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| 1 | Listening to Turkish classical music decreases patients’anxiety,pain,dissatisfaction and the dose of sedative and analgesic drugs during colonoscopy:A prospective randomized controlled trial显示文摘AIM: To determine whether listening to music decreases the requirement for dosages of sedative drugs, patients’ anxiety, pain and dissatisfaction feelings during colonoscopy and makes the procedure more comfortable and acceptable. METHODS: Patients undergoing elective colonoscopy between October 2005 and February 2006 were randomized into either listening to music (Group 1, n = 30) or not listening to music (Group 2, n = 30). Anxiolytic and analgesic drugs (intravenous midazolam and meperidine) were given according to the patients’ demand. Administered medications were monitored. We determined their levels of anxiety using the State-Trait Anxiety Inventory Test form. Patients’ satisfaction, pain, and willingness to undergo a repeated procedure were self-assessed using a visual analog scale.RESULTS: The mean dose of sedative and analgesic drugs used in group 1 (midazolam: 2.1 ± 1.4, meperidine: 18.1 ± 11.7) was smaller than group 2 (midazolam: 2.4 ± 1.0, meperidine: 20.6 ± 11.5), but without a significant difference (P > 0.05). The mean anxiety level in group 1 was lower than group 2 (36.7 ± 2.2 vs 251.0 ± 1.9, P < 0.001). The mean satisfaction score was higher in group 1 compared to group 2 (87.8 ± 3.1 vs 58.1 ± 3.4, P < 0.001). The mean pain score in group 1 was lower than group 2 (74.1 ± 4.7 vs 39.0 ± 3.9, P < 0.001).CONCLUSION: Listening to music during colonoscopy helps reduce the dose of sedative medications, as well as patients’ anxiety, pain, dissatisfaction during the procedure. Therefore, we believe that listening to music can play an adjunctive role to sedation in colonoscopy. It is a simple, inexpensive way to improve patients’ comfort during the procedure. | Nimet Ovayolu Ozlem Ucan Seda Pehlivan Yavuz Pehlivan Hakan Buyukhatipoglu M Cemil Savas Murat T Gulsen | 2006 | World Journal of Gastroenterology2006，12，46： | 10 |
| 2 | Leptin levels in the differential diagnosis between benign and malignant ascites显示文摘AIM: To evaluate the role of leptin levels in the differential diagnosis of ascites. METHODS: Ascitic leptin, TNFα and serum leptin levels were measured in 77 patients with ascites (35 with malignancies, 30 cirrhosis and 12 tuberculosis). Control serum samples were obtained from 20 healthy subjects. Leptin and TNFα levels were measured by ELISA. Body mass index (BMI) and percentage of body fat (BFM) by skin fold measurement were calculated for all patients and control groups. Peritoneal biopsy, ascites cytology and cultures or biochemical values were used for the diagnosis of patients. RESULTS: In patients with malignancies, the mean serum and ascites leptin levels and their ratios were significantly decreased compared to the other patient groups and controls. In tuberculosis peritonitis, ascitic fluid TNFα levels were significantly higher than malignant ascites and cirrhotic sterile ascites. BMI and BFM values did not distinguish between patients and controls. CONCLUSION: In patients with malignant ascites, levels of leptin and TNFα were significantly lower than in patients with tuberculous ascites. | Mehmet Buyukberber Mehmet Koruk M Cemil Savas Murat T Gulsen Yavuz Pehlivan Rukiye Deveci Alper Sevinc Serdar Gergerlioglu | 2007 | World Journal of Gastroenterology2007，13，3： | 7 |
| 3 | Therapeutic effect of caffeic acid phenethyl ester on cerulein-induced acute pancreatitis显示文摘AIM: To evaluate the therapeutic role of caffeic acid phenethyl ester (CAPE) in a rat model of ceruleaninduced acute pancreatitis (AP).METHODS: Seventy male Wistar albino rats were divided into seven groups. Acute edematous pancreatitis was induced by subcutaneous cerulein injection (20 μg/kg) four times at 1-h intervals. CAPE (30 mg/kg) was given by subcutaneous injection at the beginning (CAPE 1 group) and 12 h after the last cerulein injection (CAPE 2 group). Serum amylase, lipase, white blood cell count, and tumor necrosis factor (TNF)-α levels were measured, and pancreatic histopathology was assessed. RESULTS: In the AP group, amylase and lipase levels were found to be elevated and the histopathological evaluation showed massive edema and inflammation of the pancreas, with less fatty necrosis when compared with sham and control groups. Amylase and lipase levels and edema formation decreased signif icantly in the CAPE therapy groups (P < 0001); especially in the CAPE 2 group, edema was improved nearly completely (P = 0001). Inflammation and fatty necrosis were partially recovered by CAPE treatment. The pathologicalresults and amylase level in the placebo groups were similar to those in the AP group. White blood cell count and TNF-α concentration was nearly the same in the CAPE and placebo groups.CONCLUSION: CAPE may be useful agent in treatment of AP but more experimental and clinical studies are needed to support our observation of benef icial effects of CAPE before clinical usage of this agent. | Mehmet Buyukberber M Cemil Savas Cahit Bagci Mehmet Koruk Murat T Gulsen Ediz Tutar Tugba Bilgic Nurdan Ceylan | 2009 | World Journal of Gastroenterology2009，15，41： | 4 |
| 4 | Enteral glutamine pretreatment does not decrease plasma endotoxin level induced by ischemia-reperfusion injury in rats显示文摘AIM:To investigate whether oral glutamine pretreatment prevents impairment of intestinal mucosal integrity during ischemia-reperfusion (I/R) in rats. METHODS: The study was performed as two series with 40 rats in each. Each series of animals was divided into four groups. The first group was used as a control. Animals in the second group were only pretreated with oral glutamine, 1 g/kg for 4 d. The third group received a normal diet, and underwent intestinal I/R, while the fourth group was pretreated with oral glutamine in the same way, and underwent intestinal I/R. Intestinal mucosal permeability to 51Cr-labeled EDTA was measured in urine in the first series of animals. In the second series, histopathological changes in intestinal tissue and plasma endotoxin levels were evaluated. RESULTS: Intestinal I/R produced a significant increase in intestinal permeability, plasma endotoxin level and worsened histopathological alterations. After intestinal I/R, permeability was significantly lower in glutamine- treated rats compared to those which received a normal diet. However, no significant change was observed in plasma endotoxin levels or histopathological findings. CONCLUSION: Although glutamine pretreatment seems to be protective of intestinal integrity, upon I/R injury, such an effect was not observable in the histopathological changes or plasma endotoxin level. | Arda Demirkan Erkin Orazakunov Berna Sava■ M Ayhan Kuzu Mehmet Melli | 2008 | World Journal of Gastroenterology2008，14，3： | 2 |
| 5 | Bismaleimide monomers with amide units synthesis andproperties显示文摘 | Sava M | 2006 | Apply Polymer Sci2006，101，1： | 1 |
| 6 | Transforaminal lum- bar interbody fusion:the effect of various instrumentation tech- niques on the flexibility of the lumbar spine显示文摘 | Harris B M Hilibrand A S Savas P E | 2004 | Spine2004，29，4： | 1 |
| 7 | A novel melanin-like pigment derived from black tea leaves with immuno-stimulating activity 显示文摘 | Sava V M Galkin B N Hong M Y | 2001 | Food Research International2001，34，4： | 1 |
| 8 | Preparation and polymerization of bismaleimide compounds显示文摘 | SAVA M SAVA I COZAN V | 2007 | Journal of Applied Polymer Science2007，106，4： | 1 |
| 9 | Serum ubiquitin levels in patients with nonalcoholic steatohepatitis显示文摘 | Savas M C Koruk M Pirim I | 2003 | Hepatogastroenterology2003，50，51： | 1 |
| 10 | Intestinal atresia with segmental musculature and neural defect显示文摘 | Savas C Ozguner M | 2005 | J Pediatr Surg2005，40，8： | 1 |
| 11 | Isolation and characterization of melanicpigment显示文摘 | Sava V M Yang S M Hong M Y | 1994 | Food Science1994，，2： | 1 |
| 12 | Quetiapine and ziprasidone as adjuncts in treatment-resistant obsessive- compulsive disorder: a retrospective comparative study 显示文摘 | SAVAS H A YUMRU M OZEN M E | 2008 | Clin Drug Investig2008，28，7： | 1 |
| 13 | Epide- miologic, clinical, and imaging findings in brucellosis pa- tients with osteoarticular involvement 显示文摘 | Pourbagher A Pourbagher M A Savas L | 2006 | AJR Am J Ro- entgenol2006，187，4： | 1 |
| 14 | Serum level of acute phase proteins patients with nonalcoholic steatohepatitis显示文摘 | KORUK M TAYSI S SAVAS MC | 2003 | Turk J Gastroenterol2003，14，1： | 1 |
| 15 | Endotoxin level in is-chemia-reperfusion injury in rats:effect of glutamine pretreatment on endotoxin levels and gut morphology显示文摘 | Demirkan A Savas B Melli M | | 0，，01： | 1 |
| 16 | Experimental study of the instability of unequal-strength counter-rotating vortex pairs显示文摘 | Ortega J M Bristol R L Savas O | 2003 | Journal of Fluid Mechanics2003，474，： | 1 |
| 17 | Serum ubiquitin levels in patients with nonalcoholic steatohepatitis 显示文摘 | Savas MC Koruk M Pirim I | 2003 | Hepatogastroenterology2003，50，51： | 1 |
| 18 | Subarachnoid bleeding into the superior cerebello- pontine cistern after radiofrequency trigeminal rbizotomy: case report 显示文摘 | Savas A Sayin M | 2010 | Acta Neurochirurgica2010，152，3： | 1 |
| 19 | Intestinal Atresia with Segmental Musculature and Neural Defect显示文摘 | Ozguner IF Savas C Ozguner M | 2005 | J Pediatr Surg2005，10，8： | 1 |
| 20 | Transforaminal lum- bar interbody fusion: the effect of various instrumentation tech- niques on the flexibility of the lumbar spine 显示文摘 | Harris B M Hilibrand A S Savas P E | 2004 | Spine2004，29，4： | 1 |
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