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| 1 | Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis显示文摘The 'a disintegrin and metalloprotease' (ADAM) family contributes to regulation of the cell-cell and cell-matrix interactions that are critical determinants of malignancy. To determine the relationship between metastasis and ADAM proteins, we compared the mRNA levels of ADAM9,-10,-12,-15, and-17 in sublines of an EBC-1 lung cancer cell line that were highly metastatic to either brain or bone. ADAM9 mRNA levels were significantly higher in highly brain-metastatic sublines than in the parent or highly bonemetastalic sublines. To elucidate the role ofADAM9 in brain metastasis, we stably transfected A549 and EBC-1 cells with a fulllength ADAM9 expression vector. Compared with mock-transfectants, ADAM9 overexpression resulted in increased invasive capacity | Shintani Y Higashiyama S Ohta M Hirabayashi H Yamamoto S Yoshimasu T Matsuda H Matsuura N | 2004 | 中国神经肿瘤杂志2004，2，2： | 36 |
| 2 | Tissue distribution and immtmocytochemical localization of neurotrophin - 3 in the brain and peripheral tissure of rats 显示文摘 | Katoh - Semba R Kaisho Y Shintani A | 1996 | J Neruochtma1996，66，1： | 1 |
| 3 | Loss of p12CDK2-AP1 expression in human oral squamous cell carcinoma with disrupted transforming growth factor-beta-Smad signaling pathway显示文摘 | PENG H SHINTANI S KIM Y al | 2006 | Neoplasia2006，8，： | 1 |
| 4 | Can News be a Major Source of Aggregate Fluctuations?A Bayesian DSGE Approach显示文摘 | Fujiwara I Hirose Y Shintani M | 2011 | Journal of Money Credit and Banking2011，43，1： | 1 |
| 5 | High frequency of homo- zygous deletion and methylation of p16 (INK4A)gene in oral squa- mous cell carcinomas 显示文摘 | Nakahara Y Shintani S Mihara M | 2001 | Cancer Lett2001，163，2： | 1 |
| 6 | Intravesical instillationtherapy with bacillus Calmette - Guerin for superficial bladdercancer : study of the mechanism of bacillus Calmette - Guerin im-munotherapy 显示文摘 | Shintani Y Komatsu H Ueno A | 2007 | Int J Urol2007，14，1： | 1 |
| 7 | Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway显示文摘 | Shintani M Ogawa Y Ebihara K | 2001 | Diabetes2001，50，： | 1 |
| 8 | Ghrelin,an Endogenous Growth Hormone Secretagogue,is a Novel Orexigenic Peptide That an Tagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Pathway显示文摘 | SHINTANI M OGAWA Y EBIHARA K | 2002 | Diabetes2002，282，6： | 1 |
| 9 | Ambulatory blood pressure, blood pressure variability and the prevalence of carotid artery alteration: the Ohasama study显示文摘 | Shintani Y Kikuya M Hara A | 2007 | J Hypertens2007，25，8： | 1 |
| 10 | Overexpression of CDK2 is a prognostic indicator of oral cancer progression显示文摘 | Mihara M Shintani S Nakahara Y | 2001 | JPN J Cancer Res2001，92，3： | 1 |
| 11 | Ambulatory blood pressure, blood pressure variability and the prevalence of cm'otid artery al- treation : the Ohasama study 显示文摘 | Shintani Y Kikuya M Hara A | 2007 | J Hyperterns2007，25，8： | 1 |
| 12 | Failure of inactivated influenza A vaccine to protect healthy children aged 6-24 months显示文摘 | Maeda T Shintani Y Nakano K | 2004 | Pediatr Int2004，46，2： | 1 |
| 13 | Conservative treatment of prolonged bilateral mandibular dislocation with the help of an intermaxillary fixation screw显示文摘 | Shintani S Nakahara Y | 2006 | Br J Oral Maxillofac Surg2006，44，1： | 1 |
| 14 | Overexpression of the enzyme p-hydroxyphenylpyruvate dioxygenase in Arabi- dopsis and its relation to tocopherol biosynthesis显示文摘 | Tsegaye Y Shintani DK DellaPenna D | 2002 | Plant Physiol Biochem2002，40，： | 1 |
| 15 | Validation of D-valueby different SCD culture medium manufacturer and/or differentSCD culture medium constituent显示文摘 | Shintani H Sasaki K Kajiwara Y | 2000 | PDA J Pharm Sci Technol2000，54，1： | 1 |
| 16 | New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals显示文摘 | Hinuma S Shintani Y Fukusumi S | 2000 | Nature Cell Biology2000，2，10： | 1 |
| 17 | Epithelial to mesenchymal transition is a determinant of sensitivity to chemoradiotherapy in non-small cell lung cancer 显示文摘 | SHINTANI Y OKIMURA A SATO K | 2011 | Ann Thorac Surg2011，92，5： | 1 |
| 18 | Metastasis suppressor gene KISS-1 encode speptide ligand of a G-protein-coupled receptor显示文摘 | Ohtaki T Shintani Y Honda S | 2001 | Nature2001，411，6837： | 1 |
| 19 | Intravesical instillation thera- py with bacillus Calmette-Gu6rin for superficial bladder cancer: study of the mechanism of bacillus Calmette-Gu6rin immunotherapy显示文摘 | Shintani Y Sawada Y Inagaki T | 2007 | Int J Urol2007，14，2： | 1 |
| 20 | Metastasis suppressor gene KISS-1 encodes peptide ligand of a G-protein-coupled recep- tor显示文摘 | Ohtaki T Shintani Y Honda S | 2001 | Nature2001，411，6837： | 1 |
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