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| 1 | Timely reperfusion for ST-segment elevation myocardial infarction:Effect of direct transfer to primary angioplasty on time delays and clinical outcomes显示文摘Primary percutaneous coronary intervention(PPCI) is the preferred reperfusion therapy for patients presenting with ST-segment elevation myocardial infarction(STEMI) when it can be performed expeditiously and by experienced operators. In spite of excellent clinical results this technique is associated with longer delays than thrombolysis and this fact may nullify the benefit of selecting this therapeutic option. Several strategies have been proposed to decrease the temporal delays to deliver PPCI. Among them,prehospital diagnosis and direct transfer to the cath lab,by-passing the emergency department of hospitals,has emerged as anattractive way of diminishing delays. The purpose of this review is to address the effect of direct transfer on time delays and clinical events of patients with STEMI treated by PPCI. | Rodrigo Estévez-Loureiro ángela López-Sainz Armo Pérez de Prado Carlos Cuellas Ramón Calvio Santos Norberto Alonso-Orcajo Jorge Salgado Fernández Jose Manuel Vázquez-Rodríguez Maria López-Benito Felipe Fernández-Vázquez | 2014 | World Journal of Cardiology2014，6，6： | 6 |
| 2 | 中等收入国家年轻人脑卒中发病率增加:基于10年人口的研究显示文摘高收入国家年轻人脑卒中的发病率正在上升。然而,低收入和中等收入国家年轻人的脑卒中发病趋势仍未知。该研究旨在分析2005—2015年在巴西Joinville的年轻人的缺血性脑卒中(isehemic stroke,IS)和脑出血的发病趋势。 | 刘莉 叶鹏 Cabral NL Freire AT Conforto AB Dos Santos N Reis FI Nagel V Guesser VV Safanelli J Longo AL | 2017 | 中华高血压杂志2017，25，11： | 6 |
| 3 | Plant Growth-Promoting Traits in Rhizobacteria of Heavy Metal-Resistant Plants and Their Effects on Brassica nigra Seed Germination显示文摘Phytoremediation is an emerging technology that uses plants and their associated microbes to clean up pollutants from the soil, water, and air. In order to select the plant growth-promoting rhizobacteria(PGPR) for phytoremediation of heavy metal contamination, 60 bacterial strains were isolated from the rhizosphere of two endemic plants, Prosopis laevigata and Spharealcea angustifolia, in a heavy metal-contaminated zone in Mexico. These rhizobacterial strains were characterized for the growth at different pH and salinity, extracellular enzyme production, solubilization of phosphate, heavy metal resistance, and plant growth-promoting(PGP) traits, including production of siderophores and indol-3-acetic acid(IAA). Overall, the obtained rhizobacteria presented multiple PGP traits. These rhizobacteria were also resistant to high levels of heavy metals(including As as a metalloid)(up to 480 mmol L(-1)As(V), 24 mmol L(-1)Pb(Ⅱ), 21 mmol L(-1)Cu(Ⅱ), and 4.5 mmol L(-1)Zn(Ⅱ)). Seven rhizobacterial strains with the best PGP traits were identified as members of Alcaligenes, Bacillus, Curtobacterium, and Microbacterium, and were selected for further bioassay.The inoculation of Brassica nigra seeds with Microbacterium sp. CE3R2, Microbacterium sp. NE1R5, Curtobacterium sp. NM1R1,and Microbacterium sp. NM3E9 facilitated the root development; they significantly improved the B. nigra seed germination and root growth in the presence of heavy metals such as 2.2 mmol L(-1)Zn(Ⅱ). The rhizobacterial strains isolated in the present study had the potential to be used as efficient bioinoculants in phytorremediation of soils contaminated with multiple heavy metals. | Brenda ROMN-PONCE Diana Miryel REZA-VZQUEZ Sonia GUTIRREZ-PAREDES María de Jesús DE HARO-CRUZ Jessica MALDONADO-HERNNDEZ Yanely BAHENA-OSORIO Paulina ESTRADA-DE LOS SANTOS En Tao WANG María Soledad VSQUEZ-MURRIETA | 2017 | Pedosphere2017，27，3： | 4 |
| 4 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 5 | Diagnostic yield and clinical outcomes after capsule endoscopy in 100 consecutive patients with obscure gastrointestinal bleeding显示文摘 | Emilio Estévez Benito González-Conde José Luis Vázquez-Iglesias Maria de los Angeles Vázquez-Millán Sonia Pértega Pedro A. Alonso Joan Clofent Eva Santos José Luis Ulla Eloy Sánchez | 2006 | European Journal of Gastroenterology & Hepatology2006，，8： | 3 |
| 6 | Optimization of carotenoid production by Phaffia rhodozyma cells grown on xylose 显示文摘 | PARAJO J C SANTOS V VAZQUEZ M | 1998 | Process Biochem1998，33，2： | 1 |
| 7 | Angiostatic activity of human plasminogen fragments is highly dependent on glycosylation 显示文摘 | Santos I C Silbiger V N Higuchi D A | 2010 | Cancer Sci2010，101，2： | 1 |
| 8 | Formic acid-perocyformic acid pulping of Aspenwood and optimization study显示文摘 | Abad By S Santos V Parajo J C | 2000 | Holzforschung2000，，54： | 1 |
| 9 | Effect of CO2 Addition to Raw Milk on Proteolysis and Lipolysis at 4℃显示文摘 | MA Y BARBANO D M SANTOS M V | 2003 | J Dairy Sci2003，86，： | 1 |
| 10 | Evaluation ff mild hyp'rhomocysteinemia during the development of atherosclero- sis in apolipoprotein E- deficient and normal mice 显示文摘 | ALESSIO A C SANTOS C X DEBBAS V e! al | 2011 | Exp Mol Pathol2011，90，1： | 1 |
| 11 | Xanthan gum:production,recovery,and properties显示文摘 | Garcia-Ochoa F Santos V E Casas J A | | 0，，： | 1 |
| 12 | Xanthan gum:production,recovery,and properties显示文摘 | García-Ochoa F Santos V E Casas J A | 2000 | Biotechnology Advances2000，18，7： | 1 |
| 13 | Mechanical properties of HSLA bainitic steel subjected to controlled rolling with accelerated cooling显示文摘 | RODRIGUES P C M PERELOMA E V SANTOS D B | 2000 | Materials Science and Engineering: A2000，283，： | 1 |
| 14 | Degradation and removal methods of antibiotics from aqueousmatrices-areview显示文摘 | Homem V Santos L | 2011 | Journal of Environmental Management2011，92，10： | 1 |
| 15 | Lactic acid from wood 显示文摘 | PARAJO J C ALONSO J L SANTOS V | 1996 | Process Biochemistry1996，31，3： | 1 |
| 16 | Oxygen-uptake and mass·transfer rates on the growth of Pseudomonas putida CECT5279:Influence on biodesulfurization(BDS)capability显示文摘 | Santos V E Alcon A | 2006 | Energy & Fuels2006，20，4： | 1 |
| 17 | Dehydration studies of rare earth p-toluenesulfonate hydrates by TG/DTG and DSC 显示文摘 | Santos A V Matos J R | 2002 | Al- loyscomp2002，344，12： | 1 |
| 18 | Soil microbial metabolism and nutrient status in a Mediterranean area as affected by plant cover显示文摘 | RUTIGLIANO F A ASCOLI R D DE SANTO A V | 2004 | Soil Biology and Biochemistry2004，36，： | 1 |
| 19 | De novo synthesis of cyclooxygenase-1 counteracts the suppression of platelet thromboxane biosynthesis by aspirin 显示文摘 | Evangelista V Manarini S di Santo A | 2006 | Circ Res2006，98，5： | 1 |
| 20 | Vascular en- dothelia~ growth factor expression in the urethral epithelium of castrated adult female rats treated with tamoxifen显示文摘 | Dos Santos A R Lopes-Costa P V da Silva B B | 2009 | Gynecol Endocrinol2009，25，5： | 1 |
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