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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | The interrelationship between surface froth characteristics and industrial flotation performance显示文摘 | MOOLMAN D W ALDRICH C SCHMITZ G P J | 1996 | Minerals Engineering1996，9，8： | 1 |
| 3 | Contractual solutions to hold-up problems with quality uncertainty and unobservable investments显示文摘 | SCHMITZ P W | 2010 | Journal of Mathematical Economics2010，46，5： | 1 |
| 4 | Acid etch of automotive clear coatings ( Ⅱ ) Comparison of degradation chemistry in laboratory and field tesing 显示文摘 | P J Schmitz J W Holubka Li- Feng Xu | 2000 | Journal of Coatings Technology2000，72，902： | 1 |
| 5 | Mechanisms of environmental etch of acrylic melamine - based automotive clear coats:Identification of degradation products 显示文摘 | P J Schmitz J W Holubka Li - Feng Xu | 2000 | Journal of Coatings Technology2000，72，904： | 1 |
| 6 | Results of electrical pacing in patients with hypertrophic obstruction cardiomyopathy显示文摘 | Hassenstein P Storch HH Schmitz W | 1975 | Thoraxchir Vask Chir1975，23，5： | 1 |
| 7 | The interrelationship between surface froth characteristics and industrial flotation performance显示文摘 | Moolman D W Aldrich C Schmitz G P J | | 0，，08： | 1 |
| 8 | On monopolistic Licensing Strategies under Asymmetric Information 显示文摘 | Schmitz P W | 2002 | Journal of Economic Theory2002，，106： | 1 |
| 9 | Cognitive abilities and behavioral biases显示文摘 | Oechssler J Roider A Schmitz P W | 2009 | Joumal of Economic Behavior and Organiza- tion2009，72，1： | 1 |
| 10 | On the phylogeny and taxonomy of the genus Uromastyx Merrem 1820(Reptilia:Squamata:Agamidae:Uromastycinae)-resurrection of the genus Saara Gray 1845显示文摘 | Wilms T Bohme W Wagner P Lutzmann N Schmitz A | | 0，，： | 1 |
| 11 | On Monopolistic Licensing Strategies Under AsymmetricInformation显示文摘 | Schmitz P W | 2002 | Journal of Economic Theory2002，，106： | 1 |
| 12 | Endotoxin and cytokines induce direct cardiodepressive effects in mammalian cardiomyocytes via induction of nitric oxide synthase显示文摘 | Stein B Frank P Schmitz W | | 0，，08： | 1 |
| 13 | Adsorption of auro- cyanide complexes onto carbonaceous matter from pregrobbing gold strike ore显示文摘 | Schmitz P A Duyvesteyn S Johnson W P | 2001 | Hydrometallurgy2001，61，2： | 1 |
| 14 | The in- terrelationship between surface froth characteristics and industrial flotation performance 显示文摘 | MOOLMAN D W ALDRICH C SCHMITZ G P J | 1996 | Minerals Engineer- ing1996，9，8： | 1 |
| 15 | Endotoxin and cytokines induce direct cardiodepressive effects in mammalian cardiomyocytes via induction of nitric oxide synthase 显示文摘 | Stein B Frank P Schmitz W | 1996 | J Mol Cell Cardiol1996，28，8： | 1 |
| 16 | On monopolistic licensing strategies under asymmetric information显示文摘 | SCHMITZ P W | 2002 | Journal of Economic Theory2002，106，1： | 1 |
| 17 | Acid etch of automotive clearcoats Ⅱ : Comparison of degradation chemistry in laboratory and field testing显示文摘 | SCHMITZ P J HOLOBKA J W XU LI - FENG | 2000 | Journal of Coatings Technology2000，72，3： | 1 |
| 18 | In-vitro exam?ination of clinically relevant stent parameters显示文摘 | Schmitz K-P Schmidt W Behrens P | 2000 | Prog Bi?omed Res2000，5，： | 1 |
| 19 | Public versus private ownership : quantity contracts and the allocation of in- vestment tasks 显示文摘 | HOPPE E I SCHMITZ P W | 2009 | Journal of Public Economics2009，94，34： | 1 |
| 20 | The interrelationship between surface froth characteristics and industrial flotation performance显示文摘 | Moolman D W Aldrich C Schmitz G P J | 1996 | Minerals Engineering1996，9，8： | 1 |
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