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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Columnar specificity of microvascular oxygenation and volume responses: Implication for functional brain mapping显示文摘 | Sheth SA Nemoto M Guiou M | 2004 | Neuroseienee2004，24，： | 1 |
| 3 | Mechanisms of deep brain stimulation for obsessive compulsive disorder: effects upon cells and circuits显示文摘 | Bourne SK Eekhardt CA Sheth SA | 2012 | Front Integr Neurosei2012，14，6： | 1 |
| 4 | Predictors of cranio- plasty complications in stroke and trauma patients 显示文摘 | Walcott BP Kwon CS Sheth SA | 2013 | J Neuro- surg2013，118，4： | 1 |
| 5 | Stereotactic radiosurgery at a low marginal dose for the treatment of pediatric arteriovenous malformations:obliteration,complications,and functional outcomes显示文摘 | Potts MB Sheth SA Louie J | 2014 | J Neurosurg Pediatr2014，14，1： | 1 |
| 6 | Intraoperative rerupture during surgical treatment of aneurysmal subarachnoid hemorrhage is not associated with an increased risk of vasospasm 显示文摘 | SHETH SA HAUSRATH D NUMIS AL | 2014 | J Neurosurg>20142014，，： | 1 |
| 7 | Factors affectingsuccessful localization of the central sulcus using the somatosensoryevoked potential phase reversal technique 显示文摘 | Sheth SA Eckhardt CA Walcott BP | 2013 | Neurosurgery2013，72，5： | 1 |
| 8 | Intraoperative reruptureduring surgical treatment of aneurismal subarachnoid hemorrhageis not associated with an increased risk of vasospasm 显示文摘 | Sheth SA Hausrath D Numis AL | 2014 | JNeurosurgerg2014，120，2： | 1 |
| 9 | Predictors of cranioplasty com- plications in stroke and trauma patients 显示文摘 | Walcott BP Kwon CS Sheth SA | 2013 | J Neurosurg2013，118，4： | 1 |
| 10 | ]nterventional optical molecular imaging guidance during percutaneous biopsy 显示文摘 | Sheth RA Heidari P Esfahani SA | 2014 | Radiology2014，271，3： | 1 |
| 11 | Transsphenoidal surgery for cushing disease after nondiagnostic inferior petrosal sinus sampling显示文摘 | Sheth SA Mian MK Neal J | 2012 | Neurosurgery2012，71，1： | 1 |
| 12 | Basal ganglia neurons dynamically facilitate exploration during associative learning 显示文摘 | Sheth SA Abuelem T Gale JT | 2011 | J Neurosci2011，31，13： | 1 |
| 13 | Limbic system surgery for treatment-refractory obsessive-compulsive disorder:a prospective long-term follow-up of 64 patients显示文摘 | Sheth SA Neal J Tangherlini F | 2013 | J Neurosurg2013，118，3： | 1 |
| 14 | Predictors of cranioplasty complications in stroke and trauma patients显示文摘 | Walcott BP Kwon CS Sheth SA | 2013 | J Neurosurg2013，118，4： | 1 |
| 15 | Yeasts isolated from New Zealand vineyards and wineries显示文摘 | Zhang HY Lee SA Bradbury J Warren R Sheth H Hooks D Richards KD and Gardner RC | | 0，，： | 1 |
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