-0.80)and 43%in distal CRC mortality(RR=0.57,95%CI:0.45-0.72).CONCLUSION:This meta-analysis suggests that screening FS can reduce the incidence of proximal and distal CRC and mortality from distal CRC along with reduction in diagnosis of advanced CRC. | Jennifer Shroff Nirav Thosani Sachin Batra Harminder Singh Sushovan Guha | 2014 | World Journal of Gastroenterology2014，20，48： | 3 |
| 2 | Evaluation of the safety and effectiveness of direct oral anticoagulants and low molecular weight heparin in gastrointestinal cancer-associated venous thromboembolism显示文摘BACKGROUND Gastrointestinal cancer(GICA)is associated with a higher incidence of venous thromboembolism(VTE)compared to other solid tumors,moreover,recurrent VTE and major bleeding(MB)complications during anticoagulation treatment have an associated increase rate.GICA-VTE remains a challenging clinical scenario with MB concerns for utilization of direct oral anticoagulants(DOAC),especially with active cancer therapies.AIM To evaluate patient risk factors,effectiveness(VTE)and safety(MB)of DOACs and low molecular weight heparin(LMWH)in patients with active GICA-VTE.METHODS A retrospective chart review of patients receiving DOACs and LMWH with GICA and symptomatic or incidental VTE treated at comprehensive cancer center from November 2013 to February 2017 was performed.Inclusion criteria included active GI cancer diagnosed at any stage or treatment+/-6 mo of VTE diagnosis,whom were prescribed 6 mo or more of DOACs or LMWH.The Chi-squared test was used for overall and the Fisher exact test for pairwise comparisons of the proportions of patients experiencing recurrent VTE and MB events.Odds ratios were used to compare the relative odds of the occurrence of the outcome given exposure to the risk factor.RESULTS A total of 144 patients were prescribed anticoagulation,in which 106 fulfilled inclusion criteria apixaban(27.3%),rivaroxaban(34.9%)and enoxaparin(37.7%),and 38 were excluded.Patients median age was 66.5 years at GICA diagnosis and 67 years at CAVTE event,with 62%males,80%Caucasian,70%stage IV,pancreatic cancer(40.5%),30%Khorana Score(≥3 points),and 43.5%on active chemotherapy.Sixty-four percent of patients completed anticoagulation therapy(range 1 to 43 mo).Recurrent VTE at 6 mo was noted in 7.5%(n=3),6.8%(n=2)and 2.7%(n=1)of patients on enoxaparin,apixaban and rivaroxaban,respectively(all P=NS).MB at 6 mo were 5%(n=2)for enoxaparin,6.8%(n=2)for apixaban and 21.6%(n=8)for rivaroxaban(overall P=0.048;vs LMWH P=0.0423;all other P=NS).Significant predictors of a primary or secondary outcome for all anticoagulation therapies included:Active systemic treatment(OR=5.1,95%CI:1.3-19.3),high Khorana Score[≥3 points](OR=5.5,95%CI:1.7-17.1),active smoker(OR=6.7,95%CI:2.1-21.0),pancreatic cancer(OR=6.8,95%CI:1.9-23.2),and stage IV disease(OR=9.9,95%CI:1.2-79.1).CONCLUSION Rivaroxaban compared to apixaban and enoxaparin had a significantly higher risk of MB on GICA-VTE patients with equivocal efficacy. | Alejandro Recio-Boiles Sumana Veeravelli Jessica Vondrak Hani M Babiker Aaron J Scott Rachna T Shroff Hitendra Patel Emad Elquza Ali McBride | 2019 | World Journal of Gastrointestinal Oncology2019，11，10： | 3 |
| 3 | Abnormal High-Density Lipoprotein Induces Endothelial Dysfunction via Activation of Toll-Like Receptor-2显示文摘 | Thimoteus Speer Lucia Rohrer Przemyslaw Blyszczuk Rukshana Shroff Kira Kuschnerus Nicolle Kr?nkel Gabriela Kania Stephen Zewinger Alexander Akhmedov Yi Shi Tina Martin Damir Perisa Stephan Winnik Maja F. Müller Urban Sester Gabriel Wernicke Andreas Jung U | 2013 | Immunity2013，，： | 2 |
| 4 | A review of monitoring systems of pavement condition in paved and unpaved roads显示文摘The rising number of vehicles on roadways expedites the urge to increase efforts in implementing monitoring systems that look after road pavement conditions. This rising in number of vehicles on roadways also cause more damages and distresses on road pavement. Road pavement conditions should be accurately evaluated to identify the severity of pavement damages and types of pavement distress. Therefore, monitoring systems are considered a significant step of maintenance processes. Paved roads and unpaved roads require regular maintenance to provide for and preserve users' usability, accessibility, and safety. Transport agents and researches would spend a lot of time and money in inspecting some sections of the roadway surface;that inspection would then be followed by results recording and data analysis to diagnose the type of treatment required. These monitoring systems have been developed using various methods that include smart technologies and prepared equipment. Many related studies evaluate road pavement degradation and distress, while others focus on identifying the best maintenance monitoring approach in terms of time and cost. This paper set out to explore different monitoring techniques used to evaluate road pavement surface condition. Also, this study introduces dynamic and static monitoring systems used in both paved and unpaved roads to identify the severity of pavement degradations and types of pavement distress on road surfaces and also this study explains the used equipment in the previous monitoring studies. | Amir Shtayat Sara Moridpour Berthold Best Auinash Shroff Diuyajeetsinh Raol | 2020 | Journal of Traffic and Transportation Engineering(English Edition)2020，7，5： | 2 |
| 5 | Therapeutic potential of human embryonic stem cells in type 2 diabetes mellitus显示文摘AIM:To evaluate the safety and efficacy of human embryonic stem cells(h ESCs)for the management of type 2 diabetes mellitus(T2DM).METHODS:Patients with a previous history of diabetes and its associated complications were enrolled and injected with hE SC lines as per the defined protocol.The patients were assessed using Nutech functional score(NFS),a numeric scoring scale to evaluate the patients for 11 diagnostic parameters.Patients were evaluated at baseline and at the end of treatment period 1(T1).All the parameters were graded on the NFS scale from 1to 5.Highest possible grade(HPG)of 5 was considered as the grade of best improvement.RESULTS:Overall,94.8%of the patients showed improvement by at least one grade of NFS at the end of T1.For all the 11 parameters evaluated,54%of patients achieved HPG after treatment.The four essential parameters(improvement in glycated hemoglobin(HbA 1c)and insulin level,and fall in number of other oral hypoglycemic drugs with and without insulin)are presented in detail.For Hb A1c,72.6%of patients at the end of T1 met the World Health Organization cut off value,i.e.,6.5%of HbA 1c.For insulin level,65.9%of patients at the end of T1 were able to achieve HPG.After treatment,the improvement was seen in 16.3%of patients who required no more than two medications along with insulin.Similarly,21.5%of patients were improved as their dosage regimen for using oral drugs was reduced to 1-2 from 5.CONCLUSION:hE SC therapy is beneficial in patients with diabetes and helps in reducing their dependence on insulin and other medicines. | Geeta Shroff | 2016 | World Journal of Stem Cells2016，8，7： | 2 |
| 6 | Comparison of two different methods of preoperative marking for toric intraocular lens implantation: bubble marker versus pendulum marker显示文摘AIM: To compare the accuracy of two different methods of preoperative marking for toric intraocular lens(IOL) implantation, bubble marker versus pendulum marker, as a means of establishing the reference point for the final alignment of the toric IOL to achieve an outcome as close as possible to emmetropia.·METHODS: Toric IOLs were implanted in 180 eyes of110 patients. One group(55 patients) had preoperative marking of both eyes done with bubble marker(ASICO AE-2791TBL) and the other group(55 patients) with pendulum marker(Rumex 誖 3-193). Reference marks were placed at 3-, 6-, and 9-o'clock positions on the limbus. Slit-lamp photographs were analyzed using Adobe Photoshop(version 7.0). Amount of alignment error(in degrees) induced in each group was measured.· RESULTS: Mean absolute rotation error in the preoperative marking in the horizontal axis was 2.42±1.71 in the bubble marker group and 2.83 ±2.31 in the pendulum marker group(P =0.501). Sixty percent of the pendulum group and 70% of the bubble group had rotation error ≤3(P =0.589), and 90% eyes of the pendulum group and 96.7% of the bubble group had rotation error ≤5(P =0.612).·CONCLUSION: Both preoperative marking techniques result in approximately 3 of alignment error. Both marking techniques are simple, predictable, reproducible and easy to perform. | Javed Hussain Farooqui Archana Koul Ranjan Dutta Noshir Minoo Shroff | 2016 | International Journal of Ophthalmology(English edition)2016，9，5： | 2 |
| 7 | Multi-institutional retrospective analysis of FOLFIRI in patients with advanced biliary tract cancers显示文摘BACKGROUND Gemcitabine plus platinum is the standard of care first-line treatment for advanced biliary tract cancers(BTC).There is no established second-line therapy,and retrospective reviews report median progression-free survival(PFS)less than 3 mo on second-line therapy.5-Fluorouracil plus irinotecan(FOLFIRI)is a commonly used regimen in patients with BTC who have progressed on gemcitabine plus platinum,though there is a paucity of data regarding its efficacy in this population.AIM To assess the efficacy of FOLFIRI in patients with biliary tract cancers.METHODS We retrospectively identified patients with advanced BTC who were treated with FOLFIRI at MD Anderson,University of Michigan and Mayo Clinic in Jacksonville.Data were collected on patient demographics,BTC subtype,response per RECIST v1.1,progression and survival.RESULTS Ninety-eight patients were included of which 74(75%)had metastatic and 24(25%)had locally advanced disease at the time of treatment with FOLFIRI.The median age was 60(range,22-86)years.The number of patients with extrahepatic cholangiocarcinoma,gall bladder cancer and intrahepatic cholangiocarcinoma were 10,17 and 71,respectively.FOLFIRI was used as 1st,2nd,3rd or 4th–Nth lines in 8,50,36 and 4 patients,respectively.Median duration on FOLFIRI in the entire cohort was 2.2(range,0.5-8.4)mo.The median PFS and overall survival were 2.4(95%confidence interval(CI):1.7-3.1)and 6.6(95%CI:4.7-8.4)mo,respectively.Median PFS for patients treated with FOLFIRI in 1st,2nd,3rd or 4th–Nth lines were 3.1,2.5,2.3 and 1.5 mo,respectively.Eighteen patients received concurrent bevacizumab(n=13)or EGFR-targeted therapy(n=5)with FOLFIRI,with a median PFS of 2.7 mo(95%CI:1.7-5.1).CONCLUSION In this largest multi-institution retrospective review of 98 patients with BTC treated with FOLFIRI,efficacy appears to be modest with outcomes similar to other cytotoxic chemotherapy regimens. | Jonathan D Mizrahi Valerie Gunchick Kabir Mody Lianchun Xiao Phanikeerthi Surapaneni Rachna T Shroff Vaibhav Sahai | 2020 | World Journal of Gastrointestinal Oncology2020，12，1： | 2 |
| 8 | A tutorial on crosslayer optimization in wireless networks显示文摘 | LIN X SHROFF N B SRIKANT R | 2006 | IEEE Journal on Selected Areas in Communications2006，24，8： | 1 |
| 9 | Sulfonopeptide leukocyte adhesion 显示文摘 | Carson K G Schwender C F Shroff H N | 1997 | Bioorganic & Medicinal Chemistry Letters1997，7，6： | 1 |
| 10 | Natural history of macular status in recent-onset branch retinal vein occlusion:an optical coherence tomography study显示文摘 | Shroff D Mehta DK Arora R | 2008 | Int Ophthalmol2008，28，： | 1 |
| 11 | The clinical features,MRI findings,and outcome of optic neuritis in children显示文摘 | Wilejto M Shroff M Buncic JR | | 0，，02： | 1 |
| 12 | Comparative study of postoperative analgesia and sedation after upper abdominal surgery with thoracic epidural administration of bupivacaine with/without midazolam显示文摘 | Shroff PP Kaushal V Kamdar BM | | 0，，01： | 1 |
| 13 | Permanent and Transitory Earnings, Accounting, Recording Lag and the Earnings Coefficient 显示文摘 | Easton P P Shroff G Taylor | 2000 | Review of Accounting Studies2000，，5： | 1 |
| 14 | A retrospective analysis of spontaneous sphenoid sinus fistula: MR and CT findings 显示文摘 | SHETTY P G SHROFF M M FATTERPEKAR G M | 2000 | AJNR Am J Neuroradiol2000，21，： | 1 |
| 15 | Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis显示文摘 | Shroff RC McNair R Figg N | 2008 | Circulation2008，118，17： | 1 |
| 16 | Pathological analysis of local delivery of paclitaxel via a polymer-coated stent 显示文摘 | Farb A Heller PF Shroff S | 2001 | Circulation2001，1049，4： | 1 |
| 17 | Mid - pregnancy maternal leptin levels, birthweight for gestational age and preterm delivery 显示文摘 | Shroff MR Holzman C Tian Y | 2013 | Clin Endocrinol (Oxf)2013，78，4： | 1 |
| 18 | How (Un)Useful is the Pelvic Ring Stability Examination in Diagnosing Mechanically Unstable Pelvic Fractures in Blunt Trauma Patients?显示文摘 | Gil Z. Shlamovitz William R. Mower Jonathan Bergman Kenneth R. Chuang Jonathan Crisp David Hardy Martine Sargent Sunil D. Shroff Eric Snyder Marshall T. Morgan | 2009 | The Journal of Trauma: Injury, Infection, and Critical Care2009，，3： | 1 |
| 19 | Admission control schemes to provide class-level QoS in multiservice networks 显示文摘 | Kalyanasundaram S Chong E K P Shroff N B | 2001 | Computer Networks2001，35，2： | 1 |
| 20 | Potential for plasmid DNAs as vaccines for the new millennium 显示文摘 | Shroff KE Smith LR Baine Y | 1999 | Pharms SciTechnol Today1999，2，5： | 1 |
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