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| 1 | WRN解旋酶是治疗微卫星不稳定型癌症的新靶点显示文摘由基因突变或启动子超甲基化引发的DNA错配修复(MMR)缺陷会造成核苷酸重复区(微卫星)序列超突变,即微卫星不稳定性(MSI).MSI可促进多种癌症的发生,包括结肠(15%)、胃(22%)、子宫内膜(20%~30%)和卵巢(12%),其中有45%~60%不响应免疫检查点封锁.因此,MSI型肿瘤需要新的治疗方法.研究人员猜测由MSI导致的基因组缺陷能与其他基因的失活形成合成致死关系,协同杀死癌细胞. | Chan EM Shibue T McFarland JM | 2019 | 国际老年医学杂志2019，40，6： | 3 |
| 2 | Distinct EMT programs control normal mammary stem cells and tumour-initiating cells 显示文摘 | YE X TAM WL SHIBUE T | 2015 | Nature2015，525，7568： | 1 |
| 3 | Gas-phase Stability of Double-stranded Oligodeoxynucleotides and Their Noncovalent Complexes With DNAbinding Drugs as Revealed by Collisional Activation in an Ion Trap显示文摘 | Wan KX Gross ML Shibue T | 2000 | J Am Soc Mass Spectrom2000，11，5： | 1 |
| 4 | Effect of extrusion ratio on tensile properties of TiAl(Mn) produced by reactive sintering 显示文摘 | Furuyama T Kim M S | 1994 | Powder & Powder Metallurgy1994，41，2： | 1 |
| 5 | Annular pancreas detected in adults, diagnosed by endoscopic retrograde cholangiopancreatography: report of four cases 显示文摘 | YOGI Y SHIBUE T HASHIMOTO S | 1987 | Gastroenterol Jpn1987，22，1： | 1 |
| 6 | Metastatic colonization: settlement, ad- aptation and propagation of tumor cells in a foreign tissue envi- ronment显示文摘 | Shibue T Weinberg RA | 2011 | Semin Cancer Biol2011，21，2： | 1 |
| 7 | Sumitomo Light Metal Technical Reports显示文摘 | Shibue K Furuyama T | 1997 | 38(2): 1271997，38，2： | 1 |
| 8 | Integrin betal-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs显示文摘 | Shibue T Weinberg RA | 2009 | Proc NatlAcad Sci USA2009，106，10： | 1 |
| 9 | Therapeutic potential of proapoptotic molecule Noxa in the selective elimination of tumor cells显示文摘 | Suzuki S Nakasato M Shibue T | 2009 | Cancer Sci2009，100，4： | 1 |
| 10 | Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs显示文摘 | Shibue T Weinberg RA | 2009 | Proc Natl Acad Sci USA2009，106，10： | 1 |
| 11 | Non-covalent complexes between DNA-binding drugs and double-stranded oligodeoxynucleotides:a study by ESI ion-trap mass spectrometry显示文摘 | WAN K X SHIBUE T GROSS M L | 2000 | J Am Chem Soc2000，122，2： | 1 |
| 12 | Distinct EMT programs control normal mammary stem cells and tumour-initiating cells显示文摘 | Ye X Tam WL Shibue T | 2015 | Nature2015，525，7568： | 1 |
| 13 | Non-covalent complexes between DNA-binding drugs and double-stranded oligodeoxynucleotides:a study by ESI ion-trap mass spectrometry显示文摘 | Wan KX Shibue T Gross ML | 2000 | J Am Chem Soc2000，122，： | 1 |
| 14 | The outgrowth of micrometastases is enabled by the formation of filopodium-like protrusions显示文摘 | Shibue T Brooks MW Inan MF | 2012 | Cancer Discov2012，2，8： | 1 |
| 15 | 显示文摘 | WAN K X SHIBUE T GROSS M L | 2000 | J Am Chem Soc2000，122，2： | 1 |
| 16 | 显示文摘 | WAN K X SHIBUE T GROSS M L | 2000 | J Am Soc Mass Spectrom2000，11，： | 1 |
| 17 | Metastatic colonization:settlement,adaptation and propagation of tumor cells in a foreign tissue environment显示文摘 | SHIBUE T WEINBERG R A | | 0，，02： | 1 |
| 18 | Tumor necrosis factor alpha 5'FIN-flanking region, tumor necrosis factor receptor II , and HLA-DRB1 polymorphisms in Japanese patients with rheumatoid arthritis 显示文摘 | Shibue T Tsuchiya N Komata T | 2000 | Arthritis Rheum2000，43，4： | 1 |
| 19 | Twin roll casting of magnesium alloys with high aluminium contents显示文摘 | WATARI H HAGA T SHIBUE Y DAVEY K K KOGA N | 2006 | Journal of Achievements and Manufacturing Engineering2006，18，12： | 1 |
| 20 | Selective detection of cyste- ine and glutathione using gold nanorods 显示文摘 | Sudeep P K Shibu J S T George T K | 2005 | J Am Chem Soc2005，127，18： | 1 |
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