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| 1 | Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection显示文摘AIM: Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159)polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD)and chronic hepatitis C virus (HCV) infection.METHODS: CD14 genotyping was performed by PCR-RFLP analysis in (a) 121 HCV patients, (b) 62 patients with alcohol-associated cirrhosis (Alc-Ci), (c) 118 individuals with heavy alcohol abuse without evidence of advanced liver damage (Alc-w/o Ci), and (d) 247 healthy controls.Furthermore, serum levels of soluble CD14 (sCD14) and transaminases were determined.RESULTS: The TT genotype was significantly more frequent in Alc-Ci compared to Alc-w/o Ci or controls (40.3% vs 23.7% or 24.0%, respectively). In Alc-w/o Ci,serum levels of transaminases did not differ significantly between patients with different CD14 genotypes. In HCV patients, TT-homozygotes had significantly higher sCD14 levels and sCD14 serum levels were significantly higher in patients with advanced fibrosis or cirrhosis. However,no association was found between CD14 genotypes and histological staging or grading.CONCLUSION: Considering serum transaminases as surrogate markers for alcoholic liver damage, the CD14 polymorphism seems to exhibit different effects during the course of ALD. Differences in genotype distribution between cirrhotic HCV patients and alcoholics and the known functional impact of this polymorphism on CD14 expression levels further indicate differences in the pathophysiological role of CD14 and CD14-mediated lipopolysaccharides signal transduction with regard to the stage as well as the type of the underlying liver disease. | C Meiler M Mühlbauer M Johann A Hartmann B Schnabl N Wodarz G Schmitz J Schlmerich C Hellerbrand | 2005 | World Journal of Gastroenterology2005，11，38： | 3 |
| 2 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 3 | Left ventricular diastolic function parameters after PTCA and stent implantation显示文摘 | Schannwell CM Schoebel FC Schmitz M | 2001 | Z Kardiol2001，90，9： | 2 |
| 4 | Indian medicinal plants (Mexico) : Inhibitory activity on NF-kappa B as an anti-inflammatory model and antibacterial effects 显示文摘 | Bork P M Schmitz M L Weimann C | 1996 | Phytomedicine1996，3，3： | 1 |
| 5 | Assimilation and metabolism of formaldehyde by leaves appear unlikely to be of value for indoor air purification显示文摘 | SCHMITZ H HILGERS U WEIDNER M | 2000 | New Phytologist2000，147，2： | 1 |
| 6 | To Tag or not to tag? 显示文摘 | Thomas M Caudle D M Schmitz Cecilia M | 2009 | Library Hi Tech2009，3，： | 1 |
| 7 | Augmened vasoconstrictor response to serotonin precede development of artherosclerosis in aorta of WHHL rabbit显示文摘 | WINES P A SCHMITZ J M PFISTER S L | 1989 | Atheriosclerosis1989，9，2： | 1 |
| 8 | Assimilation and metabolism of formaldehyde by leaves appear unlikely to be of value for indoor air purification 显示文摘 | Schmitz H Hilgers U Weidner M | 2000 | New Phytologist2000，147，2： | 1 |
| 9 | Conventional chemoimmunotherapy(R-CHOEP-14)or high-dose therapy(R-Mega-CHOEP)for young,high-risk patients with aggressive B-cell lymphoma:Final results of the randomized Mega-CHOEP trial of the German High-Grade Non-Hodgkin Lymphoma Study Group(DSHNHL)显示文摘 | Schmitz N Nickelsen M Ziepert M | 2011 | J Clin Oncol2011，29，15： | 1 |
| 10 | Randomized trial of daily versus weekly administration of 2 - chlorodeoxyadenosine in patients with hairy cell leukemia: a muhicenter phase llI trial (SAKK 32/98) 显示文摘 | Zenhausern R Schmitz SF Solenthaler M | 2009 | Leuk Lymphoma2009，50，9： | 1 |
| 11 | Duodenal biopsies of HIV-infected patients with diarrhrea exhibit epithelial barrier defects but no active secretion显示文摘 | Stockmann M Fromm M Schmitz H | 1998 | AIDS1998，12，1： | 1 |
| 12 | Susceptibility oflodgepole pine to infestation by mountain pine beetles following partial cutting of stands显示文摘 | Amman G D McGregor M D Schmitz R F | 1988 | Can J For Res1988，18，： | 1 |
| 13 | Does a surgical antireflux procedure decrease the incidence of esophageal adenocarcinoma in Barrett's esophagus?A meta-analysis显示文摘 | Coery K E Schmitz S M Shaheen N J | 2003 | Am J Gastroenterol2003，98，11： | 1 |
| 14 | Soluble, Rigid-rod Polyimides with Dye-containing Side Groups v/a a Novel Precursor Route 显示文摘 | Schmitz L Rehahn M | 1993 | Macromolecules1993，26，17： | 1 |
| 15 | Neuroglobin mRNA expression after transient global brain ischemia and prolonged hypoxia in cell culture 显示文摘 | Schmidt-Kastner R Haberkamp M Schmitz C | 2006 | Brain Res2006，1103，1： | 1 |
| 16 | Soybean trypsin inhibitors reduce absorption of exogenous and in- crease loss of endogenous protein in miniature pigs 显示文摘 | BARTH C A LUNDING B SCHMITZ M | 1993 | Nutrition1993，123，12： | 1 |
| 17 | Androgens stimulate gonadotropin-II beta-subunit in eel pituitary cells in vitro 显示文摘 | Huang Y S Schmitz M Le Belle N | 1997 | Molecular and Cellular Endocrinology1997，131，2： | 1 |
| 18 | To tag or not to tag显示文摘 | Thomas M Caudle D M Schmitz C M | 2009 | Library HiTech2009，27，3： | 1 |
| 19 | An investigation of the dynamic absorber effect in high speed machining 显示文摘 | Duncan G S Tummond M F Schmitz T L | 2005 | International Journal of Machine Tools & Manufacture2005，45，45： | 1 |
| 20 | Relation of optimal lead positioning as defined by three-dimensional echocardiography to long- term benefit of cardiac resynchmnization 显示文摘 | Becker M Hoffmann R Schmitz F | 2007 | Am J Cardiol2007，100，11： | 1 |
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