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| 1 | Percutaneous assist devices in acute myocardial infarction with cardiogenic shock: Review, meta-analysis显示文摘AIM: To assess the impact of percutaneous cardiac support in cardiogenic shock(CS) complicating acute myocardial infarction(AMI), treated with percutaneous coronary intervention. METHODS: We selected all of the studies published from January 1st, 1997 to May 15 st, 2015 that compared the following percutaneous mechanical support in patients with CS due to AMI undergoing myocardial revascularization:(1) intra-aortic balloon pump(IABP) vs Medical therapy;(2) percutaneous left ventricular assist devices(PLVADs) vs IABP;(3) complete extracorporeal life support with extracorporeal membrane oxygenation(ECMO) plus IABP vs IABP alone; and(4) ECMO plus IABP vs ECMO alone, in patients with AMI and CS undergoing myocardial revascularization. We evaluated the impact of the support devices on primary and secondary endpoints. Primary endpoint was the inhospital mortality due to any cause during the same hospital stay and secondary endpoint late mortality at 6-12 moof follow-up. RESULTS: One thousand two hundred and seventytwo studies met the initial screening criteria. After detailed review, only 30 were selected. There were 6 eligible randomized controlled trials and 24 eligible observational studies totaling 15799 patients. We found that the inhospital mortality was:(1) significantly higher with IABP support vs medical therapy(RR = +15%, P = 0.0002);(2) was higher, although not significantly, with PLVADs compared to IABP(RR = +14%, P = 0.21); and(3) significantly lower in patients treated with ECMO plus IABP vs IABP(RR =-44%, P = 0.0008) or ECMO(RR =-20%, P = 0.006) alone. In addition, Trial Sequential Analysis showed that in the comparison of IABP vs medical therapy, the sample size was adequate to demonstrate a significant increase in risk due to IABP. CONCLUSION: Inhospital mortality was significantly higher with IABP vs medical therapy. PLVADs did not reduce early mortality. ECMO plus IABP significantly reduced inhospital mortality compared to IABP. | Francesco Romeo Maria Cristina Acconcia Domenico Sergi Alessia Romeo Simona Francioni Flavia Chiarotti Quintilio Caretta | 2016 | World Journal of Cardiology2016，8，1： | 29 |
| 2 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 3 | Fundamentals of case study research in family medicine and community health显示文摘The aim of this article is to introduce family medicine researchers to case study research,a rigorous research methodology commonly used in the social and health sciences and only distantly related to clinical case reports.The article begins with an overview of case study in the social and health sciences,including its definition,potential applications,historical background and core features.This is followed by a 10-step description of the process of conducting a case study project illustrated using a case study conducted about a teaching programme executed to teach international family medicine resident learners sensitive examination skills.Steps for conducting a case study include(1)conducting a literature review;(2)formulating the research questions;(3)ensuring that a case study is appropriate;(4)determining the type of case study design;(5)defining boundaries of the case(s)and selecting the case(s);(6)preparing for data collection;(7)collecting and organising the data;(8)analysing the data;(9)writing the case study report;and(10)appraising the quality.Case study research is a highly flexible and powerful research tool available to family medicine researchers for a variety of applications. | Sergi Fàbregues Michael D Fetters | 2019 | Family Medicine and Community Health2019，7，2： | 8 |
| 4 | GSTM3, but not IZUMO1, is a cryotolerance marker of boar sperm显示文摘Background: Cryopreservation is currently the most efficient method for long-term preservation of mammalian gametes and is extensively used in swine artificial insemination(AI) centres. However, it is well-known that cryopreservation procedures induce changes in the water phase in both intra and extracellular compartments,which alter the content and localisation of several proteins and ends up curtailing the structural integrity of functional sperm(i.e., cryoinjuries). Alterations and deficiencies of sperm-oocyte binding proteins during gamete recognition are one of the causes of reproductive failure both in vitro and in vivo. In this sense, characterisation of cryopreservation effects upon oocyte-binding proteins of sperm, such as IZUMO1 and GSTM3, is essential when assessing the impact of this technique in swine reproduction.Results: Cryopreservation was found to induce changes in the localisation of IZUMO1 and GSTM3 in boar sperm.However, the relative content of both proteins was not altered after thawing. Furthermore, whereas IZUMO1 content was found not to be related to the cryotolerance of boar sperm, GSTM3 content was observed to be higher in poor(PFE) than in good(GFE) freezability ejaculates in both pre-frozen(1.00 INT·mm^2± 0.14 INT·mm^2 vs.0.72 INT·mm^2± 0.15 INT·mm^2;P < 0.05) and post-thawed(0.96 INT·mm^2± 0.20 INT·mm^2 vs. 70 INT·mm^2± 0.19 INT·mm^2;P < 0.05) samples. Moreover, GSTM3 levels were found to be higher in those spermatozoa that exhibited low mitochondrial activity, high reactive oxygen species(ROS) production, and high membrane lipid disorder postthaw(P < 0.05).Conclusions: The difference in GSTM3 content between GFE and PFE, together with this protein having been found to be related to poor sperm quality post-thaw, suggests that it could be used as a cryotolerance marker of boar spermatozoa. Furthermore, both IZUMO1 and GSTM3 relocate during cryopreservation, which could contribute to the reduced fertilising capacity of frozen-thawed boar sperm. | Marc Llavanera Ariadna Delgado-Bermúdez Beatriz Fernandez-Fuertes Sandra Recuero Yentel Mateo Sergi Bonet Isabel Barranco Marc Yeste | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 4 |
| 5 | Hirschsprung's disease:Historical notes and pathological diagnosis on the occasion of the 100^(th) anniversary of Dr.Harald Hirschsprung's death显示文摘Hirschsprung's disease(HSCR) or congenital megacolon is one of the differential diagnoses of chronic constipation mostly in infancy and may indeed represent a challenge for pediatricians, pediatric surgeons, and pediatric pathologists. The diagnosis relies clearly on the identification of the absence of ganglion cells at the plexuses(submucosus and myentericus) of the bowel wall. HSCR is usually located at the terminal(distal) rectum with potential pre-terminal or proximal extension to the less distal large bowel(sigmoid colon). Astonishingly, there is some evidence that Hindu surgeons of prehistoric India may have been exposed and had considerable knowledge about HSCR, but this disease is notoriously and eponymously named to Dr. Harald Hirschsprung(1830-1916), who brilliantly presented two infants with fatal constipation at the Berlin conference of the German Society of Pediatrics more than one century ago. Historical milestones and diagnosis of HSCR(originally called 'Die Hirschsprungsche Krankheit') are reviewed. More than 100 years following his meticulous and broad description, HSCR is still a puzzling disease for both diagnosis and treatment. HSCR remains a critical area of clinical pediatrics and pediatric surgery and an intense area of investigation for both molecular and developmental biologists. | Consolato Sergi | 2015 | World Journal of Clinical Pediatrics2015，4，4： | 4 |
| 6 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 7 | 猪喘气病免疫应考虑的因素——如何发挥疫苗的最大效力显示文摘猪喘气病是由猪肺炎支原体(Mycoplasmahyopneumoniae.MH)感染引起的一种慢性消耗性疾病。临床表现咳嗽和气喘,患病动物体温、食欲变化不明显,剖检可见肺脏心叶、中间叶和尖叶有融合性支气管炎变化。国内MH的发病率为30%~50%,而感染率高达85%以上。包智祥等对扬州市的猪进行血清学调查发现,MH感染率为100%。虽然有喘气病净化成功的例子,但是在中国、美国、德国、西班牙、丹麦、荷兰、英国等主要养猪国家净化喘气病还不现实。 | 周绪斌 Sergi Bruguera 秦云 | 2007 | 养猪2007，，5： | 3 |
| 8 | Identification of Lynch syndrome: How should we proceed in the 21^(st) century?显示文摘Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is the most common form of hereditary colorectal cancer. Although great advances in the understanding of its molecular basis have taken place in the last decade, optimal selection of individuals for HNPCC genetic testing remains controversial. This is especially relevant since colonoscopy has been proven effective for reducing colorectal cancer incidence and mortality in individuals at-risk for this disorder. In this manuscript, we summarize the most significant contributions to this important issue that have appearedin the last few years. | Antoni Castells Francesc Balaguer Sergi Castellví-Bel Victòria Gonzalo Teresa Ocaa | 2007 | World Journal of Gastroenterology2007，13，33： | 3 |
| 9 | 西班牙巴塞罗那 坚决和首都明争暗斗到底显示文摘据说在西班牙首都马德里,人们常常会开这样的玩笑:你要去巴塞罗那?有签证吗?”的确。对许多西班牙人来说,加泰罗尼亚自治区虽只是一个自治区,却近乎“异邦”。 | 荣楠楠 Sergi Larripa | 2012 | 环球人文地理2012，，8： | 2 |
| 10 | Angiogenic Remodeling in Pediatric EoE Is Associated With Increased Levels of VEGF-A, Angiogenin, IL-8, and Activation of the TNF-α–NFκB Pathway显示文摘 | Rabindranath Persad Hien Q. Huynh Li Hao Jacqueline R. Ha Consolato Sergi Rahul Srivastava Sujata Persad | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012，，3： | 2 |
| 11 | Mercury uptake and effects on growth in Jatropha curcas显示文摘The use of metal-accumulating plants for the phytoremediation of contaminated soils is gaining more attention. Mercury(Hg)-contaminated soils from historical gold mines represent a potential risk to human health and the environment. Therefore, Jatropha curcas plant, that has shown its tolerance to these environments, is a species of particular interest to implement phytoremediation techniques in gold mining sites. In this work, the behavior of J. curcas was assessed in different hydroponic cultures fortified with Hg at concentrations of 5, 10, 20, 40, and 80 μg Hg/mL(T5, T10, T20, T40 and T80, respectively). After exposure,plant growth, net photosynthesis, leaf area, and Hg accumulation were determined and variables such as net Hg uptake, effective Hg accumulation, translocation and bioaccumulation factors were calculated. Accumulation of Hg in root and leaf tissues increased with respect to the Hg concentrations in the hydroponic culture, with statistically significant differences(p < 0.05) among treatments. Moreover, Hg concentration in roots was 7 and 12-fold higher in average than in plant leaves and shoots, respectively. Many effects were found in the development of plants, especially related with loss of biomass and leaf area,with significant growth inhibition related to control values(> 50% with treatment T5).Moreover, percentage of inhibition was even higher(> 60%) with same treatment for net photosynthesis. Finally, it should be highlighted that for T40 and T80 treatments, plant growth and photosynthesis were almost completely depleted(88%–95%). | Jose Marrugo-Negrete Jose Durango-Hernandez Jose Pinedo-Hernandez German Enamorado-Montes Sergi Diez | 2016 | Journal of Environmental Sciences2016，28，10： | 2 |
| 12 | Leaves of Field-Grown Mastic Trees Suffer Oxidative Stress at the Two Extremes of their Lifespan显示文摘Leaf senescence is a complex phenomenon occurring in all plant species, but it is still poorly understood in plants grown in Mediterranean field conditions and well-adapted to harsh climatic conditions. To better understand the physiological processes underlying leaf senescence in mastic trees (Pistacia lentiscus L.), we evaluated leaf growth, water and N content, photosystem II (PSII) photochemistry, lipid peroxidation and levels of photosynthetic pigments, antioxidants, abscisic acid, and salicylic acid and jasmonic acid during the complete leaf lifespan, from early expansion to late senescence in relation to natural climatic conditions in the field. While mature leaves suffered from water and N deficit during late spring and summer, both young (emerging) and old (senescing) leaves were most sensitive to photo-oxidative stress, as indicated by reductions in the F v/F m ratio and enhanced lipid peroxidation during late autumn and winter. Reductions in the F v/F m ratio were associated with low α-tocopherol (vitamin E) levels, while very old, senescing leaves additionally showed severe anthocyanin losses. We have concluded that both young (emerging) and old (senescing) leaves suffer oxidative stress in mastic trees, which may be linked in part to suboptimal temperatures during late autumn and winter as well as to low vitamin E levels. | Marta Juvany Maren Müller Sergi Munn-Bosch | 2012 | Journal of Integrative Plant Biology2012，54，8： | 2 |
| 13 | The topological relationship between the large-scale attributes and local interaction patterns of complex networks显示文摘 | Dobrin R Sergi D | 2004 | Proceedings of the National Academy of Sciences of the United States of America2004，101，17： | 1 |
| 14 | New techniques and technolo-gy to repair cerebrospinal fluid rhinorrhea显示文摘 | Paludetti G Sergi B Rigante M | 2004 | Acta Otorhinolaryngol Ital2004，24，3： | 1 |
| 15 | Protective effects of alpha-toeopherol and tie- pronin against cisplatin- induced ototoxicity显示文摘 | Fetoni AR Sergi B | 2004 | Acta Otolaryngol2004，124，4： | 1 |
| 16 | High- and lowresolution mass spectrometry coupled to liquid chromatography as confirmatory methods of anabolic residues in crude meat and infant foods 显示文摘 | GENTILI A SERGI M PERRET D | 2006 | Rapid Communications in Mass Spectrometry2006，20，12： | 1 |
| 17 | Factor V Leiden mutation in women with early recurrent pregnancy loss a recta-analysis and systematic review of the causal association显示文摘 | Sergi C | 2015 | Arch Gynecol Obstet2015，291，3： | 1 |
| 18 | The Meta-analysis of impact of drug class on adherence to antihypertensives显示文摘 | Kronish IM Woodward M Sergie Z | 2011 | Cir- culation2011，123，15： | 1 |
| 19 | A parallel genetic local search algorithm for intrusion detection in computer networks显示文摘 | Mohammad Saniee Abadeh Jafar Habibi Zeynab Barzegar Muna Sergi | 2007 | Engineering Applications of Artificial Intelligence2007，20，8： | 1 |
| 20 | An artificial moth:Chemical source localization using a robot based neuronal model of moth optomotor anemotactic search显示文摘 | PAWEL Pyk SERGI Berm'udezi Badia ULYSSES Bernardet | 2006 | Auton Robot2006，20，： | 1 |
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