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| 1 | Global epidemiology of hepatitis C virus infection显示文摘 | Colin W Shepard Lyn Finelli Miriam J Alter | 2005 | The Lancet Infectious Diseases2005，，9： | 6 |
| 2 | Hepatitis B Virus Infection: Epidemiology and Vaccination显示文摘 | Colin W. Shepard Edgar P. Simard Lyn Finelli Anthony E. Fiore Beth P. Bell | 2006 | Epidemiologic Reviews2006，，： | 6 |
| 3 | Alcohol-induced protein hyperacetylation: Mechanisms and consequences显示文摘Although the clinical manifestations of alcoholic liver disease are well-described, little is known about the molecular basis of liver injury. Recent studies have indicated that ethanol exposure induces global protein hyperacetylation. This reversible, posttranslational modification on the ε-amino groups of lysine residues has been shown to modulate multiple, diverse cellular processes ranging from transcriptional activation to microtubule stability. Thus, alcoholinduced protein hyperacetylation likely leads to major physiological consequences that contribute to alcohol-induced hepatotoxicity. Lysine acetylation is controlled by the activities of two opposing enzymes, histone acetyltransferases and histone deacetylases. Currently, efforts are aimed at determining which enzymes are responsible for the increased acetylation of specifi c substrates. However, the greater challenge will be to determine the physiological ramifications of protein hyperacetylation and how they might contribute to the progression of liver disease. In this review, we will fi rst list and discuss the proteins known to be hyperacetylated in the presence of ethanol. We will then describe what is known about the mechanisms leading to increased protein acetylation and how hyperacetylation may perturb hepatic function. | Blythe D Shepard Pamela L Tuma | 2009 | World Journal of Gastroenterology2009，15，10： | 3 |
| 4 | Alcohol-induced alterations of the hepatocyte cytoskeleton显示文摘The hepatocyte cytoskeleton consists of three fi lamentous networks: microtubules, actin microfi laments and keratin intermediate filaments. Because of the abundance of the proteins that comprise each system and the central role each network plays in a variety of cellular processes, the three fi lament systems have been the focus of a host of studies aimed at understanding the progression of alcohol-induced liver injury. In this review, we will briefly discuss the hepatic organization of each cytoskeletal network and highlight some components of each system. We will also describe what is known about ethanol-induced changes in the dynamics and distributions of each cytoskeletal system and discuss what is known about changes in protein expression levels and post-translational modifi cations. Finally, we will describe the possible consequences of these cytoskeletal alterations on hepatocyte function and how they might contribute to the progression of liver disease. | Blythe D Shepard Pamela L Tuma | 2010 | World Journal of Gastroenterology2010，16，11： | 2 |
| 5 | Radiofrequency ablation for treatment of medically inoperable stage I non–small cell lung cancer显示文摘 | Michael Lanuti Amita Sharma Subba R. Digumarthy Cameron D. Wright Dean M. Donahue John C. Wain Douglas J. Mathisen Jo-Anne O. Shepard | 2009 | The Journal of Thoracic and Cardiovascular Surgery2009，，1： | 2 |
| 6 | 心肺复苏指导对模拟儿童心脏骤停期间胸部按压中断的影响显示文摘目的确定心肺复苏(cardiopulmonaryresuscitation,CPR)指导者对模拟儿科心脏骤停期间按压停顿频率和持续时间的影响。设计本研究为一项前瞻性多中心研究视频数据的二次分析。共计40个历时18min的模拟儿科心脏骤停场景(20个无指导者团队和20个有指导者团队)。由3名临床专家进行审查,以记录每次胸外按压暂停前后发生的事件。场所加拿大和美国的4家儿科学术医疗中心。对象200名医疗服务提供者组成每组5人的跨专业复苏团队,其中包括1名CPR指导者或1名不具备CRP指导资格的临床医疗工作者。干预措施团队随机包括1名CPR指导者或额外1名不具备CRP指导资格的临床医疗工作者。测量方法与主要结果根据结果变量的分布和类型来记录每次胸部按压中断的频率、持续时间和相关因素,采用t检验、Wilcoxon秩和检验或卡方检验进行组间比较。采用混合效应线性模型探讨CPR指导对按压暂停持续时间的影响,并考虑到团队内暂停持续时间的多重测量。共确定655次暂停(非指导组n=304,指导组n=351)。与非指导组相比,接受心肺复苏指导组的总平均暂停时间(98.6比120.85 s,P=0.04)和插管暂停时间(中位4.0比15.5 s,P=0.002)降低,平均暂停频率(17.6比15.2 s,P=0.33)接近。有心肺复苏指导者的团队更有可能用语言表达暂停需求(86.5%比73.7%,P<0.001),以及协调按压者更换,心律检查和脉搏检查(31.7%比23.2%,P=0.05)。校正暂停数量及暂停期间执行任务类型后,有CPR指导者的团队按压暂停时间较短。结论与没有CPR指导者的团队相比,纳入训练有素的CPR指导者可优化暂停前语言指示,缩短暂停时间,缩短插管期间暂停时间,并更好的协调胸外按压暂停期间的关键任务。 | 方伯梁(译) 钱素云(校) Kessler DO Grabinski Z Shepard LN | 2021 | 中国小儿急救医学2021，28，10： | 2 |
| 7 | 基于砂—粉砂—黏土含量的沉积物命名方法显示文摘 | Francis P Shepard 王中波 | 2006 | 海洋地质动态2006，22，10： | 2 |
| 8 | Human disease modeling with induced pluripotent stem cells显示文摘 | Alan Trounson Kelly A Shepard Natalie D DeWitt | 2012 | Current Opinion in Genetics & Development2012，，5： | 2 |
| 9 | Radiofrequency Ablation for Stage I Non-Small Cell Lung Cancer: Management of Locoregional Recurrence显示文摘 | Michael Lanuti Amita Sharma Henning Willers Subba R. Digumarthy Douglas J. Mathisen Jo-Anne O. Shepard | 2012 | The Annals of Thoracic Surgery2012，，3： | 2 |
| 10 | A randomized controlled trial of methylprednisolone or naloxone in the treat ment of acute spinal-cord injury: result of the Second National A cute Spinal Cord Injury Study显示文摘 | Bracken MB Shepard MJ Collins WF | 1990 | N Engl J Med1990，322，20： | 1 |
| 11 | Nomenclature basede on sand-silt clay ratios显示文摘 | Shepard F P | 1954 | Journal of Sedimentary Petrology1954，24，： | 1 |
| 12 | Acute aortic occlusion:a 40 year experience显示文摘 | Dassa CD Shepard AD Reddy DJ | 1994 | Arch Surg1994，129，1： | 1 |
| 13 | Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury:results of the Third National Acute Spinal Cord Injury Study显示文摘 | Bracken MB Shepard MJ Holford TR | 1997 | JAMA1997，277，20： | 1 |
| 14 | One-point method for estimating furrows infiltration显示文摘 | Shepard J S Wallender W W Hopmans J W | 1993 | Transactiona of the ASAE1993，36，： | 1 |
| 15 | Evaluation of the upper airway in patients with obstructive sleep apnea 显示文摘 | Shepard JW Jr Gefter WB Guilleminauh C | 1991 | Sleep1991，14，4： | 1 |
| 16 | Computed tomo- graphy of localized pleural mesothelioma显示文摘 | Dedrick CG McLoud TC Shepard JAO | 1985 | A JR1985，，： | 1 |
| 17 | Genome sequences and phylogenetic analysis of K88and F18positive porcine enterotoxigenic Escherichia coli显示文摘 | Shepard S M Danzeisen J L Isaacson R E | 2012 | J Bacteriol2012，194，2： | 1 |
| 18 | Healing of articular cartilage in intra-articular fractures in rabbits显示文摘 | Mitchell N Shepard N | | 0，，04： | 1 |
| 19 | Global epidemiology of hepatitis C virus infection显示文摘 | Shepard CW Finelli L Alter M J | | 0，，09： | 1 |
| 20 | Delayed presentation of aortic injury by pedicle screws:report of two cases and review of the literature显示文摘 | Kakkos SK Shepard AD | | 0，，： | 1 |
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