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| 1 | Improved guided bone regeneration by combined application of unmodified, fresh autologous adipose derived regenerative cells and plasma rich in growth factors:A first-in-human case report and literature review显示文摘BACKGROUND Novel strategies are needed for improving guided bone regeneration(GBR) in oral surgery prior to implant placement, particularly in maxillary sinus augmentation(GBR-MSA) and in lateral alveolar ridge augmentation(LRA). This study tested the hypothesis that the combination of freshly isolated, unmodified autologous adipose-derived regenerative cells(UA-ADRCs), fraction 2 of plasma rich in growth factors(PRGF-2) and an osteoinductive scaffold(OIS)(UAADRC/PRGF-2/OIS) is superior to the combination of PRGF-2 and the same OIS alone(PRGF-2/OIS) in GBR-MSA/LRA.CASE SUMMARY A 79-year-old patient was treated with a bilateral external sinus lift procedure as well as a bilateral lateral alveolar ridge augmentation. GBR-MSA/LRA was performed with UA-ADRC/PRGF-2/OIS on the right side, and with PRGF-2/OIS on the left side. Biopsies were collected at 6 wk and 34 wk after GBRMSA/LRA. At the latter time point implants were placed. Radiographs(32 mo follow-up time) demonstrated excellent bone healing. No radiological or histological signs of inflammation were observed. Detailed histologic,histomorphometric, and immunohistochemical analysis of the biopsies evidenced that UA-ADRC/PRGF-2/OIS resulted in better and faster bone regeneration than PRGF-2/OIS.CONCLUSION GBR-MSA with UA-ADRCs, PRGF-2, and an OIS shows effectiveness without adverse effects. | ?nder Solakoglu Werner G?tz Maren C Kiessling Christopher Alt Christoph Schmitz Eckhard U Alt | 2019 | World Journal of Stem Cells2019，11，2： | 3 |
| 2 | Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection显示文摘AIM: Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159)polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD)and chronic hepatitis C virus (HCV) infection.METHODS: CD14 genotyping was performed by PCR-RFLP analysis in (a) 121 HCV patients, (b) 62 patients with alcohol-associated cirrhosis (Alc-Ci), (c) 118 individuals with heavy alcohol abuse without evidence of advanced liver damage (Alc-w/o Ci), and (d) 247 healthy controls.Furthermore, serum levels of soluble CD14 (sCD14) and transaminases were determined.RESULTS: The TT genotype was significantly more frequent in Alc-Ci compared to Alc-w/o Ci or controls (40.3% vs 23.7% or 24.0%, respectively). In Alc-w/o Ci,serum levels of transaminases did not differ significantly between patients with different CD14 genotypes. In HCV patients, TT-homozygotes had significantly higher sCD14 levels and sCD14 serum levels were significantly higher in patients with advanced fibrosis or cirrhosis. However,no association was found between CD14 genotypes and histological staging or grading.CONCLUSION: Considering serum transaminases as surrogate markers for alcoholic liver damage, the CD14 polymorphism seems to exhibit different effects during the course of ALD. Differences in genotype distribution between cirrhotic HCV patients and alcoholics and the known functional impact of this polymorphism on CD14 expression levels further indicate differences in the pathophysiological role of CD14 and CD14-mediated lipopolysaccharides signal transduction with regard to the stage as well as the type of the underlying liver disease. | C Meiler M Mühlbauer M Johann A Hartmann B Schnabl N Wodarz G Schmitz J Schlmerich C Hellerbrand | 2005 | World Journal of Gastroenterology2005，11，38： | 3 |
| 3 | Indian medicinal plants (Mexico) : Inhibitory activity on NF-kappa B as an anti-inflammatory model and antibacterial effects 显示文摘 | Bork P M Schmitz M L Weimann C | 1996 | Phytomedicine1996，3，3： | 1 |
| 4 | The interrelationship between surface froth characteristics and industrial flotation performance显示文摘 | MOOLMAN D W ALDRICH C SCHMITZ G P J | 1996 | Minerals Engineering1996，9，8： | 1 |
| 5 | Differential modulation of apopto- sis sensitivity in CD95 type I and type I显示文摘 | Seaffidi C Schmitz I Zha J | 1999 | J Biol Chem1999，274，22： | 1 |
| 6 | Rituximab Purging and/or Maintenance in Patients Undergoing Autologous Transplantation for Relapsed Follicular Lymphoma:a Prospective Randomized Trial From the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation显示文摘 | Pettengell R Schmitz N Gisselbrecht C | | 0，，3： | 1 |
| 7 | Design of robust adaptive frequency hopping for wireless medical telemetry systems显示文摘 | Park K J Park T R Schmitz C D | | 0，，02： | 1 |
| 8 | Analytical process damping stability prediction 显示文摘 | Tyler C T Schmitz T L | 2013 | Journal of Manufacturing Processes2013，15，1： | 1 |
| 9 | Postoperative pain management in orthopaedic patients: no differences in pain score,but improved stress control by epidural anaesthesia显示文摘 | Adams H A Saatweber P Schmitz C S | 2002 | Eur J Anaesthesiol2002，19，9： | 1 |
| 10 | Diagnosing mental disorders in primary care:The general health questionnaire (GHQ) and the symptom check list (SCL-90-R) as screening instruments显示文摘 | Schmitz N Kruse J Heckrath C | 1999 | Soc Psychiatry Psychiatr Epidemiol1999，34，7： | 1 |
| 11 | Neuroglobin mRNA expression after transient global brain ischemia and prolonged hypoxia in cell culture 显示文摘 | Schmidt-Kastner R Haberkamp M Schmitz C | 2006 | Brain Res2006，1103，1： | 1 |
| 12 | Soybean trypsin inhibitors reduce absorption of exogenous and in- crease loss of endogenous protein in miniature pigs 显示文摘 | BARTH C A LUNDING B SCHMITZ M | 1993 | Nutrition1993，123，12： | 1 |
| 13 | Birth weight correlates with size but not shape of the normal human placenta 显示文摘 | Haeussner E Schmitz C yon Koch F | 2013 | Placenta2013，34，7： | 1 |
| 14 | American college of sports medicine roundtable on exercise guidelines for cancer survivors显示文摘 | Schmitz KH Courneya KS Matthews C Demark-Wahnefried W Galv(a)o DA Pinto BM | | 0，，： | 1 |
| 15 | A method for predicting chatter stability for systems with speed-dependent spindle dynamics显示文摘 | Schmitz T L Ziegert J C Stanislaus C | | 0，，： | 1 |
| 16 | To tag or not to tag显示文摘 | Thomas M Caudle D M Schmitz C M | 2009 | Library HiTech2009，27，3： | 1 |
| 17 | High-density optical mapping of the human somatosensory cortex to vibrotactile stimulation显示文摘 | Koch S P Menert J Schmitz C | 2009 | Neuroimage2009，47，1： | 1 |
| 18 | Shape-selective isopropylation of naphthalene: reactivity of 2,6-diisopropylnaphthalene on dealuminated mordenites 显示文摘 | Schmitz A D Song C | 1996 | Catalysis Today1996，31，12： | 1 |
| 19 | Delivery of peptide and protein drugs over the blood-brain barrier显示文摘 | Brasnjevic I Steinbusch H W Schmitz C | 2009 | Prog Neurobiol2009，87，4： | 1 |
| 20 | Improved positioning accuracy of the PA10-6CE robot with geometric and flexibility calibration显示文摘 | Lightcap C Hamner S Schmitz T | 2008 | IEEE Transactions on Robotics2008，24，2： | 1 |
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