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| 1 | Neuroendocrine neoplasms of liver-A 5-year retrospective clinico-pathological study applying World Health Organization 2010 classification显示文摘AIM To study the clinicopathological characteristics of neuroendocrine neoplasms(NEN) on liver samples and apply World Health Organization(WHO) 2010 grading of gastroenteropancreatic(GEP) NEN.METHODS Clinicopathological features of 79 cases of NEN of the liver diagnosed between January 2011 to December 2015 were analyzed. WHO 2010 classification of GEP NEN was applied and the tumors were graded as G1, G2 or G3. Two more categories, D1/2(discordant 1/2) and D2/3(discordant 2/3) were also applied. The D1/2 grade tumors had a mitotic count of G1 and Ki-67 index of G2. The D2/3 tumors had a mitotic count of G2 and Ki-67 index of G3. The follow up details which were available till the end of the study period(December 2015) were collected.RESULTS Of the 79 tumors, 16 each were G1 and G2, and 18 were G3 tumors. Of the remaining 29 tumors, 13 were assigned to D1/2 and 16 were D2/3 grade. Male preponderance was noted in all tumors except for G2 neoplasms, which showed a slight female predilection. The median age at presentation was 47 years(range 10-82 years). The most common presentation was abdominal pain(81%). Pancreas(49%) was the most common site of primary followed by gastrointestinal tract(24.4%) and lungs(18%). Radiologically, 87% of the patients had multiple liver lesions. Histopathologically, necrosis was seen in only D2/3 and G3 tumors. Microvascular invasion was seen in all grades. Metastasis occurred in all grades of primary NEN and the grades of the metastatic tumors and their corresponding primary tumors were similar in 67% of the cases. Of the 79 patients, 36 had at least one follow up visit with a median duration of follow up of 8.5 mo(range: 1-50 mo). This study did not show any impact of the grade of tumor on the short term clinical outcome of these patients.CONCLUSION Liver biopsy is an important tool for clinicopathological characterization and grading of NEN, especially when the primary is not identified. Eighty-seven percent of the patients had multifocal liver lesions irrespective of the WHO grade, indicating a higher stage of disease at presentation. Follow up duration was inadequate to derive any meaningful conclusion on long term outcome in our study patients. | Deepak Kalyansingh Burad Thomas Alex Kodiatte Sayd Mohamed Rajeeb Ashish Goel Chundamannil Eapen Eapen Banumathi Ramakrishna | 2016 | World Journal of Gastroenterology2016，22，40： | 10 |
| 2 | Proteomic analysis reveals changes in the liver protein pattern of rats exposed to dietary folate deficiency显示文摘 | Chanson A Sayd T Rock E | 2005 | J Nutr2005，135，： | 1 |
| 3 | Proteomic analysis of Semimembranosus and biceps femoris muscles from Bayo- nne dry-cured ham 显示文摘 | Th6ron L Sayd T Pinguet J | 2011 | Meat Science2011，88，： | 1 |
| 4 | Compar- ison of sarcoplasmic proteomes between two groups of pig muscles selected for shear force of cooked meat 显示文摘 | LAVILLE E SAYD T TERLOUW C | 2007 | J Agric Food Chern2007，55，14： | 1 |
| 5 | Serine peptidase inhibitors,the best predictor of beef ageing amongst a large set ofquantitative variables显示文摘 | Zamora F Aubry L Sayd T ei ol | 2005 | Meat Science2005，71，4： | 1 |
| 6 | Differences in pig muscle proteome according to HAL genotype:Implica-tions for meat quality defects显示文摘 | Laville E Sayd T Terlouw C | 2009 | J Agric Food Chem2009，57，11： | 1 |
| 7 | Chemical oxidation decreases proteolyticsusceptibility of skeletal muscle myofibrillar proteins显示文摘 | MORZEL M GATELIER P SAYD T | 2006 | Meat Science2006，73，3： | 1 |
| 8 | Differ-ential expression of sarcoplasmic proteins in four het-erogeneouso vine skeletal muscles 显示文摘 | HAMELIN M SAYD T CHAMBON C | 2007 | Proteomics2007，7，2： | 1 |
| 9 | Chemicaloxidation decreases proteolytic susceptibility ofskeletal muscle myofibrillar proteins 显示文摘 | Morzel M GateJlier P Sayd T | 2006 | MeatScience2006，73，3： | 1 |
| 10 | Direct estimation of non-rigid registrations with image-based self-occlusion reasoning显示文摘 | Gay-Bellile V Bartoli A Sayd P | 2010 | IEEE Transactions on Pattern Analysis and Machine Intelligence2010，32，1： | 1 |
| 11 | Proteomic analy- sis of ovine muscle hypertrophy 显示文摘 | Hamelin M Sayd T Chambon C | 2006 | Journal of Animal Science2006，84，12： | 1 |
| 12 | Chemical oxidation decreases proteolytic susceptibility of skeletal muscle myofibrillar proteins显示文摘 | Morzel M Gatellier P Sayd T | 2006 | Meat Science2006，73，3： | 1 |
| 13 | Experimental infection of swine by Isospora suis Biester 1934 for species confirmation显示文摘 | Sayd S M O Kawazoe U | 1998 | Mem inst Oswaldo Cruz Rio de Janeiro1998，93，6： | 1 |
| 14 | Chemical oxidation decreases proteolytlc susceptibility of skeletal muscle myofibrillar proteins显示文摘 | Morzel M GateUier P Sayd T etal | 2006 | Meat Science2006，73，3： | 1 |
| 15 | Earlypost-mortem sarcoplasmic proteome of porcine musclerelated to protein oxidation 显示文摘 | PROMEYRAT A SAYD T LAVILLE E | 2011 | Food Chemistry2011，127，3： | 1 |
| 16 | Application to proteomics to understand and modify meat quality显示文摘 | GOBERT M SAYD T GATELLIER P | 2014 | Meat Science2014，98，3： | 1 |
| 17 | Plasma proteome analysis :2D gels and chips 显示文摘 | Herosimczyk A Dejeans N Sayd T | 2006 | J Physiol Pharmacol2006，57，7： | 1 |
| 18 | Chemical oxidation decreases proteolytic susceptibility of skeletal muscle myofibrillar proteins显示文摘 | MARTINE M GATELLIER P SAYD T | | 0，，3： | 1 |
| 19 | Characterisation of PSE zones in semimembranosus pig muscle显示文摘 | Laville E Sayd T Sante-Lhoutellier V | 2005 | Meat Science2005，70，： | 1 |
| 20 | Proteome analysis of the sarcoplasmic fraction of pig semimembranosus muscle: Implications on meat color development 显示文摘 | Sayd T Morzel M Chambon C | 2006 | Journal of Agricultural and Food Chemistry2006，54，7： | 1 |
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