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| 1 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 2 | Fundamentals of case study research in family medicine and community health显示文摘The aim of this article is to introduce family medicine researchers to case study research,a rigorous research methodology commonly used in the social and health sciences and only distantly related to clinical case reports.The article begins with an overview of case study in the social and health sciences,including its definition,potential applications,historical background and core features.This is followed by a 10-step description of the process of conducting a case study project illustrated using a case study conducted about a teaching programme executed to teach international family medicine resident learners sensitive examination skills.Steps for conducting a case study include(1)conducting a literature review;(2)formulating the research questions;(3)ensuring that a case study is appropriate;(4)determining the type of case study design;(5)defining boundaries of the case(s)and selecting the case(s);(6)preparing for data collection;(7)collecting and organising the data;(8)analysing the data;(9)writing the case study report;and(10)appraising the quality.Case study research is a highly flexible and powerful research tool available to family medicine researchers for a variety of applications. | Sergi Fàbregues Michael D Fetters | 2019 | Family Medicine and Community Health2019，7，2： | 8 |
| 3 | The topological relationship between the large-scale attributes and local interaction patterns of complex networks显示文摘 | Dobrin R Sergi D | 2004 | Proceedings of the National Academy of Sciences of the United States of America2004，101，17： | 1 |
| 4 | High- and lowresolution mass spectrometry coupled to liquid chromatography as confirmatory methods of anabolic residues in crude meat and infant foods 显示文摘 | GENTILI A SERGI M PERRET D | 2006 | Rapid Communications in Mass Spectrometry2006，20，12： | 1 |
| 5 | alphaTocopherol protective effects on gentamicin ototoxicity: an experimental study显示文摘 | Fetoni AR Sergi B Ferraresi A Paludetti G Troiani D | 2004 | Int J Audiol2004，43，3： | 1 |
| 6 | Adsorption of Phenylalanine onto Polymeric Resins: Equilibrium, Kinetics and Operation of a Parametric Pumping Unit 显示文摘 | Sergi D Anabela L Licinio F etal | 1998 | Separation and Purification Technology1998，13，： | 1 |
| 7 | The topological relationship between the large-scale attributes and local interactionpatterns of complex networks显示文摘 | Vazquez A Dobrin R Sergi D | 2004 | Proceedings of the National Academy of Sciences2004，101，17： | 1 |
| 8 | The topological relationship between the large-scale attributes and local interaction patterns of complex networks显示文摘 | Vazquez A Dobrin R Sergi D | 2004 | Proceedings of the National Academy of Sciences of the United States of America2004，101，17： | 1 |
| 9 | Nceadjuvant endocrine therapy for locally advanced breast cancer显示文摘 | Viola G Sergi D Conti F | 2007 | Clin Ter2007，158，5： | 1 |
| 10 | Micro-solid phase extraction coupled with high-performance liquid chromatographytandem mass spectrometry for the determination of stimulants,hallucinogens,ketamine and phencyclidine in oral fluids显示文摘 | Sergi M Compagnone D Curini R | 2010 | Anal Chim Acta2010，675，2： | 1 |
| 11 | Comparative expression analysis of Pax3 and pax7 during mouse myogenesis显示文摘 | Horst D Ustanina S Sergi C | 2006 | Int J Dev Biol2006，50，1： | 1 |
| 12 | Postural control and glycerol test in Meniere's disease显示文摘 | Di Girolamo S Picciotti P Sergi B D'Ecclesia A Di Nardo W | 2001 | Acta Otolaryngol2001，121，7： | 1 |
| 13 | Lack of intra-aortie balloon pump ef- fiectiveness in high-risk percutaneous coronary interventions without cardiogenic shock: a comprehensive meta-analysis of randomised trials and obsmwational studies 显示文摘 | Romeo F Aeconcia MC Sergi D | 2013 | lnt J Cardiol2013，167，5： | 1 |
| 14 | Prevalence of normal tension glaucoma in obstructive sleep apnea syndrome patients 显示文摘 | Sergi M Salemo DE Rizzi M Blini M Andreoli A Messenio D | 2007 | Glaucoma2007，15，： | 1 |
| 15 | Psyche and cancer显示文摘 | Lopez M Cauchi C Sergi D | 2010 | Clin Ter2010，161，1： | 1 |
| 16 | α-Tocopherol may influence cellular signaling by modulating jasmonic acid levels in plants显示文摘 | Sergi Munné-Bosch Elmar W. Weiler Leonor Alegre Maren Müller Petra Düchting Jon Falk | 2007 | Planta2007，，3： | 1 |
| 17 | Determination of methylmercury in human hair by ethylation followed by headspace solid-phase microextraction–gas chromatography–cold-vapour atomic fluorescence spectrometry显示文摘 | Sergi D??ez Josep M Bayona | 2002 | Journal of Chromatography A2002，，1： | 1 |
| 18 | Micro solid phase extraction coupled with high-performance liquid chro- matography tandem mass spectrometry for the determina- tion of stimulants, hallucinogens, ketamine and phencyclid- ine in oral fluids 显示文摘 | Sergi M Compagnone D Curini R | 2010 | Analytica Chimica Acta2010，，675： | 1 |
| 19 | Third-line chemotherapy in small-cell lung cancer: an intemational analysis显示文摘 | Simos D Sajjady G Sergi M | 2014 | Clin Lung Cancer2014，15，2： | 1 |
| 20 | Entropy of dialogues creates coherent structures in e-mail traffic显示文摘 | ECKMANN J P MOSES E SERGI D | 2004 | Proceedings of the National Academy of Sciences of the United States of America2004，，14： | 1 |
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