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| 1 | Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis显示文摘AIM:To evaluate the impact of metadoxine(MTD) on the 3- and 6-mo survival of patients with severe alcoholic hepatitis(AH).METHODS:This study was an open-label clinical trial,performed at the'Hospital General de México,Dr.Eduardo Liceaga'.We randomized 135 patients who met the criteria for severe AH into the following groups:35 patients received prednisone(PDN)40 mg/d,35patients received PDN+MTD 500 mg three times daily,33 patients received pentoxifylline(PTX)400 mg three times daily,and 32 patients received PTX+MTD 500 mg three times daily.The duration of the treatment for all of the groups was 30 d.RESULTS:In the groups treated with the MTD,thesurvival rate was higher at 3 mo(PTX+MTD 59.4%vs PTX 33.3%,P=0.04;PDN+MTD 68.6%vs PDN20%,P=0.0001)and at 6 mo(PTX+MTD 50%vs PTX18.2%,P=0.01;PDN+MTD 48.6%vs PDN 20%,P=0.003)than in the groups not treated with MTD.A relapse in alcohol intake was the primary independent factor predicting mortality at 6 mo.The patients receiving MTD maintained greater abstinence than those who did not receive it(74.5%vs 59.4%,P=0.02).CONCLUSION:MTD improves the 3-and 6-mo survival rates in patients with severe AH.Alcohol abstinence is a key factor for survival in these patients.The patients who received the combination therapy with MTD were more likely to maintain abstinence than those who received monotherapy with either PDN or PTX. | Fátima Higuera-de la Tijera Alfredo I Servín-Caamano Aurora E Serralde-Zúniga Javier Cruz-Herrera Eduardo Pérez-Torres Juan M Abdo-Francis Francisco Salas-Gordillo JoséL Pérez-Hernández | 2015 | World Journal of Gastroenterology2015，21，16： | 8 |
| 2 | Case of Aeromonas veronii( DNA Group 10 ) bacteremia 显示文摘 | ABBOTT S L SERVE H JANDA J M | 1994 | J Clin Microbiol1994，32，12： | 1 |
| 3 | Efficient modeling of nonconventional wells with downholeinflow control devices显示文摘 | VALVATNE P H SERVE J DURLOFSKY L J | 2003 | Journal of Petroleum Scienceand Engineering2003，39，1： | 1 |
| 4 | Characterisation of riverine particulate organic matter by pyrolysis-gas chromatography-mass spectrometry 显示文摘 | DACUNHA L C SERVE L GADEL F | 2000 | The Science of the Total Environment2000，256，23： | 1 |
| 5 | Efficient modeling of nonconventional wells with down hole inflow control device 显示文摘 | Valbatne P H Serve J Durlofsky L J | 2003 | Journal of Petroleum Science and Engineering2003，39，2： | 1 |
| 6 | Expression of the growth hormone gene in the ovine placenta:detection and cellular localization of the protein 显示文摘 | LACROIX M C DEVINOY E SERVELY J L | 1996 | Endocrinology1996，137，： | 1 |
| 7 | Case of Aeromonas veronii (DNA Group 10) Bacteremia显示文摘 | Abbott S L Serve H Janda J M | 1994 | Journal of Clinical Microbiology1994，32，12： | 1 |
| 8 | Lig- nin-derived phenolic compounds in the particulate organic mat- ter of a French Mediterranean river: seasonal and spatial varia- tions 显示文摘 | COTRIM DA CUNHA L SERVE L O GADEL F | 2001 | Organic Geochemistry2001，32，2： | 1 |
| 9 | An ex2perimental study and a randomized, double2blind, placebo2controlledclinical trial to evaluate the antisecretory activity of Lactobacillus aci2dophilus strain LB against nonrotavirus diarrhea 显示文摘 | L IV IN2LE MOAL V SARRAZ1N2DAV ILA L E SERV IN A L | 2007 | Pediatrics2007，120，4： | 1 |
| 10 | Efficient modeling of nonconventional wells with downhole inflow control device显示文摘 | Valbatne P H Serve J Durlofsky L J | 2003 | Journal of Petroleum Science and Engineering2003，39，2： | 1 |
| 11 | RGS2 is an important target gene of Flt3-ITD mutations in AML and functions in myeloid differentiation and leukemic transformation显示文摘 | Schw?ble J Choudhary C Thiede C Tickenbrock L Sargin B Steur C Rehage M Rudat A Brandts C Berdel WE Müller-Tidow C Serve H | | 0，，： | 1 |
| 12 | Is infrastructure capital productive?a dynamic heterogeneous approach显示文摘 | CALDERN C MORAL-BENITO E SERVN L | 2015 | Journal of applied econometrics2015，30，2： | 1 |
| 13 | Infrastructure and economic development in Sub-Saharan Africa显示文摘 | CALDERN C SERVN L | 2010 | Journal of African Economies2010，19，1： | 1 |
| 14 | High-quality and economically viable coating by means of tandem gas-shielded metal-arc welding显示文摘 | Appel D L Serve M Baum L | 2002 | Welding and Cutting2002，54，5： | 1 |
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