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| 1 | Role of receptor tyrosine kinases in gastric cancer: New targets for a selective therapy显示文摘受体酷氨酸家族 ases (RTK ) 象表皮的生长因素受体家庭那样包括增长和变形传播参予肿瘤形成的几步。几已知的 RTK 起来在是主要的胃的癌症调整了定制的治疗的目标。仅仅初步的数据然而,在使用上存在当前临床上可得到的药象在胃的癌症的背景的 trastuzumab, cetuximab, bevacizumab, gefitinib, erlotinib,和 imatinib 那样。现出症状之前的潜的数据建议他们的使用的一个潜在的好处,特别在有“常规”的抑制细胞的联合治疗。这评论象新途径和药一样在癌症治疗关于他们的使用总结当前的知识优化治疗成功。 | JC Becker C Müller-Tidow H Serve W Domschke T Pohle | 2006 | World Journal of Gastroenterology2006，12，21： | 19 |
| 2 | Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis显示文摘AIM:To evaluate the impact of metadoxine(MTD) on the 3- and 6-mo survival of patients with severe alcoholic hepatitis(AH).METHODS:This study was an open-label clinical trial,performed at the'Hospital General de México,Dr.Eduardo Liceaga'.We randomized 135 patients who met the criteria for severe AH into the following groups:35 patients received prednisone(PDN)40 mg/d,35patients received PDN+MTD 500 mg three times daily,33 patients received pentoxifylline(PTX)400 mg three times daily,and 32 patients received PTX+MTD 500 mg three times daily.The duration of the treatment for all of the groups was 30 d.RESULTS:In the groups treated with the MTD,thesurvival rate was higher at 3 mo(PTX+MTD 59.4%vs PTX 33.3%,P=0.04;PDN+MTD 68.6%vs PDN20%,P=0.0001)and at 6 mo(PTX+MTD 50%vs PTX18.2%,P=0.01;PDN+MTD 48.6%vs PDN 20%,P=0.003)than in the groups not treated with MTD.A relapse in alcohol intake was the primary independent factor predicting mortality at 6 mo.The patients receiving MTD maintained greater abstinence than those who did not receive it(74.5%vs 59.4%,P=0.02).CONCLUSION:MTD improves the 3-and 6-mo survival rates in patients with severe AH.Alcohol abstinence is a key factor for survival in these patients.The patients who received the combination therapy with MTD were more likely to maintain abstinence than those who received monotherapy with either PDN or PTX. | Fátima Higuera-de la Tijera Alfredo I Servín-Caamano Aurora E Serralde-Zúniga Javier Cruz-Herrera Eduardo Pérez-Torres Juan M Abdo-Francis Francisco Salas-Gordillo JoséL Pérez-Hernández | 2015 | World Journal of Gastroenterology2015，21，16： | 8 |
| 3 | Analysis of the genetic interactions between Cyclin A1, Atm and p53 during spermatogenesis显示文摘瞄准:在精子发生和 DNA 双海滨裂缝修理与 p53 和 Atm 分析 Cyclin 的功能的相互作用。方法:两倍猛烈老鼠的二根线被产生。精子发生和两倍海滨裂缝修理机制在 Cyclin A1 (Ccnal ) 被分析;p53- 和 Ccnal;Atm -- 两倍猛烈老鼠。结果:在在 mid-diplotene 阶段在 Cyclin A1-/-(Ccnal-/-) 睾丸观察的精子发生的块与 polynucleated 巨人房间被联系。我们发现 Ccnal 缺乏的睾丸和特别巨大的房间积累 DNA 双海滨打破,为 phosphorylated H2AX 由免疫组织化学检测了的 unrepaired。另外,巨大的房间逃离 apoptosis。因为睾丸缺乏 ATM,它为 develop 精子发生的所知比前期Ⅰ早逮捕,巨大的房间的发展发生在 meiotic 前期Ⅰ,别当 cyclin A1 不在时开发巨大的房间。Cyclin A1 与 CDK2 在建筑群与 p53 和 phosphorylated p53 交往了。有趣地, p53 缺乏显著地在 Ccnal 缺乏的睾丸增加了巨大的房间的数字。在变异的睾丸的 DNA 修理基因的一块面板的基因表达式分析表明任何一个都一致地没当 cyclin A1 不在时检验的基因被调整。结论:在精子发生的 Ccnal 缺乏在 DNA 双海滨裂缝修理与缺点被联系,它被 p53 的损失提高。 | Nicole Baiumer Marie-Luise Sandstede Sven Diederichs Gabriele Kohler Carol Readhead Ping Ji Feng Zhang Etmar Bulk Jorg Gromoll Wolfgang E. Berdel Hubert Serve Carsten Muller-Tidow | 2007 | Asian Journal of Andrology2007，9，6： | 4 |
| 4 | Malnutrition negatively impacts the quality of life of patients with cirrhosis: An observational study显示文摘AIM To verify how malnutrition is related to health-related quality of life(HRQL) impairment in patients with cirrhosis.METHODS Data was retrospectively abstracted from medical records and obtained by direct interview. We included patients with cirrhosis from any etiology, evaluated at the Liver Clinic from Gastroenterology Department in a tertiary healthcare center, from June 2014 to June 2016. Child-Pugh score, data about complications, and demographic, clinical and anthropometric characteristics of patients were obtained. Nutritional status was evaluated by the Subjective Global Assessment(SGA). HRQL was evaluated through the Chronic Liver Disease Questionnaire. Patients were requested to assess their global HRQL with the following code: 0 = impairment of HRQL, when it was compared with other healthy subjects; 1 = good HRQL, if it was similar to the quality of life of other healthy subjects. To compare the primary outcome between malnourished and well-nourished groups, the χ~2 test, Fisher's exact test or Student's t-test were used, based on the variable type. Associations between predictor variables and deterioration of HRQL were determined by calculating the hazard ratio and 95% confidence interval using Cox proportional hazards regression. RESULTS A total of 127 patients with cirrhosis were included, and the mean age was 54.1 ± 12.3 years-old. According to Child-Pugh scoring, 25(19.7%) were classified as A(compensated), 76(59.8%) as B, and 26(20.5%) as C(B/C = decompensated). According to SGA, 58(45.7%) patients were classified as well-nourished. Sixty-nine patients identified HRQL as good, and 76 patients(59.8%) perceived impairment of their HRQL. Multivariate analysis to determine associations between predictor variables and self-perception of an impairment of HRQL found strong association with malnutrition(P < 0.0001). The most important impaired characteristics in malnourished patients were: Presence of body pain, dyspnea on exertion with daily activities, decreased appetite, generalized weakness, trouble lifting or carrying heavy objects, and decreased level of energy(P < 0.0001).CONCLUSION Malnutrition is a key factor related to impairment of HRQL in patients with cirrhosis. | Gabriela Rojas-Loureiro Alfredo Servín-Caamano Elizabeth Pérez-Reyes Luis Servín-Abad Fátima Higuerade la Tijera | 2017 | World Journal of Hepatology2017，9，5： | 3 |
| 5 | Simulating global soil-CO_2 flux and its response to climate change显示文摘It has been argued that increased soil respiration would become a major atmospheric source of CO\-2 in the event of global warming. The simple statistical models were developed based on a georeferenced database with 0 5°×0 5° longitude/latitude resolution to simulate global soil\|CO\-2 fluxes, to investigate climatic effects on these fluxes using sensitivity experiments, and to assess possible responses of soil\|CO\-2 fluxes to various climate change scenarios. The statistical models yield a value of 69 PgC/a of global soil\|CO\-2 fluxes for current condition. Sensitivity experiments confirm that the fluxes are responsive to changes in temperature, precipitation and actual evapotranspiration, but increases in temperature and actual evapotranspiration affect soil\|CO 2 fluxes more than increases in precipitation. Using climatic change projections from four global circulation models, each corresponding to an equilibrium doubling of CO 2, it can be found that the largest increases in soil\|CO 2 fluxes were associated with the boreal and tundra regions. The globally averaged soil\|CO 2 fluxes were estimated to increase by about 35% above current values, providing a positive feedback to the greenhouse effect. | PENG Chang\|hui 1* , Michael J. Apps\+2 (1 Ontario Forest Research Institute, Ministry of Natural Resources, 1235 Queen Street East, Sault Ste. Marie, ON P6A 2E5,Canada. E\|mail: pengc@gov.on.ca 2 Morthern Forestry Center, Canadian Forest Serv | 2000 | Journal of Environmental Sciences2000，12，3： | 2 |
| 6 | Progress and challenges in the comprehensive management of chronic viral hepatitis: Key ways to achieve the elimination显示文摘Chronic viral hepatitis is a significant health problem throughout the world,which already represents high annual mortality.By 2040,chronic viral hepatitis due to virus B and virus C and their complications cirrhosis and hepatocellular carcinoma will be more deadly than malaria,vitellogenesis-inhibiting hormone,and tuberculosis altogether.In this review,we analyze the global impact of chronic viral hepatitis with a focus on the most vulnerable groups,the goals set by the World Health Organization for the year 2030,and the key points to achieve them,such as timely access to antiviral treatment of direct-acting antiviral,which represents the key to achieving hepatitis C virus elimination.Likewise,we review the strategies to prevent transmission and achieve control of hepatitis B virus.Finally,we address the impact that the coronavirus disease 2019 pandemic has had on implementing elimination strategies and the advantages of implementing telemedicine programs. | Fátima Higuera-de la Tijera Alfredo Servín-Caamaño Luis Servín-Abad | 2021 | World Journal of Gastroenterology2021，27，26： | 2 |
| 7 | Kinetic basis for the substrate specificity during hydrolysis of phospholipids by secreted phospholipase A2 显示文摘 | ROGERS J YU B Z SERVES S V | 1996 | Biochemistry1996，35，29： | 1 |
| 8 | Case of Aeromonas veronii( DNA Group 10 ) bacteremia 显示文摘 | ABBOTT S L SERVE H JANDA J M | 1994 | J Clin Microbiol1994，32，12： | 1 |
| 9 | Expression of the growth hormone gene in ovine placenta:detection and cellular localization of the protein显示文摘 | Lacroix MC Devinoy E Servely JL | 1996 | Endocrinology1996，137，： | 1 |
| 10 | E-and A-type cyelins as markers for cancer diagnosis and prognosis 显示文摘 | Yasmeen A Berdel WE Serve H | 2003 | Expert Rev Mol Diagn2003，3，5： | 1 |
| 11 | A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia ( AML ) or not amenable to conventional therapy for the disease显示文摘 | Fiedler W Serve H Dohenr H | 2005 | Blood2005，105，3： | 1 |
| 12 | Determination of antimony species with high-performance liquid chromatography using element specific detection显示文摘 | LINTSCHINGER J KOCH I SERVES S | 1997 | Fresenius''J Anal Chem1997，359，： | 1 |
| 13 | A phase I study of SUI1248 in the treatment of patients with refractory or resistant acute myeloid leukemia(AMI)or not amenable to conventional therapy for the disease显示文摘 | Fiedler W Serve H Dohner H | 2005 | Blood2005，105，： | 1 |
| 14 | E-and A-type eye- lins as markers for cancer diagnosis and prognosis 显示文摘 | Yasmeen A Berdel W E Serve H | 2003 | Ex- pert Rev Mol Diagn2003，3，61： | 1 |
| 15 | Ubiquitination and selective autophagy显示文摘 | Shaid S Brandts CH Serve H | 2013 | Cell Death Differ2013，20，： | 1 |
| 16 | A phase Ⅰ study of SU11248 in tile treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease 显示文摘 | Fiedler W Serve H Dohner H | 2005 | Blood2005，105，3： | 1 |
| 17 | E-and A-type cyclins as markers for cancer diagnosis and prognosis 显示文摘 | Yasmeen A Berdel W E Serve H | 2003 | ExpertRevMolDiagn2003，3，5： | 1 |
| 18 | A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease 显示文摘 | FIEDLER W SERVE H DOHNER H | 2005 | Blood2005，105，3： | 1 |
| 19 | Efficient modeling of nonconventional wells with downholeinflow control devices显示文摘 | VALVATNE P H SERVE J DURLOFSKY L J | 2003 | Journal of Petroleum Scienceand Engineering2003，39，1： | 1 |
| 20 | Characterisation of riverine particulate organic matter by pyrolysis-gas chromatography-mass spectrometry 显示文摘 | DACUNHA L C SERVE L GADEL F | 2000 | The Science of the Total Environment2000，256，23： | 1 |
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