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| 1 | Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions显示文摘AIM To assess the levels of different immune modulators in patients with hepatocellular carcinoma(HCC),in relation to other hepatic diseases.METHODS Eighty-eight patients were included in the current study and represented patients with HCC(20),liver cirrhosis(28) and chronic hepatitis(CH;25),and normal controls(NC;15).Peripheral blood was isolated for immunophenotyping of active myeloid dendritic cells(m DCs;CD1 c and CD40),mature inactive myeloid cells(CD1 c and HLA),active plasmacytoid cells(p DCs;CD303 and CD40),mature inactive p DCs(CD30 and HLA),active natural killer(NK) cells(CD56 and CD161),active NK cells(CD56 and CD314) and inactive NK cells(CD56 and CD158) was done by flow cytometry.Serum levels of interleukin(IL)-2,IL-10,IL-12,IL-1β,interferon(IFN)-α,IFN-γ and tumor necrosis factor(TNF)-αR2 were assessed by ELISA.RESULTS Active m DCs(CD1 C+/CD40+) and inactive m DCs(CD1 c+/HLA+) were significantly decreased in HCC patients in relation to NC(P < 0.001).CD40+ expression on active p DCs was decreased in HCC patients(P < 0.001),and its level was not significantly changed among other groups.Inactive p DCs(CD303+/HLA+),inactive NKs(CD56+/CD158+) and active NKs(CD56+/CD161+) were not statistically changed among the four groups studied;however,the latter was increased in CH(P < 0.05).NKG2 D was statistically decreased in HCC,CH and cirrhosis(P < 0.001),and it was not expressed in 63%(12/20) of HCC patients.There was significant decrease of IL-2,IFN-α and IFN-γ(P < 0.001),and a significant increase in IL-10,IL-1β,and TNF-αR2(P <0.01,P < 0.001 and P < 0.001;respectively) in HCC patients.There was inverted correlation between IL-12 and IL-1β in HCC(r =-0.565,P < 0.01),with a strong correlation between p DCs(CD303+/CD40+) and NKs(CD56+/CD161+;r = 0.512,P < 0.05) as well as inactive m DCs(CD1 c+/HLA+) and inactive NK cells(CD56+/CD158+;r = 0.945,P < 0.001).CONCLUSION NKG2 D,CD40,IL-2 and IL-10 are important modulators in the development and progression of HCC. | Abdel-Rahman N Zekri Somaya El Deeb Abeer A Bahnassy Abeer M Badr Mona S Abdellateif Gamal Esmat Hosny Salama Marwa Mohanad Ahmed Esam El-dien Shimaa Rabah Assmaa Abd Elkader | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 2 | Phytochemical studies and anti-ulcerative colitis effect of Moringa oleifera seeds and Egyptian propolis methanol extracts in a rat model显示文摘Objective: To analyze the phytochemical constituents, and to explore potential protective effect of the methanol extract of Moringa oleifera(M. oleifera) seeds and Egyptian propolis, each alone or concurrently administered on acetic acid-induced ulcerative colitis in rats. Methods: Eight groups of 5 rats each were used: normal control group with distilled water, model group, two groups with M. oleifera seeds(100 and 200 mg/kg), two groups with propolis(50 and 100 mg/kg), one group with concurrent administration of both, and one group with prednisolone(reference drug). Macro-and microscopic picture, ulcer index and lesion scores, oxidative markers, inflammatory mediators, in vitro activity of the inflammatory enzymes and 1, 1-diphenyl-2-picrylhydrazyl free radicals scavenging activity were evaluated. The phytochemical constituents of both extracts were explored by GC-MS analysis. Results: Both treatments modulated the macro-and microscopic picture, decreased the ulcerative index, lesion score, oxidative markers and inflammatory mediators, and inhibited the COX-1 and COX-2 enzymes. Propolis appeared to be powerful free radicals scavenger. A powerful synergistic effect of both treatments in modulating the course of the disease was reported. GCMS analysis of methanol extract of M. oleifera seeds and propolis revealed the presence of 50 and 34 compounds, respectively. Conclusions: M. oleifera seeds and propolis methanol extracts have modulated the course of acetic acid-induced ulcerative colitis. Moreover, both treatments induce a good synergistic effect against the disease. Isolation of the active constituents is recommended. | Attia H.Atta Samar M.Mouneir Soad M.Nasr Doaa Sedky Amany M.Mohamed Shimaa A.Atta Hassan Mohamed Desouky | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，3： | 4 |
| 3 | Functionalized CVD monolayer graphene for label-free impedimetric biosensing显示文摘在大区域 graphene 生长的最近的进展在不同区域导致了许多应用。在现在的学习,化学蒸汽扔了(CVD ) 在玻璃底层上支持的单层 graphene 为电气化学的 biosensing 应用作为电极材料被检验。我们由在酸的水的答案在 situ 准备的 carboxyphenyl 重氮基盐的电气化学的减小为 CVD 单层 graphene 的共有原子价 functionalization 报导灵巧的策略。修改 carboxyphenyl 的 graphene 用拉曼光谱学, X 光检查光电子光谱学(XPS ) ,和原子力量被描绘显微镜学(AFM ) ,以及电气化学的阻抗光谱学(EIS ) 。我们也证明 graphene 表面上的 grafted carboxyphenyl 组的数字能被扫描为 electrografting 使用了的周期的 voltammetry (CV ) 的数字控制。我们进一步在 grafted 的激活以后在 graphene 表面上基于 ovalbumin 抗体的固定介绍 immunosensor 的制造和描述经由 EDC/NHS 化学的羧基的组。在使表面不能调动的抗体和 ovalbumin 之间的绑定然后用 Faradaic EIS 被监视在[Fe (CN )< 潜水艇 class= “ a-plus-plus ” > 6 ] 3/4 答案。费用转移抵抗的百分比变化(R < 潜水艇 class= “ a-plus-plus ” > 在绑定以后的 ct ) 为从 1.0 pg 的 ovalbumin 集中展出了线性依赖? | Shimaa Eissa Gaston Contreras Jimenez Farzaneh Mahvash Abdeladim Guermoune Chaker Tlili Thomas Szkopek Mohammed Zourob Mohamed Siaj | 2015 | Nano Research2015，8，5： | 3 |
| 4 | 超声处理触变铸造A356合金的显微组织特征和拉伸性能(英文)显示文摘在A356合金凝固过程中,对锭坯进行超声振动处理。采用不同工艺将锭坯重新加热至半固态,然后采用模铸机进行触变铸造。结果表明,经重新加热和触变铸造后,超声处理的锭坯具有均匀分布的细小球状α(Al)。与未进行超声处理的锭坯相比,经超声处理的触变铸造锭坯具有更高的拉伸强度和伸长率。经超声处理的触变铸造锭坯在拉力作用下表现出韧性断裂倾向,而未经处理的锭坯则呈现出明显的小刻面,表现为脆性断裂。超声熔体处理作为一种触变铸造的处理方法具有可行性和竞争力。 | Waleed KHALIFA Shimaa EL-HADAD Yoshiki TSUNEKAWA | 2015 | Transactions of Nonferrous Metals Society of China2015，25，10： | 3 |
| 5 | Survival and outcomes for co-infection of chronic hepatitis C with and without cirrhosis and COVID-19: A multicenter retrospective study显示文摘BACKGROUND Chronic liver disease,particularly cirrhosis,is associated with worse outcomes in patients infected with coronavirus disease 2019(COVID-19).AIM To assess outcomes of COVID-19 infection among patients with pre-existing hepatitis C with or without liver cirrhosis.METHODS This multicenter,retrospective cohort study included all cases of confirmed coinfection of severe acute respiratory syndrome coronavirus 2 and chronic hepatitis C with or without liver cirrhosis who were admitted to six hospitals(Al-Sahel Hospital,Al-Matareya Hospital,Al-Ahrar Hospital,Ahmed Maher Teaching Hospital,Al-Gomhoreya Hospital,and the National Hepatology and Tropical Medicine Research Institute)affiliated with the General Organization for Teaching Hospitals and Institutes in Egypt.Patients were recruited from May 1,2020,to July 31,2020.Demographic,laboratory,imaging features,and outcomes were collected.Multivariate regression analysis was performed to detect factors affecting mortality.RESULTS This retrospective cohort study included 125 patients with chronic hepatitis C and COVID-19 co-infection,of which 64(51.20%)had liver cirrhosis and 40(32.00%)died.Fever,cough,dyspnea,and fatigue were the most frequent symptoms in patients with liver cirrhosis.Cough,sore throat,fatigue,myalgia,and diarrhea were significantly more common in patients with liver cirrhosis than in noncirrhotic patients.There was no difference between patients with and without cirrhosis regarding comorbidities.Fifteen patients(23.40%)with liver cirrhosis presented with hepatic encephalopathy.Patients with liver cirrhosis were more likely than non-cirrhotic patients to have combined ground-glass opacities and consolidations in CT chest scans:28(43.75%)vs 4(6.55%),respectively(P value<0.001).These patients also were more likely to have severe COVID-19 infection,compared to patients without liver cirrhosis:29(45.31%)vs 11(18.04%),respectively(P value<0.003).Mortality was higher in patients with liver cirrhosis,compared to those with no cirrhosis:33(51.56%)vs 9(14.75%),respectively(P value<0.001).All patients in Child-Pugh class A recovered and were discharged.Cirrhotic mortality occurred among decompensated patients only.A multivariate regression analysis revealed the following independent factors affecting mortality:Male gender(OR 7.17,95%CI:2.19–23.51;P value=0.001),diabetes mellitus(OR 4.03,95%CI:1.49–10.91;P value=0.006),and liver cirrhosis(OR 1.103,95%CI:1.037–1.282;P value<0.0001).We found no differences in liver function,COVID-19 disease severity,or outcomes between patients who previously received direct-acting antiviral therapy(and achieved sustained virological response)and patients who did not receive this therapy.CONCLUSION Patients with liver cirrhosis are susceptible to higher severity and mortality if infected with COVID-19.Male gender,diabetes mellitus,and liver cirrhosis are independent factors associated with increased mortality risk. | Shimaa Afify Basem Eysa Fatma Abdel Hamid Omnia M Abo-Elazm Mohamed A Edris Rabab Maher Ahmed Abdelhalim Muhammad Mostafa Abdel Ghaffar Dalia A Omran Hend Ibrahim Shousha | 2021 | World Journal of Gastroenterology2021，27，42： | 2 |
| 6 | 添加Si/Ti对粉末冶金FiNiCrCo高熵合金物理力学和化学性能的影响显示文摘用粉末冶金法制备FiNiCrCoSi_(x)和FiNiCrCoTi_(x)高熵合金(HEAs)。其中x为0、0.3%、0.6%和0.9%(质量分数)。所有合金中均形成均匀分布的固溶体。与FiNiCrCo高熵合金相比,加入Si和Ti后,合金的密度和硬度提高,研究合金在不同载荷下的磨损率。结果表明,含0.3%Si和0.9%Ti的高熵合金磨损率最低。用XRD、SEM和EDX研究HEAs的相组或、晶粒尺寸和显微组织。通过H_(2)SO_(4)、HNO_(3)和HCl溶液浸泡实验,研究Si和Ti含量对烧结态FiNiCrCoSi_(x)和FiNiCrCoTi_(x) HEAs腐蚀行为和表面形貌的影响。在样品表面观察到不同尺寸的均匀腐蚀和局部点烛,且FiNiCrCoSi0.3合金具有更小,更少的蚀坑,和优异的显微组织。 | Sarah HEDYA Lamiaa MOHAMED Ghalia GABER Omayma ELKADY Hassan MEGAHED Shimaa ABOLKASSEM | 2022 | Transactions of Nonferrous Metals Society of China2022，32，8： | 2 |
| 7 | Evaluation of copper removal efficiency using water treatment sludge显示文摘Large quantities of sludge are produced during water treatment processes. Recently, sludge has been treated as waste and disposed of in landfills, which increases the environmental burdens and the operational cost. Therefore, sludge reuse has become a significant environmental issue. In this study, adsorption of copper ions (Cu^2+) onto calcined sludge was investigated under various operational conditions (with varying temperature, Cu^2+ initial concentration, pH, and sludge dosage). The prepared sludge material was characterized with transmission electron microscopy (TEM), X-ray diffraction (XRD), dynamic light scattering (DLS), and Brunauer-Emmett-Teller (BET) surface area. The sorption capacity of sludge was directly proportional to the initial Cu^2+ concentration and inversely proportional to the sludge dosage. The optimum operational pH and solution temperature were 6.6 and 80℃, respectively. The experimental results followed a Langmuir isotherm and pseudo-first-order adsorption kinetics. Thermodynamic parameters such as activation energy, change in free energy, enthalpy, and entropy were calculated. Thermodynamic analyses indicated that the sorption of copper ions onto the calcined sludge was driven by a physical adsorption process. The prepared sludge was proven to be an excellent adsorbent material for the removal of Cu^2+ from an aqueous solution under optimum conditions. | Shimaa A.Shahin Mohamed Mossad Moharram Fouad | 2019 | Water Science and Engineering2019，12，1： | 2 |
| 8 | The Cloud Computing: The Future of BI in the Cloud显示文摘 | Shimaa Our Mona Nasr | 2011 | International Journal of Computer Theory and Engineering2011，3，6： | 1 |
| 9 | Correction of hypertriglyceridemia with low high-density lipoprotein cholesterol by the novel compound NO-1886, a lipoprotein lipase-promoting agent,in STZ-induced diabetic rats显示文摘 | INOUEY SHIMAA etal | 1995 | Diabetes1995，44，： | 1 |
| 10 | Insulin inter-vention to preserve beta cells in slowly progressive insulin-de-pendent(type 1)diabetes mellitus显示文摘 | Kobayashi T MaruyamaT Shimaa A | | 0，，： | 1 |
| 11 | Hepatoprotective and Antioxidant Effects ofSilybum marianum Plant in Rat显示文摘 | Shimaa I Ramadan MA Shalaby | 2011 | IJAVMS2011，，5： | 1 |
| 12 | Environmental and economic impact assessment of construction and demolition waste disposal using system dynamics显示文摘 | Marzouk M Shimaa A | 2014 | Resources Conservation and Recycling2014，82，： | 1 |
| 13 | Renoprotective effect of sitagliptin against hypertensive nephropathy induced by chronic administration of L-NAME in rats: Role of GLP-1 and GLP-1 receptor显示文摘 | Dalia M. Abd El Motteleb Shimaa M. Elshazly | 2013 | European Journal of Pharmacology . 2013 (1-3)2013，，1： | 1 |
| 14 | Ameliorative effect of nicorandil on high fat diet induced non-alcoholic fatty liver disease in rats显示文摘 | Shimaa M. Elshazly | 2014 | European Journal of Pharmacology2014，，： | 1 |
| 15 | Removal of organic pollutants by lanthanide-doped MIL-53(Fe) metal-organic frameworks:Effect of dopant type in magnetite precursor显示文摘A series of undoped and lanthanide doped MIL-53(Fe)/Ln-Fe_(3)O_(4)(Ln=La,Nd,or Gd) metal-organic frameworks(MOFs) were prepared by the solvothermal method.All prepared samples were characterized by X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FT-IR),Brunauer-Emmett-Teller(BET) measurements,scanning electron microscopy(SEM),and thermal analysis.XRD and FT-IR results ascertain the successful MOF formation for all prepared samples.MIL-53(Fe)/La-Fe_(3)O_(4) has the smallest particle size of 8.6 nm,the largest BET surface area of 54.2 m^(2)/g,and the highest porosity.Undoped and different lanthanide doped MIL-53(Fe) we re employed as sorbents for the removal of methylene blue(MB)dye from aqueous solutions to examine the doping benefit and the effect of the dopant size on the sorption performance.Doping causes MOFs to act as pH-independent sorbents,which make it applicable at any condition.Adsorption follows pseudo-second-order kinetic model,and doped sorbents attain equilibrium faster.Langmuir isotherms are followed,except for MIL-53(Fe)/La-Fe_(3)O_(4).The adsorption capacity increases with increasing the dopant ion size,100.5 mg/g for La-doped MOF,which is about four times higher than that of undoped MOF.The adsorption mechanism involves chemical interactions between Lewis acid in magnetite MIL-53(Fe) series and Lewis base in MB. | Shimaa M.Ali Khadija M.Emran Fedaa M.M.Alrashedee | 2023 | Journal of Rare Earths2023，41，1： | 1 |
| 16 | Wear of AI/AI3Zr functionally graded materials fabricated by centrifugal solid-particle method 显示文摘 | Shimaa E H Hisashi S Yoshimi W | 2010 | Journal of Materials Processing Technology2010，210，15： | 1 |
| 17 | Optical properties and radiative rates of Nd^(3+) doped zinc-sodium phosphate glasses显示文摘Preparation using melt quenching technique and optical characterizations of Nd^(3+) doped Zn-Na phosphate glasses are presented. The structure of the present glasses was studied using X-ray diffraction and FT-IR spectroscopy. UV-vis spectra of the present glasses were analyzed at different concentrations of Nd_2 O_3. The effect of neodymium concentration on the density and energy band gap was investigated. The density of the present glasses slightly increases with the increasing of Nd_2 O_3. A small variation of energy band gap with the increasing of neodymium content is observed as well, while E_g values decrease with the increase of Nd_2 O_3 content. The E_g values lie between 4.36 and 4.69 eV. Based on the measured optical spectra, Judd-Ofelt theory was used to determine the optical parameters such as line strengths, optical intensity parameters(Ω_t), transition probabilities, and transition lifetimes. Hypersensitive transitions were identified in the absorption spectrum, the greatest line strengths are recorded at the transitions^2 G_(7/2)+ ~4 G_(5/2), ~4 S_(3/2) + ~4 F_(7/2) and ~4 D_(1/2) + ~4 D_(3/2)+ ~4 D_(5/2) + ~2 I_(11/2) with wavelengths of 580, 475 and 355 nm,respectively. Lifetimes of the important ~4 F_(3/2) laser-level were determined; which show decreasing trend with the increasing of Nd_2 O_3 content and are found to be between 0.838 and 1.595 ms. The uncertainty of the present results was estimated. The RMS deviations were determined, which show lower values than those in the literature. | A.A.El-Maaref Shimaa Badr Kh.S.Shaaban E.A.Abdel Wahab M.M.ElOkr | 2019 | Journal of Rare Earths2019，37，3： | 1 |
| 18 | β- lactoglobulin based on electrografting of organic film on graphene modified screen-printed carbon electrodes显示文摘 | Shimaa Eissa Chaker Tlili Lamia L'Hocine et Electrochemical immunosensor for the milk allergen al | 2012 | Biosensors and Bioelectronics2012，38，1： | 1 |
| 19 | Melatonin and schistosomal antigens ameliorate the anti-oxidative and biochemical response to Schistosoma mansoni infection in hamster显示文摘The present study was designed to investigate the potential protective effect of melatonin as an antioxidant separately or in combination with antigens (cercarial; CAP or soluble worm; SWAP) against Schistosoma mansoni infection in hamsters. Each hamster was sensitized with an initial immunization of 0.6 ml of the extracted antigen (30 μg protein/mL). After four days,a second injection of 0.4 mL was given (20 μg protein/mL). Then,each hamster was exposed to 260±20 S.mansoni cercariae followed with melatonin treatment (3.5 mg/kg) for thirty days from the 1st day of post infection. Levels of lipid peroxidation (LPO) products,catalase (CAT) activity,hepatic glutathione (GSH) and biochemical changes in the liver and kidneys functions were investigated. The results revealed a high significant increasing of LPO and decreasing of CAT and GSH in liver of infected hamsters. Biochemical observations showed severe damage in the liver enzyme activities and increasing cholesterol level in infected animals. Melatonin co-treatment with antigen to the infected-hamster attenuated the increase of LPO and restored the activity of CAT and levels of hepatic GSH. Also,the biochemical damages in the liver and kidneys functions were reduced. The present study suggests that melatonin may be useful in combating free radical-induced damage due to infection toxicity. The immunization with previous antigens resulted in a remarkable improvement on the liver enzyme activities,which were increased after infection. Thus,vaccination of hamsters with antigens (both CAP and SWAP) and melatonin treatment has more potent effect on the enhancement of antioxidant and biochemical of S.mansoni infected-hamster than each treatment separately. Immunization of the hamster with SWAP followed by melatonin was the best way among the other regime treatments to improve the biochemical and antioxidant parameters of the | Nahla S. El-SHENAWY Maha F. M. SOLIMAN Shimaa E. Abel-RAHMAN | 2009 | Current Zoology2009，55，2： | 1 |
| 20 | 锌在酸性介质中的腐蚀控制:葫芦巴绿色抑制剂(英文)显示文摘利用葫芦巴种子提取物作为绿色腐蚀抑制剂,采用失重法和电化学方法研究锌在2.0 mol/L硫酸和2.0 mol/L盐酸中的腐蚀行为。扫描电子显微镜结果表明添加抑制剂后,锌的表面腐蚀得到减缓。光电子能谱分析表明腐蚀产物为Zn O,验证了抑制剂的吸收机理。当添加200 m L/L葫芦巴提取物时,在硫酸溶液中腐蚀1 h和盐酸溶液中腐蚀0.5 h可得到最大抑制率,分别为90.7%和66.6%。在HCl溶液中添加I-离子时,由于协同作用可大幅度提高葫芦巴种子提取物对锌腐蚀的抑制率。动电位极化和EIS分析表明葫芦巴种子提取物对锌在盐酸中的腐蚀有抑制作用。添加葫芦巴种子提取物可降低腐蚀电流,增加电荷转移电阻。 | Shimaa M.ALI Hamedh A.Al LEHAIBI | 2016 | Transactions of Nonferrous Metals Society of China2016，26，11： | 1 |
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